FI865025A0 - 2-(3,5-dihalogen-4-aminobensyl) imidazoliner. - Google Patents
2-(3,5-dihalogen-4-aminobensyl) imidazoliner.Info
- Publication number
- FI865025A0 FI865025A0 FI865025A FI865025A FI865025A0 FI 865025 A0 FI865025 A0 FI 865025A0 FI 865025 A FI865025 A FI 865025A FI 865025 A FI865025 A FI 865025A FI 865025 A0 FI865025 A0 FI 865025A0
- Authority
- FI
- Finland
- Prior art keywords
- imidazoliner
- aminobensyl
- dihalogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/24—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/807,921 US4665095A (en) | 1985-12-11 | 1985-12-11 | Use of 2-[(3,5-dihalo-4-aminobenzyl)]imidazolines to stimulate alpha-1 adrenergic receptors and to treat nasal congestion |
Publications (2)
Publication Number | Publication Date |
---|---|
FI865025A0 true FI865025A0 (fi) | 1986-12-10 |
FI865025A FI865025A (fi) | 1987-06-12 |
Family
ID=25197433
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI865025A FI865025A (fi) | 1985-12-11 | 1986-12-10 | 2-(3,5-dihalogen-4-aminobensyl) imidazoliner. |
Country Status (9)
Country | Link |
---|---|
US (1) | US4665095A (fi) |
EP (1) | EP0230532B1 (fi) |
JP (1) | JPH07116038B2 (fi) |
AU (1) | AU591740B2 (fi) |
CA (1) | CA1282334C (fi) |
DE (1) | DE3674569D1 (fi) |
FI (1) | FI865025A (fi) |
NO (1) | NO864993L (fi) |
NZ (1) | NZ218334A (fi) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4970240A (en) * | 1989-10-18 | 1990-11-13 | Schering Corporation | Fruity flavored nasal decongestant composition |
US5114979A (en) * | 1989-10-18 | 1992-05-19 | Schering Corporation | Fruity flavored nasal decongestant composition |
JP4096363B2 (ja) * | 1997-03-14 | 2008-06-04 | 日本新薬株式会社 | 鼻又は眼の充血治療剤 |
SG72827A1 (en) * | 1997-06-23 | 2000-05-23 | Hoffmann La Roche | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives |
EP1075486A1 (en) * | 1998-05-06 | 2001-02-14 | Duke University | Method of treating bladder and lower urinary tract syndromes |
BRPI0707315A2 (pt) * | 2006-01-27 | 2011-05-03 | Hoffmann La Roche | uso de 2-imidazol substituìdo de derivados de imidazolina |
ES2381589T3 (es) * | 2006-10-19 | 2012-05-29 | F. Hoffmann-La Roche Ag | Aminometil-4-imidazoles |
EP2076496B1 (en) * | 2006-10-19 | 2010-03-31 | F. Hoffmann-Roche AG | Aminomethyl-2-imidazoles with affinity with the trace amine associated receptors |
WO2008052907A1 (en) * | 2006-11-02 | 2008-05-08 | F. Hoffmann-La Roche Ag | Substituted 2-imidazoles as modulators of the trace amine associated receptors |
RU2456281C2 (ru) * | 2006-11-16 | 2012-07-20 | Ф. Хоффманн-Ля Рош Аг | Замещенные 4-имидазолы, способ их получения и их применение |
AU2007332641A1 (en) * | 2006-12-13 | 2008-06-19 | F. Hoffmann-La Roche Ag | Novel 2 -imidazoles as ligands for trace amine associated receptors (TAAR) |
US20080146523A1 (en) * | 2006-12-18 | 2008-06-19 | Guido Galley | Imidazole derivatives |
RU2473545C2 (ru) * | 2007-02-02 | 2013-01-27 | Ф.Хоффманн-Ля Рош Аг | Новые 2-аминооксазолины в качестве лигандов taar1 для заболеваний цнс |
RU2460725C2 (ru) * | 2007-02-15 | 2012-09-10 | Ф. Хоффманн-Ля Рош Аг | Новые 2-аминооксазолины в качестве лигандов taar1 |
MX2009013742A (es) | 2007-07-02 | 2010-01-26 | Hoffmann La Roche | 2-imidazolinas. |
AU2008270444A1 (en) * | 2007-07-03 | 2009-01-08 | F. Hoffmann-La Roche Ag | 4-imidazolines and their use as antidepressants |
RU2010104632A (ru) * | 2007-07-27 | 2011-09-20 | Ф.Хоффманн-Ля Рош Аг (Ch) | 2-азетидинметанамины и 2-пирролидинметанамины в качестве лигандов taar |
BRPI0815038A2 (pt) * | 2007-08-02 | 2015-03-17 | Hoffmann La Roche | Uso de derivados de benzamida para o tratamento de transtornos do cns |
JP5341084B2 (ja) * | 2007-08-03 | 2013-11-13 | エフ.ホフマン−ラ ロシュ アーゲー | Taar1リガンドとしてのピリジンカルボキシアミド及びベンズアミド誘導体 |
TW200922547A (en) * | 2007-10-02 | 2009-06-01 | Paer Johansson | Systemic pro-hemostatic effect of sympathicomimetics with agonistic effects on α-adrenergic and/or β-adrenergic receptors of the sympathetic nervous system, related to improved clot strength |
WO2010010014A1 (en) * | 2008-07-24 | 2010-01-28 | F. Hoffmann-La Roche Ag | 4,5-dihydro-oxazol-2-yl derivatives |
US8242153B2 (en) * | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
US20100311798A1 (en) * | 2009-06-05 | 2010-12-09 | Decoret Guillaume | 2-aminooxazolines as taar1 ligands |
US8354441B2 (en) * | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
RU2731095C2 (ru) | 2016-03-17 | 2020-08-28 | Ф. Хоффманн-Ля Рош Аг | Производное 5-этил-4-метил-пиразол-3-карбоксамида, обладающее активностью агониста taar |
CA3066361A1 (en) | 2017-06-07 | 2018-12-13 | Shifamed Holdings, Llc | Intravascular fluid movement devices, systems, and methods of use |
CN111556763B (zh) | 2017-11-13 | 2023-09-01 | 施菲姆德控股有限责任公司 | 血管内流体运动装置、系统 |
EP3746149A4 (en) | 2018-02-01 | 2021-10-27 | Shifamed Holdings, LLC | INTRAVASCULAR BLOOD PUMPS AND METHODS OF USE AND METHODS OF MANUFACTURING |
WO2021011473A1 (en) | 2019-07-12 | 2021-01-21 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of manufacture and use |
WO2021016372A1 (en) | 2019-07-22 | 2021-01-28 | Shifamed Holdings, Llc | Intravascular blood pumps with struts and methods of use and manufacture |
US11724089B2 (en) | 2019-09-25 | 2023-08-15 | Shifamed Holdings, Llc | Intravascular blood pump systems and methods of use and control thereof |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2731471A (en) * | 1956-01-17 | Nxg hi | ||
US2868802A (en) * | 1959-01-13 | Nxchj | ||
DE1617618B2 (de) * | 1966-06-18 | 1976-05-20 | Merck Patent Gmbh, 6100 Darmstadt | Schleimhautabschwellende mittel zur lokalen applikation |
DE1618005A1 (de) * | 1966-09-22 | 1971-09-09 | Thomae Gmbh Dr K | Verfahren zur Herstellung von neuen Amino-dihalogen-phenyl-aethylaminen |
US3660423A (en) * | 1970-02-13 | 1972-05-02 | Dow Chemical Co | 2-(substituted benzyl)methyl-2-imidazolines |
US3922282A (en) * | 1975-01-17 | 1975-11-25 | American Home Prod | 2-Aryl-2-imidazoline-1-propionic acids and their esters |
AU1623483A (en) * | 1978-02-01 | 1983-10-13 | Wellcome Foundation Limited, The | Formulations of imidazole derivatives |
US4506074A (en) * | 1982-11-08 | 1985-03-19 | Merck & Co., Inc. | 2-[2-Pyridinyloxy(thio or amino)methyl]-1H-imidazoles and derivatives |
US4461914A (en) * | 1983-02-01 | 1984-07-24 | American Cyanamid Company | Method for the preparation of 1-(4'-amino-3',5'-dichlorophenyl)-2-alkyl(or dialkyl)aminoethanols |
FR2549049B1 (fr) * | 1983-07-13 | 1986-06-20 | Chauvin Blache Lab | Nouvelles amidines, leur procede de preparation et leur application therapeutique |
-
1985
- 1985-12-11 US US06/807,921 patent/US4665095A/en not_active Expired - Fee Related
-
1986
- 1986-10-30 EP EP86115057A patent/EP0230532B1/en not_active Expired - Lifetime
- 1986-10-30 DE DE8686115057T patent/DE3674569D1/de not_active Expired - Fee Related
- 1986-11-19 NZ NZ218334A patent/NZ218334A/xx unknown
- 1986-11-28 JP JP61282192A patent/JPH07116038B2/ja not_active Expired - Lifetime
- 1986-12-02 CA CA000524368A patent/CA1282334C/en not_active Expired - Fee Related
- 1986-12-09 AU AU66319/86A patent/AU591740B2/en not_active Ceased
- 1986-12-10 FI FI865025A patent/FI865025A/fi not_active Application Discontinuation
- 1986-12-10 NO NO864993A patent/NO864993L/no unknown
Also Published As
Publication number | Publication date |
---|---|
JPS62145067A (ja) | 1987-06-29 |
NO864993D0 (no) | 1986-12-10 |
NZ218334A (en) | 1989-03-29 |
AU6631986A (en) | 1987-06-18 |
JPH07116038B2 (ja) | 1995-12-13 |
NO864993L (no) | 1987-06-12 |
CA1282334C (en) | 1991-04-02 |
EP0230532A1 (en) | 1987-08-05 |
DE3674569D1 (de) | 1990-10-31 |
AU591740B2 (en) | 1989-12-14 |
FI865025A (fi) | 1987-06-12 |
EP0230532B1 (en) | 1990-09-26 |
US4665095A (en) | 1987-05-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Application refused | ||
FC | Application refused |
Owner name: ABBOTT LABORATORIES |