ATE252575T1 - Indole und 2,3-dihydroindolderivate, ihre herstellung und verwendung - Google Patents
Indole und 2,3-dihydroindolderivate, ihre herstellung und verwendungInfo
- Publication number
- ATE252575T1 ATE252575T1 AT98936270T AT98936270T ATE252575T1 AT E252575 T1 ATE252575 T1 AT E252575T1 AT 98936270 T AT98936270 T AT 98936270T AT 98936270 T AT98936270 T AT 98936270T AT E252575 T1 ATE252575 T1 AT E252575T1
- Authority
- AT
- Austria
- Prior art keywords
- indoles
- production
- dihydroindole derivatives
- dihydroindole
- derivatives
- Prior art date
Links
- LPAGFVYQRIESJQ-UHFFFAOYSA-N indoline Chemical class C1=CC=C2NCCC2=C1 LPAGFVYQRIESJQ-UHFFFAOYSA-N 0.000 title abstract 2
- 150000002475 indoles Chemical class 0.000 title 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 2
- 102100022738 5-hydroxytryptamine receptor 1A Human genes 0.000 abstract 1
- 101710138638 5-hydroxytryptamine receptor 1A Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000003772 serotonin uptake inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5371397P | 1997-07-25 | 1997-07-25 | |
| DK89297 | 1997-07-25 | ||
| PCT/DK1998/000336 WO1999005140A1 (en) | 1997-07-25 | 1998-07-20 | Indole and 2,3-dihydroindole derivatives, their preparation and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE252575T1 true ATE252575T1 (de) | 2003-11-15 |
Family
ID=26064857
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98936270T ATE252575T1 (de) | 1997-07-25 | 1998-07-20 | Indole und 2,3-dihydroindolderivate, ihre herstellung und verwendung |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6476035B1 (de) |
| EP (1) | EP1007523B9 (de) |
| JP (1) | JP2003524571A (de) |
| KR (1) | KR100545329B1 (de) |
| AT (1) | ATE252575T1 (de) |
| AU (1) | AU736596B2 (de) |
| BG (1) | BG64904B1 (de) |
| CA (1) | CA2297825C (de) |
| CZ (1) | CZ295937B6 (de) |
| DE (1) | DE69819173T2 (de) |
| ES (1) | ES2206963T3 (de) |
| HU (1) | HU225101B1 (de) |
| NZ (1) | NZ502252A (de) |
| PT (1) | PT1007523E (de) |
| WO (1) | WO1999005140A1 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19730989A1 (de) * | 1997-07-18 | 1999-01-21 | Merck Patent Gmbh | Piperazin-Derivate |
| AR019178A1 (es) | 1998-06-30 | 2001-12-26 | Lilly Co Eli | Compuestos de 7-(benzo(b)tiofeno, furan e indolpiridil o tetrahidropiridilo), efectivos sobre sistemas relacionados con la serotonina, composicionesfarmaceuticas formuladas con dichos compuestos; compuestos intermediarios utiles para preparar dichos compuestos de tiofeno, furan e indolpiridilo otetr |
| EP1146045A1 (de) * | 1998-06-30 | 2001-10-17 | Eli Lilly And Company | Auf Serotonin-verwandte Systeme wirkende Piperidin-Derivate |
| BR0013498A (pt) * | 1999-08-23 | 2002-05-14 | Solvay Pharm Bv | Composto, método para a preparação do mesmo, composição farmacêutica, e, métodos para a preparação da mesma e para o tratamento de distúrbios do snc |
| MXPA02001994A (es) * | 1999-09-29 | 2002-09-18 | Lilly Co Eli | Derivados de piperidina como inhibidores de la reabsorcion. |
| CA2386085A1 (en) | 1999-09-29 | 2001-04-05 | Yao-Chang Xu | Piperidine derivatives |
| WO2002048105A2 (en) * | 2000-11-16 | 2002-06-20 | Wyeth | Aryloxy piperidinyl derivatives for the treatment of depression |
| MXPA03006250A (es) | 2001-01-16 | 2003-09-22 | Astrazeneca Ab | Compuestos heterociclicos terapeuticos. |
| AR032712A1 (es) * | 2001-02-21 | 2003-11-19 | Solvay Pharm Bv | Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen |
| US6656950B2 (en) | 2001-04-25 | 2003-12-02 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine |
| EP1411052B1 (de) | 2001-07-05 | 2011-10-05 | Takeda Pharmaceutical Company Limited | Benzokondensierte 5gliedrige heterocyclische verbindungen, verfahren zu deren herstellung und deren verwendung |
| ATE424825T1 (de) * | 2001-07-20 | 2009-03-15 | Psychogenics Inc | Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten |
| KR100636475B1 (ko) * | 2002-05-13 | 2006-10-18 | 에프. 호프만-라 로슈 아게 | 5-ｈｔ6 조절제로서 벤족사진 유도체 및 이의 용도 |
| DE10326940A1 (de) * | 2003-06-16 | 2005-01-05 | Merck Patent Gmbh | Indol-Derivate |
| DE10326939A1 (de) * | 2003-06-16 | 2005-01-05 | Merck Patent Gmbh | Indol-Derivate |
| JP2008523028A (ja) * | 2004-12-07 | 2008-07-03 | ソルベイ・フアーマシユーチカルズ・ベー・ブイ | ドーパミン−ｄ２受容体に関する親和力およびセロトニン再吸収部位の組み合わせを有するベンズジオキサンピペラジン誘導体 |
| US7371769B2 (en) | 2004-12-07 | 2008-05-13 | Solvay Pharmaceuticals B.V. | Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites |
| US8101619B2 (en) | 2004-12-08 | 2012-01-24 | Solvay Pharmaceuticals B.V. | Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition |
| DE102004063797A1 (de) * | 2004-12-30 | 2006-07-13 | Schwarz Pharma Ag | Sauerstoffhaltige annelierte Phenylpiperazin- und Phenyldiazepancarboxamide |
| KR20080035653A (ko) * | 2005-07-22 | 2008-04-23 | 프로제닉스 파머슈티컬스, 인코포레이티드 | Ｈｉｖ―１ 감염 환자에서 바이러스 부하를 감소시키는방법 |
| GT200600414A (es) * | 2005-09-12 | 2007-09-20 | Sal de glucuranato de compuesto de piperazine | |
| TW200901974A (en) * | 2007-01-16 | 2009-01-16 | Wyeth Corp | Compounds, compositions, and methods of making and using them |
| BRPI1009252A2 (pt) | 2009-03-10 | 2016-03-15 | Takeda Pharmaceutical | composto, pró-droga, composição farmacêutica, métodos para prevenir ou tratar doenças do sistema nervoso central, e mal de alzheimer, e, uso do composto ou de uma pró-droga do mesmo |
| US8367676B2 (en) | 2009-06-30 | 2013-02-05 | Astrazeneca Ab | 2-carboxamide-7-piperazinyl-benzofuran derivatives 774 |
| WO2012087229A1 (en) | 2010-12-20 | 2012-06-28 | Astrazeneca Ab | 2-carboxamide-4-piperazinyl-benzofuran derivative |
| PL395469A1 (pl) | 2011-06-29 | 2013-01-07 | Adamed Spólka Z Ograniczona Odpowiedzialnoscia | Pochodne indoloamin do leczenia chorób osrodkowego ukladu nerwowego |
| JP6502265B2 (ja) * | 2013-02-05 | 2019-04-17 | スリーエム イノベイティブ プロパティズ カンパニー | グラフィック物品 |
| WO2015014256A1 (en) | 2013-07-29 | 2015-02-05 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use thereof |
| WO2016192657A1 (en) | 2015-06-03 | 2016-12-08 | Sunshine Lake Pharma Co., Ltd. | Substituted piperazine compounds and methods of use and use thereof |
| IL316401A (en) * | 2022-04-19 | 2024-12-01 | Mindset Pharma Inc | Indoline derivatives as estrogenic agents for the treatment of disorders |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3412097A (en) * | 1964-09-07 | 1968-11-19 | Koninklijke Pharma Fab Nv | Indole derivatives |
| US5200948A (en) * | 1988-02-05 | 1993-04-06 | Tandy Corporation | Recording method and apparatus |
| GB8830312D0 (en) * | 1988-12-28 | 1989-02-22 | Lundbeck & Co As H | Heterocyclic compounds |
| DE4127849A1 (de) | 1991-08-22 | 1993-02-25 | Merck Patent Gmbh | Benzodioxanderivate |
| FR2692264B1 (fr) * | 1992-06-12 | 1994-08-05 | Adir | Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant. |
| DE4333254A1 (de) * | 1993-09-30 | 1995-04-06 | Merck Patent Gmbh | Piperidine und Piperazine |
| DE4414113A1 (de) | 1994-04-22 | 1995-10-26 | Merck Patent Gmbh | 3-Indolylpiperidine |
| CA2134038C (en) * | 1994-06-16 | 1997-06-03 | David Taiwai Wong | Potentiation of drug response |
| EP0714663A3 (de) * | 1994-11-28 | 1997-01-15 | Lilly Co Eli | Potenzierung von Wirkstoffresponz durch Serotonin 1A Rezeptor Antagonisten |
| ATE246683T1 (de) * | 1996-12-20 | 2003-08-15 | Lundbeck & Co As H | Indan- oder dihydroindol-derivate |
| AR022303A1 (es) * | 1999-01-22 | 2002-09-04 | Lundbeck & Co As H | Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion |
-
1998
- 1998-07-20 PT PT98936270T patent/PT1007523E/pt unknown
- 1998-07-20 CA CA002297825A patent/CA2297825C/en not_active Expired - Fee Related
- 1998-07-20 JP JP2000504136A patent/JP2003524571A/ja active Pending
- 1998-07-20 HU HU0002830A patent/HU225101B1/hu not_active IP Right Cessation
- 1998-07-20 NZ NZ502252A patent/NZ502252A/en unknown
- 1998-07-20 WO PCT/DK1998/000336 patent/WO1999005140A1/en not_active Ceased
- 1998-07-20 AU AU85340/98A patent/AU736596B2/en not_active Ceased
- 1998-07-20 ES ES98936270T patent/ES2206963T3/es not_active Expired - Lifetime
- 1998-07-20 EP EP98936270A patent/EP1007523B9/de not_active Expired - Lifetime
- 1998-07-20 DE DE69819173T patent/DE69819173T2/de not_active Expired - Fee Related
- 1998-07-20 AT AT98936270T patent/ATE252575T1/de not_active IP Right Cessation
- 1998-07-20 CZ CZ2000285A patent/CZ295937B6/cs not_active IP Right Cessation
- 1998-07-20 KR KR1020007000802A patent/KR100545329B1/ko not_active Expired - Fee Related
-
2000
- 2000-01-25 US US09/491,204 patent/US6476035B1/en not_active Expired - Fee Related
- 2000-02-10 BG BG104148A patent/BG64904B1/bg unknown
-
2002
- 2002-08-16 US US10/223,046 patent/US6727263B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69819173D1 (de) | 2003-11-27 |
| CZ2000285A3 (cs) | 2000-06-14 |
| CA2297825C (en) | 2006-03-14 |
| AU8534098A (en) | 1999-02-16 |
| EP1007523A1 (de) | 2000-06-14 |
| KR20010022229A (ko) | 2001-03-15 |
| US6727263B2 (en) | 2004-04-27 |
| US20030018050A1 (en) | 2003-01-23 |
| WO1999005140A1 (en) | 1999-02-04 |
| ES2206963T3 (es) | 2004-05-16 |
| HUP0002830A3 (en) | 2001-10-29 |
| PT1007523E (pt) | 2004-02-27 |
| EP1007523B9 (de) | 2004-09-08 |
| EP1007523B1 (de) | 2003-10-22 |
| US6476035B1 (en) | 2002-11-05 |
| JP2003524571A (ja) | 2003-08-19 |
| HUP0002830A2 (hu) | 2001-09-28 |
| CZ295937B6 (cs) | 2005-12-14 |
| CA2297825A1 (en) | 1999-02-04 |
| NZ502252A (en) | 2001-09-28 |
| HU225101B1 (en) | 2006-06-28 |
| KR100545329B1 (ko) | 2006-01-24 |
| AU736596B2 (en) | 2001-08-02 |
| BG64904B1 (bg) | 2006-08-31 |
| BG104148A (en) | 2001-05-31 |
| DE69819173T2 (de) | 2004-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1007523 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |