CY1403A - Benzazepin-2-ones - Google Patents

Benzazepin-2-ones

Info

Publication number
CY1403A
CY1403A CY140382A CY140382A CY1403A CY 1403 A CY1403 A CY 1403A CY 140382 A CY140382 A CY 140382A CY 140382 A CY140382 A CY 140382A CY 1403 A CY1403 A CY 1403A
Authority
CY
Cyprus
Prior art keywords
benzazepin
ones
Prior art date
Application number
CY140382A
Inventor
William Herbert Watthe Jeffrey
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US29190781A priority Critical
Priority to US31986381A priority
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of CY1403A publication Critical patent/CY1403A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16Benzazepines; Hydrogenated benzazepines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06086Dipeptides with the first amino acid being basic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
CY140382A 1981-08-11 1982-08-05 Benzazepin-2-ones CY1403A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US29190781A true 1981-08-11 1981-08-11
US31986381A true 1981-11-09 1981-11-09

Publications (1)

Publication Number Publication Date
CY1403A true CY1403A (en) 1987-12-18

Family

ID=26967047

Family Applications (1)

Application Number Title Priority Date Filing Date
CY140382A CY1403A (en) 1981-08-11 1982-08-05 Benzazepin-2-ones

Country Status (22)

Country Link
EP (1) EP0072352B1 (en)
KR (3) KR890003425B1 (en)
AR (3) AR240806A1 (en)
AT (1) AT18397T (en)
AU (1) AU561395B2 (en)
CA (1) CA1196636A (en)
CY (1) CY1403A (en)
DD (1) DD202546A5 (en)
DE (1) DE3269625D1 (en)
DK (1) DK157881C (en)
ES (6) ES514856A0 (en)
FI (1) FI76074C (en)
GB (1) GB2103614B (en)
GR (1) GR77256B (en)
HK (1) HK93387A (en)
HU (1) HU189628B (en)
IE (1) IE53668B1 (en)
IL (1) IL66501A (en)
NL (1) NL930112I2 (en)
NO (1) NO161558C (en)
NZ (1) NZ201555A (en)
PT (1) PT75395B (en)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
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US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
US4575503A (en) * 1983-02-10 1986-03-11 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
DE3373469D1 (en) * 1982-09-30 1987-10-15 Merck & Co Inc 1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents
DE3242599A1 (en) * 1982-11-18 1984-05-24 Thomae Gmbh Dr K New benzazepine derivatives, their production and their use as medicinal products
US4564612A (en) * 1983-04-22 1986-01-14 Takeda Chemical Industries, Ltd. Condensed, seven-membered ring compounds and their use
US4539150A (en) * 1983-06-29 1985-09-03 Mitsui Toatsu Chemicals, Inc. Benzothiazepine derivatives and their methods of preparation
JPS608284A (en) * 1983-06-29 1985-01-17 Mitsui Toatsu Chem Inc Benzothiazepine derivative and its preparation
IL72523A (en) * 1983-08-12 1988-06-30 Takeda Chemical Industries Ltd 3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives,their production and pharmaceutical compositions containing them
AU570710B2 (en) * 1983-08-12 1988-03-24 Takeda Chemical Industries Ltd. 4-oxo-2, 3, 4, 5-tetrahydro-1, 5-benzoxazepine derivatives
US4638000A (en) * 1983-08-12 1987-01-20 Takeda Chemical Industries, Ltd. Condensed seven-membered ring compounds, their production and use
EP0166354B1 (en) * 1984-06-26 1992-08-05 Merck & Co., Inc. Benzofused lactam compounds and pharmaceutical compositions containing them
CA1266647A (en) * 1984-06-26 1990-03-13 William H. Parsons Benzofused lactams useful as antihypertensive agents and as cholecystokinin antagonists
EP0166357A3 (en) * 1984-06-26 1988-10-26 Merck & Co., Inc. Benzofused lactams and pharmaceutical compositions containing them
US4785089A (en) * 1985-06-13 1988-11-15 Ciba-Geigy Corporation Novel sulfonic acid esters and their preparation
DE3704661A1 (en) * 1987-02-14 1988-08-25 Hoechst Ag Felected azepinone and azocinone derivatives, method for the production thereof, their containers and their use, and intermediate products in their production
EP0322779A3 (en) * 1987-12-29 1991-05-08 Yoshitomi Pharmaceutical Industries, Ltd. Benzolactam compounds and pharmaceutical uses thereof
TW197945B (en) * 1990-11-27 1993-01-11 Hoechst Ag
GB9100028D0 (en) * 1991-01-02 1991-02-20 Ici Plc Compounds
GB9212308D0 (en) * 1992-06-10 1992-07-22 Ici Plc Therapeutic compositions
US5504080A (en) * 1992-10-28 1996-04-02 Bristol-Myers Squibb Co. Benzo-fused lactams
EP0673371A1 (en) * 1992-12-11 1995-09-27 Novartis AG Benzazepinone derivatives
GB9310075D0 (en) * 1993-05-17 1993-06-30 Fujisawa Pharmaceutical Co New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
US5801168A (en) * 1994-06-09 1998-09-01 Zeneca Limited Substituted nitrogen heterocycles
GB9311948D0 (en) * 1993-06-10 1993-07-28 Zeneca Ltd Substituted nitrogen heterocycles
US5597922A (en) * 1994-07-29 1997-01-28 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Glycine receptor antagonist pharmacophore
US6514965B1 (en) * 1999-11-18 2003-02-04 Antex Pharma Inc. Substituted 1-benzazepines and derivatives thereof
JP4508528B2 (en) 2000-12-27 2010-07-21 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung Process for producing α-amino substituted carboxylic acid amide
WO2002076375A2 (en) 2001-03-27 2002-10-03 Ranbaxy Laboratories Limited Process for the preparation of benazepril
US6984645B2 (en) 2001-11-16 2006-01-10 Bristol-Myers Squibb Company Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
AU2003250086A1 (en) * 2002-07-26 2004-02-23 Ciba Specialty Chemicals Holging Inc. Crystalline polymorphic and amorphous forms of benazepril hydrochloride
KR100710548B1 (en) * 2002-12-26 2007-04-24 에스케이 주식회사 Method for preparing s-3-amino-2,3,4,5- tetrahydro-2-oxo-1H-1-benzazepin-1-acetic acid and ester compound thereof
US7459474B2 (en) 2003-06-11 2008-12-02 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor and method
US8080579B2 (en) 2005-10-03 2011-12-20 The Regents Of The University Of Michigan Compositions and methods for treatment of inflammatory bowel disease
US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
WO2008057862A2 (en) 2006-11-01 2008-05-15 Bristol-Myers Squibb Company MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF
WO2008057857A1 (en) 2006-11-01 2008-05-15 Bristol-Myers Squibb Company MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF
CN101772513B (en) 2007-06-04 2013-11-13 协同医药品公司 Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US7828840B2 (en) 2007-11-15 2010-11-09 Med Institute, Inc. Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists
EP2810951B1 (en) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CN102149710A (en) 2008-06-24 2011-08-10 百时美施贵宝公司 Cyclopentathiophene modulators of the glucocorticoid receptor, AP-1, and/or NF-Kappa B activity and use thereof
JP2011528375A (en) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer, and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
EP3004138A2 (en) 2013-06-05 2016-04-13 Synergy Pharmaceuticals Inc. Ultra-pure agonists of guanylate cyclase c, method of making and using same
US9593113B2 (en) 2013-08-22 2017-03-14 Bristol-Myers Squibb Company Imide and acylurea derivatives as modulators of the glucocorticoid receptor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3395150A (en) * 1965-02-26 1968-07-30 Squibb & Sons Inc Benzothiazepine carboxamides and derivatives thereof
GB1305278A (en) * 1970-03-12 1973-01-31

Also Published As

Publication number Publication date
AU8701482A (en) 1983-05-12
CA1196636A (en) 1985-11-12
ES530658D0 (en)
KR900001190B1 (en) 1990-02-28
ES526886A0 (en) 1985-11-01
NO161558C (en) 1989-08-30
FI822770D0 (en)
AT18397T (en) 1986-03-15
AR240807A2 (en) 1991-02-28
HK93387A (en) 1987-12-18
AR240806A1 (en) 1991-02-28
FI822770A (en)
ES526888D0 (en)
HU189628B (en) 1986-07-28
ES8602682A1 (en) 1985-12-01
NL930112I2 (en) 1996-11-01
KR900001191B1 (en) 1990-02-28
FI822770L (en) 1983-02-12
ES8504728A1 (en) 1985-04-16
IL66501A (en) 1987-10-20
IE53668B1 (en) 1989-01-04
ES8601142A1 (en) 1985-11-01
PT75395B (en) 1985-11-15
DE3269625D1 (en) 1986-04-10
AR241222A1 (en) 1992-02-28
FI76074B (en) 1988-05-31
GB2103614A (en) 1983-02-23
ES526888A0 (en) 1985-04-16
ES526887D0 (en)
NL930112I1 (en) 1993-10-18
FI76074C (en) 1988-09-09
DK157881C (en) 1990-07-23
AR240807A1 (en) 1991-02-28
NZ201555A (en) 1986-06-11
KR890003425B1 (en) 1989-09-20
ES526887A0 (en) 1986-04-16
ES526886D0 (en)
DK157881B (en) 1990-02-26
ES526889A0 (en) 1986-02-01
ES8606285A1 (en) 1986-04-16
CA1196636A1 (en)
EP0072352A1 (en) 1983-02-16
AU561395B2 (en) 1987-05-07
FI822770A0 (en) 1982-08-09
NO822722L (en) 1983-02-14
ES530658A0 (en) 1985-12-01
AR240806A2 (en) 1991-02-28
EP0072352B1 (en) 1986-03-05
DD202546A5 (en) 1983-09-21
ES514856D0 (en)
NO161558B (en) 1989-05-22
GR77256B (en) 1984-09-11
KR840001139A (en) 1984-03-28
GB2103614B (en) 1984-11-21
ES8604523A1 (en) 1986-02-01
ES8502974A1 (en) 1985-02-01
DK358682A (en) 1983-02-12
ES514856A0 (en) 1985-02-01
PT75395A (en) 1982-09-01
IE821929L (en) 1983-02-11
IL66501D0 (en) 1982-12-31
ES526889D0 (en)

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