MX2020004100A - Metodo para generacion in vivo de anticuerpos multiespecificos a partir de anticuerpos monoespecificos. - Google Patents

Metodo para generacion in vivo de anticuerpos multiespecificos a partir de anticuerpos monoespecificos.

Info

Publication number
MX2020004100A
MX2020004100A MX2020004100A MX2020004100A MX2020004100A MX 2020004100 A MX2020004100 A MX 2020004100A MX 2020004100 A MX2020004100 A MX 2020004100A MX 2020004100 A MX2020004100 A MX 2020004100A MX 2020004100 A MX2020004100 A MX 2020004100A
Authority
MX
Mexico
Prior art keywords
antibodies
multispecific antibodies
generation
vivo generation
monospecific
Prior art date
Application number
MX2020004100A
Other languages
English (en)
Inventor
Ulrich Brinkmann
Klaus Mayer
Steffen Dickopf
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2020004100A publication Critical patent/MX2020004100A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

En la presente se reporta un método para la generación de anticuerpos multiespecíficos directamente en la superficie celular en el sitio de acción mediante una reacción de intercambio de mitades de anticuerpos entre dos 2/3-IgG o dos 2/3-BiFab desestabilizadas por la mitad mediante mutaciones perturbadoras asimétricas que fomentan la generación de anticuerpos biespecíficos o multiespecíficos de longitud completa correctamente ensamblados. El método se realiza en la ausencia de enlaces de disulfuro de región bisagra en las 2/3-IgG o 2/3-BiFab iniciales.
MX2020004100A 2017-10-30 2018-10-29 Metodo para generacion in vivo de anticuerpos multiespecificos a partir de anticuerpos monoespecificos. MX2020004100A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17199086 2017-10-30
PCT/EP2018/079523 WO2019086362A1 (en) 2017-10-30 2018-10-29 Method for in vivo generation of multispecific antibodies from monospecific antibodies

Publications (1)

Publication Number Publication Date
MX2020004100A true MX2020004100A (es) 2020-07-24

Family

ID=60413028

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020004100A MX2020004100A (es) 2017-10-30 2018-10-29 Metodo para generacion in vivo de anticuerpos multiespecificos a partir de anticuerpos monoespecificos.

Country Status (12)

Country Link
US (2) US12180279B2 (es)
EP (1) EP3704145A1 (es)
JP (2) JP7438942B2 (es)
KR (1) KR102831164B1 (es)
CN (1) CN111372947B (es)
AU (1) AU2018358883B2 (es)
BR (1) BR112020007736A2 (es)
CA (1) CA3078676A1 (es)
IL (1) IL274071B2 (es)
MX (1) MX2020004100A (es)
TW (1) TWI832824B (es)
WO (1) WO2019086362A1 (es)

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TW202106715A (zh) * 2019-04-25 2021-02-16 瑞士商赫孚孟拉羅股份公司 藉由多肽鏈交換活化之治療性多特異性多肽
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US20230212320A1 (en) * 2020-06-01 2023-07-06 Mustbio Co., Ltd. Bispecific Antibody Or Antigen-Binding Fragment Thereof, And Preparation Method Therefor
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CN116601175A (zh) * 2020-12-18 2023-08-15 豪夫迈·罗氏有限公司 用于靶向疗法的前体蛋白和试剂盒
WO2024104933A1 (en) * 2022-11-15 2024-05-23 F. Hoffmann-La Roche Ag Antigen binding molecules
CN120603846A (zh) * 2023-01-25 2025-09-05 豪夫迈·罗氏有限公司 承载有效载荷的多特异性抗体
EP4574839A1 (en) * 2023-12-22 2025-06-25 BioNTech SE Co-delivery system
TW202527999A (zh) 2023-11-10 2025-07-16 德商拜恩技術股份公司 共同遞送系統
CN117467025B (zh) * 2023-12-28 2024-04-16 上海鼎新基因科技有限公司 一种抗vegf和补体双功能融合蛋白及其应用

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TW201932494A (zh) 2019-08-16
US12180279B2 (en) 2024-12-31
KR20200074195A (ko) 2020-06-24
JP2021501181A (ja) 2021-01-14
CN111372947B (zh) 2025-08-15
JP2024001197A (ja) 2024-01-09
EP3704145A1 (en) 2020-09-09
CN111372947A (zh) 2020-07-03
TWI832824B (zh) 2024-02-21
WO2019086362A1 (en) 2019-05-09
IL274071B1 (en) 2025-06-01
IL274071B2 (en) 2025-10-01
US20250206821A1 (en) 2025-06-26
AU2018358883B2 (en) 2025-09-25
IL274071A (en) 2020-06-30
BR112020007736A2 (pt) 2020-10-20
US20200255522A1 (en) 2020-08-13
KR102831164B1 (ko) 2025-07-07
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JP7438942B2 (ja) 2024-02-27
CA3078676A1 (en) 2019-05-09

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