GB1305278A - - Google Patents

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Publication number
GB1305278A
GB1305278A GB1305278DA GB1305278A GB 1305278 A GB1305278 A GB 1305278A GB 1305278D A GB1305278D A GB 1305278DA GB 1305278 A GB1305278 A GB 1305278A
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GB
United Kingdom
Prior art keywords
alkyl
substituted
hydrogen atom
group
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GB1305278A publication Critical patent/GB1305278A/en
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1305278 Quinoline, benzazepine and benzazocine derivatives E R SQUIBB & SONS Inc 12 March 1970 11970/70 Heading C2C Novel quinoline, benzazepine and benzaxocine derivatives of the general formula wherein each of X and X<SP>1</SP> is a hydroxy, C 1-8 alkyl, halo-C 1-8 alkyl, benzyloxy or C 1-8 alkoxy group or a halogen atom, R is a C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, aralkyl, X-substituted aralkyl or aralkenyl group, each of R<SP>1</SP> and R<SP>2</SP> is a hydrogen atom or R<SP>1</SP> and R<SP>2</SP> together form an oxygen atom, A is an alkylene group, each of p and q is 0, 1, 2 or 3, m is 1 or 2, n is 0 or 1 and NR<SP>3</SP>R<SP>4</SP> is a basic radical of less than 14 carbon atoms, in which each of R<SP>3</SP> and R<SP>4</SP> is a hydrogen atom or a C 1-8 alkyl, cycloalkyl alkyl, alkenyl, alkynyl, X-substituted phenyl, X-substituted thienyl, X-substituted furyl, X-substituted pyridyl, X-substituted aralkyl or X-substituted cinnamyl group or NR<SP>3</SP>R<SP>4</SP> is a saturated radical of the formula wherein X<SP>11</SP> is NR<SP>6</SP>, CHR<SP>6</SP>, O or S, t is 1, 2, or 3 and each of R<SP>5</SP> and R<SP>6</SP> is a hydrogen atom or a C 1-8 alkyl, hydroxy-C 1-8 alkyl, C 1-14 alkanoyloxy-C 1-8 alkyl, C 1-14 alkanoyloxy-C 1-8 alkoxy- C 1-8 alkyl, hydroxy-C 1-8 alkoxy-C 1-8 alkyl, di- (C 1-8 alkyl) amino-C 1-8 alkyl, di-(C 1-8 alkyl)- amino-C 1-8 alkoxy-C 1-8 alkyl, X-substituted aryl or X-substituted aryl-C 1-8 alkyl group, and acid addition and quaternary ammonium salts thereof are prepared by reaction of a lactam of the general formula with halogen-alkylene-NR<SP>3</SP>R<SP>4</SP> in the presence of a base and optional reduction of the resulting compound of the first general formula above, wherein R<SP>1</SP> and R<SP>2</SP> together form an oxygen atom to give the corresponding compound in which each of R<SP>1</SP> and R<SP>2</SP> is a hydrogen atom, followed optionally by salification of the product. Lactams of the second general formula above are prepared by alkylation, alkenylation or alkynylation of the corresponding compound in which R is a hydrogen atom in the presence of a base.
GB1305278D 1970-03-12 1970-03-12 Expired GB1305278A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1197070 1970-03-12

Publications (1)

Publication Number Publication Date
GB1305278A true GB1305278A (en) 1973-01-31

Family

ID=9996018

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1305278D Expired GB1305278A (en) 1970-03-12 1970-03-12

Country Status (1)

Country Link
GB (1) GB1305278A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0072352A1 (en) * 1981-08-11 1983-02-16 Ciba-Geigy Ag Benzazepin-2-ones, process for their preparation, pharmaceutical preparations containing these compounds and the compounds for therapeutical use
US4410807A (en) * 1982-03-26 1983-10-18 Kay Industries, Inc. Regulating device for polyphase electrical circuits
US4410520A (en) * 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
WO1986000617A1 (en) * 1984-07-13 1986-01-30 Takeda Chemical Industries, Ltd. Condensed 7-membered ring compounds and process for their preparation
EP0212216A1 (en) * 1985-07-20 1987-03-04 Hoechst Aktiengesellschaft Dihydroquinolinone derivatives, processes for their preparation, medicaments containing them, the use of these medicaments, and intermediates for their preparation
US6855726B1 (en) 1998-03-31 2005-02-15 Warner-Lambert Company Llc Quinolones as serine protease inhibitors

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0072352A1 (en) * 1981-08-11 1983-02-16 Ciba-Geigy Ag Benzazepin-2-ones, process for their preparation, pharmaceutical preparations containing these compounds and the compounds for therapeutical use
US4410520A (en) * 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4410807A (en) * 1982-03-26 1983-10-18 Kay Industries, Inc. Regulating device for polyphase electrical circuits
US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
WO1986000617A1 (en) * 1984-07-13 1986-01-30 Takeda Chemical Industries, Ltd. Condensed 7-membered ring compounds and process for their preparation
EP0212216A1 (en) * 1985-07-20 1987-03-04 Hoechst Aktiengesellschaft Dihydroquinolinone derivatives, processes for their preparation, medicaments containing them, the use of these medicaments, and intermediates for their preparation
US4778793A (en) * 1985-07-20 1988-10-18 Hoechst Aktiengesellschaft Dihydroquinolinone derivatives, processes for their preparation, medicaments containing them and their use, and intermediate products for their preparation
US6855726B1 (en) 1998-03-31 2005-02-15 Warner-Lambert Company Llc Quinolones as serine protease inhibitors

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee