DK358682A - METHOD FOR PREPARING 3-AMINO (1) BENZAZEPIN-2-ON-1 ALKANIC ACIDS OR STEREOISOMERS, SALTS OR COMPLEXES THEREOF - Google Patents

METHOD FOR PREPARING 3-AMINO (1) BENZAZEPIN-2-ON-1 ALKANIC ACIDS OR STEREOISOMERS, SALTS OR COMPLEXES THEREOF Download PDF

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Publication number
DK358682A
DK358682A DK358682A DK358682A DK358682A DK 358682 A DK358682 A DK 358682A DK 358682 A DK358682 A DK 358682A DK 358682 A DK358682 A DK 358682A DK 358682 A DK358682 A DK 358682A
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DK
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Prior art keywords
benzazepin
stereoisomers
complexes
salts
amino
Prior art date
Application number
DK358682A
Other languages
Danish (da)
Other versions
DK157881C (en
DK157881B (en
Inventor
Jeffrey W H Watthey
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK358682A publication Critical patent/DK358682A/en
Publication of DK157881B publication Critical patent/DK157881B/en
Application granted granted Critical
Publication of DK157881C publication Critical patent/DK157881C/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK358682A 1981-08-11 1982-08-10 METHOD OF ANALOGUE FOR THE PREPARATION OF 3-AMINO- (1) BENZAZEPIN-2-ON-1-ALKANIC ACIDS OR DERIVATIVES THEREOF OR STEREOISOMERS OR SALTS THEREOF DK157881C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US29190781A 1981-08-11 1981-08-11
US29190781 1981-08-11
US31986381A 1981-11-09 1981-11-09
US31986381 1981-11-09

Publications (3)

Publication Number Publication Date
DK358682A true DK358682A (en) 1983-02-12
DK157881B DK157881B (en) 1990-02-26
DK157881C DK157881C (en) 1990-07-23

Family

ID=26967047

Family Applications (1)

Application Number Title Priority Date Filing Date
DK358682A DK157881C (en) 1981-08-11 1982-08-10 METHOD OF ANALOGUE FOR THE PREPARATION OF 3-AMINO- (1) BENZAZEPIN-2-ON-1-ALKANIC ACIDS OR DERIVATIVES THEREOF OR STEREOISOMERS OR SALTS THEREOF

Country Status (22)

Country Link
EP (1) EP0072352B1 (en)
KR (3) KR890003425B1 (en)
AR (3) AR240806A1 (en)
AT (1) ATE18397T1 (en)
AU (1) AU561395B2 (en)
CA (1) CA1196636A (en)
CY (1) CY1403A (en)
DD (1) DD202546A5 (en)
DE (1) DE3269625D1 (en)
DK (1) DK157881C (en)
ES (6) ES8502974A1 (en)
FI (1) FI76074C (en)
GB (1) GB2103614B (en)
GR (1) GR77256B (en)
HK (1) HK93387A (en)
HU (1) HU189628B (en)
IE (1) IE53668B1 (en)
IL (1) IL66501A (en)
NL (1) NL930112I2 (en)
NO (1) NO161558C (en)
NZ (1) NZ201555A (en)
PT (1) PT75395B (en)

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DE3242599A1 (en) * 1982-11-18 1984-05-24 Dr. Karl Thomae Gmbh, 7950 Biberach NEW BENZAZEPINE DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
DE3373469D1 (en) * 1982-09-30 1987-10-15 Merck & Co Inc 1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents
US4575503A (en) * 1983-02-10 1986-03-11 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4564612A (en) * 1983-04-22 1986-01-14 Takeda Chemical Industries, Ltd. Condensed, seven-membered ring compounds and their use
JPS608284A (en) * 1983-06-29 1985-01-17 Mitsui Toatsu Chem Inc Benzothiazepine derivative and its preparation
US4539150A (en) * 1983-06-29 1985-09-03 Mitsui Toatsu Chemicals, Inc. Benzothiazepine derivatives and their methods of preparation
IL72523A (en) * 1983-08-12 1988-06-30 Takeda Chemical Industries Ltd 3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives,their production and pharmaceutical compositions containing them
AU570710B2 (en) * 1983-08-12 1988-03-24 Takeda Chemical Industries Ltd. 4-oxo-2, 3, 4, 5-tetrahydro-1, 5-benzoxazepine derivatives
US4638000A (en) * 1983-08-12 1987-01-20 Takeda Chemical Industries, Ltd. Condensed seven-membered ring compounds, their production and use
CA1266647A (en) * 1984-06-26 1990-03-13 William H. Parsons Benzofused lactams useful as antihypertensive agents and as cholecystokinin antagonists
EP0166354B1 (en) * 1984-06-26 1992-08-05 Merck & Co. Inc. Benzofused lactam compounds and pharmaceutical compositions containing them
EP0166357A3 (en) * 1984-06-26 1988-10-26 Merck & Co. Inc. Benzofused lactams and pharmaceutical compositions containing them
US4785089A (en) * 1985-06-13 1988-11-15 Ciba-Geigy Corporation Novel sulfonic acid esters and their preparation
DE3704661A1 (en) * 1987-02-14 1988-08-25 Hoechst Ag FELECTED AZEPINONE AND AZOCINONE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR CONTAINERS AND THEIR USE, AND INTERMEDIATE PRODUCTS IN THEIR PRODUCTION
EP0322779A3 (en) * 1987-12-29 1991-05-08 Yoshitomi Pharmaceutical Industries, Ltd. Benzolactam compounds and pharmaceutical uses thereof
TW197945B (en) * 1990-11-27 1993-01-11 Hoechst Ag
GB9100028D0 (en) * 1991-01-02 1991-02-20 Ici Plc Compounds
GB9212308D0 (en) * 1992-06-10 1992-07-22 Ici Plc Therapeutic compositions
US5504080A (en) * 1992-10-28 1996-04-02 Bristol-Myers Squibb Co. Benzo-fused lactams
US5610153A (en) * 1992-12-11 1997-03-11 Ciba-Geigy Corporation Benzazepinone derivatives
GB9310075D0 (en) * 1993-05-17 1993-06-30 Fujisawa Pharmaceutical Co New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
GB9311948D0 (en) * 1993-06-10 1993-07-28 Zeneca Ltd Substituted nitrogen heterocycles
US5801168A (en) * 1994-06-09 1998-09-01 Zeneca Limited Substituted nitrogen heterocycles
US5597922A (en) * 1994-07-29 1997-01-28 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Glycine receptor antagonist pharmacophore
EP1229913A4 (en) * 1999-11-18 2005-01-19 Antexpharma Inc Substituted 1-benzazepines and derivatives thereof
JP4508528B2 (en) 2000-12-27 2010-07-21 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング Process for producing α-amino substituted carboxylic acid amide
RU2003131337A (en) 2001-03-27 2005-05-10 Рэнбакси Лабораториз Лимитед (IN) Рэнбакси Лабораториз Лимитед (IN) METHOD FOR PRODUCING BENAZEPRIL
AU2002348276A1 (en) 2001-11-16 2003-06-10 Bristol-Myers Squibb Company Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
US20050107359A1 (en) * 2002-07-26 2005-05-19 Van Der Schaaf Paul A. Crystalline polymorphic and amorphous forms of benazepril hydrochloride
KR100710548B1 (en) * 2002-12-26 2007-04-24 에스케이 주식회사 Method for preparing s-3-amino-2,3,4,5- tetrahydro-2-oxo-1H-1-benzazepin-1-acetic acid and ester compound thereof
US7459474B2 (en) 2003-06-11 2008-12-02 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor and method
US8080579B2 (en) 2005-10-03 2011-12-20 The Regents Of The University Of Michigan Compositions and methods for treatment of inflammatory bowel disease
US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
WO2008057862A2 (en) 2006-11-01 2008-05-15 Bristol-Myers Squibb Company MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF
EP2099767A1 (en) 2006-11-01 2009-09-16 Brystol-Myers Squibb Company Modulators of glucocorticoid receptor, ap-1, and/or nf- b activity and use thereof
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX354786B (en) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc AGONISTS OF GUANYLATE CYCLASE USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS, INFLAMMATION, CANCER and OTHER DISORDERS.
US7828840B2 (en) 2007-11-15 2010-11-09 Med Institute, Inc. Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CN102149710A (en) 2008-06-24 2011-08-10 百时美施贵宝公司 Cyclopentathiophene modulators of the glucocorticoid receptor, AP-1, and/or NF-Kappa B activity and use thereof
WO2010009319A2 (en) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
JP6606491B2 (en) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド Ultra high purity agonist of guanylate cyclase C, method for producing and using the same
WO2015027021A1 (en) 2013-08-22 2015-02-26 Bristol-Myers Squibb Company Imide and acylurea derivatives as modulators of the glucocorticoid receptor
CN113292495B (en) * 2021-06-18 2022-09-13 迪嘉药业集团有限公司 Synthesis method of (S) -amino compound

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3395150A (en) * 1965-02-26 1968-07-30 Squibb & Sons Inc Benzothiazepine carboxamides and derivatives thereof
GB1305278A (en) * 1970-03-12 1973-01-31

Also Published As

Publication number Publication date
ES526888A0 (en) 1985-04-16
IE821929L (en) 1983-02-11
ES8601142A1 (en) 1985-11-01
IL66501A0 (en) 1982-12-31
HU189628B (en) 1986-07-28
GB2103614B (en) 1984-11-21
AU561395B2 (en) 1987-05-07
GR77256B (en) 1984-09-11
EP0072352B1 (en) 1986-03-05
PT75395B (en) 1985-11-15
GB2103614A (en) 1983-02-23
ES526889A0 (en) 1986-02-01
NL930112I2 (en) 1996-11-01
KR900001190B1 (en) 1990-02-28
AU8701482A (en) 1983-05-12
AR240807A2 (en) 1991-02-28
KR890003425B1 (en) 1989-09-20
AR241222A1 (en) 1992-02-28
KR840001139A (en) 1984-03-28
AR240806A1 (en) 1991-02-28
ES514856A0 (en) 1985-02-01
AR240806A2 (en) 1991-02-28
FI822770L (en) 1983-02-12
NO822722L (en) 1983-02-14
IE53668B1 (en) 1989-01-04
ES8604523A1 (en) 1986-02-01
PT75395A (en) 1982-09-01
FI76074C (en) 1988-09-09
AR240807A1 (en) 1991-02-28
ATE18397T1 (en) 1986-03-15
KR900001191B1 (en) 1990-02-28
ES8602682A1 (en) 1985-12-01
DD202546A5 (en) 1983-09-21
CY1403A (en) 1987-12-18
DE3269625D1 (en) 1986-04-10
FI822770A0 (en) 1982-08-09
NZ201555A (en) 1986-06-11
NO161558B (en) 1989-05-22
EP0072352A1 (en) 1983-02-16
IL66501A (en) 1987-10-20
ES530658A0 (en) 1985-12-01
ES8606285A1 (en) 1986-04-16
NL930112I1 (en) 1993-10-18
DK157881C (en) 1990-07-23
NO161558C (en) 1989-08-30
ES526886A0 (en) 1985-11-01
ES526887A0 (en) 1986-04-16
HK93387A (en) 1987-12-18
ES8504728A1 (en) 1985-04-16
FI76074B (en) 1988-05-31
ES8502974A1 (en) 1985-02-01
CA1196636A (en) 1985-11-12
DK157881B (en) 1990-02-26

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