ATE165357T1 - Neue verwendung bis-heterocyclische verbindungen und dessen zusammensetzungen - Google Patents
Neue verwendung bis-heterocyclische verbindungen und dessen zusammensetzungenInfo
- Publication number
- ATE165357T1 ATE165357T1 AT94909794T AT94909794T ATE165357T1 AT E165357 T1 ATE165357 T1 AT E165357T1 AT 94909794 T AT94909794 T AT 94909794T AT 94909794 T AT94909794 T AT 94909794T AT E165357 T1 ATE165357 T1 AT E165357T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- compositions
- heterocyclic compounds
- new use
- bis
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- TYGUTURXHKSOBP-UHFFFAOYSA-N 10-bromo-5,12-dihydroindolo[2,3-g]carbazole-2,3-diol Chemical class C1=C(Br)C=C2NC3=C(C4=C(C=C(C(=C4)O)O)N4)C4=CC=C3C2=C1 TYGUTURXHKSOBP-UHFFFAOYSA-N 0.000 abstract 1
- AUJKXAIGSXKZBR-UHFFFAOYSA-N Dragmacidin Natural products BrC1=CC(O)=C2C(C3CN(C(CN3)C=3C4=CC=C(Br)C=C4NC=3)C)=CNC2=C1Br AUJKXAIGSXKZBR-UHFFFAOYSA-N 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 229930186849 nortopsentin Natural products 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- ONYVJPZNVCOAFF-UHFFFAOYSA-N topsentin Natural products Oc1ccc2cc([nH]c2c1)C(=O)c3ncc([nH]3)c4c[nH]c5ccccc45 ONYVJPZNVCOAFF-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Characterised By The Charging Evacuation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/021,929 US5290777A (en) | 1993-02-24 | 1993-02-24 | Use for topsentin compounds and pharmaceutical compositions containing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE165357T1 true ATE165357T1 (de) | 1998-05-15 |
Family
ID=21806918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94909794T ATE165357T1 (de) | 1993-02-24 | 1994-02-24 | Neue verwendung bis-heterocyclische verbindungen und dessen zusammensetzungen |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US5290777A (de) |
| EP (1) | EP0686154B1 (de) |
| JP (1) | JP4028888B2 (de) |
| AT (1) | ATE165357T1 (de) |
| CA (1) | CA2155323C (de) |
| DE (1) | DE69409796T2 (de) |
| ES (1) | ES2115220T3 (de) |
| WO (1) | WO1994019343A2 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639468A (en) * | 1995-06-07 | 1997-06-17 | University Of Southern California | Method for reducing or preventing post-surgical adhesion formation using manoalide and analogs thereof |
| US5977117A (en) * | 1996-01-05 | 1999-11-02 | Texas Biotechnology Corporation | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin |
| EP0935463B1 (de) * | 1996-10-31 | 2004-01-21 | Harbor Branch Oceanographic Institution, Inc. | Verwendung neurogen-entzuendungshemmender verbindungen und zusammensetzungen |
| US6291501B1 (en) | 1998-02-20 | 2001-09-18 | Harbor Branch Oceanographic Institution, Inc. | Compounds and methods of use for treatment of neurogenic inflammation |
| US6589975B2 (en) | 1998-07-08 | 2003-07-08 | The Regents Of The University Of California | Synthetic compounds for treatment of inflammation |
| US6323233B1 (en) | 1998-07-08 | 2001-11-27 | Harbor Branch Oceanographic Institution Inc. | Synthetic compounds for treatment of inflammation |
| US6492406B1 (en) | 1999-05-21 | 2002-12-10 | Astrazeneca Ab | Pharmaceutically active compounds |
| US6087363A (en) * | 1999-07-16 | 2000-07-11 | Harbor Branch Oceanographic Institution, Inc. | Use of imidazole and indole compounds as inhibitors of nitric oxide synthase |
| KR100404580B1 (ko) * | 2000-04-20 | 2003-11-05 | 한국해양연구원 | 원도닌 ａ 및 그의 제조방법 |
| CA2460345A1 (en) * | 2001-09-13 | 2003-03-20 | Synta Pharmaceuticals Corp. | 2-aroylimidazole compounds for treating cancer |
| US7573159B1 (en) | 2001-10-22 | 2009-08-11 | Apple Inc. | Power adapters for powering and/or charging peripheral devices |
| WO2016023106A1 (en) * | 2014-08-15 | 2016-02-18 | The University Of British Columbia | Bis-indole alkaloids for use in the treatment of infections |
| CN107814790B (zh) * | 2016-09-12 | 2021-03-30 | 南开大学 | Topsentin类衍生物及其制备和在抗植物病毒和病菌中的应用 |
| CN107810961B (zh) * | 2016-09-12 | 2021-04-02 | 南开大学 | Topsentin类生物碱在抗植物病毒和病菌中的应用 |
| CN109418267B (zh) * | 2017-08-21 | 2021-03-30 | 南开大学 | Nortopsentin类生物碱及其衍生物在防治植物病虫害中的应用 |
| CN109422734B (zh) * | 2017-08-21 | 2021-03-30 | 南开大学 | Nortopsentin类生物碱衍生物及其制备和在防治病虫害中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0272810A3 (de) * | 1986-11-26 | 1988-07-20 | Harbor Branch Oceanographic Institution, Inc. | Antitumor- und Antiviral-Alkaloide |
| US4895844A (en) * | 1987-03-25 | 1990-01-23 | Harbor Branch Oceanographic Institution, Inc. | Indole alkaloid compositions and their methods of use |
| US4866084A (en) * | 1987-07-17 | 1989-09-12 | Harbor Branch Oceanographic Institution, Inc. | Topsentin compounds effective against viruses and certain tumors |
| SK75289A3 (en) * | 1988-02-10 | 1998-05-06 | Hoffmann La Roche | Substituted pyrroles, their use for producing a drug, and the drug on their base |
| US4970226A (en) * | 1989-10-03 | 1990-11-13 | Harbor Branch Oceanographic Institution, Inc. | Bis-indole imidazole compounds which are useful antitumor and antimicrobial agents |
-
1993
- 1993-02-24 US US08/021,929 patent/US5290777A/en not_active Expired - Lifetime
-
1994
- 1994-02-24 CA CA002155323A patent/CA2155323C/en not_active Expired - Fee Related
- 1994-02-24 JP JP51928294A patent/JP4028888B2/ja not_active Expired - Fee Related
- 1994-02-24 AT AT94909794T patent/ATE165357T1/de not_active IP Right Cessation
- 1994-02-24 US US08/201,309 patent/US5464835A/en not_active Expired - Lifetime
- 1994-02-24 ES ES94909794T patent/ES2115220T3/es not_active Expired - Lifetime
- 1994-02-24 DE DE69409796T patent/DE69409796T2/de not_active Expired - Fee Related
- 1994-02-24 EP EP94909794A patent/EP0686154B1/de not_active Expired - Lifetime
- 1994-02-24 WO PCT/US1994/002031 patent/WO1994019343A2/en not_active Ceased
- 1994-10-28 US US08/330,651 patent/US5496950A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69409796T2 (de) | 1998-08-13 |
| US5290777A (en) | 1994-03-01 |
| CA2155323A1 (en) | 1994-09-01 |
| US5464835A (en) | 1995-11-07 |
| WO1994019343A2 (en) | 1994-09-01 |
| ES2115220T3 (es) | 1998-06-16 |
| JP4028888B2 (ja) | 2007-12-26 |
| DE69409796D1 (de) | 1998-05-28 |
| JPH09500091A (ja) | 1997-01-07 |
| US5496950A (en) | 1996-03-05 |
| WO1994019343A3 (en) | 1994-10-27 |
| CA2155323C (en) | 2005-06-14 |
| EP0686154B1 (de) | 1998-04-22 |
| EP0686154A1 (de) | 1995-12-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |