DE3677316D1 - 4(4-oxo-1,4-dihydropyridin-1-yl)phenyl-derivate. - Google Patents
4(4-oxo-1,4-dihydropyridin-1-yl)phenyl-derivate.Info
- Publication number
- DE3677316D1 DE3677316D1 DE8686307911T DE3677316T DE3677316D1 DE 3677316 D1 DE3677316 D1 DE 3677316D1 DE 8686307911 T DE8686307911 T DE 8686307911T DE 3677316 T DE3677316 T DE 3677316T DE 3677316 D1 DE3677316 D1 DE 3677316D1
- Authority
- DE
- Germany
- Prior art keywords
- dihydropyridin
- oxo
- phenyl derivatives
- phenyl
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- -1 (4-OXO-1,4-DIHYDROPYRIDIN-1-YL) PHENYL Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB858525654A GB8525654D0 (en) | 1985-10-17 | 1985-10-17 | Chemical compounds |
| GB868601667A GB8601667D0 (en) | 1986-01-23 | 1986-01-23 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3677316D1 true DE3677316D1 (de) | 1991-03-07 |
Family
ID=26289898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8686307911T Expired - Lifetime DE3677316D1 (de) | 1985-10-17 | 1986-10-13 | 4(4-oxo-1,4-dihydropyridin-1-yl)phenyl-derivate. |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US4906628A (de) |
| EP (1) | EP0220044B1 (de) |
| CN (1) | CN1009092B (de) |
| AU (1) | AU586042B2 (de) |
| DE (1) | DE3677316D1 (de) |
| DK (1) | DK491186A (de) |
| ES (1) | ES2031821T3 (de) |
| FI (1) | FI864193A (de) |
| GR (1) | GR3001555T3 (de) |
| HU (1) | HU196788B (de) |
| IL (1) | IL80296A (de) |
| NO (1) | NO864126L (de) |
| NZ (1) | NZ217931A (de) |
| PH (1) | PH22428A (de) |
| PT (1) | PT83530B (de) |
| ZW (1) | ZW20586A1 (de) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4962110A (en) * | 1985-03-12 | 1990-10-09 | Smith Kline & French Laboratories Limited | Pyridazinone derivatives |
| GB8610369D0 (en) * | 1986-04-28 | 1986-06-04 | Smith Kline French Lab | Heterocyclic compounds |
| GB8621864D0 (en) * | 1986-09-11 | 1986-10-15 | Smith Kline French Lab | Chemical process |
| GB8901836D0 (en) * | 1989-01-27 | 1989-03-15 | Sobio Lab | Compounds |
| DE3913597A1 (de) * | 1989-04-25 | 1990-11-08 | Heumann Pharma Gmbh & Co | Diazinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| ATE194835T1 (de) * | 1990-04-25 | 2000-08-15 | Nissan Chemical Ind Ltd | Pyridazinonderivat |
| ES2131506T3 (es) * | 1990-09-21 | 1999-08-01 | Rohm & Haas | Dihidropiridacinonas y piridacinonas como fungicidas. |
| CN1038249C (zh) * | 1991-08-28 | 1998-05-06 | 罗姆和哈斯公司 | 含有二氢哒嗪酮及其相关化合物的杀菌组合物 |
| US5958926A (en) * | 1996-11-01 | 1999-09-28 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| DE102004011512B4 (de) | 2004-03-08 | 2022-01-13 | Boehringer Ingelheim Vetmedica Gmbh | Pharmazeutische Zubereitung enthaltend Pimobendan |
| US8980894B2 (en) | 2004-03-25 | 2015-03-17 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure |
| EP1579862A1 (de) * | 2004-03-25 | 2005-09-28 | Boehringer Ingelheim Vetmedica Gmbh | Verwendung von PDE III Ihibitoren zur Reduktion der Herzgrösse in an Herzversagen leidenden Säugern |
| EP2258359A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin |
| JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス，インコーポレイティド | ムスカリン性受容体調節による神経発生 |
| AU2006304787A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
| CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| EP2218442A1 (de) | 2005-11-09 | 2010-08-18 | CombinatoRx, Inc. | Verfahren, Zusammensetzungen und Kits zur Behandlung von ophthalmologischen Erkrankungen |
| CA2629367C (en) * | 2005-11-14 | 2016-05-03 | Boehringer Ingelheim Vetmedica Gmbh | Use of pde iii inhibitors and/or calcium sensitizers for the treatment of asymptomatic (occult) heart failure |
| US20100216734A1 (en) * | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| WO2007104035A1 (en) * | 2006-03-08 | 2007-09-13 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| US7678808B2 (en) | 2006-05-09 | 2010-03-16 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
| US20100009983A1 (en) * | 2006-05-09 | 2010-01-14 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| EP2068872A1 (de) * | 2006-09-08 | 2009-06-17 | Braincells, Inc. | Kombinationen mit einem 4-acylaminopyridin-derivat |
| AU2007299920A1 (en) * | 2006-09-19 | 2008-03-27 | Braincells, Inc. | PPAR Mediated Modulation of Neurogenesis |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| EP1920785A1 (de) * | 2006-11-07 | 2008-05-14 | Boehringer Ingelheim Vetmedica Gmbh | Pimobendan-Cyclodextrin Komplex enthaltendes flüssiges Präparat |
| MX354786B (es) | 2007-06-04 | 2018-03-21 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos. |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| CA2726917C (en) | 2008-06-04 | 2018-06-26 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| WO2010009319A2 (en) | 2008-07-16 | 2010-01-21 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| ES2436716T3 (es) | 2008-11-25 | 2014-01-03 | Boehringer Ingelheim Vetmedica Gmbh | Pimobendan para uso en el tratamiento de la cardiomiopatía hipertrófica en gatos |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| US9580471B2 (en) | 2011-03-01 | 2017-02-28 | Synergy Pharmaceuticals, Inc. | Process of preparing guanylate cyclase C agonists |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| EP3167876B1 (de) | 2012-03-15 | 2021-09-08 | Boehringer Ingelheim Vetmedica GmbH | Pharmazeutische tablettenformulierung für den veterinärmedizinischen sektor, verfahren zur herstellung und verwendung davon |
| US9545446B2 (en) | 2013-02-25 | 2017-01-17 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| WO2014151200A2 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| EP2970384A1 (de) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonisten der guanylatcyclase und deren verwendungen |
| JP6606491B2 (ja) | 2013-06-05 | 2019-11-13 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法 |
| CN113181110A (zh) | 2013-07-19 | 2021-07-30 | 勃林格殷格翰动物保健有限公司 | 含有防腐的醚化的环糊精衍生物的液体水性药物组合物 |
| JP6694385B2 (ja) | 2013-08-09 | 2020-05-13 | アーデリクス，インコーポレーテッド | リン酸塩輸送阻害のための化合物及び方法 |
| BR112016011111B1 (pt) | 2013-12-04 | 2022-11-16 | Boehringer Ingelheim Vetmedica Gmbh | Composições farmacêuticas aprimoradas de pimobendan |
| US10537570B2 (en) | 2016-04-06 | 2020-01-21 | Boehringer Ingelheim Vetmedica Gmbh | Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease |
| US11897867B2 (en) | 2017-08-04 | 2024-02-13 | Bayer Aktiengesellschaft | 6-phenyl-4,5-dihydropyridazin-3(2H)-one derivatives as PDE3A and PDE3B inhibitors for treating cancer |
| JOP20200024A1 (ar) | 2017-08-04 | 2020-02-02 | Bayer Ag | مركبات ثنائي هيدروكساديازينون |
| WO2020237096A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
| DE102021105255B4 (de) * | 2021-03-04 | 2022-10-13 | Festo Se & Co. Kg | Vorrichtung mit über eine Verbindungsschnittstelle verbundenen Bauteilen und Verfahren zur Verbindung von Bauteilen |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL69407A (en) * | 1982-08-23 | 1987-10-20 | Warner Lambert Co | 2(1h)-pyridinones,their preparation and pharmaceutical compositions containing them |
| DE3600891A1 (de) * | 1986-01-15 | 1987-07-16 | Bayer Ag | 1,8-verbrueckte 4-chinolon-3-carbonsaeuren und diese enthaltende arzneimittel |
-
1986
- 1986-10-13 PT PT83530A patent/PT83530B/pt not_active IP Right Cessation
- 1986-10-13 EP EP86307911A patent/EP0220044B1/de not_active Expired - Lifetime
- 1986-10-13 DE DE8686307911T patent/DE3677316D1/de not_active Expired - Lifetime
- 1986-10-13 ES ES198686307911T patent/ES2031821T3/es not_active Expired - Lifetime
- 1986-10-13 ZW ZW205/86A patent/ZW20586A1/xx unknown
- 1986-10-14 US US06/918,425 patent/US4906628A/en not_active Expired - Lifetime
- 1986-10-14 IL IL80296A patent/IL80296A/xx unknown
- 1986-10-14 PH PH34365A patent/PH22428A/en unknown
- 1986-10-14 DK DK491186A patent/DK491186A/da not_active Application Discontinuation
- 1986-10-15 NZ NZ217931A patent/NZ217931A/xx unknown
- 1986-10-16 FI FI864193A patent/FI864193A/fi not_active IP Right Cessation
- 1986-10-16 NO NO864126A patent/NO864126L/no unknown
- 1986-10-16 HU HU864319A patent/HU196788B/hu not_active IP Right Cessation
- 1986-10-16 CN CN86106546A patent/CN1009092B/zh not_active Expired
- 1986-10-16 AU AU64166/86A patent/AU586042B2/en not_active Ceased
-
1989
- 1989-12-18 US US07/452,072 patent/US5066653A/en not_active Expired - Lifetime
-
1991
- 1991-03-05 GR GR91400270T patent/GR3001555T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ217931A (en) | 1989-04-26 |
| FI864193A (fi) | 1987-04-18 |
| PT83530B (pt) | 1989-05-31 |
| PT83530A (en) | 1986-11-01 |
| HU196788B (en) | 1989-01-30 |
| GR3001555T3 (en) | 1992-11-23 |
| ES2031821T3 (es) | 1993-01-01 |
| HUT41769A (en) | 1987-05-28 |
| US5066653A (en) | 1991-11-19 |
| AU6416686A (en) | 1987-04-30 |
| CN86106546A (zh) | 1987-05-20 |
| CN1009092B (zh) | 1990-08-08 |
| EP0220044A3 (en) | 1988-02-24 |
| PH22428A (en) | 1988-09-12 |
| DK491186D0 (da) | 1986-10-14 |
| NO864126L (no) | 1987-04-21 |
| DK491186A (da) | 1987-04-18 |
| US4906628A (en) | 1990-03-06 |
| EP0220044A2 (de) | 1987-04-29 |
| FI864193A0 (fi) | 1986-10-16 |
| EP0220044B1 (de) | 1991-01-30 |
| NO864126D0 (no) | 1986-10-16 |
| ZW20586A1 (en) | 1988-05-25 |
| AU586042B2 (en) | 1989-06-29 |
| IL80296A (en) | 1990-06-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |