ATE252575T1 - Indole und 2,3-dihydroindolderivate, ihre herstellung und verwendung - Google Patents
Indole und 2,3-dihydroindolderivate, ihre herstellung und verwendungInfo
- Publication number
- ATE252575T1 ATE252575T1 AT98936270T AT98936270T ATE252575T1 AT E252575 T1 ATE252575 T1 AT E252575T1 AT 98936270 T AT98936270 T AT 98936270T AT 98936270 T AT98936270 T AT 98936270T AT E252575 T1 ATE252575 T1 AT E252575T1
- Authority
- AT
- Austria
- Prior art keywords
- indoles
- production
- dihydroindole derivatives
- dihydroindole
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5371397P | 1997-07-25 | 1997-07-25 | |
DK89297 | 1997-07-25 | ||
PCT/DK1998/000336 WO1999005140A1 (en) | 1997-07-25 | 1998-07-20 | Indole and 2,3-dihydroindole derivatives, their preparation and use |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE252575T1 true ATE252575T1 (de) | 2003-11-15 |
Family
ID=26064857
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98936270T ATE252575T1 (de) | 1997-07-25 | 1998-07-20 | Indole und 2,3-dihydroindolderivate, ihre herstellung und verwendung |
Country Status (15)
Country | Link |
---|---|
US (2) | US6476035B1 (de) |
EP (1) | EP1007523B9 (de) |
JP (1) | JP2003524571A (de) |
KR (1) | KR100545329B1 (de) |
AT (1) | ATE252575T1 (de) |
AU (1) | AU736596B2 (de) |
BG (1) | BG64904B1 (de) |
CA (1) | CA2297825C (de) |
CZ (1) | CZ295937B6 (de) |
DE (1) | DE69819173T2 (de) |
ES (1) | ES2206963T3 (de) |
HU (1) | HU225101B1 (de) |
NZ (1) | NZ502252A (de) |
PT (1) | PT1007523E (de) |
WO (1) | WO1999005140A1 (de) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19730989A1 (de) * | 1997-07-18 | 1999-01-21 | Merck Patent Gmbh | Piperazin-Derivate |
EP1146045A1 (de) * | 1998-06-30 | 2001-10-17 | Eli Lilly And Company | Auf Serotonin-verwandte Systeme wirkende Piperidin-Derivate |
US6436964B1 (en) | 1998-06-30 | 2002-08-20 | Eli Lilly And Company | Piperidine derivatives having effects on serotonin related systems |
RU2246494C2 (ru) * | 1999-08-23 | 2005-02-20 | Солвей Фармасьютикалс Б.В. | Новые фенилпиперазины |
US6664274B1 (en) | 1999-09-29 | 2003-12-16 | Eli Lilly And Company | Piperidine derivatives as serotonine reuptake inhibitors |
CA2386092A1 (en) * | 1999-09-29 | 2001-04-05 | Yao-Chang Xu | Piperidine derivatives |
WO2002048105A2 (en) * | 2000-11-16 | 2002-06-20 | Wyeth | Aryloxy piperidinyl derivatives for the treatment of depression |
CN100509794C (zh) * | 2001-01-16 | 2009-07-08 | 阿斯特拉曾尼卡有限公司 | 治疗性杂环化合物 |
AR032712A1 (es) * | 2001-02-21 | 2003-11-19 | Solvay Pharm Bv | Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen |
US6656950B2 (en) * | 2001-04-25 | 2003-12-02 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine |
CA2452596C (en) | 2001-07-05 | 2010-12-21 | Takeda Chemical Industries, Ltd. | Benzo-fused 5-membered heterocyclic compounds, their production and use |
DE60231507D1 (de) | 2001-07-20 | 2010-07-01 | Psychogenics Inc | Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten |
ES2256744T3 (es) * | 2002-05-13 | 2006-07-16 | F. Hoffmann-La Roche Ag | Derivados de benzoxazina como moduladores de 5-ht6 y usos de los mismos. |
DE10326940A1 (de) * | 2003-06-16 | 2005-01-05 | Merck Patent Gmbh | Indol-Derivate |
DE10326939A1 (de) * | 2003-06-16 | 2005-01-05 | Merck Patent Gmbh | Indol-Derivate |
TW200631952A (en) * | 2004-12-07 | 2006-09-16 | Solvay Pharm Bv | Benzdioxan piperazine derivatives with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites |
US7371769B2 (en) | 2004-12-07 | 2008-05-13 | Solvay Pharmaceuticals B.V. | Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites |
US20060122247A1 (en) | 2004-12-08 | 2006-06-08 | Solvay Pharmaceuticals B.V. | Aryloxyethylamine and phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition |
DE102004063797A1 (de) * | 2004-12-30 | 2006-07-13 | Schwarz Pharma Ag | Sauerstoffhaltige annelierte Phenylpiperazin- und Phenyldiazepancarboxamide |
KR20080035653A (ko) * | 2005-07-22 | 2008-04-23 | 프로제닉스 파머슈티컬스, 인코포레이티드 | Hiv―1 감염 환자에서 바이러스 부하를 감소시키는방법 |
GT200600414A (es) * | 2005-09-12 | 2007-09-20 | Sal de glucuranato de compuesto de piperazine | |
CL2008000119A1 (es) * | 2007-01-16 | 2008-05-16 | Wyeth Corp | Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia. |
WO2010104194A1 (en) | 2009-03-10 | 2010-09-16 | Takeda Pharmaceutical Company Limited | Benzofuran derivatives |
US8367676B2 (en) * | 2009-06-30 | 2013-02-05 | Astrazeneca Ab | 2-carboxamide-7-piperazinyl-benzofuran derivatives 774 |
MX2013006670A (es) | 2010-12-20 | 2013-07-29 | Astrazeneca Ab | Derivado de 2-carboxamida-4-piperazinil-benzofurano. |
PL395469A1 (pl) | 2011-06-29 | 2013-01-07 | Adamed Spólka Z Ograniczona Odpowiedzialnoscia | Pochodne indoloamin do leczenia chorób osrodkowego ukladu nerwowego |
JP6502265B2 (ja) * | 2013-02-05 | 2019-04-17 | スリーエム イノベイティブ プロパティズ カンパニー | グラフィック物品 |
CN104337812B (zh) | 2013-07-29 | 2018-09-14 | 广东东阳光药业有限公司 | 取代的杂芳基化合物及其使用方法和用途 |
WO2016192657A1 (en) | 2015-06-03 | 2016-12-08 | Sunshine Lake Pharma Co., Ltd. | Substituted piperazine compounds and methods of use and use thereof |
WO2023201423A1 (en) * | 2022-04-19 | 2023-10-26 | Mindset Pharma Inc. | Indoline derivatives as serotonergic agents useful for the treatment of disorders related thereto |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3412097A (en) * | 1964-09-07 | 1968-11-19 | Koninklijke Pharma Fab Nv | Indole derivatives |
US5200948A (en) * | 1988-02-05 | 1993-04-06 | Tandy Corporation | Recording method and apparatus |
GB8830312D0 (en) * | 1988-12-28 | 1989-02-22 | Lundbeck & Co As H | Heterocyclic compounds |
DE4127849A1 (de) | 1991-08-22 | 1993-02-25 | Merck Patent Gmbh | Benzodioxanderivate |
FR2692264B1 (fr) | 1992-06-12 | 1994-08-05 | Adir | Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant. |
DE4333254A1 (de) * | 1993-09-30 | 1995-04-06 | Merck Patent Gmbh | Piperidine und Piperazine |
DE4414113A1 (de) | 1994-04-22 | 1995-10-26 | Merck Patent Gmbh | 3-Indolylpiperidine |
CA2134038C (en) * | 1994-06-16 | 1997-06-03 | David Taiwai Wong | Potentiation of drug response |
EP0714663A3 (de) * | 1994-11-28 | 1997-01-15 | Lilly Co Eli | Potenzierung von Wirkstoffresponz durch Serotonin 1A Rezeptor Antagonisten |
EP0946538B1 (de) * | 1996-12-20 | 2003-08-06 | H. Lundbeck A/S | Indan- oder dihydroindol-derivate |
AR022303A1 (es) * | 1999-01-22 | 2002-09-04 | Lundbeck & Co As H | Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion |
-
1998
- 1998-07-20 KR KR1020007000802A patent/KR100545329B1/ko not_active IP Right Cessation
- 1998-07-20 AU AU85340/98A patent/AU736596B2/en not_active Ceased
- 1998-07-20 JP JP2000504136A patent/JP2003524571A/ja active Pending
- 1998-07-20 PT PT98936270T patent/PT1007523E/pt unknown
- 1998-07-20 DE DE69819173T patent/DE69819173T2/de not_active Expired - Fee Related
- 1998-07-20 HU HU0002830A patent/HU225101B1/hu not_active IP Right Cessation
- 1998-07-20 EP EP98936270A patent/EP1007523B9/de not_active Expired - Lifetime
- 1998-07-20 CA CA002297825A patent/CA2297825C/en not_active Expired - Fee Related
- 1998-07-20 AT AT98936270T patent/ATE252575T1/de not_active IP Right Cessation
- 1998-07-20 CZ CZ2000285A patent/CZ295937B6/cs not_active IP Right Cessation
- 1998-07-20 WO PCT/DK1998/000336 patent/WO1999005140A1/en active IP Right Grant
- 1998-07-20 ES ES98936270T patent/ES2206963T3/es not_active Expired - Lifetime
- 1998-07-20 NZ NZ502252A patent/NZ502252A/en unknown
-
2000
- 2000-01-25 US US09/491,204 patent/US6476035B1/en not_active Expired - Fee Related
- 2000-02-10 BG BG104148A patent/BG64904B1/bg unknown
-
2002
- 2002-08-16 US US10/223,046 patent/US6727263B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1999005140A1 (en) | 1999-02-04 |
CZ2000285A3 (cs) | 2000-06-14 |
EP1007523A1 (de) | 2000-06-14 |
DE69819173T2 (de) | 2004-04-15 |
KR20010022229A (ko) | 2001-03-15 |
HUP0002830A3 (en) | 2001-10-29 |
PT1007523E (pt) | 2004-02-27 |
CZ295937B6 (cs) | 2005-12-14 |
CA2297825C (en) | 2006-03-14 |
BG64904B1 (bg) | 2006-08-31 |
US6727263B2 (en) | 2004-04-27 |
AU736596B2 (en) | 2001-08-02 |
HU225101B1 (en) | 2006-06-28 |
EP1007523B9 (de) | 2004-09-08 |
AU8534098A (en) | 1999-02-16 |
US20030018050A1 (en) | 2003-01-23 |
EP1007523B1 (de) | 2003-10-22 |
HUP0002830A2 (hu) | 2001-09-28 |
BG104148A (en) | 2001-05-31 |
US6476035B1 (en) | 2002-11-05 |
ES2206963T3 (es) | 2004-05-16 |
KR100545329B1 (ko) | 2006-01-24 |
CA2297825A1 (en) | 1999-02-04 |
DE69819173D1 (de) | 2003-11-27 |
NZ502252A (en) | 2001-09-28 |
JP2003524571A (ja) | 2003-08-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1007523 Country of ref document: EP |
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REN | Ceased due to non-payment of the annual fee |