JO3799B1 - الأجسام المضادة ل bcma، جزيئات ربط الانتيجين ثنائية التحديد التي تربط bcma و cd3، و استخداماتها - Google Patents

الأجسام المضادة ل bcma، جزيئات ربط الانتيجين ثنائية التحديد التي تربط bcma و cd3، و استخداماتها

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Publication number
JO3799B1
JO3799B1 JOP/2016/0184A JOP20160184A JO3799B1 JO 3799 B1 JO3799 B1 JO 3799B1 JO P20160184 A JOP20160184 A JO P20160184A JO 3799 B1 JO3799 B1 JO 3799B1
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Prior art keywords
bcma
antibodies
antigen
binding fragments
cancer
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JOP/2016/0184A
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English (en)
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Attar Ricardo
D Powers Gordon
Gaudet Francois
Pillarisetti Kodandaram
Thomas Baldwin Eric
Maria Fernandes Cardoso Rosa
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Janssen Pharmaceutica Nv
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    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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Abstract

<strong><span dir="RTL">تم بهذه الوثيقة توفير أجسام مضادة ترتبط على نحو محدد مناعيًا بـ</span> BCMA. <span dir="RTL">ورد أيضًا وصف للبولي نوكليوتيدات ذات الصلة التي يمكنها تشفير الأجسام المضادة التي تم توفيرها والتي لها نوعية تجاه</span> BCMA <span dir="RTL">أو الشظايا الرابطة لمولِّدات الضد، أو خلايا تعبر عن الأجسام المضادة التي تم توفيرها أو الشظايا الرابطة لمولدات الضد، وكذلك النواقل المرتبطة والأجسام المضادة المرقَّمة بصورة قابلة للكشف والشظايا الرابطة لمولدات الضد. إضافةً إلى ذلك، تم وصف طرق لاستخدام الأجسام المضادة التي تم توفيرها. فعلى سبيل المثال، قد يتم استخدام الأجسام المضادة المتوفرة لتشخيص أو معالجة أو مراقبة مدى تقدم السرطان الذي يعبر عن</span> BCMA <span dir="RTL">أو تراجعه أو استقراره؛ وذلك لتحديد ما إذا كان من الضروري علاج المريض من السرطان أم لا، أو لتحديد إذا ما كان الشخص موضوع الدراسة مصابًا بسرطان يعبر عن</span> BCMA <span dir="RTL">ومن ثم اتخاذ قرار حول ما إذا كان من المناسب علاجه بدواء مضاد للسرطان خاص بـ</span> BCMA<span dir="RTL">، مثل الأجسام المضادة متعددة النوعية تجاه</span> BCMA <span dir="RTL">و</span>CD3 <span dir="RTL">اللذين ورد وصفهما هنا</span>.</strong>
JOP/2016/0184A 2015-08-17 2016-08-16 الأجسام المضادة ل bcma، جزيئات ربط الانتيجين ثنائية التحديد التي تربط bcma و cd3، و استخداماتها JO3799B1 (ar)

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