TR200201613T2 - Antitümör tesirli 2-(1H-indol-3-il)-2-okso asetamidler - Google Patents

Antitümör tesirli 2-(1H-indol-3-il)-2-okso asetamidler

Info

Publication number
TR200201613T2
TR200201613T2 TR2002/01613T TR200201613T TR200201613T2 TR 200201613 T2 TR200201613 T2 TR 200201613T2 TR 2002/01613 T TR2002/01613 T TR 2002/01613T TR 200201613 T TR200201613 T TR 200201613T TR 200201613 T2 TR200201613 T2 TR 200201613T2
Authority
TR
Turkey
Prior art keywords
acetamides
indol
oxo
antitumor effect
tumors
Prior art date
Application number
TR2002/01613T
Other languages
English (en)
Inventor
Menta Ernesto
Pescalli Nicoletta
Original Assignee
Novuspharma S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novuspharma S.P.A. filed Critical Novuspharma S.P.A.
Publication of TR200201613T2 publication Critical patent/TR200201613T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Yukaridaki formül (I)'in özellikle sert tümörler, daha ayrintili olarak da bagirsak ve akciger tümörleri karsisinda antitümör tesiri sergileyen 2-(1H-indol-3-il)-2-okso-asetamidleri olup, bu formüldeki Y oksijen veya sülfür atomu ve X,R1,R2,R3,R4, ve R5 de istem 1'de tanimlandigi gibidir.
TR2002/01613T 1999-12-23 2000-12-21 Antitümör tesirli 2-(1H-indol-3-il)-2-okso asetamidler TR200201613T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999MI002693A IT1315267B1 (it) 1999-12-23 1999-12-23 Derivati di 2-(1h-indol-3-il)-2-oxo-acetammidi ad attivita'antitumorale

Publications (1)

Publication Number Publication Date
TR200201613T2 true TR200201613T2 (tr) 2002-10-21

Family

ID=11384182

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2002/01613T TR200201613T2 (tr) 1999-12-23 2000-12-21 Antitümör tesirli 2-(1H-indol-3-il)-2-okso asetamidler

Country Status (24)

Country Link
US (1) US6753342B2 (tr)
EP (1) EP1244652B1 (tr)
JP (1) JP2003519140A (tr)
KR (1) KR100795533B1 (tr)
CN (1) CN1250542C (tr)
AT (1) ATE302772T1 (tr)
AU (1) AU776332B2 (tr)
BR (1) BR0016553A (tr)
CA (1) CA2395205A1 (tr)
CZ (1) CZ20022170A3 (tr)
DE (1) DE60022227T2 (tr)
EA (1) EA004925B1 (tr)
ES (1) ES2246918T3 (tr)
HU (1) HUP0203524A3 (tr)
IL (2) IL150329A0 (tr)
IT (1) IT1315267B1 (tr)
MX (1) MXPA02006217A (tr)
NO (1) NO323312B1 (tr)
NZ (1) NZ519689A (tr)
PL (1) PL356541A1 (tr)
SK (1) SK285682B6 (tr)
TR (1) TR200201613T2 (tr)
WO (1) WO2001047916A1 (tr)
ZA (1) ZA200204964B (tr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA59443C2 (uk) 1998-04-28 2003-09-15 Арцнайміттельверк Дрезден Гмбх Гідроксііндол, спосіб його одержання, лікарська форма на його основі та спосіб її одержання
IT1318641B1 (it) 2000-07-25 2003-08-27 Novuspharma Spa Ammidi di acidi 2-(1h-indol-3-il)-2-oxo-acetici ad attivita'antitumorale.
DE10037310A1 (de) * 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
EA013371B1 (ru) * 2002-07-09 2010-04-30 Фасджен, Ллс. Новые соединения, содержащие их фармацевтические композиции и способы их применения
AU2004270733B2 (en) 2003-09-11 2011-05-19 Itherx Pharma, Inc. Cytokine inhibitors
EP1740171B1 (en) * 2004-03-11 2010-06-09 Actelion Pharmaceuticals Ltd. Indol-1-yl-acetic acid derivatives
DK3091011T3 (en) 2006-04-07 2018-02-26 Vertex Pharma MODULATORS OF ATP BINDING CASSETTE TRANSPORT
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
EA018724B1 (ru) * 2006-08-07 2013-10-30 Айронвуд Фармасьютикалз, Инк. Соединения индола
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
SG184987A1 (en) 2010-04-22 2012-11-29 Vertex Pharma Process of producing cycloalkylcarboxamido-indole compounds
AR084433A1 (es) 2010-12-22 2013-05-15 Ironwood Pharmaceuticals Inc Inhibidores de la faah y composiciones farmaceuticas que los contienen
US9056851B2 (en) 2011-03-25 2015-06-16 The Research Foundation For The State University Of New York Thiolactone antibiotics
AU2013290444B2 (en) 2012-07-16 2018-04-26 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of (R)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) cyclopropanecarboxamide and administration thereof
PL3925607T3 (pl) 2014-04-15 2023-10-30 Vertex Pharmaceuticals Incorporated Kompozycje farmaceutyczne do leczenia chorób, w których pośredniczy mukowiscydozowy przezbłonowy regulator przewodnictwa
CN115785079B (zh) * 2022-11-28 2024-02-13 沈阳药科大学 4-(1h-吲哚-5-基)氨基呋喃-2(5h)-酮类化合物及其制备和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP866A (en) * 1995-08-02 2000-08-17 Newcastle Univ Ventures Limited Benzimidazole compounds.
CO4970714A1 (es) * 1997-09-05 2000-11-07 Boehringer Mannheim Gmbh Derivados ureido y tioureido de 4-amino-2(5h)-furanonas y 4-amino-2(5h) tiofenonas como agentes antitumorales
DE19814838C2 (de) 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
UA59443C2 (uk) * 1998-04-28 2003-09-15 Арцнайміттельверк Дрезден Гмбх Гідроксііндол, спосіб його одержання, лікарська форма на його основі та спосіб її одержання

Also Published As

Publication number Publication date
SK285682B6 (sk) 2007-06-07
BR0016553A (pt) 2002-09-17
AU2170401A (en) 2001-07-09
HUP0203524A2 (hu) 2003-03-28
EA004925B1 (ru) 2004-10-28
DE60022227T2 (de) 2006-06-22
ES2246918T3 (es) 2006-03-01
AU776332B2 (en) 2004-09-02
US20030158153A1 (en) 2003-08-21
US6753342B2 (en) 2004-06-22
IL150329A0 (en) 2002-12-01
ITMI992693A0 (it) 1999-12-23
ATE302772T1 (de) 2005-09-15
CN1413205A (zh) 2003-04-23
ITMI992693A1 (it) 2001-06-23
WO2001047916A1 (en) 2001-07-05
KR20020063247A (ko) 2002-08-01
IL150329A (en) 2006-07-05
HUP0203524A3 (en) 2008-01-28
CA2395205A1 (en) 2001-07-05
EP1244652B1 (en) 2005-08-24
JP2003519140A (ja) 2003-06-17
CN1250542C (zh) 2006-04-12
EP1244652A1 (en) 2002-10-02
ZA200204964B (en) 2004-01-29
MXPA02006217A (es) 2004-02-26
NO323312B1 (no) 2007-03-12
DE60022227D1 (de) 2005-09-29
KR100795533B1 (ko) 2008-01-16
IT1315267B1 (it) 2003-02-03
SK8962002A3 (en) 2002-11-06
CZ20022170A3 (cs) 2002-09-11
PL356541A1 (en) 2004-06-28
NO20022976D0 (no) 2002-06-20
NO20022976L (no) 2002-06-20
NZ519689A (en) 2004-02-27
EA200200558A1 (ru) 2002-12-26

Similar Documents

Publication Publication Date Title
TR200201613T2 (tr) Antitümör tesirli 2-(1H-indol-3-il)-2-okso asetamidler
NL350077I2 (nl) Cyprosulfamide
DE69918422D1 (de) Phthalazinone pde iii/iv hemmer
PT1109812E (pt) Pirrolobenzodiazepinas
ES2152414T3 (es) Dihidrobenzofuranos.
TR199901653T2 (tr) Fitalazinonlar.
DK1200418T3 (da) Nematodicide trifluorbutener
MXPA02010088A (es) Derivados de ecteinascidina antitumorales.
EE200000033A (et) Uudsed tetrasoolderivaadid
PT1042319E (pt) Di-hidro-benzofuranos
ATE311389T1 (de) Wirkstoffvorläufer von imidazopyridin-derivaten
ATE287403T1 (de) 6-phenylbenzonaphthyidine
SE9903290D0 (sv) Novel compounds
ES2178765T3 (es) Nuevos derivados de 1,7,7-trimetil-biciclo (2.2.1) heptano.
TR199901386T2 (tr) Imidazopiridazinler.
DE60136430D1 (de) Heterosubstituierte c7-taxanacetate als antitumormittel
TR199701298T1 (tr) Tetralinler.
ATE213236T1 (de) Substituierte benzyloxyimino-verbindungen
TR200003203T2 (tr) Karboksaldehitin saflaştırılması
MXPA04000506A (es) Nuevos derivados de et-743 antitumorales.
ATE265418T1 (de) Neue substituierte 3-phenoxy- und 3- phenylalkyloxy-2-phenyl-propylamine
ATE263560T1 (de) Neue verwendung von citreamicinen
RS51143B (sr) Novi benzonaftiridini
PE61999A1 (es) Compuestos de tetrahidropiridina
BR0109394A (pt) Compostos de esponja antitumores