ES2134212T3 - Anticuerpo humano reconstituido contra el receptor de la interleuquina 6 humano. - Google Patents

Anticuerpo humano reconstituido contra el receptor de la interleuquina 6 humano.

Info

Publication number
ES2134212T3
ES2134212T3 ES92909376T ES92909376T ES2134212T3 ES 2134212 T3 ES2134212 T3 ES 2134212T3 ES 92909376 T ES92909376 T ES 92909376T ES 92909376 T ES92909376 T ES 92909376T ES 2134212 T3 ES2134212 T3 ES 2134212T3
Authority
ES
Spain
Prior art keywords
human
chain
region
interleukin
reconstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92909376T
Other languages
English (en)
Inventor
Masayuki Tsuchiya
Koh Sato
Mary Margaret Bendig
Steven Tarran Jones
Jose William Saldanha
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26370596&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2134212(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from JP3095476A external-priority patent/JPH05236966A/ja
Priority claimed from JP4032084A external-priority patent/JPH05227970A/ja
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2134212T3 publication Critical patent/ES2134212T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

SE PRESENTA UN ANTICUERPO HUMANO RECONSTITUIDO CONTRA EL RECEPTOR DE LA INTERLEUQUINA-6 HUMANA (IL-6R) QUE SE COMPONE DE A) UNA CADENA L COMPUESTA DE (1) LA REGION C DE UNA CADENA L HUMANA Y (2) LA REGION V DE UNA CADENA L QUE COMPRENDA LA REGION ESTRUCTURAL (FR) DE UNA CADENA L HUMANA Y LA REGION DE DETERMINACION COMPLEMENTARIA (CDR) DE LA CADENA I DE UN ANTICUERPO MONOCLONAL DE UN RATON CONTRA LA IL-6R HUMANA, Y B) UNA CADENA H COMPUESTA DE (1) LA REGION C DE UNA CADENA H HUMANA Y (2) LA REGION V DE UNA CADENA H QUE COMPRENDA LA FR DE UNA CADENA H HUMANA Y LA CDR DE LA CADENA H DE UN ANTICUERPO MONOCLONAL DE UN RATON CONTRA UNA IL-6R HUMANA. DESDE EL MOMENTO QUE LA MAYORIA DEL ANTICUERPO HUMANO RECONSTITUIDO SE ORIGINA EN ANTICUERPOS HUMANOS Y LA CDR ES LEVEMENTE ANTIGENICA, ESTE ANTICUERPO ES LEVEMENTE ANTIGENICO CONTRA EL SER HUMANO Y POR LO TANTO PUEDE UTILIZARSE COMO AGENTE TERAPEUTICO.
ES92909376T 1991-04-25 1992-04-24 Anticuerpo humano reconstituido contra el receptor de la interleuquina 6 humano. Expired - Lifetime ES2134212T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP3095476A JPH05236966A (ja) 1991-04-25 1991-04-25 ヒトインターロイキン−６レセプターに対するマウスモノクローナル抗体の可変領域をコードするｄｎａ
JP4032084A JPH05227970A (ja) 1992-02-19 1992-02-19 ヒトインターロイキン−６受容体に対する再構成ヒト抗体

Publications (1)

Publication Number Publication Date
ES2134212T3 true ES2134212T3 (es) 1999-10-01

Family

ID=26370596

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92909376T Expired - Lifetime ES2134212T3 (es) 1991-04-25 1992-04-24 Anticuerpo humano reconstituido contra el receptor de la interleuquina 6 humano.

Country Status (16)

Country Link
US (3) US5795965A (es)
EP (1) EP0628639B1 (es)
JP (6) JP3370324B2 (es)
KR (1) KR100249937B1 (es)
AT (1) ATE181575T1 (es)
AU (2) AU668349B2 (es)
DE (2) DE69229482T2 (es)
DK (1) DK0628639T3 (es)
ES (1) ES2134212T3 (es)
GR (1) GR3031174T3 (es)
HU (1) HU218140B (es)
LU (1) LU91556I2 (es)
NL (1) NL300383I2 (es)
RU (1) RU2139351C1 (es)
TW (1) TW205553B (es)
WO (1) WO1992019759A1 (es)

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