EA202192505A1 - Способы получения композиций антитела к фно - Google Patents

Способы получения композиций антитела к фно

Info

Publication number
EA202192505A1
EA202192505A1 EA202192505A EA202192505A EA202192505A1 EA 202192505 A1 EA202192505 A1 EA 202192505A1 EA 202192505 A EA202192505 A EA 202192505A EA 202192505 A EA202192505 A EA 202192505A EA 202192505 A1 EA202192505 A1 EA 202192505A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tnf
antibodies
methods
obtaining compositions
compositions
Prior art date
Application number
EA202192505A
Other languages
English (en)
Inventor
Кристофер Барнтаус
Субинай Гангули
Мартен Груневелд
мл. Мануэль А. Лопес
Майкл Недвед
Кевин Д. Смит
Original Assignee
Янссен Байотек, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Байотек, Инк. filed Critical Янссен Байотек, Инк.
Publication of EA202192505A1 publication Critical patent/EA202192505A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

В настоящем документе представлены способы получения рекомбинантного антитела к ФНО, имеющего тяжелую цепь (HC), содержащую SEQ ID NO:38, и легкую цепь (LC), содержащую SEQ ID NO:37, а также композиции, содержащие рекомбинантное антитело к ФНО.
EA202192505A 2019-03-14 2020-02-26 Способы получения композиций антитела к фно EA202192505A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962818316P 2019-03-14 2019-03-14
PCT/IB2020/051635 WO2020183270A1 (en) 2019-03-14 2020-02-26 Methods for producing anti-tnf antibody compositions

Publications (1)

Publication Number Publication Date
EA202192505A1 true EA202192505A1 (ru) 2022-03-29

Family

ID=69784490

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202192505A EA202192505A1 (ru) 2019-03-14 2020-02-26 Способы получения композиций антитела к фно

Country Status (12)

Country Link
US (1) US20220144934A1 (ru)
EP (1) EP3938391A1 (ru)
JP (1) JP2022526881A (ru)
KR (1) KR20210141976A (ru)
CN (1) CN113825769A (ru)
AR (1) AR118354A1 (ru)
CA (1) CA3133383A1 (ru)
EA (1) EA202192505A1 (ru)
IL (1) IL286309A (ru)
MA (1) MA55283A (ru)
TW (1) TW202100553A (ru)
WO (1) WO2020183270A1 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240034218A (ko) * 2021-07-09 2024-03-13 얀센 바이오테크 인코포레이티드 항-tnf 항체 조성물을 생산하기 위한 제조 방법

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CN113825769A (zh) 2021-12-21
AR118354A1 (es) 2021-09-29
US20220144934A1 (en) 2022-05-12
JP2022526881A (ja) 2022-05-27
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