EA200200727A1 - Новые производные индола - Google Patents

Новые производные индола

Info

Publication number
EA200200727A1
EA200200727A1 EA200200727A EA200200727A EA200200727A1 EA 200200727 A1 EA200200727 A1 EA 200200727A1 EA 200200727 A EA200200727 A EA 200200727A EA 200200727 A EA200200727 A EA 200200727A EA 200200727 A1 EA200200727 A1 EA 200200727A1
Authority
EA
Eurasian Patent Office
Prior art keywords
indol derivatives
compounds
new indol
new
derivatives
Prior art date
Application number
EA200200727A
Other languages
English (en)
Inventor
Томас Руланд
Кристиан Крог-Енсен
Марио Роттлендер
Гитте Миккельсен
Ким Андерсен
Айнер Кнуд Молтсен
Original Assignee
Х. Лундбекк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х. Лундбекк А/С filed Critical Х. Лундбекк А/С
Publication of EA200200727A1 publication Critical patent/EA200200727A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Настоящее изобретение относится к соединениям формулы (I), в которой Х означает О или S; n равно 2, 3, 4, 5, 6, 7, 8, 9 или 10; m равно 2 или 3; Y означает N, С или СН; пунктирная линия означает необязательную связь; R, R, R, R, R, R, R, R, R, R, R, Rи Rимеют значения, приведенные в описании изобретения. Указанные соединения являются лигандами рецепторов 5-HT.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200200727A 1999-12-30 2000-12-29 Новые производные индола EA200200727A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA199901889 1999-12-30
PCT/DK2000/000742 WO2001049680A1 (en) 1999-12-30 2000-12-29 Novel indole derivatives

Publications (1)

Publication Number Publication Date
EA200200727A1 true EA200200727A1 (ru) 2002-12-26

Family

ID=8108836

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200727A EA200200727A1 (ru) 1999-12-30 2000-12-29 Новые производные индола

Country Status (23)

Country Link
US (1) US20030050307A1 (ru)
EP (1) EP1246818A1 (ru)
JP (1) JP2003519226A (ru)
KR (1) KR20020063288A (ru)
CN (1) CN1437598A (ru)
AR (1) AR027134A1 (ru)
AU (1) AU2352101A (ru)
BG (1) BG106937A (ru)
BR (1) BR0016955A (ru)
CA (1) CA2395606A1 (ru)
CZ (1) CZ20022489A3 (ru)
EA (1) EA200200727A1 (ru)
HU (1) HUP0203767A3 (ru)
IL (1) IL150336A0 (ru)
IS (1) IS6434A (ru)
MX (1) MXPA02006498A (ru)
NO (1) NO20023148L (ru)
NZ (1) NZ519648A (ru)
PL (1) PL355538A1 (ru)
SK (1) SK9452002A3 (ru)
TR (1) TR200201689T2 (ru)
WO (1) WO2001049680A1 (ru)
ZA (1) ZA200204969B (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002243394A1 (en) 2000-11-16 2002-06-24 Wyeth Aryloxy piperidinyl derivatives for the treatment of depression
US6656950B2 (en) * 2001-04-25 2003-12-02 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine
AU2002344950B2 (en) * 2001-06-29 2008-04-03 H. Lundbeck A/S Novel indole derivatives
ES2326078T3 (es) 2002-08-22 2009-09-30 Dainippon Sumitomo Pharma Co., Ltd. Medicamento destinado al sindrome de la disfuncion de integracion.
KR101113630B1 (ko) 2003-06-23 2012-02-13 다이닛본 스미토모 세이야꾸 가부시끼가이샤 노인성 치매 치료제
EP1726952A4 (en) 2004-02-20 2008-06-18 Dainippon Sumitomo Pharma Co METHOD FOR IN VIVO SCREENING OF A THERAPEUTIC FOR A MEMORY / LEARNING FUNCTION THROUGH SCHIZOPHRENIA
AR055203A1 (es) * 2005-08-31 2007-08-08 Otsuka Pharma Co Ltd Derivados de benzotiofeno con propiedades antipsicoticas
JP4785881B2 (ja) * 2007-02-27 2011-10-05 大塚製薬株式会社 医薬
US8258139B2 (en) 2010-11-08 2012-09-04 Dainippon Sumitomo Pharma Co., Ltd. Method of treatment for mental disorders
PL395469A1 (pl) * 2011-06-29 2013-01-07 Adamed Spólka Z Ograniczona Odpowiedzialnoscia Pochodne indoloamin do leczenia chorób osrodkowego ukladu nerwowego

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2567884B1 (fr) * 1984-07-19 1987-03-06 Roussel Uclaf Nouveaux derives de l'indole, leur preparation, leur application comme medicaments et les compositions les renfermant
GB8830312D0 (en) * 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
DK148392D0 (da) * 1992-12-09 1992-12-09 Lundbeck & Co As H Heterocykliske forbindelser
EP0900792B1 (en) * 1997-09-02 2003-10-29 Duphar International Research B.V Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists
EP1076647A2 (en) * 1998-04-29 2001-02-21 American Home Products Corporation Antipsychotic indolyl derivatives

Also Published As

Publication number Publication date
NO20023148D0 (no) 2002-06-28
MXPA02006498A (es) 2002-11-29
BR0016955A (pt) 2003-04-29
IL150336A0 (en) 2002-12-01
CN1437598A (zh) 2003-08-20
HUP0203767A2 (hu) 2003-03-28
ZA200204969B (en) 2003-09-22
CZ20022489A3 (cs) 2002-10-16
TR200201689T2 (tr) 2002-10-21
PL355538A1 (en) 2004-05-04
CA2395606A1 (en) 2001-07-12
AU2352101A (en) 2001-07-16
NZ519648A (en) 2004-05-28
US20030050307A1 (en) 2003-03-13
WO2001049680A1 (en) 2001-07-12
JP2003519226A (ja) 2003-06-17
EP1246818A1 (en) 2002-10-09
AR027134A1 (es) 2003-03-12
BG106937A (en) 2003-04-30
NO20023148L (no) 2002-06-28
HUP0203767A3 (en) 2004-06-28
IS6434A (is) 2002-06-19
SK9452002A3 (en) 2002-11-06
KR20020063288A (ko) 2002-08-01

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