NO994104L - 5-hydroksymetyl-2-aminotetraliner i form av kardiovaskulaere midler - Google Patents

5-hydroksymetyl-2-aminotetraliner i form av kardiovaskulaere midler

Info

Publication number
NO994104L
NO994104L NO994104A NO994104A NO994104L NO 994104 L NO994104 L NO 994104L NO 994104 A NO994104 A NO 994104A NO 994104 A NO994104 A NO 994104A NO 994104 L NO994104 L NO 994104L
Authority
NO
Norway
Prior art keywords
aminotetralins
hydroxymethyl
cardiovascular agents
compounds
useful
Prior art date
Application number
NO994104A
Other languages
English (en)
Other versions
NO994104D0 (no
Inventor
Stefania Montanari
Paolo Cavalleri
Francesco Santangelo
Francesco Marchini
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of NO994104D0 publication Critical patent/NO994104D0/no
Publication of NO994104L publication Critical patent/NO994104L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Forbindelser med formel (I) hvori RI og Rj uavhengig av hverandre er hydrogen eller en eventuelt forgrenet Ci-^-alkylgruppe, og stjernen markerer et asymmetrisk karbonatom, og de farmasøytisk akseptable salter derav, anvendbare innen det kardiovaskulære område, er beskrevet.
NO994104A 1997-02-26 1999-08-25 5-hydroksymetyl-2-aminotetraliner i form av kardiovaskulaere midler NO994104L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97MI000414A IT1289979B1 (it) 1997-02-26 1997-02-26 5-idrossimetil-6-idrossi-2-amminotetraline attive come agenti cardiovascolari
PCT/EP1998/000589 WO1998038155A1 (en) 1997-02-26 1998-02-04 5-hydroxymethyl-2-aminotetralins as cardiovascular agents

Publications (2)

Publication Number Publication Date
NO994104D0 NO994104D0 (no) 1999-08-25
NO994104L true NO994104L (no) 1999-10-26

Family

ID=11376182

Family Applications (1)

Application Number Title Priority Date Filing Date
NO994104A NO994104L (no) 1997-02-26 1999-08-25 5-hydroksymetyl-2-aminotetraliner i form av kardiovaskulaere midler

Country Status (16)

Country Link
US (1) US6063964A (no)
EP (1) EP0970042B1 (no)
JP (1) JP2001513763A (no)
KR (1) KR20000075736A (no)
AT (1) ATE211727T1 (no)
AU (1) AU733001B2 (no)
CA (1) CA2282388A1 (no)
DE (1) DE69803445T2 (no)
DK (1) DK0970042T3 (no)
ES (1) ES2169909T3 (no)
HU (1) HUP0001058A3 (no)
IT (1) IT1289979B1 (no)
NO (1) NO994104L (no)
NZ (1) NZ336680A (no)
PT (1) PT970042E (no)
WO (1) WO1998038155A1 (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CR20200225A (es) 2017-11-24 2020-07-25 H Lundbeck As Nuevos fármacos de catecolamina para uso en el tratamiento de la enfermedad de parkinson
US11111263B2 (en) 2019-05-20 2021-09-07 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11130775B2 (en) 2019-05-20 2021-09-28 H. Lundbeck A/S Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11104697B2 (en) 2019-05-20 2021-08-31 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11168056B2 (en) 2019-05-20 2021-11-09 H. Lundbeck A/S Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2803582A1 (de) * 1978-01-27 1979-08-02 Sandoz Ag Neue tetralinderivate, ihre herstellung und verwendung
IT1271411B (it) * 1993-09-14 1997-05-28 Zambon Spa Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare

Also Published As

Publication number Publication date
EP0970042A1 (en) 2000-01-12
AU6619898A (en) 1998-09-18
PT970042E (pt) 2002-06-28
HUP0001058A3 (en) 2001-07-30
CA2282388A1 (en) 1998-09-03
NZ336680A (en) 2000-02-28
HUP0001058A2 (hu) 2001-06-28
DE69803445D1 (en) 2002-02-28
WO1998038155A1 (en) 1998-09-03
JP2001513763A (ja) 2001-09-04
KR20000075736A (ko) 2000-12-26
DK0970042T3 (da) 2002-04-29
ITMI970414A1 (it) 1998-08-26
EP0970042B1 (en) 2002-01-09
ATE211727T1 (de) 2002-01-15
IT1289979B1 (it) 1998-10-19
ES2169909T3 (es) 2002-07-16
DE69803445T2 (de) 2002-08-29
US6063964A (en) 2000-05-16
NO994104D0 (no) 1999-08-25
AU733001B2 (en) 2001-05-03

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application