EA200200558A1 - 2-( 1h-индол-3-ил)-2-оксоацетамиды, обладающие противоопухолевой активностью - Google Patents

2-( 1h-индол-3-ил)-2-оксоацетамиды, обладающие противоопухолевой активностью

Info

Publication number
EA200200558A1
EA200200558A1 EA200200558A EA200200558A EA200200558A1 EA 200200558 A1 EA200200558 A1 EA 200200558A1 EA 200200558 A EA200200558 A EA 200200558A EA 200200558 A EA200200558 A EA 200200558A EA 200200558 A1 EA200200558 A1 EA 200200558A1
Authority
EA
Eurasian Patent Office
Prior art keywords
oxoacetamides
indol
tumor activity
possessing anti
possessing
Prior art date
Application number
EA200200558A
Other languages
English (en)
Other versions
EA004925B1 (ru
Inventor
Эрнесто Мента
Николетта Пескалли
Original Assignee
Новусфарма С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новусфарма С.П.А. filed Critical Новусфарма С.П.А.
Publication of EA200200558A1 publication Critical patent/EA200200558A1/ru
Publication of EA004925B1 publication Critical patent/EA004925B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

2-(1Н-индол-3-ил)-2-оксоацетамиды, обладающие противоопухолевой активностью, в частности, в отношении твердых опухолей, точнее против опухоли толстой кишки и опухоли легких, следующей формулы (I), где Y представляет собой атом кислорода или серы и X, R1, R2, R3, R4 и R5 являются такими, как определено в п.1 формулы изобретения.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200200558A 1999-12-23 2000-12-21 2-(1h-индол-3-ил)-2-оксоацетамиды, обладающие противоопухолевой активностью EA004925B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI002693A IT1315267B1 (it) 1999-12-23 1999-12-23 Derivati di 2-(1h-indol-3-il)-2-oxo-acetammidi ad attivita'antitumorale
PCT/EP2000/013068 WO2001047916A1 (en) 1999-12-23 2000-12-21 2-(1h-indol-3-yl)-2-oxo-acetamides with antitumor activity

Publications (2)

Publication Number Publication Date
EA200200558A1 true EA200200558A1 (ru) 2002-12-26
EA004925B1 EA004925B1 (ru) 2004-10-28

Family

ID=11384182

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200558A EA004925B1 (ru) 1999-12-23 2000-12-21 2-(1h-индол-3-ил)-2-оксоацетамиды, обладающие противоопухолевой активностью

Country Status (24)

Country Link
US (1) US6753342B2 (ru)
EP (1) EP1244652B1 (ru)
JP (1) JP2003519140A (ru)
KR (1) KR100795533B1 (ru)
CN (1) CN1250542C (ru)
AT (1) ATE302772T1 (ru)
AU (1) AU776332B2 (ru)
BR (1) BR0016553A (ru)
CA (1) CA2395205A1 (ru)
CZ (1) CZ20022170A3 (ru)
DE (1) DE60022227T2 (ru)
EA (1) EA004925B1 (ru)
ES (1) ES2246918T3 (ru)
HU (1) HUP0203524A3 (ru)
IL (2) IL150329A0 (ru)
IT (1) IT1315267B1 (ru)
MX (1) MXPA02006217A (ru)
NO (1) NO323312B1 (ru)
NZ (1) NZ519689A (ru)
PL (1) PL356541A1 (ru)
SK (1) SK285682B6 (ru)
TR (1) TR200201613T2 (ru)
WO (1) WO2001047916A1 (ru)
ZA (1) ZA200204964B (ru)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200003130T2 (tr) 1998-04-28 2001-01-22 Arzneimittelwerk Dresden Gmbh Yeni hidroksiindoller, bunların fosfodiesteraz 4 inhibitörleri olarak kullanımları ve hazırlanmaları için işlemler
IT1318641B1 (it) * 2000-07-25 2003-08-27 Novuspharma Spa Ammidi di acidi 2-(1h-indol-3-il)-2-oxo-acetici ad attivita'antitumorale.
DE10037310A1 (de) 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
BRPI0312649A2 (pt) * 2002-07-09 2017-05-16 Fasgen Llc compostos, composições farmacêuticas contendo os mesmos, e processos de uso para os mesmos.
AU2004270733B2 (en) 2003-09-11 2011-05-19 Itherx Pharma, Inc. Cytokine inhibitors
AU2005229522A1 (en) * 2004-03-11 2005-10-13 Actelion Pharmaceuticals Ltd. Indol-1-yl-acetic acid derivatives
EP2007756B1 (en) 2006-04-07 2015-08-26 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters
US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
CA2660704A1 (en) * 2006-08-07 2008-02-14 Ironwood Pharmaceuticals, Inc. Indole compounds
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
MX342288B (es) 2010-04-22 2016-09-23 Vertex Pharma Proceso para producir compuestos de cicloalquilcarboxamido-indol.
AR084433A1 (es) 2010-12-22 2013-05-15 Ironwood Pharmaceuticals Inc Inhibidores de la faah y composiciones farmaceuticas que los contienen
US9056851B2 (en) 2011-03-25 2015-06-16 The Research Foundation For The State University Of New York Thiolactone antibiotics
US9012496B2 (en) 2012-07-16 2015-04-21 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of (R)-1-(2,2-difluorobenzo[D][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide and administration thereof
ES2957761T3 (es) 2014-04-15 2024-01-25 Vertex Pharma Composiciones farmacéuticas para el tratamiento de enfermedades mediadas por el regulador de la conductancia transmembrana de fibrosis quística
CN115785079B (zh) * 2022-11-28 2024-02-13 沈阳药科大学 4-(1h-吲哚-5-基)氨基呋喃-2(5h)-酮类化合物及其制备和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP9901092A3 (en) * 1995-08-02 2001-11-28 Univ Newcastle Ventures Ltd Benzimidazole compounds and their pharmaceutical use
CO4970714A1 (es) * 1997-09-05 2000-11-07 Boehringer Mannheim Gmbh Derivados ureido y tioureido de 4-amino-2(5h)-furanonas y 4-amino-2(5h) tiofenonas como agentes antitumorales
DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
TR200003130T2 (tr) * 1998-04-28 2001-01-22 Arzneimittelwerk Dresden Gmbh Yeni hidroksiindoller, bunların fosfodiesteraz 4 inhibitörleri olarak kullanımları ve hazırlanmaları için işlemler

Also Published As

Publication number Publication date
JP2003519140A (ja) 2003-06-17
IT1315267B1 (it) 2003-02-03
DE60022227D1 (de) 2005-09-29
HUP0203524A3 (en) 2008-01-28
BR0016553A (pt) 2002-09-17
TR200201613T2 (tr) 2002-10-21
AU2170401A (en) 2001-07-09
CN1413205A (zh) 2003-04-23
CA2395205A1 (en) 2001-07-05
US20030158153A1 (en) 2003-08-21
AU776332B2 (en) 2004-09-02
MXPA02006217A (es) 2004-02-26
ATE302772T1 (de) 2005-09-15
EP1244652A1 (en) 2002-10-02
IL150329A (en) 2006-07-05
WO2001047916A1 (en) 2001-07-05
IL150329A0 (en) 2002-12-01
SK8962002A3 (en) 2002-11-06
ES2246918T3 (es) 2006-03-01
ZA200204964B (en) 2004-01-29
KR20020063247A (ko) 2002-08-01
KR100795533B1 (ko) 2008-01-16
HUP0203524A2 (hu) 2003-03-28
PL356541A1 (en) 2004-06-28
CZ20022170A3 (cs) 2002-09-11
NO323312B1 (no) 2007-03-12
EP1244652B1 (en) 2005-08-24
ITMI992693A0 (it) 1999-12-23
SK285682B6 (sk) 2007-06-07
NO20022976L (no) 2002-06-20
EA004925B1 (ru) 2004-10-28
ITMI992693A1 (it) 2001-06-23
US6753342B2 (en) 2004-06-22
CN1250542C (zh) 2006-04-12
NZ519689A (en) 2004-02-27
NO20022976D0 (no) 2002-06-20
DE60022227T2 (de) 2006-06-22

Similar Documents

Publication Publication Date Title
EA200200558A1 (ru) 2-( 1h-индол-3-ил)-2-оксоацетамиды, обладающие противоопухолевой активностью
EA200100315A1 (ru) Простые тетрагидропиридовые эфиры
DE69918422D1 (de) Phthalazinone pde iii/iv hemmer
EA199900936A1 (ru) Фунгицидные трифторметилалкиламинотриазолопиримидины
EA199900620A1 (ru) Фталазиноны
DE69919700D1 (de) Überbrückte indenopyrrolocarbazole
ATE245642T1 (de) Benzamide mit tetrahydrofuranyloxy-substituenten als inhibitoren der phosphodiesterase 4
SE9903290D0 (sv) Novel compounds
DE60202669D1 (de) 6-phenylbenzonaphthyidine
EA200200727A1 (ru) Новые производные индола
TR200001080T2 (tr) 2 ile ikame edilmiş 1,2-Benisotiyazol türevleri ve bunların serrotonın antagonistleri
MA24197A1 (fr) Nouvelles fungarrestines
EA200401099A1 (ru) Производные гетероциклического амида
ATE213236T1 (de) Substituierte benzyloxyimino-verbindungen
NZ333854A (en) Intermediates for the preparation of 2-imidazoline-5-ones
EA200100151A1 (ru) Производные пиперазинона и их применение
EA200100073A1 (ru) Изохинолины в качестве ингибиторов урокиназы
TR200100475T2 (tr) N-İkameli azabisikloheptan türevlerinin üretimleri ve kullanımları.
DE59905355D1 (de) Verwendung von katecholderivaten als proteinaseinhibitoren
CY1110529T1 (el) Παρασκευη ν-υποκατεστημενων 2,7-διαλκυλο-4-υδροξυ-5-αμινο-8-αρυλοοκτανοϋλαμιδιων
DE602004018276D1 (de) Nitratester von phenylaminothiophen-essigsäurederivaten
MY127539A (en) Bridged indenopyrrolocarbazoles

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU