MD1744F2 - Săruri ale acidului clavulanic şi procedeu de obţinere a lor - Google Patents

Săruri ale acidului clavulanic şi procedeu de obţinere a lor

Info

Publication number
MD1744F2
MD1744F2 MD97-0269A MD970269A MD1744F2 MD 1744 F2 MD1744 F2 MD 1744F2 MD 970269 A MD970269 A MD 970269A MD 1744 F2 MD1744 F2 MD 1744F2
Authority
MD
Moldova
Prior art keywords
clavulanic acid
acid salts
obtaining
salt
benzhydrylamine
Prior art date
Application number
MD97-0269A
Other languages
English (en)
Russian (ru)
Other versions
MD970269A (ro
Inventor
George Leo Callewaert
Original Assignee
Spurcourt Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26306586&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MD1744(F2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9503839.4A external-priority patent/GB9503839D0/en
Application filed by Spurcourt Limited filed Critical Spurcourt Limited
Publication of MD970269A publication Critical patent/MD970269A/ro
Publication of MD1744F2 publication Critical patent/MD1744F2/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D503/10—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Sunt revendicate săruri ale acidului clavulanic, obţinute prin interacţiunea acidului clavulanic (sau a unei sări a acestuia) şi benzhidrilaminei (sau a unei sări a acesteia) cu formula Iîn care fiecare din radicalii R1 şi R2, independent, reprezintă atom de hidrogen sau un aşa substituent, pentru care sarea acidului clavulanic este acceptabilă farmaceutic.Aceste săruri se pot utiliza în formulări farmaceutice împreună cu un purtător acceptabil farmaceutic şi, opţional, cu un antibiotic beta-lactamic.
MD97-0269A 1995-02-25 1996-02-21 Săruri ale acidului clavulanic şi procedeu de obţinere a lor MD1744F2 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9503839.4A GB9503839D0 (en) 1995-02-25 1995-02-25 Claulanic acid salt
GBGB9520915.1A GB9520915D0 (en) 1995-02-25 1995-10-12 Clavulanic acid salt
PCT/GB1996/000382 WO1996026944A1 (en) 1995-02-25 1996-02-21 Clavulanic acid salts

Publications (2)

Publication Number Publication Date
MD970269A MD970269A (ro) 1999-05-31
MD1744F2 true MD1744F2 (ro) 2001-09-30

Family

ID=26306586

Family Applications (1)

Application Number Title Priority Date Filing Date
MD97-0269A MD1744F2 (ro) 1995-02-25 1996-02-21 Săruri ale acidului clavulanic şi procedeu de obţinere a lor

Country Status (26)

Country Link
US (1) US5726170A (ro)
EP (1) EP0729961B1 (ro)
JP (1) JPH11501023A (ro)
CN (1) CN1175952A (ro)
AP (2) AP749A (ro)
AT (1) ATE211143T1 (ro)
AU (1) AU691727B2 (ro)
BG (1) BG62490B1 (ro)
BR (1) BR9607258A (ro)
CA (1) CA2213563A1 (ro)
CZ (1) CZ266697A3 (ro)
DE (1) DE69618045D1 (ro)
EE (1) EE9700186A (ro)
FI (1) FI973287A7 (ro)
IL (1) IL117217A0 (ro)
IS (1) IS4541A (ro)
MD (1) MD1744F2 (ro)
NO (1) NO973744D0 (ro)
NZ (1) NZ301765A (ro)
OA (1) OA10444A (ro)
PL (1) PL321871A1 (ro)
SE (1) SE9703056D0 (ro)
SK (1) SK111197A3 (ro)
TR (1) TR199700828T1 (ro)
WO (1) WO1996026944A1 (ro)
ZA (1) ZA961457B (ro)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (de) * 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9400107A (en) 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
SI9500134B (sl) 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
US6414142B1 (en) * 1996-06-13 2002-07-02 Smithkline Beecham Corporation Process for preparing potassium clavulanate
DZ2456A1 (fr) * 1997-04-04 2003-01-18 Smithkline Beecham Plc Procédé de préparation de sels de l'acide clavulanique.
US8034120B2 (en) * 2002-12-20 2011-10-11 Ossur Hf Suspension liner system with seal
CN103304583B (zh) * 2013-07-09 2016-01-20 山东新时代药业有限公司 一种从克拉维酸胺盐结晶母液中回收克拉维酸的方法
CN105384758B (zh) * 2015-12-01 2018-05-01 国药集团威奇达药业有限公司 克拉维酸胺盐的制备方法
CN113979856B (zh) * 2021-11-09 2024-04-19 国药集团威奇达药业有限公司 从克拉维酸钾釜残液中回收叔丁胺和异辛酸盐的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1578739A (en) * 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
GB2264944A (en) * 1992-03-10 1993-09-15 Biochemie Gmbh 2-amino-2,4,4-trimethylpentane salt of clavulanic acid
WO1993025557A1 (en) * 1992-06-11 1993-12-23 Smithkline Beecham Plc Process for the preparation of clavulanic acid

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB157873A (en) * 1920-01-16 1921-08-17 Schneider & Cie Improvements in gas turbines
GB704438A (en) * 1951-04-06 1954-02-24 Chimiotherapie Lab Franc Penicillin preparations for injection
GB1508977A (en) * 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
GB1543563A (en) * 1975-02-07 1979-04-04 Glaxo Lab Ltd Beta-lactam antibiotic in purified form
BE862211A (fr) * 1977-12-22 1978-06-22 Beecham Group Ltd Agents antibacteriens
EP0026044B1 (en) * 1979-08-24 1983-06-08 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
AR245221A1 (es) * 1984-10-27 1993-12-30 Beecham Group Plc Un metodo para la produccion de acido clavulanico por fermentacion de s. clavuligerus
ES2010143A6 (es) * 1989-03-01 1989-10-16 Pharma Mar S A Pharmar Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.
DE69400334T2 (de) * 1993-03-26 1997-02-13 Gist Brocades Nv Diaminsalze von clavulansäure

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1578739A (en) * 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
GB2264944A (en) * 1992-03-10 1993-09-15 Biochemie Gmbh 2-amino-2,4,4-trimethylpentane salt of clavulanic acid
WO1993025557A1 (en) * 1992-06-11 1993-12-23 Smithkline Beecham Plc Process for the preparation of clavulanic acid

Also Published As

Publication number Publication date
AP749A (en) 1999-07-05
IL117217A0 (en) 1996-06-18
AU4726196A (en) 1996-09-18
JPH11501023A (ja) 1999-01-26
PL321871A1 (en) 1997-12-22
HK1006571A1 (en) 1999-03-05
BR9607258A (pt) 1997-12-30
FI973287L (fi) 1997-08-22
NO973744L (no) 1997-08-14
ATE211143T1 (de) 2002-01-15
EP0729961B1 (en) 2001-12-19
BG101884A (en) 1998-10-30
WO1996026944A1 (en) 1996-09-06
CN1175952A (zh) 1998-03-11
ZA961457B (en) 1996-09-26
AP9701067A0 (en) 1997-10-31
SE9703056L (sv) 1997-08-25
FI973287A7 (fi) 1997-08-22
MX9706461A (es) 1998-06-28
CA2213563A1 (en) 1996-09-06
IS4541A (is) 1997-08-08
AP9701116A0 (en) 1997-10-31
TR199700828T1 (xx) 1998-04-21
FI973287A0 (fi) 1997-08-08
OA10444A (en) 2002-03-26
CZ266697A3 (en) 1997-11-12
SE9703056D0 (sv) 1997-08-25
NZ301765A (en) 1999-10-28
US5726170A (en) 1998-03-10
EE9700186A (et) 1998-02-16
DE69618045D1 (de) 2002-01-31
NO973744D0 (no) 1997-08-14
SK111197A3 (en) 1998-01-14
MD970269A (ro) 1999-05-31
AU691727B2 (en) 1998-05-21
EP0729961A1 (en) 1996-09-04
BG62490B1 (bg) 1999-12-30

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