DE69819173D1 - Indole und 2,3-dihydroindolderivate, ihre herstellung und verwendung - Google Patents

Indole und 2,3-dihydroindolderivate, ihre herstellung und verwendung

Info

Publication number
DE69819173D1
DE69819173D1 DE69819173T DE69819173T DE69819173D1 DE 69819173 D1 DE69819173 D1 DE 69819173D1 DE 69819173 T DE69819173 T DE 69819173T DE 69819173 T DE69819173 T DE 69819173T DE 69819173 D1 DE69819173 D1 DE 69819173D1
Authority
DE
Germany
Prior art keywords
derivatives
dihydroindol
indoles
production
enantiometers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69819173T
Other languages
English (en)
Other versions
DE69819173T2 (de
Inventor
Knud Moltzen
Kristian Perregaard
Ivan Mikkelsen
Paul Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Application granted granted Critical
Publication of DE69819173D1 publication Critical patent/DE69819173D1/de
Publication of DE69819173T2 publication Critical patent/DE69819173T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
DE69819173T 1997-07-25 1998-07-20 Indole und 2,3-dihydroindolderivate, ihre herstellung und verwendung Expired - Fee Related DE69819173T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5371397P 1997-07-25 1997-07-25
DK89297 1997-07-25
DK89297 1997-07-25
US53713 1997-07-25
PCT/DK1998/000336 WO1999005140A1 (en) 1997-07-25 1998-07-20 Indole and 2,3-dihydroindole derivatives, their preparation and use

Publications (2)

Publication Number Publication Date
DE69819173D1 true DE69819173D1 (de) 2003-11-27
DE69819173T2 DE69819173T2 (de) 2004-04-15

Family

ID=26064857

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69819173T Expired - Fee Related DE69819173T2 (de) 1997-07-25 1998-07-20 Indole und 2,3-dihydroindolderivate, ihre herstellung und verwendung

Country Status (15)

Country Link
US (2) US6476035B1 (de)
EP (1) EP1007523B9 (de)
JP (1) JP2003524571A (de)
KR (1) KR100545329B1 (de)
AT (1) ATE252575T1 (de)
AU (1) AU736596B2 (de)
BG (1) BG64904B1 (de)
CA (1) CA2297825C (de)
CZ (1) CZ295937B6 (de)
DE (1) DE69819173T2 (de)
ES (1) ES2206963T3 (de)
HU (1) HU225101B1 (de)
NZ (1) NZ502252A (de)
PT (1) PT1007523E (de)
WO (1) WO1999005140A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19730989A1 (de) * 1997-07-18 1999-01-21 Merck Patent Gmbh Piperazin-Derivate
WO2000000198A1 (en) 1998-06-30 2000-01-06 Eli Lilly And Company Piperidine derivatives having effects on serotonin related systems
EP1146045A1 (de) * 1998-06-30 2001-10-17 Eli Lilly And Company Auf Serotonin-verwandte Systeme wirkende Piperidin-Derivate
AU772189B2 (en) * 1999-08-23 2004-04-08 Solvay Pharmaceuticals B.V. New phenylpiperazines
US6664274B1 (en) 1999-09-29 2003-12-16 Eli Lilly And Company Piperidine derivatives as serotonine reuptake inhibitors
US6828332B1 (en) * 1999-09-29 2004-12-07 Eli Lilly And Company Piperidine derivatives as reuptake inhibitors
WO2002048105A2 (en) * 2000-11-16 2002-06-20 Wyeth Aryloxy piperidinyl derivatives for the treatment of depression
MXPA03006250A (es) 2001-01-16 2003-09-22 Astrazeneca Ab Compuestos heterociclicos terapeuticos.
AR032712A1 (es) 2001-02-21 2003-11-19 Solvay Pharm Bv Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen
US6656950B2 (en) * 2001-04-25 2003-12-02 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine
EP1411052B1 (de) 2001-07-05 2011-10-05 Takeda Pharmaceutical Company Limited Benzokondensierte 5gliedrige heterocyclische verbindungen, verfahren zu deren herstellung und deren verwendung
EP1408976B3 (de) 2001-07-20 2010-08-25 Psychogenics Inc. Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten
CN100429206C (zh) * 2002-05-13 2008-10-29 弗·哈夫曼-拉罗切有限公司 作为5－ht6调节剂的苯并嗪衍生物及其用途
DE10326939A1 (de) * 2003-06-16 2005-01-05 Merck Patent Gmbh Indol-Derivate
DE10326940A1 (de) * 2003-06-16 2005-01-05 Merck Patent Gmbh Indol-Derivate
WO2006061374A1 (en) * 2004-12-07 2006-06-15 Solvay Pharmaceuticals B.V. Benzdioxane piperazine derivatives with a combination of affinity for dopamine-d2 receptors and serotonin reuptake sites
US7371769B2 (en) 2004-12-07 2008-05-13 Solvay Pharmaceuticals B.V. Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
US8101619B2 (en) 2004-12-08 2012-01-24 Solvay Pharmaceuticals B.V. Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
DE102004063797A1 (de) * 2004-12-30 2006-07-13 Schwarz Pharma Ag Sauerstoffhaltige annelierte Phenylpiperazin- und Phenyldiazepancarboxamide
KR20080035653A (ko) * 2005-07-22 2008-04-23 프로제닉스 파머슈티컬스, 인코포레이티드 Ｈｉｖ―１ 감염 환자에서 바이러스 부하를 감소시키는방법
GT200600414A (es) * 2005-09-12 2007-09-20 Sal de glucuranato de compuesto de piperazine
CL2008000119A1 (es) * 2007-01-16 2008-05-16 Wyeth Corp Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia.
PL2406243T3 (pl) 2009-03-10 2014-10-31 Takeda Pharmaceuticals Co Pochodne benzofuranu
US8367676B2 (en) * 2009-06-30 2013-02-05 Astrazeneca Ab 2-carboxamide-7-piperazinyl-benzofuran derivatives 774
CN103380129B (zh) 2010-12-20 2016-04-20 阿克图拉姆生命科学股份公司 2-甲酰胺-4-哌嗪基-苯并呋喃衍生物
PL395469A1 (pl) 2011-06-29 2013-01-07 Adamed Spólka Z Ograniczona Odpowiedzialnoscia Pochodne indoloamin do leczenia chorób osrodkowego ukladu nerwowego
US11248097B2 (en) * 2013-02-05 2022-02-15 3M Innovative Properties Company Graphic article
CN104337812B (zh) 2013-07-29 2018-09-14 广东东阳光药业有限公司 取代的杂芳基化合物及其使用方法和用途
US10316025B2 (en) 2015-06-03 2019-06-11 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof
WO2023201423A1 (en) * 2022-04-19 2023-10-26 Mindset Pharma Inc. Indoline derivatives as serotonergic agents useful for the treatment of disorders related thereto

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3412097A (en) * 1964-09-07 1968-11-19 Koninklijke Pharma Fab Nv Indole derivatives
US5200948A (en) * 1988-02-05 1993-04-06 Tandy Corporation Recording method and apparatus
GB8830312D0 (en) * 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
DE4127849A1 (de) 1991-08-22 1993-02-25 Merck Patent Gmbh Benzodioxanderivate
FR2692264B1 (fr) * 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
DE4333254A1 (de) * 1993-09-30 1995-04-06 Merck Patent Gmbh Piperidine und Piperazine
DE4414113A1 (de) 1994-04-22 1995-10-26 Merck Patent Gmbh 3-Indolylpiperidine
CA2134038C (en) * 1994-06-16 1997-06-03 David Taiwai Wong Potentiation of drug response
EP0714663A3 (de) * 1994-11-28 1997-01-15 Lilly Co Eli Potenzierung von Wirkstoffresponz durch Serotonin 1A Rezeptor Antagonisten
DE69724000T2 (de) * 1996-12-20 2004-07-22 H. Lundbeck A/S Indan- oder dihydroindol-derivate
AR022303A1 (es) * 1999-01-22 2002-09-04 Lundbeck & Co As H Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion

Also Published As

Publication number Publication date
ES2206963T3 (es) 2004-05-16
WO1999005140A1 (en) 1999-02-04
US6476035B1 (en) 2002-11-05
CZ2000285A3 (cs) 2000-06-14
CA2297825C (en) 2006-03-14
CA2297825A1 (en) 1999-02-04
ATE252575T1 (de) 2003-11-15
HUP0002830A2 (hu) 2001-09-28
HU225101B1 (en) 2006-06-28
HUP0002830A3 (en) 2001-10-29
AU8534098A (en) 1999-02-16
BG104148A (en) 2001-05-31
EP1007523B1 (de) 2003-10-22
PT1007523E (pt) 2004-02-27
BG64904B1 (bg) 2006-08-31
DE69819173T2 (de) 2004-04-15
AU736596B2 (en) 2001-08-02
JP2003524571A (ja) 2003-08-19
US6727263B2 (en) 2004-04-27
NZ502252A (en) 2001-09-28
EP1007523A1 (de) 2000-06-14
KR100545329B1 (ko) 2006-01-24
EP1007523B9 (de) 2004-09-08
CZ295937B6 (cs) 2005-12-14
US20030018050A1 (en) 2003-01-23
KR20010022229A (ko) 2001-03-15

Similar Documents

Publication Publication Date Title
ATE252575T1 (de) Indole und 2,3-dihydroindolderivate, ihre herstellung und verwendung
DE60004066D1 (de) Benzofurylpiperazine: 5-ht2c serotoninrezeptor agonisten
TR200101744T2 (tr) Fenilglisin türevleri.
ATE469892T1 (de) Substituierte 1h-dihydropyrazole, ihre herstellung und verwendung
DK0889876T3 (da) Meta-substituerede phenylensulfonamidderivater
BG103964A (en) SUBSTITUTED PYRAZOLS AS p38 KINASE INHIBITORS
HRP20050213A2 (en) 2,4-substituted indoles and their use as 5-ht6 modulators
SE9702773D0 (sv) Novel compounds
ATE237585T1 (de) Substituierte 3,3-diamino-2-propennitrile, ihre herstellung und verwendung
CA2356985A1 (en) 5ht1 antagonists for antidepressant therapy
TR200200125T2 (tr) Yeni aminotiyazol türevleri, bunların hazırlanması ve bunları içeren farmasötik kompozisyonlar.
DK0902018T3 (da) 2-(arylpheny)amino-imidazolinderivater
CY1108837T1 (el) ΝΕΑ ΠΑΡΑΓΩΓΑ ΑΜΙΝΟΠΥΡΙΔΙΝΗΣ ΩΣ ΑΝΤΑΓΩΝΙΣΤΕΣ mGluR5
EA200200727A1 (ru) Новые производные индола
TR200001080T2 (tr) 2 ile ikame edilmiş 1,2-Benisotiyazol türevleri ve bunların serrotonın antagonistleri
YU78100A (sh) 4,5,6 i 7-indol i indolin derivati, njihova izrada i upotreba
DE59901563D1 (de) N-substituierte azabicycloheptan-derivate, ihre herstellung und verwendung
ATE207471T1 (de) Dibenzo-oxazepin- und dioxepin-derivate und ihre verwendung als antitumormittel
ATE213236T1 (de) Substituierte benzyloxyimino-verbindungen
EA200000162A1 (ru) Производные индола и 2,3-дигидроиндола, их получение и использование
EE200100062A (et) Uued 2,3,3a,4,9,9a-heksahüdro-8-hydroxy-1H-bens(f)indoolid, meetodid nende valmistamiseks ja nende kasutamine ravimitena
DE59905342D1 (de) N-substituierte azabicycloheptan-derivate, ihre herstellung und verwendung
ATE264320T1 (de) 5-aminoalkyl- und 5-aminocarbonylsubstituierte indole
CY1115291T1 (el) Ινδολη, αζαϊνδολη και σχετικα ετεροκυκλικα αμιδια 4-αλκενυλ πιπεριδινης

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee