ATE146474T1 - Imidazoindolizinderivate mit angiotensin-ii hemmwirkung - Google Patents
Imidazoindolizinderivate mit angiotensin-ii hemmwirkungInfo
- Publication number
- ATE146474T1 ATE146474T1 AT92114987T AT92114987T ATE146474T1 AT E146474 T1 ATE146474 T1 AT E146474T1 AT 92114987 T AT92114987 T AT 92114987T AT 92114987 T AT92114987 T AT 92114987T AT E146474 T1 ATE146474 T1 AT E146474T1
- Authority
- AT
- Austria
- Prior art keywords
- imidazoindolizine
- angiotensin
- substituted
- inhibiting effect
- derivatives
- Prior art date
Links
- ZTJVDMYOVFOUDV-UHFFFAOYSA-N 5h-imidazo[4,5-g]indolizine Chemical class C1C=C2N=CN=C2C2=CC=CN12 ZTJVDMYOVFOUDV-UHFFFAOYSA-N 0.000 title abstract 3
- 102000005862 Angiotensin II Human genes 0.000 title abstract 2
- 101800000733 Angiotensin-2 Proteins 0.000 title abstract 2
- CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 title abstract 2
- 229950006323 angiotensin ii Drugs 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical class [*:2]C([*:1])=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP30856091 | 1991-09-10 | ||
| JP5304492 | 1992-01-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE146474T1 true ATE146474T1 (de) | 1997-01-15 |
Family
ID=26393753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92114987T ATE146474T1 (de) | 1991-09-10 | 1992-09-02 | Imidazoindolizinderivate mit angiotensin-ii hemmwirkung |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5268377A (de) |
| EP (1) | EP0531876B1 (de) |
| JP (1) | JP2590797B2 (de) |
| KR (1) | KR0168457B1 (de) |
| AT (1) | ATE146474T1 (de) |
| AU (1) | AU644539B2 (de) |
| CA (1) | CA2077420C (de) |
| DE (1) | DE69216013T2 (de) |
| DK (1) | DK0531876T3 (de) |
| ES (1) | ES2098403T3 (de) |
| FI (1) | FI98369C (de) |
| GR (1) | GR3022106T3 (de) |
| ID (1) | ID902B (de) |
| IL (1) | IL103021A (de) |
| MY (1) | MY129927A (de) |
| SG (1) | SG42962A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06271576A (ja) * | 1993-03-19 | 1994-09-27 | Upjohn Co:The | イミダゾール誘導体の製法 |
| FR2712592B1 (fr) * | 1993-11-17 | 1995-12-22 | Adir | Nouveaux dérivés tricycliques azotés, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| US8034782B2 (en) | 2008-07-16 | 2011-10-11 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| WO2008151257A2 (en) | 2007-06-04 | 2008-12-11 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| EP2810951B1 (de) | 2008-06-04 | 2017-03-15 | Synergy Pharmaceuticals Inc. | Für die Behandlung von gastrointestinalen Erkrankungen, Entzündungen, Krebs und anderen Erkrankungen geeignete Agonisten von Guanylatcyclase |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
| US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| CN105764916B (zh) | 2013-06-05 | 2021-05-18 | 博士医疗爱尔兰有限公司 | 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法 |
| TW201811759A (zh) | 2016-06-29 | 2018-04-01 | 加拿大蒙特利爾大學 | 二芳基甲基雜環 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1047148A1 (ru) * | 1981-03-30 | 1986-12-23 | Институт физико-органической химии и углехимии АН УССР | Бензилиденпроизводные имидазо-[4,5-L]-индолизинов,обладающие бактериостатической и фунгистатической активностью |
| US4686226A (en) * | 1985-09-03 | 1987-08-11 | Merck & Co., Inc. | Substituted benzo[b]furo- and benzo[b]thieno quinolizines |
| US4812462A (en) * | 1986-04-01 | 1989-03-14 | Warner-Lambert Company | 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity |
| US4816463A (en) * | 1986-04-01 | 1989-03-28 | Warner-Lambert Company | Substituted diimidazo [1,5-a: 4',5'-d]pyridines having antihypertensive activity |
| CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
| DE3928177A1 (de) * | 1989-04-08 | 1991-02-28 | Thomae Gmbh Dr K | Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| IL96019A0 (en) * | 1989-10-31 | 1991-07-18 | Fujisawa Pharmaceutical Co | Imidazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
-
1992
- 1992-09-02 DK DK92114987.8T patent/DK0531876T3/da active
- 1992-09-02 ES ES92114987T patent/ES2098403T3/es not_active Expired - Lifetime
- 1992-09-02 IL IL10302192A patent/IL103021A/en not_active IP Right Cessation
- 1992-09-02 DE DE69216013T patent/DE69216013T2/de not_active Expired - Fee Related
- 1992-09-02 SG SG1996001486A patent/SG42962A1/en unknown
- 1992-09-02 CA CA002077420A patent/CA2077420C/en not_active Expired - Fee Related
- 1992-09-02 AT AT92114987T patent/ATE146474T1/de not_active IP Right Cessation
- 1992-09-02 AU AU22056/92A patent/AU644539B2/en not_active Ceased
- 1992-09-02 EP EP92114987A patent/EP0531876B1/de not_active Expired - Lifetime
- 1992-09-03 US US07/939,652 patent/US5268377A/en not_active Expired - Fee Related
- 1992-09-07 MY MYPI92001597A patent/MY129927A/en unknown
- 1992-09-08 KR KR1019920016409A patent/KR0168457B1/ko not_active Expired - Fee Related
- 1992-09-08 JP JP4239080A patent/JP2590797B2/ja not_active Expired - Lifetime
- 1992-09-10 FI FI924043A patent/FI98369C/fi active
- 1992-09-10 ID IDP469892A patent/ID902B/id unknown
-
1996
- 1996-12-19 GR GR960403177T patent/GR3022106T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MY129927A (en) | 2007-05-31 |
| ES2098403T3 (es) | 1997-05-01 |
| EP0531876B1 (de) | 1996-12-18 |
| FI98369C (fi) | 1997-06-10 |
| KR930006024A (ko) | 1993-04-20 |
| KR0168457B1 (ko) | 1999-01-15 |
| DK0531876T3 (de) | 1997-02-17 |
| FI924043L (fi) | 1993-03-11 |
| DE69216013D1 (de) | 1997-01-30 |
| ID902B (id) | 1996-09-09 |
| IL103021A0 (en) | 1993-02-21 |
| DE69216013T2 (de) | 1997-05-07 |
| JP2590797B2 (ja) | 1997-03-12 |
| SG42962A1 (en) | 1997-10-17 |
| FI98369B (fi) | 1997-02-28 |
| GR3022106T3 (en) | 1997-03-31 |
| US5268377A (en) | 1993-12-07 |
| EP0531876A2 (de) | 1993-03-17 |
| EP0531876A3 (de) | 1993-05-05 |
| FI924043A0 (fi) | 1992-09-10 |
| IL103021A (en) | 1996-10-16 |
| CA2077420C (en) | 1998-08-25 |
| AU2205692A (en) | 1993-03-11 |
| AU644539B2 (en) | 1993-12-09 |
| CA2077420A1 (en) | 1993-03-11 |
| JPH05279365A (ja) | 1993-10-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |