ES2071325T3 - Derivados de 4-alquilimidazol. - Google Patents

Derivados de 4-alquilimidazol.

Info

Publication number
ES2071325T3
ES2071325T3 ES91914167T ES91914167T ES2071325T3 ES 2071325 T3 ES2071325 T3 ES 2071325T3 ES 91914167 T ES91914167 T ES 91914167T ES 91914167 T ES91914167 T ES 91914167T ES 2071325 T3 ES2071325 T3 ES 2071325T3
Authority
ES
Spain
Prior art keywords
alkylimidazole
derivatives
hypersentitive
angiotensin
cooh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91914167T
Other languages
English (en)
Inventor
David John Carini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Application granted granted Critical
Publication of ES2071325T3 publication Critical patent/ES2071325T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Lubricants (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

COMPUESTOS ANTIHIPERSENTITIVOS ANTAGONISTAS DE ANGIOTENSINA II COMO LOS REPRESENTADOS POR LA FORMULA (I), DONDE R2 ES CHO O COOH Y R1 ES ETILO, POSEEN EFICACIA ORAL IMPORTANTE.
ES91914167T 1990-07-13 1991-07-15 Derivados de 4-alquilimidazol. Expired - Lifetime ES2071325T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55263790A 1990-07-13 1990-07-13
US07/650,258 US5137902A (en) 1990-07-13 1991-02-04 4-alkylimidazole derivatives and anti-hypertensive use thereof

Publications (1)

Publication Number Publication Date
ES2071325T3 true ES2071325T3 (es) 1995-06-16

Family

ID=27070086

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91914167T Expired - Lifetime ES2071325T3 (es) 1990-07-13 1991-07-15 Derivados de 4-alquilimidazol.

Country Status (23)

Country Link
US (1) US5137902A (es)
EP (1) EP0539509B1 (es)
JP (1) JP2550455B2 (es)
KR (1) KR0162669B1 (es)
AT (1) ATE121087T1 (es)
AU (1) AU639400B2 (es)
BG (1) BG61341B1 (es)
CA (1) CA2087274C (es)
CZ (1) CZ280018B6 (es)
DE (1) DE69108913T2 (es)
DK (1) DK0539509T3 (es)
ES (1) ES2071325T3 (es)
FI (1) FI102752B1 (es)
HU (2) HUT63411A (es)
IE (1) IE69849B1 (es)
IL (1) IL98794A (es)
MY (1) MY140243A (es)
NO (1) NO303015B1 (es)
NZ (1) NZ238920A (es)
PL (1) PL168311B1 (es)
RO (1) RO111270B1 (es)
SK (1) SK279326B6 (es)
WO (1) WO1992000977A2 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
DE4132633A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Cyclisch substituierte imidazolyl-propensaeurederivate
US5250558A (en) * 1992-01-28 1993-10-05 Merck & Co., Inc. Substituted triazolinones, triazolinethiones, and triazolinimines as neurotensin antagonists used to treat psychosis
US5326776A (en) * 1992-03-02 1994-07-05 Abbott Laboratories Angiotensin II receptor antagonists
GB9218449D0 (en) 1992-08-29 1992-10-14 Boots Co Plc Therapeutic agents
US5310929A (en) * 1992-08-06 1994-05-10 E. I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
NO304429B1 (no) * 1992-12-17 1998-12-14 Sankyo Co Bifenylderivater, farmas°ytisk preparat og deres anvendelse for fremstilling av et medikament for behandling av hypertensjon og hjertesykdom
US5338740A (en) * 1993-07-13 1994-08-16 Pfizer Inc. Angiotensin II receptor antagonists
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
WO2001082858A2 (de) * 2000-05-04 2001-11-08 Ipf Pharmaceuticals Gmbh Neue verbindungen zur behandlung inflammatorischer und kardiovaskulärer erkrankungen
EP1750862B1 (en) 2004-06-04 2011-01-05 Teva Pharmaceutical Industries Ltd. Pharmaceutical composition containing irbesartan
KR20090102883A (ko) * 2004-09-02 2009-09-30 테바 파마슈티컬 인더스트리즈 리미티드 올메살탄 메독소밀의 정제
US20070054948A1 (en) * 2004-09-02 2007-03-08 Lilach Hedvati Purification of olmesartan medoxomil
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
EA201592263A1 (ru) 2013-06-05 2016-05-31 Синерджи Фармасьютикалз, Инк. Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
US5064825A (en) * 1989-06-01 1991-11-12 Merck & Co., Inc. Angiotensin ii antagonists
EP0479903B1 (en) * 1989-06-30 1996-02-21 E.I. Du Pont De Nemours And Company Substituted imidazoles useful as angiotensin ii blockers
JP2568315B2 (ja) * 1989-06-30 1997-01-08 イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー 縮合環アリール置換イミダゾール
DE4132633A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Cyclisch substituierte imidazolyl-propensaeurederivate

Also Published As

Publication number Publication date
HU9204058D0 (en) 1993-03-29
BG61341B1 (en) 1997-06-30
IL98794A0 (en) 1992-07-15
EP0539509A1 (en) 1993-05-05
AU8311691A (en) 1992-02-04
HU223530B1 (hu) 2004-08-30
KR0162669B1 (ko) 1998-12-01
WO1992000977A2 (en) 1992-01-23
SK391292A3 (en) 1993-07-07
SK279326B6 (sk) 1998-10-07
IE69849B1 (en) 1996-10-02
FI102752B (fi) 1999-02-15
US5137902A (en) 1992-08-11
PL297616A1 (es) 1992-07-13
ATE121087T1 (de) 1995-04-15
PL168311B1 (pl) 1996-02-29
BG97438A (bg) 1994-03-24
NZ238920A (en) 1993-07-27
DE69108913T2 (de) 1995-08-24
EP0539509B1 (en) 1995-04-12
FI930109A0 (fi) 1993-01-12
DE69108913D1 (de) 1995-05-18
IL98794A (en) 1995-11-27
WO1992000977A3 (en) 1992-02-20
RO111270B1 (ro) 1996-08-30
NO303015B1 (no) 1998-05-18
IE912438A1 (en) 1992-01-15
CZ391292A3 (en) 1993-12-15
JPH05508415A (ja) 1993-11-25
AU639400B2 (en) 1993-07-22
HUT63411A (en) 1993-08-30
CA2087274C (en) 2002-02-19
DK0539509T3 (da) 1995-07-03
NO930088L (no) 1993-01-11
JP2550455B2 (ja) 1996-11-06
MY140243A (en) 2009-12-31
NO930088D0 (no) 1993-01-11
FI102752B1 (fi) 1999-02-15
FI930109A (fi) 1993-01-12
CZ280018B6 (cs) 1995-09-13
CA2087274A1 (en) 1992-01-14

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