EA201201435A1 - ГЕТЕРОДИМЕРНЫЕ АНТИТЕЛО-Fc-СОДЕРЖАЩИЕ БЕЛКИ И СПОСОБЫ ИХ ПОЛУЧЕНИЯ - Google Patents

ГЕТЕРОДИМЕРНЫЕ АНТИТЕЛО-Fc-СОДЕРЖАЩИЕ БЕЛКИ И СПОСОБЫ ИХ ПОЛУЧЕНИЯ

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Publication number
EA201201435A1
EA201201435A1 EA201201435A EA201201435A EA201201435A1 EA 201201435 A1 EA201201435 A1 EA 201201435A1 EA 201201435 A EA201201435 A EA 201201435A EA 201201435 A EA201201435 A EA 201201435A EA 201201435 A1 EA201201435 A1 EA 201201435A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
antibody
heterodimerny
receiving
containing proteins
Prior art date
Application number
EA201201435A
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English (en)
Inventor
Аран Франк Лабрейн
Йойсе Местерс
Эвалд ван ден Бремер
Йост Й. Нейссен
Патрик ван Беркел
Барт де Гуэй
Том Винк
Ян Ван Де Винкел
Янине Схюирман
Пауль Паррен
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Генмаб А/С
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Application filed by Генмаб А/С filed Critical Генмаб А/С
Publication of EA201201435A1 publication Critical patent/EA201201435A1/ru

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    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
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    • C07K2317/00—Immunoglobulins specific features
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Abstract

Описываются новые гетеродимерные антитело-Fc-содержащие белки, такие как биспецифические антитела, и новые способы получения таких белков.
EA201201435A 2010-04-20 2011-04-20 ГЕТЕРОДИМЕРНЫЕ АНТИТЕЛО-Fc-СОДЕРЖАЩИЕ БЕЛКИ И СПОСОБЫ ИХ ПОЛУЧЕНИЯ EA201201435A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32608210P 2010-04-20 2010-04-20
DKPA201000330 2010-04-20
DKPA201001066 2010-11-24
PCT/EP2011/056388 WO2011131746A2 (en) 2010-04-20 2011-04-20 Heterodimeric antibody fc-containing proteins and methods for production thereof

Publications (1)

Publication Number Publication Date
EA201201435A1 true EA201201435A1 (ru) 2013-04-30

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ID=44226045

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EA201201435A EA201201435A1 (ru) 2010-04-20 2011-04-20 ГЕТЕРОДИМЕРНЫЕ АНТИТЕЛО-Fc-СОДЕРЖАЩИЕ БЕЛКИ И СПОСОБЫ ИХ ПОЛУЧЕНИЯ

Country Status (14)

Country Link
US (4) US9150663B2 (ru)
EP (1) EP2560993A2 (ru)
JP (3) JP6040148B2 (ru)
KR (2) KR101930964B1 (ru)
CN (2) CN110066339A (ru)
AU (1) AU2011244282A1 (ru)
BR (1) BR122021015749B1 (ru)
CA (1) CA2796181C (ru)
EA (1) EA201201435A1 (ru)
IL (1) IL222507B (ru)
MX (1) MX353144B (ru)
NZ (1) NZ701825A (ru)
SG (2) SG10201800757TA (ru)
WO (1) WO2011131746A2 (ru)

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