DE69920455D1 - Bis-indolederivate und ihre verwendung als entzündungshemmende mittel - Google Patents

Bis-indolederivate und ihre verwendung als entzündungshemmende mittel

Info

Publication number
DE69920455D1
DE69920455D1 DE69920455T DE69920455T DE69920455D1 DE 69920455 D1 DE69920455 D1 DE 69920455D1 DE 69920455 T DE69920455 T DE 69920455T DE 69920455 T DE69920455 T DE 69920455T DE 69920455 D1 DE69920455 D1 DE 69920455D1
Authority
DE
Germany
Prior art keywords
bis
compounds
indolederivate
inflammatory agent
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69920455T
Other languages
English (en)
Other versions
DE69920455T2 (de
Inventor
E Wright
Ralph Mattern
S Jacobs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Harbor Branch Oceanographic Institution Inc
Original Assignee
University of California
Harbor Branch Oceanographic Institution Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California, Harbor Branch Oceanographic Institution Inc filed Critical University of California
Publication of DE69920455D1 publication Critical patent/DE69920455D1/de
Application granted granted Critical
Publication of DE69920455T2 publication Critical patent/DE69920455T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69920455T 1998-07-08 1999-07-08 Bis-indolederivate und ihre verwendung als entzündungshemmende mittel Expired - Fee Related DE69920455T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9199198P 1998-07-08 1998-07-08
US91991P 1998-07-08
PCT/US1999/015376 WO2000002857A1 (en) 1998-07-08 1999-07-08 Bis-indole derivatives and their use as antiinflammatory agents

Publications (2)

Publication Number Publication Date
DE69920455D1 true DE69920455D1 (de) 2004-10-28
DE69920455T2 DE69920455T2 (de) 2005-01-20

Family

ID=22230663

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69920455T Expired - Fee Related DE69920455T2 (de) 1998-07-08 1999-07-08 Bis-indolederivate und ihre verwendung als entzündungshemmende mittel

Country Status (8)

Country Link
US (2) US6323233B1 (de)
EP (1) EP1093455B1 (de)
JP (1) JP2002520315A (de)
AT (1) ATE277010T1 (de)
CA (1) CA2335254A1 (de)
DE (1) DE69920455T2 (de)
ES (1) ES2229736T3 (de)
WO (1) WO2000002857A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2229736T3 (es) * 1998-07-08 2005-04-16 Harbor Branch Oceanographic Institution, Inc. Derivados de bis-indol y su uso como agentes antiinflamatorios.
US6589975B2 (en) 1998-07-08 2003-07-08 The Regents Of The University Of California Synthetic compounds for treatment of inflammation
JP2005504789A (ja) 2001-09-13 2005-02-17 シンタ ファーマスーティカルズ コーポレイション 癌治療のための２−アロイルイミダゾール化合物
US6800655B2 (en) * 2002-08-20 2004-10-05 Sri International Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents
US7074938B2 (en) * 2002-11-19 2006-07-11 The Regents Of The University Of California Method for the synthesis of soritin compounds
US7232771B2 (en) * 2003-11-04 2007-06-19 Regents Of The University Of Minnesota Method and apparatus for depositing charge and/or nanoparticles
US7592269B2 (en) * 2003-11-04 2009-09-22 Regents Of The University Of Minnesota Method and apparatus for depositing charge and/or nanoparticles
ATE497762T1 (de) 2004-12-30 2011-02-15 Bioresponse Llc Verwendung von diindolylmethan-verwandten indolen zur behandlung und prävention von erkrankungen im zusammenhang mit dem respiratory syncytial virus
CA2609980C (en) * 2005-05-27 2015-10-13 Queen's University At Kingston Treatment of protein folding disorders
UA95788C2 (en) 2005-12-15 2011-09-12 Ф. Хоффманн-Ля Рош Аг Fused pyrrole derivatives
US8586621B2 (en) 2006-10-27 2013-11-19 Michael A. Zeligs Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles
WO2008091581A1 (en) 2007-01-22 2008-07-31 The University Of Minnesota Nanoparticles with grafted organic molecules
US10799479B2 (en) 2015-04-10 2020-10-13 Bioresponse, L.L.C. Self-emulsifying formulations of DIM-related indoles
CN108822116A (zh) * 2018-06-04 2018-11-16 南京中医药大学 具有抗肿瘤活性的吲哚生物碱及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1403617A (fr) 1962-04-02 1965-06-25 Rhone Poulenc Sa Nouveaux dérivés de l'indole et leur préparation
US4866084A (en) 1987-07-17 1989-09-12 Harbor Branch Oceanographic Institution, Inc. Topsentin compounds effective against viruses and certain tumors
IL94274A0 (en) * 1989-05-05 1991-03-10 Goedecke Ag Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
US4970226A (en) 1989-10-03 1990-11-13 Harbor Branch Oceanographic Institution, Inc. Bis-indole imidazole compounds which are useful antitumor and antimicrobial agents
CA2046801C (en) * 1990-08-07 2002-02-26 Peter D. Davis Substituted pyrroles
US5290777A (en) 1993-02-24 1994-03-01 Regents Of The Univ. Of California Use for topsentin compounds and pharmaceutical compositions containing same
US5955462A (en) * 1996-10-31 1999-09-21 Harbor Branch Oceanographic Institution, Inc. Anti-neurogenic inflammatory compounds and compositions and methods of use thereof
EP0887348A1 (de) * 1997-06-25 1998-12-30 Boehringer Mannheim Italia S.p.A. Bis-Indolderivative mit antimetastatischer Wirkung, Verfahren für deren Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
ES2229736T3 (es) * 1998-07-08 2005-04-16 Harbor Branch Oceanographic Institution, Inc. Derivados de bis-indol y su uso como agentes antiinflamatorios.

Also Published As

Publication number Publication date
CA2335254A1 (en) 2000-01-20
EP1093455B1 (de) 2004-09-22
US20010056112A1 (en) 2001-12-27
DE69920455T2 (de) 2005-01-20
US6323233B1 (en) 2001-11-27
US6444697B2 (en) 2002-09-03
JP2002520315A (ja) 2002-07-09
ES2229736T3 (es) 2005-04-16
ATE277010T1 (de) 2004-10-15
WO2000002857A9 (en) 2000-07-20
WO2000002857A1 (en) 2000-01-20
EP1093455A1 (de) 2001-04-25

Similar Documents

Publication Publication Date Title
ATE396993T1 (de) Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität
BR0315547A (pt) Derivados de quinolina como antagonistas de crth2
ATE496884T1 (de) Sulphonylaminoessigsaeure derivate und deren verwendung als orexin rezeptor antagoniste
TR200100694T2 (tr) Opioid alıcı aktivitesine sahip 4,4-Biarilpiperidin türevleri
DE69920455D1 (de) Bis-indolederivate und ihre verwendung als entzündungshemmende mittel
DE69630214D1 (de) Benzamidin-derivate, deren herstellung und deren verwendung als anti-koagulantien
ATE253545T1 (de) Biarylessigsäure-derivate und ihre verwendung als cox-2 inhibitoren
ATE286500T1 (de) 1,2,3,4-tetrahydroisochinolin-derivate
FR2838439B1 (fr) Derives de terphenyle, leur preparation, les compositions pharmaceutqiues en contenant
TR200101567T2 (tr) Yeni triazolo(4.5-D)pirimidin bileşimleri.
ES2271063T3 (es) Moduladores ciclopentilos de la actividad del receptor de la quimioquina.
DK1725536T3 (da) Imidazolin-derivater med CB1-antagonistisk aktivitet
EA200400466A1 (ru) Производные пиперазина с антагонистической активностью к рецептору ccr1
DE69935153D1 (de) Benzamide als kaliumkanal-inhibitoren
ATE346068T1 (de) Chinolin- und aza-indolderivate und deren verwendung als 5-ht6 liganden
ATE242246T1 (de) (1,2,3)-triazolo(4,5-d)pyrimidin-derivate als antithrombotische mittel
DE602004012426D1 (de) Bestimmte substituierte spirocyclische lactame und deren verwendung als pharmazeutika
ATE383345T1 (de) Quinoxalin-3-on-verdindungen als orexin-rezeptor antagonisten.
ATE269340T1 (de) Thiazolopyrimidine und ihre verwendung als modulatoren der chemokin-rezeptor-aktivität
DE60326263D1 (de) Pyrimidin-sulfonamide und ihre verwendung als endothelin-rezeptor-antagonisten
DE60116106D1 (de) Benzofuran derivate und ihre verwendung als antibakterielle wirkstoffe
ATE386525T1 (de) 3-substituierte 6,7- dihydroxytetrahydroisochinolin-derivate zur verwendung als antibkaterielle mittel
ATE258050T1 (de) Verwendung neurogen-entzuendungshemmender verbindungen und zusammensetzungen
DE60007289T2 (de) Verwendung von manzaminen als entzündungshemmende mittel
ATE344242T1 (de) N-cyclopentylmodulatoren der chemokine rezeptoraktivität

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee