BR112019000512A2 - anticorpo, ácido nucleico, vetor de expressão, célula hospedeira, composição, métodos de tratamento de uma doença, para produzir um anticorpo biespecífico e para detectar se a reticulação entre as células que expressam cd40 e cd137 ocorre em uma amostra, uso de um anticorpo multiespecífico, e, kit - Google Patents
anticorpo, ácido nucleico, vetor de expressão, célula hospedeira, composição, métodos de tratamento de uma doença, para produzir um anticorpo biespecífico e para detectar se a reticulação entre as células que expressam cd40 e cd137 ocorre em uma amostra, uso de um anticorpo multiespecífico, e, kitInfo
- Publication number
- BR112019000512A2 BR112019000512A2 BR112019000512-9A BR112019000512A BR112019000512A2 BR 112019000512 A2 BR112019000512 A2 BR 112019000512A2 BR 112019000512 A BR112019000512 A BR 112019000512A BR 112019000512 A2 BR112019000512 A2 BR 112019000512A2
- Authority
- BR
- Brazil
- Prior art keywords
- antibody
- methods
- kit
- linking
- disease
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000004132 cross linking Methods 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000013604 expression vector Substances 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
anticorpos multiespecíficos ligando à cd40 humana e cd137 humana, métodos para preparar tais anticorpos multiespecíficos e métodos de usar tais anticorpos multiespecíficos para propósitos terapêuticos ou outros.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP2016066840 | 2016-07-14 | ||
EPPCT/EP2016/066840 | 2016-07-14 | ||
PCT/EP2017/067924 WO2018011421A1 (en) | 2016-07-14 | 2017-07-14 | Multispecific antibodies against cd40 and cd137 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112019000512A2 true BR112019000512A2 (pt) | 2019-04-24 |
Family
ID=59501399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112019000512-9A BR112019000512A2 (pt) | 2016-07-14 | 2017-07-14 | anticorpo, ácido nucleico, vetor de expressão, célula hospedeira, composição, métodos de tratamento de uma doença, para produzir um anticorpo biespecífico e para detectar se a reticulação entre as células que expressam cd40 e cd137 ocorre em uma amostra, uso de um anticorpo multiespecífico, e, kit |
Country Status (14)
Country | Link |
---|---|
US (6) | US11091557B2 (pt) |
EP (1) | EP3484922A1 (pt) |
JP (2) | JP7138630B2 (pt) |
KR (2) | KR102632202B1 (pt) |
CN (2) | CN109641959B (pt) |
AU (1) | AU2017296095A1 (pt) |
BR (1) | BR112019000512A2 (pt) |
CA (1) | CA3030636A1 (pt) |
EA (1) | EA201990293A1 (pt) |
IL (1) | IL264142A (pt) |
MA (1) | MA45672A (pt) |
MX (1) | MX2018015853A (pt) |
SG (1) | SG11201811431VA (pt) |
WO (1) | WO2018011421A1 (pt) |
Families Citing this family (22)
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HUE059219T2 (hu) | 2015-01-08 | 2022-10-28 | BioNTech SE | Agonista TNF receptor kötõ ágensek |
BR112019000512A2 (pt) | 2016-07-14 | 2019-04-24 | Genmab A/S | anticorpo, ácido nucleico, vetor de expressão, célula hospedeira, composição, métodos de tratamento de uma doença, para produzir um anticorpo biespecífico e para detectar se a reticulação entre as células que expressam cd40 e cd137 ocorre em uma amostra, uso de um anticorpo multiespecífico, e, kit |
EP3496536A4 (en) * | 2016-07-20 | 2020-02-12 | IGM Biosciences, Inc. | MULTIMERIC MOLECULES ATTACHING CD40 AND USES THEREOF |
CN116333131A (zh) * | 2017-08-04 | 2023-06-27 | 健玛保 | 与pd-l1和cd137结合的结合剂及其用途 |
CN111511762A (zh) * | 2017-08-21 | 2020-08-07 | 天演药业公司 | 抗cd137分子及其用途 |
EA202090791A1 (ru) * | 2017-09-19 | 2020-06-17 | Мэб Дискавери Гмбх | Агонистические антитела против cd40 |
WO2019148445A1 (en) | 2018-02-02 | 2019-08-08 | Adagene Inc. | Precision/context-dependent activatable antibodies, and methods of making and using the same |
WO2020077635A1 (zh) * | 2018-10-19 | 2020-04-23 | 苏州丁孚靶点生物技术有限公司 | 抗cd137抗体及其应用 |
CN113454111A (zh) * | 2018-11-06 | 2021-09-28 | 健玛保 | 抗体配制剂 |
KR20210095891A (ko) * | 2018-11-23 | 2021-08-03 | 스트라이크 파마 아베 | 이중 특이적 접합체 |
CN110229232B (zh) * | 2019-06-19 | 2020-05-19 | 北京智仁美博生物科技有限公司 | 双特异性抗体及其用途 |
EP4137155A1 (en) * | 2020-04-17 | 2023-02-22 | Dingfu Biotarget Co., Ltd | Preparation specifically bound with cd137 and use thereof |
GB202008003D0 (en) * | 2020-05-28 | 2020-07-15 | Quine Medical Ab | Anti-CD40 antibody |
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CN112321700A (zh) * | 2020-09-21 | 2021-02-05 | 四川省人民医院 | 一种新型冠状病毒感染的外周血tcr标志物及其检测试剂盒和应用 |
CN114560940B (zh) * | 2020-11-27 | 2023-07-14 | 缔码生物科技(武汉)有限公司 | 一种抗SIRPα兔重组单克隆抗体及其制备方法和应用 |
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2017
- 2017-07-14 BR BR112019000512-9A patent/BR112019000512A2/pt unknown
- 2017-07-14 MA MA045672A patent/MA45672A/fr unknown
- 2017-07-14 SG SG11201811431VA patent/SG11201811431VA/en unknown
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- 2017-07-14 AU AU2017296095A patent/AU2017296095A1/en active Pending
- 2017-07-14 CN CN201780043547.1A patent/CN109641959B/zh active Active
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- 2017-07-14 CA CA3030636A patent/CA3030636A1/en active Pending
- 2017-07-14 KR KR1020247003328A patent/KR20240017129A/ko active Application Filing
- 2017-07-14 CN CN202311054532.9A patent/CN117247458A/zh active Pending
- 2017-07-14 WO PCT/EP2017/067924 patent/WO2018011421A1/en unknown
- 2017-07-14 US US16/316,534 patent/US11091557B2/en active Active
- 2017-07-14 EA EA201990293A patent/EA201990293A1/ru unknown
- 2017-07-14 JP JP2019523182A patent/JP7138630B2/ja active Active
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US20220064317A1 (en) | 2022-03-03 |
SG11201811431VA (en) | 2019-01-30 |
US11440966B2 (en) | 2022-09-13 |
US20220033510A1 (en) | 2022-02-03 |
WO2018011421A1 (en) | 2018-01-18 |
JP7138630B2 (ja) | 2022-09-16 |
US20210317225A1 (en) | 2021-10-14 |
US11084882B2 (en) | 2021-08-10 |
JP2022184871A (ja) | 2022-12-13 |
EA201990293A1 (ru) | 2019-07-31 |
CN117247458A (zh) | 2023-12-19 |
KR20240017129A (ko) | 2024-02-06 |
US11091557B2 (en) | 2021-08-17 |
CN109641959A (zh) | 2019-04-16 |
US20230089969A1 (en) | 2023-03-23 |
MA45672A (fr) | 2019-05-22 |
MX2018015853A (es) | 2019-08-21 |
US20200247899A1 (en) | 2020-08-06 |
EP3484922A1 (en) | 2019-05-22 |
US20200062853A1 (en) | 2020-02-27 |
CA3030636A1 (en) | 2018-01-18 |
IL264142A (en) | 2019-02-28 |
JP2019533466A (ja) | 2019-11-21 |
KR20190028508A (ko) | 2019-03-18 |
CN109641959B (zh) | 2023-08-22 |
KR102632202B1 (ko) | 2024-02-02 |
AU2017296095A1 (en) | 2019-01-17 |
US11939388B2 (en) | 2024-03-26 |
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