ATE258050T1 - Verwendung neurogen-entzuendungshemmender verbindungen und zusammensetzungen - Google Patents

Verwendung neurogen-entzuendungshemmender verbindungen und zusammensetzungen

Info

Publication number
ATE258050T1
ATE258050T1 AT97946578T AT97946578T ATE258050T1 AT E258050 T1 ATE258050 T1 AT E258050T1 AT 97946578 T AT97946578 T AT 97946578T AT 97946578 T AT97946578 T AT 97946578T AT E258050 T1 ATE258050 T1 AT E258050T1
Authority
AT
Austria
Prior art keywords
compounds
bis
indole
compositions
inflammatory compounds
Prior art date
Application number
AT97946578T
Other languages
English (en)
Inventor
Robert S Jacobs
Shirley Pomponi
Sarath Gunasekera
Amy Wright
Original Assignee
Harbor Branch Oceanographic
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harbor Branch Oceanographic, Univ California filed Critical Harbor Branch Oceanographic
Application granted granted Critical
Publication of ATE258050T1 publication Critical patent/ATE258050T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT97946578T 1996-10-31 1997-10-31 Verwendung neurogen-entzuendungshemmender verbindungen und zusammensetzungen ATE258050T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3026196P 1996-10-31 1996-10-31
PCT/US1997/020300 WO1998018466A2 (en) 1996-10-31 1997-10-31 Anti-neurogenic inflammatory compounds and compositions and methods of use thereof

Publications (1)

Publication Number Publication Date
ATE258050T1 true ATE258050T1 (de) 2004-02-15

Family

ID=21853343

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97946578T ATE258050T1 (de) 1996-10-31 1997-10-31 Verwendung neurogen-entzuendungshemmender verbindungen und zusammensetzungen

Country Status (8)

Country Link
US (2) US5955462A (de)
EP (1) EP0935463B1 (de)
JP (1) JP2001503414A (de)
AT (1) ATE258050T1 (de)
CA (1) CA2268399C (de)
DE (1) DE69727305T2 (de)
ES (1) ES2212814T3 (de)
WO (1) WO1998018466A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999042092A2 (en) * 1998-02-20 1999-08-26 Harbor Branch Oceanographic Institution, Inc. Compounds and methods of use for treatment of neurogenic inflammation
JP2002520315A (ja) 1998-07-08 2002-07-09 ハーバー ブランチ オーシャノグラフィック インスティテューション インク． ビスインドール誘導体および抗炎症剤としてのそれらの使用
US6589975B2 (en) 1998-07-08 2003-07-08 The Regents Of The University Of California Synthetic compounds for treatment of inflammation
AU2002323475B2 (en) 2001-09-13 2006-09-28 Synta Pharmaceuticals Corp 2-aroylimidazole compounds for treating cancer
ATE421877T1 (de) * 2001-09-17 2009-02-15 Johnson & Johnson Consumer Verwendung von totarol zur behandlung von pruritus
EP2969503B1 (de) * 2013-03-14 2022-08-17 The Coca-Cola Company Gasbarrieren-verstärkungsmittel und verfahren
US9522168B2 (en) 2014-05-29 2016-12-20 Johnson & Johnson Consumer Inc. Topical compositions comprising Acmella oleracea extracts and uses thereof
CA3133803A1 (en) 2019-04-11 2020-10-15 Angion Biomedica Corp. Solid forms of (e)-3-[2-(2-thienyl)vinyl]-1h-pyrazole
KR20220124176A (ko) 2019-12-06 2022-09-13 버텍스 파마슈티칼스 인코포레이티드 나트륨 채널의 조절제로서의 치환된 테트라하이드로푸란
IL295374A (en) 2020-02-04 2022-10-01 Mindset Pharma Inc 3-pyrrolidine indole derivatives as serotonergic psychedelics for the treatment of central nervous system disorders
KR20230074174A (ko) 2020-09-21 2023-05-26 란도스 바이오파마, 인크. Nlrx1 리간드
AU2022284886A1 (en) 2021-06-04 2023-11-30 Vertex Pharmaceuticals Incorporated N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels
CN113480524B (zh) * 2021-08-10 2022-08-30 河北工业大学 生物碱hamacanthins系列衍生物及其制备方法和用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4895844A (en) * 1987-03-25 1990-01-23 Harbor Branch Oceanographic Institution, Inc. Indole alkaloid compositions and their methods of use
US4866084A (en) * 1987-07-17 1989-09-12 Harbor Branch Oceanographic Institution, Inc. Topsentin compounds effective against viruses and certain tumors
NZ227850A (en) * 1988-02-10 1991-11-26 Hoffmann La Roche Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders
MC2096A1 (fr) * 1989-02-23 1991-02-15 Hoffmann La Roche Pyrroles substitues
IL94274A0 (en) * 1989-05-05 1991-03-10 Goedecke Ag Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
US4970226A (en) * 1989-10-03 1990-11-13 Harbor Branch Oceanographic Institution, Inc. Bis-indole imidazole compounds which are useful antitumor and antimicrobial agents
CA2046801C (en) * 1990-08-07 2002-02-26 Peter D. Davis Substituted pyrroles
EP1000930A3 (de) * 1992-08-13 2003-10-29 Warner-Lambert Company Tachykinin Antagoniste
US5290777A (en) * 1993-02-24 1994-03-01 Regents Of The Univ. Of California Use for topsentin compounds and pharmaceutical compositions containing same
US5962486A (en) * 1994-06-01 1999-10-05 Zeneca Limited Indole derivatives as prodrugs of 5-HT1 -like receptor agonists
DE69523154T2 (de) * 1994-06-06 2002-06-06 Warner Lambert Co Tachykinin (nk1) rezeptor antagonisten
FR2731224B1 (fr) * 1995-03-02 1997-05-30 Pf Medicament Nouveaux derives bi-tryptaminiques sulfonamides, leur procede de preparation et leur utilisation a titre de medicaments
WO1997013512A1 (en) * 1995-10-10 1997-04-17 Eli Lilly And Company N-[2-substituted-3-(2-aminoethyl)-1h-indol-5-yl]-amides: new 5-ht1f agonists
WO1997038692A1 (en) * 1996-04-12 1997-10-23 Eli Lilly And Company Bisindoles for treating pain or nociception

Also Published As

Publication number Publication date
DE69727305D1 (de) 2004-02-26
WO1998018466A2 (en) 1998-05-07
CA2268399A1 (en) 1998-05-07
CA2268399C (en) 2008-08-19
EP0935463B1 (de) 2004-01-21
ES2212814T3 (es) 2004-08-01
DE69727305T2 (de) 2004-06-24
US5955462A (en) 1999-09-21
WO1998018466A3 (en) 1998-08-13
US6090811A (en) 2000-07-18
EP0935463A2 (de) 1999-08-18
JP2001503414A (ja) 2001-03-13

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