DE3674569D1 - 2-((3,5-dihalo-4-aminobenzyl))imidazole. - Google Patents
2-((3,5-dihalo-4-aminobenzyl))imidazole.Info
- Publication number
- DE3674569D1 DE3674569D1 DE8686115057T DE3674569T DE3674569D1 DE 3674569 D1 DE3674569 D1 DE 3674569D1 DE 8686115057 T DE8686115057 T DE 8686115057T DE 3674569 T DE3674569 T DE 3674569T DE 3674569 D1 DE3674569 D1 DE 3674569D1
- Authority
- DE
- Germany
- Prior art keywords
- aminobenzyl
- dihalo
- imidazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/24—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/807,921 US4665095A (en) | 1985-12-11 | 1985-12-11 | Use of 2-[(3,5-dihalo-4-aminobenzyl)]imidazolines to stimulate alpha-1 adrenergic receptors and to treat nasal congestion |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3674569D1 true DE3674569D1 (de) | 1990-10-31 |
Family
ID=25197433
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8686115057T Expired - Fee Related DE3674569D1 (de) | 1985-12-11 | 1986-10-30 | 2-((3,5-dihalo-4-aminobenzyl))imidazole. |
Country Status (9)
Country | Link |
---|---|
US (1) | US4665095A (de) |
EP (1) | EP0230532B1 (de) |
JP (1) | JPH07116038B2 (de) |
AU (1) | AU591740B2 (de) |
CA (1) | CA1282334C (de) |
DE (1) | DE3674569D1 (de) |
FI (1) | FI865025A (de) |
NO (1) | NO864993L (de) |
NZ (1) | NZ218334A (de) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4970240A (en) * | 1989-10-18 | 1990-11-13 | Schering Corporation | Fruity flavored nasal decongestant composition |
US5114979A (en) * | 1989-10-18 | 1992-05-19 | Schering Corporation | Fruity flavored nasal decongestant composition |
JP4096363B2 (ja) * | 1997-03-14 | 2008-06-04 | 日本新薬株式会社 | 鼻又は眼の充血治療剤 |
SG72827A1 (en) * | 1997-06-23 | 2000-05-23 | Hoffmann La Roche | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives |
EP1075486A1 (de) * | 1998-05-06 | 2001-02-14 | Duke University | Verfahren zur behandlung von syndromen der niere und der unteren harnwege |
JP2009524617A (ja) * | 2006-01-27 | 2009-07-02 | エフ.ホフマン−ラ ロシュ アーゲー | 置換2−イミダゾール又はイミダゾリン誘導体の使用 |
JP5335681B2 (ja) * | 2006-10-19 | 2013-11-06 | エフ.ホフマン−ラ ロシュ アーゲー | アミノメチル−4−イミダゾール |
KR101172940B1 (ko) * | 2006-10-19 | 2012-08-10 | 에프. 호프만-라 로슈 아게 | 트레이스 아민 관련 수용체에 대해 친화도를 갖는 아미노메틸-2-이미다졸 |
CA2668454A1 (en) * | 2006-11-02 | 2008-05-08 | F. Hoffmann-La Roche Ag | Substituted 2-imidazoles |
CN101535298A (zh) * | 2006-11-16 | 2009-09-16 | 弗·哈夫曼-拉罗切有限公司 | 取代的4-咪唑类化合物 |
CA2672617A1 (en) * | 2006-12-13 | 2008-06-19 | F. Hoffmann-La Roche Ag | Novel 2-imidazoles as ligands for trace amine associated receptors (taar) |
US20080146523A1 (en) * | 2006-12-18 | 2008-06-19 | Guido Galley | Imidazole derivatives |
KR101275405B1 (ko) * | 2007-02-02 | 2013-06-17 | 에프. 호프만-라 로슈 아게 | 중추 신경계 장애의 치료용 taar1 리간드로서 2-아미노옥사졸린 |
BRPI0807813A2 (pt) * | 2007-02-15 | 2014-08-05 | Hoffmann La Roche | 2-amino-oxazolinas como ligantes de taar1 |
AU2008270445A1 (en) | 2007-07-02 | 2009-01-08 | F. Hoffmann-La Roche Ag | 2 -imidazolines having a good affinity to the trace amine associated receptors (TAARs) |
CA2691704A1 (en) * | 2007-07-03 | 2009-01-08 | F. Hoffmann-La Roche Ag | 4-imidazolines and their use as antidepressants |
CA2694362A1 (en) * | 2007-07-27 | 2009-02-05 | F. Hoffmann-La Roche Ag | 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as taar-ligands |
AU2008281877A1 (en) * | 2007-08-02 | 2009-02-05 | F. Hoffmann-La Roche Ag | The use of benzamide derivatives for the treatment of CNS disorders |
BRPI0814758A2 (pt) * | 2007-08-03 | 2015-03-03 | Hoffmann La Roche | Piridinacarboxamida e derivados de benzamida como ligantes taar1 |
TW200922547A (en) * | 2007-10-02 | 2009-06-01 | Paer Johansson | Systemic pro-hemostatic effect of sympathicomimetics with agonistic effects on α-adrenergic and/or β-adrenergic receptors of the sympathetic nervous system, related to improved clot strength |
US8242153B2 (en) * | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
RU2513086C2 (ru) * | 2008-07-24 | 2014-04-20 | Ф.Хоффманн-Ля Рош Аг | Производные 4,5-дигидро-оксазол-2-ила |
US20100311798A1 (en) * | 2009-06-05 | 2010-12-09 | Decoret Guillaume | 2-aminooxazolines as taar1 ligands |
US8354441B2 (en) * | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
MA43706B1 (fr) | 2016-03-17 | 2020-09-30 | Hoffmann La Roche | Dérivé de 5-éthyl-4-méthyl-pyrazole-3-carboxamide ayant une activité en tant qu'agoniste de taar |
JP7414529B2 (ja) | 2017-06-07 | 2024-01-16 | シファメド・ホールディングス・エルエルシー | 血管内流体移動デバイス、システム、および使用方法 |
JP7319266B2 (ja) | 2017-11-13 | 2023-08-01 | シファメド・ホールディングス・エルエルシー | 血管内流体移動デバイス、システム、および使用方法 |
CN117959583A (zh) | 2018-02-01 | 2024-05-03 | 施菲姆德控股有限责任公司 | 血管内血泵以及使用和制造方法 |
EP3996797A4 (de) | 2019-07-12 | 2023-08-02 | Shifamed Holdings, LLC | Intravaskuläre blutpumpen und verfahren zur herstellung und verwendung |
WO2021016372A1 (en) | 2019-07-22 | 2021-01-28 | Shifamed Holdings, Llc | Intravascular blood pumps with struts and methods of use and manufacture |
US11724089B2 (en) | 2019-09-25 | 2023-08-15 | Shifamed Holdings, Llc | Intravascular blood pump systems and methods of use and control thereof |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2731471A (en) * | 1956-01-17 | Nxg hi | ||
US2868802A (en) * | 1959-01-13 | Nxchj | ||
DE1617618B2 (de) * | 1966-06-18 | 1976-05-20 | Merck Patent Gmbh, 6100 Darmstadt | Schleimhautabschwellende mittel zur lokalen applikation |
DE1618005A1 (de) * | 1966-09-22 | 1971-09-09 | Thomae Gmbh Dr K | Verfahren zur Herstellung von neuen Amino-dihalogen-phenyl-aethylaminen |
US3660423A (en) * | 1970-02-13 | 1972-05-02 | Dow Chemical Co | 2-(substituted benzyl)methyl-2-imidazolines |
US3922282A (en) * | 1975-01-17 | 1975-11-25 | American Home Prod | 2-Aryl-2-imidazoline-1-propionic acids and their esters |
AU1623483A (en) * | 1978-02-01 | 1983-10-13 | Wellcome Foundation Limited, The | Formulations of imidazole derivatives |
US4506074A (en) * | 1982-11-08 | 1985-03-19 | Merck & Co., Inc. | 2-[2-Pyridinyloxy(thio or amino)methyl]-1H-imidazoles and derivatives |
US4461914A (en) * | 1983-02-01 | 1984-07-24 | American Cyanamid Company | Method for the preparation of 1-(4'-amino-3',5'-dichlorophenyl)-2-alkyl(or dialkyl)aminoethanols |
FR2549049B1 (fr) * | 1983-07-13 | 1986-06-20 | Chauvin Blache Lab | Nouvelles amidines, leur procede de preparation et leur application therapeutique |
-
1985
- 1985-12-11 US US06/807,921 patent/US4665095A/en not_active Expired - Fee Related
-
1986
- 1986-10-30 DE DE8686115057T patent/DE3674569D1/de not_active Expired - Fee Related
- 1986-10-30 EP EP86115057A patent/EP0230532B1/de not_active Expired - Lifetime
- 1986-11-19 NZ NZ218334A patent/NZ218334A/xx unknown
- 1986-11-28 JP JP61282192A patent/JPH07116038B2/ja not_active Expired - Lifetime
- 1986-12-02 CA CA000524368A patent/CA1282334C/en not_active Expired - Fee Related
- 1986-12-09 AU AU66319/86A patent/AU591740B2/en not_active Ceased
- 1986-12-10 FI FI865025A patent/FI865025A/fi not_active Application Discontinuation
- 1986-12-10 NO NO864993A patent/NO864993L/no unknown
Also Published As
Publication number | Publication date |
---|---|
JPH07116038B2 (ja) | 1995-12-13 |
EP0230532B1 (de) | 1990-09-26 |
US4665095A (en) | 1987-05-12 |
FI865025A (fi) | 1987-06-12 |
EP0230532A1 (de) | 1987-08-05 |
NZ218334A (en) | 1989-03-29 |
NO864993D0 (no) | 1986-12-10 |
JPS62145067A (ja) | 1987-06-29 |
CA1282334C (en) | 1991-04-02 |
AU6631986A (en) | 1987-06-18 |
FI865025A0 (fi) | 1986-12-10 |
NO864993L (no) | 1987-06-12 |
AU591740B2 (en) | 1989-12-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3674569D1 (de) | 2-((3,5-dihalo-4-aminobenzyl))imidazole. | |
FI853193L (fi) | Smaertstillande 1,2-benzisotiazol-3 -ylpiperazinderivat. | |
DE3669876D1 (de) | 3,4-dihydrobenzopyranderivate. | |
FI863532A (fi) | Raekneanordning foer fiskar, i synnerhet fiskyngel. | |
FI871692A0 (fi) | Sorteringsmaskin, i synnerhet foer smaopaket. | |
MX21592A (es) | 1,3-oxazolidin-2-ona. | |
NL971040I2 (nl) | 1-Dimethylcarbamoyl-3-gesubstitueerde-5-gesubstitueerde-1H-1,2,4-triazolen. | |
ATE45741T1 (de) | 1-oxa-3-oxo-4,8-diaza-spiro-(4,5>decanverbindungen. | |
IT8521944A0 (it) | 1,4-diidropiridine-2-sostituite. | |
DE3585315D1 (de) | 5,6,7,8-tetrafluoranthrachinonderivate. | |
DE3586745D1 (de) | 9,11-epoxy-21-hydroxypregnan-derivate. | |
NO863304D0 (no) | 7-okso-4-tia-1-azabicyklo(3,2,0)hept-2-derivater. | |
FI861950A0 (fi) | 1,3-dioxan-etrar. | |
ATE74912T1 (de) | 2,2'-bi-1h-imidazole. | |
FI853421A0 (fi) | 7-oxo-4-tia-1-azabicyklo/3,2,0/ hept-2-enderivat. | |
FI855182A0 (fi) | Foerfarande foer framstaellning av 1,3 -disubstituerade tetrahydropyridiner. | |
FI865158A0 (fi) | 1-h-pyrido/3,2//1,4/-tiaziner. | |
DE3586541T2 (de) | 1,3-dithiol-2-ylidenderivate. | |
IT8620495A0 (it) | 2,4-dicloro-5-nitro-tiazolo. | |
DE3674284D1 (de) | Kationische 1,2,3-thiadiazolazoverbindungen. | |
ATE64389T1 (de) | 1-dimethylcarbamoyl-3-substituierte-5substituierte-1h-1,2,4-triazole. | |
ATE45349T1 (de) | Substituierte 2,3,4,9-tetrahydro-1h-carbazol-1essigs|urederivate. | |
NO892008L (no) | Substituert 1,2,4-oksadiazol. | |
NO864343D0 (no) | Substituerte 1,1,2-trifenylbut-1-ener. | |
ATE58134T1 (de) | 1,3-dioxanaether. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |