EA201070888A1 - Антитела и их производные - Google Patents
Антитела и их производныеInfo
- Publication number
- EA201070888A1 EA201070888A1 EA201070888A EA201070888A EA201070888A1 EA 201070888 A1 EA201070888 A1 EA 201070888A1 EA 201070888 A EA201070888 A EA 201070888A EA 201070888 A EA201070888 A EA 201070888A EA 201070888 A1 EA201070888 A1 EA 201070888A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- antibodies
- derivatives
- variants
- chain variable
- variable region
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/30—Fuel from waste, e.g. synthetic alcohol or diesel
Abstract
Предложено антитело против TrkA, которое включает: a) вариабельную область тяжелой цепи, включающую последовательность, выбранную из BXhVH1, BXhVH2, BXhVH3, BXhVH4, BXhVH5 или HuVHWOv, приведенных на фиг. 1a; или из вариантов любой из указанных последовательностей; и/или b) вариабельную область легкой цепи, включающую последовательность, выбранную из: BXhVL1, BXhVL2, BXhVL3, BXhVL4, BXhVL5, BXhVL6, BXhVL7 или BXhVL8, приведенных на фиг. 1b, или из вариантов любой из указанных последовательностей. Также предложены производные антител, которые связывают TrkA. Антитела или производные антител согласно настоящему изобретению полезны в ряде способов лечения, включая терапию боли.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2599508P | 2008-02-04 | 2008-02-04 | |
PCT/EP2009/051285 WO2009098238A1 (en) | 2008-02-04 | 2009-02-04 | Anti-trka antibodies and derivatives thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201070888A1 true EA201070888A1 (ru) | 2011-04-29 |
EA021284B1 EA021284B1 (ru) | 2015-05-29 |
Family
ID=40521960
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201070888A EA021284B1 (ru) | 2008-02-04 | 2009-02-04 | Антитела и их производные |
Country Status (21)
Country | Link |
---|---|
US (1) | US9751947B2 (ru) |
EP (1) | EP2252633B9 (ru) |
JP (1) | JP5719596B2 (ru) |
KR (1) | KR101782857B1 (ru) |
CN (1) | CN101939337B (ru) |
AP (1) | AP2929A (ru) |
AU (1) | AU2009211340B2 (ru) |
BR (1) | BRPI0905955A8 (ru) |
CA (1) | CA2713786A1 (ru) |
DK (1) | DK2252633T3 (ru) |
EA (1) | EA021284B1 (ru) |
ES (1) | ES2435917T3 (ru) |
HK (1) | HK1150314A1 (ru) |
IL (1) | IL207390A (ru) |
MX (1) | MX2010008571A (ru) |
MY (1) | MY191348A (ru) |
NZ (1) | NZ587701A (ru) |
PL (1) | PL2252633T3 (ru) |
PT (1) | PT2252633E (ru) |
WO (1) | WO2009098238A1 (ru) |
ZA (1) | ZA201006218B (ru) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1306704B1 (it) | 1999-05-26 | 2001-10-02 | Sirs Societa Italiana Per La R | Anticorpi monoclonali e suoi derivati sintetici o biotecnologici ingrado di agire come molecole antagoniste per il ngf. |
ITRM20050290A1 (it) | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
ITRM20050332A1 (it) | 2005-06-24 | 2006-12-25 | Lay Line Genomics Spa | Uso di molecole in grado di bloccare l'attivita' di trka per potenziare gli effetti di analgesici oppiacei sul dolore. |
ES2435917T3 (es) | 2008-02-04 | 2013-12-26 | Lay Line Genomics S.P.A. | Anticuerpos anti-Trk-A y derivados de los mismos |
WO2010029497A1 (en) * | 2008-09-12 | 2010-03-18 | Pfizer Limited | Treatment of endometriosis |
US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
KR20190112175A (ko) | 2010-12-01 | 2019-10-02 | 앨더바이오 홀딩스 엘엘씨 | 항―ngf 조성물 및 그의 용도 |
US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
US20150183885A1 (en) * | 2012-06-08 | 2015-07-02 | Glenmark Pharmaceuticals S.A. | Anti-trka antibodies with enhanced inhibitory properties and derivatives thereof |
AP2014008145A0 (en) | 2012-06-08 | 2014-12-31 | Glenmark Pharmaceuticals Sa | Humanized anti-trkA antibodies with animo acid substitutions |
EP2674439B1 (en) | 2012-06-13 | 2017-02-01 | Rottapharm Biotech S.r.l. | Anti-TrkA antibodies, derivatives and uses thereof |
MA41097A (fr) * | 2014-12-05 | 2017-10-10 | Glenmark Pharmaceuticals Sa | Anticorps anti-trka à propriétés inhibitrices améliorées et dérivés desdits anticorps destinés à être utilisés pour traiter les douleurs osseuses |
US10793634B2 (en) | 2017-06-09 | 2020-10-06 | Boehringer Ingelheim International Gmbh | Anti-TrkB antibodies |
AR114110A1 (es) | 2018-02-28 | 2020-07-22 | Lilly Co Eli | Anticuerpo anti-trka |
CN109628425A (zh) * | 2019-01-02 | 2019-04-16 | 周越 | 一种人原肌球蛋白受体激酶a突变体及应用 |
CN112010978B (zh) * | 2019-05-30 | 2022-04-08 | 广东东阳光药业有限公司 | TrkA的抗体及其应用 |
WO2021092482A1 (en) * | 2019-11-06 | 2021-05-14 | The Regents Of The University Of California | Compositions and methods for transferrin receptor 1 targeting |
US20230357411A1 (en) * | 2020-11-20 | 2023-11-09 | Sunshine Lake Pharma Co., Ltd. | Humanized anti-trka antibodies and uses thereof |
CN112961244B (zh) | 2021-02-28 | 2023-08-29 | 熙源安健医药(上海)有限公司 | 抗TrkA抗体或其抗原结合片段、其制备方法和应用 |
WO2023125477A1 (en) * | 2021-12-28 | 2023-07-06 | 4B Technologies (Beijing) Co., Limited | TrkA ANTIBODY AND APPLICATION THEREOF |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0307434B2 (en) * | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Altered antibodies |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US6491916B1 (en) * | 1994-06-01 | 2002-12-10 | Tolerance Therapeutics, Inc. | Methods and materials for modulation of the immunosuppresive activity and toxicity of monoclonal antibodies |
GB9525180D0 (en) | 1995-12-08 | 1996-02-07 | Univ Mcgill | Design of hormone-like antibodies with agonistic and antagonistic fuctions |
WO1998045435A2 (en) | 1997-04-10 | 1998-10-15 | Genetics Institute, Inc. | SECRETED EXPRESSED SEQUENCE TAGS (sESTs) |
US6194551B1 (en) * | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
GB2340334B (en) * | 1998-07-29 | 2003-06-25 | Ericsson Telefon Ab L M | Telephone apparatus |
IT1306704B1 (it) * | 1999-05-26 | 2001-10-02 | Sirs Societa Italiana Per La R | Anticorpi monoclonali e suoi derivati sintetici o biotecnologici ingrado di agire come molecole antagoniste per il ngf. |
FR2807660A1 (fr) | 2000-04-13 | 2001-10-19 | Warner Lambert Co | Utilisation d'antagonistes du ngf pour la prevention ou le traitement de douleurs viscerales chroniques |
AU2003304238A1 (en) | 2002-10-08 | 2005-01-13 | Rinat Neuroscience Corp. | Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody and compositions containing the same |
PL211654B1 (pl) | 2002-10-08 | 2012-06-29 | Rinat Neuroscience Corp | Przeciwciało skierowane przeciwko NGF do zastosowania w leczeniu bólu pooperacyjnego, zastosowanie tego przeciwciała do wytwarzania leku do leczenia bólu pooperacyjnego i kompozycja farmaceutyczna zawierająca przeciwciało skierowane przeciwko NGF do zastosowania w leczeniu bólu pooperacyjnego |
UA80447C2 (en) | 2002-10-08 | 2007-09-25 | Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic | |
ITRM20030601A1 (it) * | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
JP5301152B2 (ja) | 2004-04-07 | 2013-09-25 | ライナット ニューロサイエンス コーポレイション | 神経成長因子アンタゴニストを投与することによって骨癌の疼痛を処置するための方法 |
ITRM20050290A1 (it) | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
ITRM20050332A1 (it) * | 2005-06-24 | 2006-12-25 | Lay Line Genomics Spa | Uso di molecole in grado di bloccare l'attivita' di trka per potenziare gli effetti di analgesici oppiacei sul dolore. |
ES2435917T3 (es) | 2008-02-04 | 2013-12-26 | Lay Line Genomics S.P.A. | Anticuerpos anti-Trk-A y derivados de los mismos |
US8460657B2 (en) | 2008-06-25 | 2013-06-11 | H. Lundbeck A/S | Modulation of the TrpV: Vps10p receptor system for the treatment of pain |
-
2009
- 2009-02-04 ES ES09708019T patent/ES2435917T3/es active Active
- 2009-02-04 MY MYPI2010003574A patent/MY191348A/en unknown
- 2009-02-04 JP JP2010544733A patent/JP5719596B2/ja not_active Expired - Fee Related
- 2009-02-04 PT PT97080196T patent/PT2252633E/pt unknown
- 2009-02-04 NZ NZ587701A patent/NZ587701A/xx not_active IP Right Cessation
- 2009-02-04 KR KR1020107019748A patent/KR101782857B1/ko active IP Right Grant
- 2009-02-04 CN CN200980104123.7A patent/CN101939337B/zh not_active Expired - Fee Related
- 2009-02-04 EA EA201070888A patent/EA021284B1/ru unknown
- 2009-02-04 BR BRPI0905955A patent/BRPI0905955A8/pt not_active Application Discontinuation
- 2009-02-04 US US12/866,184 patent/US9751947B2/en active Active
- 2009-02-04 AU AU2009211340A patent/AU2009211340B2/en not_active Ceased
- 2009-02-04 DK DK09708019.6T patent/DK2252633T3/da active
- 2009-02-04 WO PCT/EP2009/051285 patent/WO2009098238A1/en active Application Filing
- 2009-02-04 EP EP09708019.6A patent/EP2252633B9/en active Active
- 2009-02-04 MX MX2010008571A patent/MX2010008571A/es active IP Right Grant
- 2009-02-04 AP AP2010005379A patent/AP2929A/xx active
- 2009-02-04 CA CA2713786A patent/CA2713786A1/en not_active Abandoned
- 2009-02-04 PL PL09708019T patent/PL2252633T3/pl unknown
-
2010
- 2010-08-03 IL IL207390A patent/IL207390A/en active IP Right Grant
- 2010-08-31 ZA ZA2010/06218A patent/ZA201006218B/en unknown
-
2011
- 2011-04-12 HK HK11103684.2A patent/HK1150314A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP2252633B1 (en) | 2013-08-14 |
KR20100114536A (ko) | 2010-10-25 |
ES2435917T3 (es) | 2013-12-26 |
JP5719596B2 (ja) | 2015-05-20 |
CN101939337B (zh) | 2016-03-09 |
PL2252633T3 (pl) | 2014-02-28 |
HK1150314A1 (en) | 2011-11-25 |
MY191348A (en) | 2022-06-17 |
NZ587701A (en) | 2013-03-28 |
BRPI0905955A2 (pt) | 2015-08-04 |
AU2009211340A1 (en) | 2009-08-13 |
ES2435917T9 (es) | 2014-04-02 |
AP2010005379A0 (en) | 2010-08-31 |
PT2252633E (pt) | 2013-11-19 |
CA2713786A1 (en) | 2009-08-13 |
EA021284B1 (ru) | 2015-05-29 |
EP2252633B9 (en) | 2014-02-19 |
MX2010008571A (es) | 2010-12-02 |
IL207390A0 (en) | 2010-12-30 |
US20110145941A1 (en) | 2011-06-16 |
KR101782857B1 (ko) | 2017-09-28 |
BRPI0905955A8 (pt) | 2018-05-08 |
IL207390A (en) | 2015-06-30 |
CN101939337A (zh) | 2011-01-05 |
WO2009098238A1 (en) | 2009-08-13 |
DK2252633T3 (da) | 2013-11-11 |
AU2009211340B2 (en) | 2013-09-12 |
JP2011514314A (ja) | 2011-05-06 |
ZA201006218B (en) | 2011-08-31 |
US9751947B2 (en) | 2017-09-05 |
EP2252633A1 (en) | 2010-11-24 |
AP2929A (en) | 2014-06-30 |
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