ES2169909T3 - 5-hidroximetil-2-aminotetralinas como agentes cardiovasculares. - Google Patents

5-hidroximetil-2-aminotetralinas como agentes cardiovasculares.

Info

Publication number
ES2169909T3
ES2169909T3 ES98908052T ES98908052T ES2169909T3 ES 2169909 T3 ES2169909 T3 ES 2169909T3 ES 98908052 T ES98908052 T ES 98908052T ES 98908052 T ES98908052 T ES 98908052T ES 2169909 T3 ES2169909 T3 ES 2169909T3
Authority
ES
Spain
Prior art keywords
hydroximethyl
aminotetralins
sub
cardiovascular agents
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98908052T
Other languages
English (en)
Inventor
Stefania Montanari
Paolo Cavalleri
Francesco Santangelo
Francesco Marchini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zambon Group SpA
Zambon SpA
Original Assignee
Zambon Group SpA
Zambon SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Group SpA, Zambon SpA filed Critical Zambon Group SpA
Application granted granted Critical
Publication of ES2169909T3 publication Critical patent/ES2169909T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se describen compuestos de fórmula (I) *fórmula* en la que R{sub,1} y R{sub,2} son independientemente hidrógeno o un grupo alquilo C{sub,1-4} opcionalmente ramificado; el asterisco marca un tomo De carbono asimétrico; y las sales farmacéuticamente aceptables de éstos, útiles en el campo cardiovascular.
ES98908052T 1997-02-26 1998-02-04 5-hidroximetil-2-aminotetralinas como agentes cardiovasculares. Expired - Lifetime ES2169909T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI000414A IT1289979B1 (it) 1997-02-26 1997-02-26 5-idrossimetil-6-idrossi-2-amminotetraline attive come agenti cardiovascolari

Publications (1)

Publication Number Publication Date
ES2169909T3 true ES2169909T3 (es) 2002-07-16

Family

ID=11376182

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98908052T Expired - Lifetime ES2169909T3 (es) 1997-02-26 1998-02-04 5-hidroximetil-2-aminotetralinas como agentes cardiovasculares.

Country Status (16)

Country Link
US (1) US6063964A (es)
EP (1) EP0970042B1 (es)
JP (1) JP2001513763A (es)
KR (1) KR20000075736A (es)
AT (1) ATE211727T1 (es)
AU (1) AU733001B2 (es)
CA (1) CA2282388A1 (es)
DE (1) DE69803445T2 (es)
DK (1) DK0970042T3 (es)
ES (1) ES2169909T3 (es)
HU (1) HUP0001058A3 (es)
IT (1) IT1289979B1 (es)
NO (1) NO994104L (es)
NZ (1) NZ336680A (es)
PT (1) PT970042E (es)
WO (1) WO1998038155A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2020005366A (es) 2017-11-24 2020-08-13 H Lundbeck As Nuevos profarmacos de catecolamina para uso en el tratamiento de la enfermedad de parkinson.
US11104697B2 (en) 2019-05-20 2021-08-31 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11130775B2 (en) 2019-05-20 2021-09-28 H. Lundbeck A/S Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11168056B2 (en) 2019-05-20 2021-11-09 H. Lundbeck A/S Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol
US11111263B2 (en) 2019-05-20 2021-09-07 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2803582A1 (de) * 1978-01-27 1979-08-02 Sandoz Ag Neue tetralinderivate, ihre herstellung und verwendung
IT1271411B (it) * 1993-09-14 1997-05-28 Zambon Spa Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare

Also Published As

Publication number Publication date
ATE211727T1 (de) 2002-01-15
IT1289979B1 (it) 1998-10-19
ITMI970414A1 (it) 1998-08-26
PT970042E (pt) 2002-06-28
EP0970042A1 (en) 2000-01-12
DK0970042T3 (da) 2002-04-29
HUP0001058A3 (en) 2001-07-30
NO994104L (no) 1999-10-26
WO1998038155A1 (en) 1998-09-03
DE69803445D1 (en) 2002-02-28
AU733001B2 (en) 2001-05-03
US6063964A (en) 2000-05-16
DE69803445T2 (de) 2002-08-29
NZ336680A (en) 2000-02-28
HUP0001058A2 (hu) 2001-06-28
NO994104D0 (no) 1999-08-25
CA2282388A1 (en) 1998-09-03
AU6619898A (en) 1998-09-18
JP2001513763A (ja) 2001-09-04
EP0970042B1 (en) 2002-01-09
KR20000075736A (ko) 2000-12-26

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