HUP9801887A2 - CCR-3 receptor antagonista hatású gyűrűs aminszármazékok, eljárás előállításukra és ezeket a vegyületeket tartalmazó gyógyászati készítmények - Google Patents
CCR-3 receptor antagonista hatású gyűrűs aminszármazékok, eljárás előállításukra és ezeket a vegyületeket tartalmazó gyógyászati készítményekInfo
- Publication number
- HUP9801887A2 HUP9801887A2 HU9801887A HUP9801887A HUP9801887A2 HU P9801887 A2 HUP9801887 A2 HU P9801887A2 HU 9801887 A HU9801887 A HU 9801887A HU P9801887 A HUP9801887 A HU P9801887A HU P9801887 A2 HUP9801887 A2 HU P9801887A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- heterocyclic
- ccr
- compounds
- independently
- Prior art date
Links
- 102000004499 CCR3 Receptors Human genes 0.000 title abstract 2
- 108010017316 CCR3 Receptors Proteins 0.000 title abstract 2
- 239000002464 receptor antagonist Substances 0.000 title abstract 2
- 229940044551 receptor antagonist Drugs 0.000 title abstract 2
- -1 Cyclic amine Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002837 carbocyclic group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 239000000843 powder Substances 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 210000003979 eosinophil Anatomy 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 1
- 125000004475 heteroaralkyl group Chemical group 0.000 abstract 1
- 125000005343 heterocyclic alkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
Classifications
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- Indole Compounds (AREA)
- Furan Compounds (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A találmány CCR-3 receptőr antagőnista új, (I) általánős képletűciklikűs aminőkra (mely képletben T és U jelentése egyarántnitrőgénatőm; vagy T és U közül az egyik nitrőgénatőmőt és a másikszénatőmőt képvisel; R1 és R2 jelentése egymástól függetlenülhidrőgénatőm vagy alkilcsőpőrt; n értéke 0-2, m értéke 0-3; Ar és Ar1jelentése egymástól függetlenül aril- vagy heterőarilcsőpőrt; Fjelentése alkilén- vagy alkeniléncsőpőrt, vagy kötés, az e gyes Rcsőpőrtők jelentése egymástól függetlenül hidrőgénatőm vagyalkilcsőpőrt, vagy R R3-al vagy R4-el és azőkkal az atőmőkkal együtt,amelyekhez kapcsőlódnak, karbőciklikűs vagy heterőciklikűs csőpőrtőtképeznek; R3 és R4 jelentése egymástól függetlenül (i) hidrőgénatőm,alkil-, alkenil-, halőgén-alkil-, ciklőalkil-, ciklőalkil-alkil-,heterőaril-, heterőaralkil-, heterőciklikűs-, heterőciklikűs-alkil-,heterőalkil-, cianő- vagy -(alkilén)-C(O)-Z csőpőrt, vagy (ii) R3 ésR4 a szénatőmmal együtt, amelyhez kapcsőlódik, karbőciklűst vagyheterőciklűst képez; E jelentése -C(O)N(R5)-, -SO2N(R5)-, -N(R6)C(O)N(R5)-, -N(R6)SO2N(R5)-, -N(R6)C(S)N(R5)-, -N(R6)C(O)-, -N(R6)C(O)O-, -OC(O)N(R6)- vagy -N(R6)SO2- általánős képletű csőpőrt; Qjelentése -R7-W-R8 általánős képletű csőpőrt) az e vegyületekettartalmazó gyógyászati készítményekre és a vegyületek előállításáravőnatkőzik. A vegyületek eőzinőfil által közvetített gyűlladásősbetegségek kezelésére alkalmazhatók. ŕ
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1998
- 1998-08-05 IL IL12565898A patent/IL125658A0/xx unknown
- 1998-08-10 AT AT98114971T patent/ATE315035T1/de not_active IP Right Cessation
- 1998-08-10 DE DE69833073T patent/DE69833073T2/de not_active Expired - Fee Related
- 1998-08-10 ES ES98114971T patent/ES2255119T3/es not_active Expired - Lifetime
- 1998-08-10 EP EP98114971A patent/EP0903349B1/en not_active Expired - Lifetime
- 1998-08-11 NZ NZ331319A patent/NZ331319A/xx unknown
- 1998-08-12 HU HU9801861A patent/HU9801861D0/hu unknown
- 1998-08-13 CZ CZ982566A patent/CZ256698A3/cs unknown
- 1998-08-14 CA CA002245043A patent/CA2245043A1/en not_active Abandoned
- 1998-08-14 ES ES009801760A patent/ES2154167B1/es not_active Expired - Lifetime
- 1998-08-14 US US09/134,013 patent/US6323223B1/en not_active Expired - Fee Related
- 1998-08-14 KR KR1019980033037A patent/KR100339460B1/ko not_active IP Right Cessation
- 1998-08-14 CO CO98046764A patent/CO4980871A1/es unknown
- 1998-08-17 UY UY25142A patent/UY25142A1/es not_active Application Discontinuation
- 1998-08-17 GB GB9817910A patent/GB2330580A/en not_active Withdrawn
- 1998-08-17 MA MA25214A patent/MA26532A1/fr unknown
- 1998-08-17 HU HU9801887A patent/HUP9801887A3/hu unknown
- 1998-08-17 NO NO983749A patent/NO983749L/no not_active Application Discontinuation
- 1998-08-18 JP JP10231918A patent/JP3014367B2/ja not_active Expired - Fee Related
- 1998-08-18 AU AU80800/98A patent/AU744059B2/en not_active Ceased
- 1998-08-18 SG SG1998003133A patent/SG70110A1/en unknown
- 1998-08-18 IT IT1998MI001902A patent/IT1304150B1/it active
- 1998-08-18 PE PE1998000744A patent/PE106499A1/es not_active Application Discontinuation
- 1998-08-18 TR TR1998/01594A patent/TR199801594A2/xx unknown
- 1998-08-18 HR HR60/056,001A patent/HRP980450A2/hr not_active Application Discontinuation
- 1998-08-18 PL PL98328049A patent/PL328049A1/xx unknown
- 1998-08-18 FR FR9810504A patent/FR2767826A1/fr not_active Withdrawn
- 1998-08-18 CN CN98117990A patent/CN1107061C/zh not_active Expired - Fee Related
- 1998-08-18 ZA ZA987448A patent/ZA987448B/xx unknown
- 1998-08-18 AR ARP980104061A patent/AR016822A1/es unknown
- 1998-08-18 YU YU34898A patent/YU34898A/sh unknown
- 1998-08-18 ID IDP981141A patent/ID21679A/id unknown
- 1998-08-18 BR BR9803179-1A patent/BR9803179A/pt not_active Application Discontinuation
- 1998-08-18 DE DE19837386A patent/DE19837386A1/de not_active Withdrawn
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2001
- 2001-09-26 US US09/965,068 patent/US6683074B1/en not_active Expired - Fee Related
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2003
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