IT1306704B1 - Anticorpi monoclonali e suoi derivati sintetici o biotecnologici ingrado di agire come molecole antagoniste per il ngf. - Google Patents
Anticorpi monoclonali e suoi derivati sintetici o biotecnologici ingrado di agire come molecole antagoniste per il ngf.Info
- Publication number
- IT1306704B1 IT1306704B1 IT1999RM000333A ITRM990333A IT1306704B1 IT 1306704 B1 IT1306704 B1 IT 1306704B1 IT 1999RM000333 A IT1999RM000333 A IT 1999RM000333A IT RM990333 A ITRM990333 A IT RM990333A IT 1306704 B1 IT1306704 B1 IT 1306704B1
- Authority
- IT
- Italy
- Prior art keywords
- ngf
- act
- synthetic
- monoclonal antibodies
- antagonist molecules
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1999RM000333A IT1306704B1 (it) | 1999-05-26 | 1999-05-26 | Anticorpi monoclonali e suoi derivati sintetici o biotecnologici ingrado di agire come molecole antagoniste per il ngf. |
US09/979,710 US7601352B1 (en) | 1999-05-26 | 2000-05-26 | Monoclonal antibodies and antigen binding fragments thereof capable of binding TrkA and inhibiting the functional activation of TrkA |
DK00935482.0T DK1181318T4 (da) | 1999-05-26 | 2000-05-26 | Monoklonale antistoffer samt syntetiske og bioteknologiske derivater deraf, der virker som NGF-antagonistmolekyler |
AU51019/00A AU776457B2 (en) | 1999-05-26 | 2000-05-26 | Monoclonal antibodies, synthetic and biotechnological derivatives thereof acting as NGF-antagonist molecules |
PT00935482T PT1181318E (pt) | 1999-05-26 | 2000-05-26 | Anticorpos monoclonais seus derivados sinteticos e biotecnologicos actuando como moleculas antagonistas de nge |
EP00935482A EP1181318B2 (en) | 1999-05-26 | 2000-05-26 | Monoclonal antibodies, synthetic and biotechnological derivatives thereof acting as ngf-antagonist molecules |
JP2001500668A JP4917226B2 (ja) | 1999-05-26 | 2000-05-26 | Ngf−アンタゴニスト分子として作用するモノクローナル抗体、その合成及び生命工学的誘導体 |
ES00935482T ES2218163T5 (es) | 1999-05-26 | 2000-05-26 | Anticuerpos monoclonales y sus derivados sintéticos y biotecnológicos que actúan como moléculas antagonistas de NGF |
AT00935482T ATE263188T1 (de) | 1999-05-26 | 2000-05-26 | Als ngf-antagonisten wirkende monoklonale antiköper und deren synthetische und biotechnologische derivate |
PCT/IT2000/000218 WO2000073344A2 (en) | 1999-05-26 | 2000-05-26 | Monoclonal antibodies, synthetic and biotechnological derivatives thereof acting as ngf-antagonist molecules |
DE60009484T DE60009484T3 (de) | 1999-05-26 | 2000-05-26 | Als ngf-antagonisten wirkende monoklonale antiköper und deren synthetische und biotechnologische derivate |
CA2373274A CA2373274C (en) | 1999-05-26 | 2000-05-26 | Monoclonal antibodies, synthetic and biotechnological derivatives thereof acting as ngf-antagonist molecules |
US12/557,825 US8486401B2 (en) | 1999-05-26 | 2009-09-11 | Monoclonal antibodies binding to TrkA and acting as NGF-antagonist molecules and their use for treating pain induced by NGF |
JP2011180419A JP2012040007A (ja) | 1999-05-26 | 2011-08-22 | Ngf−アンタゴニスト分子として作用するモノクローナル抗体、その合成及び生命工学的誘導体 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1999RM000333A IT1306704B1 (it) | 1999-05-26 | 1999-05-26 | Anticorpi monoclonali e suoi derivati sintetici o biotecnologici ingrado di agire come molecole antagoniste per il ngf. |
Publications (3)
Publication Number | Publication Date |
---|---|
ITRM990333A0 ITRM990333A0 (it) | 1999-05-26 |
ITRM990333A1 ITRM990333A1 (it) | 2000-11-26 |
IT1306704B1 true IT1306704B1 (it) | 2001-10-02 |
Family
ID=11406787
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT1999RM000333A IT1306704B1 (it) | 1999-05-26 | 1999-05-26 | Anticorpi monoclonali e suoi derivati sintetici o biotecnologici ingrado di agire come molecole antagoniste per il ngf. |
Country Status (12)
Country | Link |
---|---|
US (2) | US7601352B1 (it) |
EP (1) | EP1181318B2 (it) |
JP (2) | JP4917226B2 (it) |
AT (1) | ATE263188T1 (it) |
AU (1) | AU776457B2 (it) |
CA (1) | CA2373274C (it) |
DE (1) | DE60009484T3 (it) |
DK (1) | DK1181318T4 (it) |
ES (1) | ES2218163T5 (it) |
IT (1) | IT1306704B1 (it) |
PT (1) | PT1181318E (it) |
WO (1) | WO2000073344A2 (it) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1306704B1 (it) * | 1999-05-26 | 2001-10-02 | Sirs Societa Italiana Per La R | Anticorpi monoclonali e suoi derivati sintetici o biotecnologici ingrado di agire come molecole antagoniste per il ngf. |
FR2807660A1 (fr) * | 2000-04-13 | 2001-10-19 | Warner Lambert Co | Utilisation d'antagonistes du ngf pour la prevention ou le traitement de douleurs viscerales chroniques |
CA2448956C (en) * | 2001-05-30 | 2017-10-03 | Genentech, Inc. | Anti-ngf antibodies for the treatment of various disorders |
JP2006500004A (ja) * | 2001-12-31 | 2006-01-05 | スージェン・インコーポレーテッド | 遠縁ホモログを検出する方法および該方法により同定される新規キナーゼ |
UA80447C2 (en) | 2002-10-08 | 2007-09-25 | Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic | |
DE60335957D1 (de) | 2002-10-08 | 2011-03-17 | Rinat Neuroscience Corp | Verfahren zur behandlung von postoperativen schmerzen durch verabreichung eines antikörpers gegen nervenwachstumsfaktor und diesen enthaltende zusammensetzungen |
DK1575517T3 (da) | 2002-12-24 | 2012-05-14 | Rinat Neuroscience Corp | Anti-ngf-antistoffer og fremgangsmåder til anvendelse af samme |
US7569364B2 (en) | 2002-12-24 | 2009-08-04 | Pfizer Inc. | Anti-NGF antibodies and methods using same |
US9498530B2 (en) | 2002-12-24 | 2016-11-22 | Rinat Neuroscience Corp. | Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same |
CA2516454A1 (en) | 2003-02-19 | 2004-09-02 | Rinat Neuroscience Corp. | Methods for treating pain by administering a nerve growth factor antagonist and an nsaid and compositions containing the same |
ITRM20030601A1 (it) | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
TWI367101B (en) | 2004-04-07 | 2012-07-01 | Rinat Neuroscience Corp | Methods for treating bone cancer pain by administering a nerve growth factor antagonist |
AU2006207338B2 (en) | 2005-01-24 | 2011-12-08 | Elan Pharma International Limited | Specific binding members for NGF |
NZ561525A (en) | 2005-02-16 | 2010-11-26 | Astrazeneca Ab | Benzimidazole compounds and analogues, containing a pyrazole ring, for inhibition of Trk activity, affecting cancer |
WO2006123113A2 (en) | 2005-05-16 | 2006-11-23 | Astrazeneca Ab | Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors |
ITRM20050290A1 (it) * | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
ITRM20050332A1 (it) | 2005-06-24 | 2006-12-25 | Lay Line Genomics Spa | Uso di molecole in grado di bloccare l'attivita' di trka per potenziare gli effetti di analgesici oppiacei sul dolore. |
DK1945631T3 (da) | 2005-10-28 | 2012-10-22 | Astrazeneca Ab | 4- (3-aminopyrazole) pyrimidinderivater til anvendelse som tyrosinkinaseinhibitorer til behandling af cancer |
TW200826937A (en) * | 2006-11-01 | 2008-07-01 | Astrazeneca Ab | New use |
UA99459C2 (en) | 2007-05-04 | 2012-08-27 | Астразенека Аб | 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer |
US8309088B2 (en) | 2007-08-10 | 2012-11-13 | Regeneron Pharmaceuticals, Inc. | Method of treating osteoarthritis with an antibody to NGF |
ME02239B (me) | 2007-08-10 | 2015-04-30 | Regeneron Pharma | Humana antitela visokog afiniteta prema humanom nervnom faktoru rasta |
NZ587701A (en) | 2008-02-04 | 2013-03-28 | Lay Line Genomics Spa | Anti-trka antibodies and derivatives thereof |
KR101805754B1 (ko) | 2008-12-08 | 2017-12-07 | 먼디파머 인터내셔널 코포레이션 리미티드 | 단백질 수용체 티로신 키나아제 억제제의 조성물 |
SI2448970T1 (sl) | 2009-05-04 | 2014-11-28 | Abbvie Research B.V. | Protitelesa proti živčnemu rastnemu faktorju (NGF) s povečano stabilnostjo in vivo |
PL3333188T3 (pl) | 2010-08-19 | 2022-05-09 | Zoetis Belgium S.A. | Przeciwciała anty-ngf i ich zastosowanie |
US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
US9783601B2 (en) | 2010-12-01 | 2017-10-10 | Alderbio Holdings Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
WO2013009582A1 (en) | 2011-07-12 | 2013-01-17 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
WO2013176970A1 (en) | 2012-05-22 | 2013-11-28 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
US9617334B2 (en) | 2012-06-06 | 2017-04-11 | Zoetis Services Llc | Caninized anti-NGF antibodies and methods thereof |
EP2859019B1 (en) | 2012-06-08 | 2018-02-21 | Glenmark Pharmaceuticals S.A. | Humanized anti-trka antibodies with amino acid substitutions |
EP2674439B1 (en) | 2012-06-13 | 2017-02-01 | Rottapharm Biotech S.r.l. | Anti-TrkA antibodies, derivatives and uses thereof |
WO2015039334A1 (en) | 2013-09-22 | 2015-03-26 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
WO2015039333A1 (en) | 2013-09-22 | 2015-03-26 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
NZ721057A (en) | 2014-02-05 | 2023-04-28 | VM Oncology LLC | Compositions of compounds and uses thereof |
WO2015143652A1 (en) | 2014-03-26 | 2015-10-01 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF |
WO2015143653A1 (en) | 2014-03-26 | 2015-10-01 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF |
WO2015143654A1 (en) | 2014-03-26 | 2015-10-01 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF |
MA41097A (fr) * | 2014-12-05 | 2017-10-10 | Glenmark Pharmaceuticals Sa | Anticorps anti-trka à propriétés inhibitrices améliorées et dérivés desdits anticorps destinés à être utilisés pour traiter les douleurs osseuses |
WO2016161572A1 (en) | 2015-04-08 | 2016-10-13 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
AR114110A1 (es) | 2018-02-28 | 2020-07-22 | Lilly Co Eli | Anticuerpo anti-trka |
BR112020017701A2 (pt) | 2018-03-12 | 2020-12-29 | Zoetis Services Llc | Anticorpos anti-ngf e métodos dos mesmos |
TW202210467A (zh) | 2020-05-28 | 2022-03-16 | 美商美國禮來大藥廠 | TrkA抑制劑 |
WO2023125490A1 (en) * | 2021-12-28 | 2023-07-06 | 4B Technologies (Suzhou) Limited | TrkA ANTIBODY AND APPLICATION THEREOF |
US20230348608A1 (en) | 2022-04-27 | 2023-11-02 | Regeneron Pharmaceuticals, Inc. | Treatment Of Arthropathy Based Upon Stratification Of Osteoarthritis Polygenic Risk Score |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989009225A1 (en) * | 1988-03-28 | 1989-10-05 | The Regents Of The University Of California | Nerve growth factor peptides |
IL162181A (en) * | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
EP0471205A1 (en) | 1990-08-15 | 1992-02-19 | E.R. SQUIBB & SONS, INC. | Monoclonal antibodies which bind TRK proto-oncogene protein |
DE69233204T2 (de) * | 1991-12-13 | 2004-07-15 | Xoma Corp., Berkeley | Verfahren und materialien zur herstellung von modifizierten variablen antikörperdomänen und ihre therapeutische verwendung |
DE69333524T2 (de) * | 1992-09-07 | 2005-06-16 | Kyowa Hakko Kogyo Co., Ltd. | Humanisierte Antikörper, die mit dem GM2-Gangliosid reagieren |
SK285035B6 (sk) * | 1992-10-28 | 2006-05-04 | Genentech, Inc. | Antagonisty rastového faktora vaskulárnych endotelových buniek |
US5753225A (en) | 1993-12-03 | 1998-05-19 | The Regents Of The University Of California | Antibodies that mimic actions of neurotrophins |
US6811779B2 (en) * | 1994-02-10 | 2004-11-02 | Imclone Systems Incorporated | Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy |
ATE283926T1 (de) * | 1995-09-11 | 2004-12-15 | Kyowa Hakko Kogyo Kk | Antikörper gegen die alpha-kette von humanem interleukin 5 rezeptor |
GB9525180D0 (en) | 1995-12-08 | 1996-02-07 | Univ Mcgill | Design of hormone-like antibodies with agonistic and antagonistic fuctions |
US20020064528A1 (en) * | 2000-01-28 | 2002-05-30 | Zhenping Zhu | Antibodies specific to KDR and uses thereof |
IT1306704B1 (it) * | 1999-05-26 | 2001-10-02 | Sirs Societa Italiana Per La R | Anticorpi monoclonali e suoi derivati sintetici o biotecnologici ingrado di agire come molecole antagoniste per il ngf. |
AT411997B (de) * | 1999-09-14 | 2004-08-26 | Baxter Ag | Faktor ix/faktor ixa aktivierende antikörper und antikörper-derivate |
FR2807660A1 (fr) | 2000-04-13 | 2001-10-19 | Warner Lambert Co | Utilisation d'antagonistes du ngf pour la prevention ou le traitement de douleurs viscerales chroniques |
NZ587701A (en) | 2008-02-04 | 2013-03-28 | Lay Line Genomics Spa | Anti-trka antibodies and derivatives thereof |
-
1999
- 1999-05-26 IT IT1999RM000333A patent/IT1306704B1/it active
-
2000
- 2000-05-26 US US09/979,710 patent/US7601352B1/en not_active Expired - Fee Related
- 2000-05-26 AT AT00935482T patent/ATE263188T1/de active
- 2000-05-26 ES ES00935482T patent/ES2218163T5/es not_active Expired - Lifetime
- 2000-05-26 DE DE60009484T patent/DE60009484T3/de not_active Expired - Lifetime
- 2000-05-26 WO PCT/IT2000/000218 patent/WO2000073344A2/en active IP Right Grant
- 2000-05-26 JP JP2001500668A patent/JP4917226B2/ja not_active Expired - Lifetime
- 2000-05-26 EP EP00935482A patent/EP1181318B2/en not_active Expired - Lifetime
- 2000-05-26 DK DK00935482.0T patent/DK1181318T4/da active
- 2000-05-26 CA CA2373274A patent/CA2373274C/en not_active Expired - Lifetime
- 2000-05-26 PT PT00935482T patent/PT1181318E/pt unknown
- 2000-05-26 AU AU51019/00A patent/AU776457B2/en not_active Expired
-
2009
- 2009-09-11 US US12/557,825 patent/US8486401B2/en not_active Expired - Fee Related
-
2011
- 2011-08-22 JP JP2011180419A patent/JP2012040007A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US7601352B1 (en) | 2009-10-13 |
CA2373274C (en) | 2012-08-14 |
ES2218163T3 (es) | 2004-11-16 |
US20110206682A1 (en) | 2011-08-25 |
AU776457B2 (en) | 2004-09-09 |
PT1181318E (pt) | 2004-08-31 |
DK1181318T3 (da) | 2004-07-12 |
CA2373274A1 (en) | 2000-12-07 |
DE60009484T2 (de) | 2005-03-24 |
AU5101900A (en) | 2000-12-18 |
JP4917226B2 (ja) | 2012-04-18 |
WO2000073344A9 (en) | 2002-03-07 |
DK1181318T4 (da) | 2012-05-29 |
DE60009484D1 (de) | 2004-05-06 |
WO2000073344A3 (en) | 2001-06-28 |
US8486401B2 (en) | 2013-07-16 |
DE60009484T3 (de) | 2012-06-14 |
ITRM990333A0 (it) | 1999-05-26 |
WO2000073344A2 (en) | 2000-12-07 |
ES2218163T5 (es) | 2012-06-06 |
EP1181318B1 (en) | 2004-03-31 |
JP2003502029A (ja) | 2003-01-21 |
ATE263188T1 (de) | 2004-04-15 |
EP1181318A2 (en) | 2002-02-27 |
JP2012040007A (ja) | 2012-03-01 |
EP1181318B2 (en) | 2012-03-28 |
ITRM990333A1 (it) | 2000-11-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IT1306704B1 (it) | Anticorpi monoclonali e suoi derivati sintetici o biotecnologici ingrado di agire come molecole antagoniste per il ngf. | |
DK1287130T3 (da) | Cytokinreceptorunderenhedproteiner fra pattedyr, tilhörende reagenser og fremgangsmåder | |
NO20062886L (no) | IL-23 og dens reseptor, beslektede reagenser og fremgangsmater | |
DE60025832D1 (de) | Mehrere zytokin-antikörper komplexen | |
CY1109093T1 (el) | Πρωτεϊνες των υποδοχεων θηλαστικων, σχετικα αντιδραστηρια και σχετικες μεθοδοι | |
BR0113921A (pt) | ácidos nucléicos e polipeptìdeos receptores | |
ATE469913T1 (de) | Antagonisten des nogo-rezeptors | |
WO2001090358A3 (en) | Mammalian receptor proteins; related reagents and methods | |
EP1433792A8 (en) | Human receptor proteins, related reagents and methods | |
PT759942E (pt) | Receptor de interleucina-15 | |
EP2292760A3 (en) | Mammalian cytokines, receptors, related reagents and methods | |
WO1999046379A3 (en) | Human receptor proteins; related reagents and methods | |
NZ515382A (en) | OX2 receptor homologs | |
BR9611947A (pt) | Isoindolonas fundidas como inibidores da quinase da proteina c | |
WO2005065711A3 (en) | Mammalian receptor proteins; related reagents and methods | |
DE60045637D1 (de) | Nicotin-acetylcholin rezeptoruntereinheit, deren isolierung und verwendung | |
CY1114280T1 (el) | Αντισωματα ανταγωνιστων των κυτοκινων θηλαστικων ή οι υποδοχεις τους για την αγωγη της αλλεργιας |