EA201592263A1 - Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования - Google Patents

Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования

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Publication number
EA201592263A1
EA201592263A1 EA201592263A EA201592263A EA201592263A1 EA 201592263 A1 EA201592263 A1 EA 201592263A1 EA 201592263 A EA201592263 A EA 201592263A EA 201592263 A EA201592263 A EA 201592263A EA 201592263 A1 EA201592263 A1 EA 201592263A1
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EA
Eurasian Patent Office
Prior art keywords
ultrascular
guanylacyclase
agonists
receiving
stage
Prior art date
Application number
EA201592263A
Other languages
English (en)
Inventor
Кунвар Шайлубхай
Стефен Комиски
Жун Фэн
Цзюньцай Бай
Жопин Чжан
Цзюнь Цзя
Цзюньфэн Чжоу
Цяо Чжао
Гоцин Чжан
Original Assignee
Синерджи Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51062980&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201592263(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Синерджи Фармасьютикалз, Инк. filed Critical Синерджи Фармасьютикалз, Инк.
Publication of EA201592263A1 publication Critical patent/EA201592263A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y406/00—Phosphorus-oxygen lyases (4.6)
    • C12Y406/01—Phosphorus-oxygen lyases (4.6.1)
    • C12Y406/01002—Guanylate cyclase (4.6.1.2)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Изобретение относится к способам очистки пептида, содержащего последовательность агониста GCC, выбранную из группы, состоящей из SEQ ID NO: 1-251, описываемым в настоящем документе. Способы включают в себя стадию замены растворителя перед стадией сублимационной сушки (лиофилизации).
EA201592263A 2013-06-05 2014-06-05 Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования EA201592263A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361831402P 2013-06-05 2013-06-05
PCT/US2014/041143 WO2014197720A2 (en) 2013-06-05 2014-06-05 Ultra-pure agonists of guanylate cyclase c, method of making and using same

Publications (1)

Publication Number Publication Date
EA201592263A1 true EA201592263A1 (ru) 2016-05-31

Family

ID=51062980

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201592263A EA201592263A1 (ru) 2013-06-05 2014-06-05 Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования

Country Status (18)

Country Link
US (7) US10011637B2 (ru)
EP (2) EP4424697A2 (ru)
JP (1) JP6606491B2 (ru)
KR (1) KR102272746B1 (ru)
CN (2) CN105764916B (ru)
AU (3) AU2014274812B2 (ru)
BR (1) BR112015030326A2 (ru)
CA (1) CA2913737A1 (ru)
EA (1) EA201592263A1 (ru)
ES (1) ES2981866T3 (ru)
HK (1) HK1221959A1 (ru)
HR (1) HRP20240805T1 (ru)
IL (1) IL242939B (ru)
PL (1) PL3004138T3 (ru)
PT (1) PT3004138T (ru)
RS (1) RS65632B1 (ru)
SI (1) SI3004138T1 (ru)
WO (1) WO2014197720A2 (ru)

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MX354786B (es) * 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
JP6393037B2 (ja) * 2010-09-15 2018-09-19 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃアゴニストの製剤および使用方法
EA201592263A1 (ru) * 2013-06-05 2016-05-31 Синерджи Фармасьютикалз, Инк. Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования
US20160235807A1 (en) * 2013-10-09 2016-08-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for downregulation of pro-inflammatory cytokines
CN104628827B (zh) * 2015-03-10 2018-01-19 南京工业大学 一种普利卡那肽的制备方法
CN108884130B (zh) 2016-01-11 2022-09-13 博士医疗爱尔兰有限公司 用于治疗溃疡性结肠炎的制剂和方法
CN108864254B (zh) * 2017-05-10 2021-03-16 深圳翰宇药业股份有限公司 一种普利卡那肽的制备方法
CN107383170A (zh) * 2017-08-15 2017-11-24 苏州科技大学 一种普卡那肽的简易合成方法
CN107383171A (zh) * 2017-08-15 2017-11-24 苏州科技大学 一种通过二次环化固相合成普卡那肽的方法
CN110835365B (zh) * 2018-08-15 2021-09-17 深圳翰宇药业股份有限公司 一种普卡那肽的制备方法
KR20210102362A (ko) * 2018-12-08 2021-08-19 엔진 바이오사이언스 리미티드 플레카나타이드의 개선된 제조 방법
WO2020250102A1 (en) * 2019-06-10 2020-12-17 Auro Peptides Ltd An improved process for the preparation of plecanatide
WO2021255639A1 (en) * 2020-06-17 2021-12-23 Anthem Biosciences Private Limited Synthesis of a guanylate cyclase agonist by fragments based approach
CN116056719A (zh) * 2020-06-30 2023-05-02 索伦·欧克维克 包含鸟苷酸环化酶c(gucy2c)激动剂和短链脂肪酸或其前药的组合的药物组合物
CN112194708A (zh) * 2020-10-28 2021-01-08 杭州信海医药科技有限公司 一种普卡那肽的制备方法
CN113244791B (zh) * 2021-05-12 2022-06-17 佳木斯大学 一种共混大黄素的酚酞聚醚砜超滤膜的制备方法
CN114573662B (zh) * 2021-09-30 2024-06-11 深圳翰宇药业股份有限公司 一种普卡那肽铵盐的制备方法
CN116789764A (zh) * 2023-05-30 2023-09-22 北京悦康科创医药科技股份有限公司 一种高效广谱的抗冠状病毒多肽的制备方法
CN117538461B (zh) * 2024-01-10 2024-03-26 地奥集团成都药业股份有限公司 一种盐酸贝那普利片有关物质的检测方法

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