|
US4331647A
(en)
|
1980-03-03 |
1982-05-25 |
Goldenberg Milton David |
Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
|
|
US4376110A
(en)
|
1980-08-04 |
1983-03-08 |
Hybritech, Incorporated |
Immunometric assays using monoclonal antibodies
|
|
US4411993A
(en)
|
1981-04-29 |
1983-10-25 |
Steven Gillis |
Hybridoma antibody which inhibits interleukin 2 activity
|
|
US4427115A
(en)
|
1981-10-19 |
1984-01-24 |
Laipply Thomas C |
One piece alcohol preparation device
|
|
USRE32011E
(en)
|
1981-12-14 |
1985-10-22 |
Scripps Clinic And Research Foundation |
Ultrapurification of factor VIII using monoclonal antibodies
|
|
US4543439A
(en)
|
1982-12-13 |
1985-09-24 |
Massachusetts Institute Of Technology |
Production and use of monoclonal antibodies to phosphotyrosine-containing proteins
|
|
US6054561A
(en)
|
1984-02-08 |
2000-04-25 |
Chiron Corporation |
Antigen-binding sites of antibody molecules specific for cancer antigens
|
|
DE3417525C1
(de)
|
1984-05-11 |
1986-01-09 |
Matter + Siegmann Ag, Wohlen |
Vorrichtung zur quantitativen und qualitativen Erfassung von kohlenwasserstoffhaltigen Schwebeteilchen in Gasen
|
|
US4902614A
(en)
|
1984-12-03 |
1990-02-20 |
Teijin Limited |
Monoclonal antibody to human protein C
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
US5571714A
(en)
|
1988-12-22 |
1996-11-05 |
Celtrix Pharmaceuticals, Inc. |
Monoclonal antibodies which bind both transforming growth factors β1 and β2 and methods of use
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5549910A
(en)
|
1989-03-31 |
1996-08-27 |
The Regents Of The University Of California |
Preparation of liposome and lipid complex compositions
|
|
US5177197A
(en)
|
1990-02-27 |
1993-01-05 |
Ludwig Institute For Cancer Research |
Isolated nucleotide sequence expressing human transforming growth factor-β1-binding protein
|
|
US5466468A
(en)
|
1990-04-03 |
1995-11-14 |
Ciba-Geigy Corporation |
Parenterally administrable liposome formulation comprising synthetic lipids
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
JP3218637B2
(ja)
|
1990-07-26 |
2001-10-15 |
大正製薬株式会社 |
安定なリポソーム水懸濁液
|
|
CA2090126C
(en)
|
1990-08-02 |
2002-10-22 |
John W. Schrader |
Methods for the production of proteins with a desired function
|
|
JP2958076B2
(ja)
|
1990-08-27 |
1999-10-06 |
株式会社ビタミン研究所 |
遺伝子導入用多重膜リポソーム及び遺伝子捕捉多重膜リポソーム製剤並びにその製法
|
|
US5877397A
(en)
|
1990-08-29 |
1999-03-02 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5698426A
(en)
|
1990-09-28 |
1997-12-16 |
Ixsys, Incorporated |
Surface expression libraries of heteromeric receptors
|
|
JPH04141095A
(ja)
|
1990-10-02 |
1992-05-14 |
Chemo Sero Therapeut Res Inst |
組換え抗ｈｉｖ改変抗体および改変抗体の調製方法
|
|
US5070108A
(en)
|
1990-10-12 |
1991-12-03 |
Trustees Of The University Of Pennsylvania |
Methods of treating osteoporosis, increasing bone mineral content and preventing the occurrence of compression fractures in a mammal
|
|
JPH06502311A
(ja)
|
1990-10-22 |
1994-03-17 |
フォックス・チェイス・キャンサー・センター |
Ｒｎａ療法を提供するためのｄｎａ構造
|
|
US5145684A
(en)
|
1991-01-25 |
1992-09-08 |
Sterling Drug Inc. |
Surface modified drug nanoparticles
|
|
US5399363A
(en)
|
1991-01-25 |
1995-03-21 |
Eastman Kodak Company |
Surface modified anticancer nanoparticles
|
|
ES2134212T3
(es)
|
1991-04-25 |
1999-10-01 |
Chugai Pharmaceutical Co Ltd |
Anticuerpo humano reconstituido contra el receptor de la interleuquina 6 humano.
|
|
CA2164505A1
(en)
|
1993-06-07 |
1994-12-22 |
Phillip W. Berman |
Hiv envelope polypeptides
|
|
US5543158A
(en)
|
1993-07-23 |
1996-08-06 |
Massachusetts Institute Of Technology |
Biodegradable injectable nanoparticles
|
|
US5453492A
(en)
|
1993-07-28 |
1995-09-26 |
La Jolla Cancer Research Foundation |
60 kDa transforming growth factor-β-binding protein and its use to detect or purify TGF-β
|
|
US5837458A
(en)
|
1994-02-17 |
1998-11-17 |
Maxygen, Inc. |
Methods and compositions for cellular and metabolic engineering
|
|
US5605793A
(en)
|
1994-02-17 |
1997-02-25 |
Affymax Technologies N.V. |
Methods for in vitro recombination
|
|
CA2187902A1
(en)
|
1994-04-29 |
1995-11-09 |
Peter Ten Dijke |
Morphogenic protein-specific cell surface receptors and uses therefor
|
|
NZ288997A
(en)
|
1994-06-24 |
1999-01-28 |
Immunex Corp |
Controlled release pharmaceutical formulation comprising polypeptide encapsulated in alginate
|
|
DE4427221A1
(de)
|
1994-08-01 |
1996-02-08 |
Gsf Forschungszentrum Umwelt |
Retrovirus-induzierte Osteoklasten-Modulation für die Osteoporose-Therapie
|
|
US5846770A
(en)
|
1994-11-22 |
1998-12-08 |
Genetics Institute, Inc. |
DNA molecules encoding human chordin
|
|
US6057421A
(en)
|
1994-11-30 |
2000-05-02 |
Immpheron, Inc. |
Variable heavy and light chain regions of murine monoclonal antibody 1F7
|
|
US5795587A
(en)
|
1995-01-23 |
1998-08-18 |
University Of Pittsburgh |
Stable lipid-comprising drug delivery complexes and methods for their production
|
|
IL112834A
(en)
|
1995-03-01 |
2000-12-06 |
Yeda Res & Dev |
Pharmaceutical compositions for controlled release of soluble receptors
|
|
IE80468B1
(en)
|
1995-04-04 |
1998-07-29 |
Elan Corp Plc |
Controlled release biodegradable nanoparticles containing insulin
|
|
EP0871705A4
(en)
|
1995-06-05 |
2000-01-26 |
Human Genome Sciences Inc |
CCN TYPE HUMAN GROWTH FACTOR
|
|
US5738868A
(en)
|
1995-07-18 |
1998-04-14 |
Lipogenics Ltd. |
Liposome compositions and kits therefor
|
|
ATE403001T1
(de)
|
1996-05-22 |
2008-08-15 |
Viventia Biotech Inc |
Antigenbindungsfragmente die spezifisch krebszellen nachweisen, nukleotide die für diese fragmente kodieren, und deren verwendung zur vorbeugung und zum nachweis von krebs
|
|
US6133426A
(en)
|
1997-02-21 |
2000-10-17 |
Genentech, Inc. |
Humanized anti-IL-8 monoclonal antibodies
|
|
US5989909A
(en)
|
1997-09-26 |
1999-11-23 |
Millennium Biotherapeutics, Inc. |
Huchordin and uses thereof
|
|
AU6959898A
(en)
|
1997-04-11 |
1998-11-11 |
David J. Grainger |
Compounds and therapies for the prevention of vascular and non-vascular pathol ogies
|
|
US6020004A
(en)
|
1997-04-17 |
2000-02-01 |
Amgen Inc. |
Biodegradable microparticles for the sustained delivery of therapeutic drugs
|
|
US6673901B2
(en)
|
1997-06-12 |
2004-01-06 |
Research Corporation Technologies, Inc. |
Artificial antibody polypeptides
|
|
US6075007A
(en)
|
1997-07-17 |
2000-06-13 |
Regeneron Pharmaceuticals, Inc. |
Modified noggin polypeptide and compositions
|
|
WO1999006554A2
(en)
|
1997-08-01 |
1999-02-11 |
Genset |
5' ESTs FOR SECRETED PROTEINS EXPRESSED IN MUSCLE AND OTHER MESODERMAL TISSUES
|
|
US6815201B2
(en)
|
1997-09-08 |
2004-11-09 |
The Public Health Research Institute Of The City Of New York, Inc. |
HIV-1 gp120 V1/V2 domain epitopes capable of generating neutralizing antibodies
|
|
US6541606B2
(en)
|
1997-12-31 |
2003-04-01 |
Altus Biologics Inc. |
Stabilized protein crystals formulations containing them and methods of making them
|
|
US6432449B1
(en)
|
1998-05-18 |
2002-08-13 |
Amgen Inc. |
Biodegradable sustained-release alginate gels
|
|
US6541033B1
(en)
|
1998-06-30 |
2003-04-01 |
Amgen Inc. |
Thermosensitive biodegradable hydrogels for sustained delivery of leptin
|
|
US6544485B1
(en)
|
2001-01-29 |
2003-04-08 |
Sharper Image Corporation |
Electro-kinetic device with enhanced anti-microorganism capability
|
|
US6395511B1
(en)
|
1998-11-27 |
2002-05-28 |
Darwin Discovery, Ltd. |
Nucleic acids encoding a novel family of TGF-β binding proteins from humans
|
|
US20040009535A1
(en)
|
1998-11-27 |
2004-01-15 |
Celltech R&D, Inc. |
Compositions and methods for increasing bone mineralization
|
|
US6245740B1
(en)
|
1998-12-23 |
2001-06-12 |
Amgen Inc. |
Polyol:oil suspensions for the sustained release of proteins
|
|
US6451346B1
(en)
|
1998-12-23 |
2002-09-17 |
Amgen Inc |
Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents
|
|
JP2002536968A
(ja)
|
1999-01-29 |
2002-11-05 |
イムクローン システムズ インコーポレイティド |
Ｋｄｒに特異的な抗体およびその使用
|
|
AU4851900A
(en)
|
1999-06-09 |
2000-12-28 |
Genentech Inc. |
Compositions and methods for the treatment of tumor
|
|
EP1266000A1
(en)
|
2000-03-02 |
2002-12-18 |
Amgen Inc. |
Chordin-like-2 molecules and uses thereof
|
|
WO2001092308A2
(en)
|
2000-06-01 |
2001-12-06 |
Amgen, Inc. |
Cystine-knot polypeptides: cloaked-2 molecules and uses thereof
|
|
JP2004520005A
(ja)
|
2000-06-19 |
2004-07-08 |
エフ．ホフマン−ラ ロシュ アーゲー |
オステオレビン遺伝子多型性
|
|
AU2002216610A1
(en)
|
2000-09-01 |
2002-04-02 |
Genentech Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
|
AU1344102A
(en)
|
2000-10-12 |
2002-04-22 |
Genentech Inc |
Reduced-viscosity concentrated protein formulations
|
|
KR20030074693A
(ko)
*
|
2000-12-28 |
2003-09-19 |
알투스 바이올로직스 인코포레이티드 |
전항체 및 이의 단편의 결정과 이의 제조 및 사용 방법
|
|
US20030133939A1
(en)
|
2001-01-17 |
2003-07-17 |
Genecraft, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
CA2374027A1
(en)
|
2001-03-13 |
2002-09-13 |
The Minister Of National Defence |
Cloning, expression, sequencing, and functional enhancement of monoclonal scfv antibody against venezuelan equine encephalitis virus(vee)
|
|
DE10145772A1
(de)
|
2001-09-17 |
2003-04-10 |
Bayer Cropscience Ag |
DELTA·1·-Pyrroline
|
|
EP1451560B1
(en)
|
2001-12-06 |
2017-11-29 |
BioControl Systems, Inc. |
Sample collection and testing system
|
|
US20030186915A1
(en)
|
2002-02-11 |
2003-10-02 |
Yang Pan |
Regulatory polynucleotides and uses thereof
|
|
WO2003073991A2
(en)
|
2002-03-01 |
2003-09-12 |
Celltech R & D, Inc. |
Methods to increase or decrease bone density
|
|
WO2003087763A2
(en)
|
2002-04-03 |
2003-10-23 |
Celltech R & D, Inc. |
Association of polymorphisms in the sost gene region with bone mineral density
|
|
US20040023356A1
(en)
|
2002-06-14 |
2004-02-05 |
Robb Krumlauf |
Wise/Sost nucleic acid sequences and amino acid sequences
|
|
US7893218B2
(en)
|
2003-06-16 |
2011-02-22 |
Stowers Institute For Medical Research |
Antibodies that specifically bind SOST peptides
|
|
US7758876B2
(en)
|
2002-11-01 |
2010-07-20 |
The United States Of America As Represented By The Department Of Health And Human Services |
Method of preventing infections from bioterrorism agents with immunostimulatory CpG oligonucleotides
|
|
US7642238B2
(en)
|
2002-12-05 |
2010-01-05 |
Shaughnessy John D |
Molecular determinants of myeloma bone disease and uses thereof
|
|
US20040141875A1
(en)
|
2003-01-15 |
2004-07-22 |
Rajiv Doshi |
System and method for treating microorganisms within motor vehicle heating, ventilation, and air conditioning units
|
|
PT1608399E
(pt)
|
2003-03-14 |
2012-04-13 |
Ucb Mfg Inc |
Complexo de esclerostina e noguina ou cordina, e agentes que modulam a formação do referido complexo
|
|
US20050158303A1
(en)
|
2003-04-04 |
2005-07-21 |
Genentech, Inc. |
Methods of treating IgE-mediated disorders comprising the administration of high concentration anti-IgE antibody formulations
|
|
CU23403A1
(es)
|
2003-04-23 |
2009-08-04 |
Centro Inmunologia Molecular |
Anticuerpos recombinantes y fragmentos que reconocen el gangliósido n-glicolil gm3 y su uso para diagnóstico y tratamiento de tumores
|
|
NZ544618A
(en)
|
2003-06-16 |
2009-02-28 |
Celltech R & D Inc |
Antibodies specific for sclerostin and methods for increasing bone mineralization
|
|
US8461155B2
(en)
|
2003-09-22 |
2013-06-11 |
University Of Connecticut |
Sclerostin and the inhibition of WNT signaling and bone formation
|
|
US20050267233A1
(en)
|
2004-05-25 |
2005-12-01 |
Joshi Ashok V |
Anti-microbial handle system
|
|
JP4994232B2
(ja)
*
|
2004-07-23 |
2012-08-08 |
ジェネンテック， インコーポレイテッド |
抗体又はその断片の結晶化
|
|
WO2006015373A2
(en)
|
2004-08-04 |
2006-02-09 |
Amgen Inc |
Antibodies to dkk-1
|
|
US8003108B2
(en)
|
2005-05-03 |
2011-08-23 |
Amgen Inc. |
Sclerostin epitopes
|
|
US7592429B2
(en)
|
2005-05-03 |
2009-09-22 |
Ucb Sa |
Sclerostin-binding antibody
|
|
WO2007080129A1
(en)
|
2006-01-13 |
2007-07-19 |
A Chan Holding B.V. |
Treatment and diagnosis of abnormal bone density with an inhibitor of the glypican-sclerostin interaction
|
|
EP2097450A2
(en)
|
2006-11-10 |
2009-09-09 |
Amgen Inc. |
Antibody-based diagnostics and therapeutics
|
|
US20100015665A1
(en)
|
2006-11-10 |
2010-01-21 |
Ucb Pharma S.A. |
Antibodies and diagnostics
|
|
PL3345607T3
(pl)
|
2006-12-29 |
2023-01-09 |
Ossifi-Mab Llc |
Sposoby modyfikowania wzrostu kości poprzez podanie antagonisty lub agonisty sost lub wise
|
|
EA200901031A1
(ru)
|
2007-02-02 |
2010-04-30 |
Новартис Аг |
Модуляторы склеростин-связывающих партнеров для лечения костных расстройств
|
|
WO2008115732A2
(en)
|
2007-03-20 |
2008-09-25 |
Eli Lilly And Company |
Anti-sclerostin antibodies
|
|
NZ598881A
(en)
*
|
2007-03-29 |
2013-11-29 |
Abbvie Inc |
Crystalline anti-human il-12 antibodies
|
|
US8753839B2
(en)
*
|
2007-08-08 |
2014-06-17 |
Abbvie Inc. |
Compositions and methods for crystallizing antibodies
|
|
CL2008002775A1
(es)
|
2007-09-17 |
2008-11-07 |
Amgen Inc |
Uso de un agente de unión a esclerostina para inhibir la resorción ósea.
|
|
AR068767A1
(es)
|
2007-10-12 |
2009-12-02 |
Novartis Ag |
Anticuerpos contra esclerostina, composiciones y metodos de uso de estos anticuerpos para tratar un trastorno patologico mediado por esclerostina
|
|
DK2567709T3
(en)
|
2007-11-02 |
2018-03-12 |
Novartis Ag |
Molecules and Methods for Modulating Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6)
|
|
AU2008338464A1
(en)
|
2007-12-14 |
2009-06-25 |
Amgen Inc. |
Method for treating bone fracture with anti-sclerostin antibodies
|
|
CA2726087A1
(en)
|
2008-06-03 |
2009-12-10 |
Tariq Ghayur |
Dual variable domain immunoglobulins and uses thereof
|
|
WO2010100200A2
(en)
|
2009-03-05 |
2010-09-10 |
Novartis Ag |
Lyophilised antibody formulation
|
|
WO2010100179A2
(en)
|
2009-03-05 |
2010-09-10 |
Novartis Ag |
Self-forming gel system for sustained drug delivery
|
|
WO2010115932A1
(en)
|
2009-04-08 |
2010-10-14 |
Novartis Ag |
Combination for the treatment of bone loss
|
|
WO2010130830A2
(en)
|
2009-05-15 |
2010-11-18 |
Ablynx N.V. |
Amino acid sequences directed against sclerostin and polypeptides comprising the same for the treatment of bone diseases and disorders
|
|
WO2012028683A1
(en)
|
2010-09-02 |
2012-03-08 |
Novartis Ag |
Antibody gel system for sustained drug delivery
|
|
TWI636994B
(zh)
|
2010-10-27 |
2018-10-01 |
安美基公司 |
Ｄｋｋ１抗體及使用方法
|
|
EP2797953B1
(en)
|
2011-12-28 |
2020-06-03 |
Amgen Inc. |
Method of treating alveolar bone loss through the use of anti-sclerostin antibodies
|