RU95104939A - Тетрациклические соединения, способ их получения и промежуточные соединения для этого и применение их в качестве противоопухолевых веществ - Google Patents
Тетрациклические соединения, способ их получения и промежуточные соединения для этого и применение их в качестве противоопухолевых веществInfo
- Publication number
- RU95104939A RU95104939A RU95104939/04A RU95104939A RU95104939A RU 95104939 A RU95104939 A RU 95104939A RU 95104939/04 A RU95104939/04 A RU 95104939/04A RU 95104939 A RU95104939 A RU 95104939A RU 95104939 A RU95104939 A RU 95104939A
- Authority
- RU
- Russia
- Prior art keywords
- compounds
- synthesis
- antitumor agents
- indoles
- heterocyclic compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Изобретение относится к гетероциклическим соединениям формулы (I), которые, как было установлено, проявляют противоопухолевую активность. В частности, изобретение касается пиррол [3, 2 - b] - карбазолов, IH-бензофуро [3, 2 - f] индолов и IH-[I] бензотиено [2, 3 - f]-индолов, способа их получения, промежуточных соединений, лекарственных форм, содержащих эти соединения, и применения их в качестве противоопухолевых средств.
Claims (1)
- Изобретение относится к гетероциклическим соединениям формулы (I), которые, как было установлено, проявляют противоопухолевую активность. В частности, изобретение касается пиррол [3, 2 - b] - карбазолов, IH-бензофуро [3, 2 - f] индолов и IH-[I] бензотиено [2, 3 - f]-индолов, способа их получения, промежуточных соединений, лекарственных форм, содержащих эти соединения, и применения их в качестве противоопухолевых средств.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9215361.8 | 1992-07-20 | ||
GB929215361A GB9215361D0 (en) | 1992-07-20 | 1992-07-20 | Heterocyclic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
RU95104939A true RU95104939A (ru) | 1996-10-27 |
Family
ID=10718981
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU95104939/04A RU95104939A (ru) | 1992-07-20 | 1993-07-19 | Тетрациклические соединения, способ их получения и промежуточные соединения для этого и применение их в качестве противоопухолевых веществ |
Country Status (23)
Country | Link |
---|---|
EP (1) | EP0651750A1 (ru) |
JP (1) | JPH08502037A (ru) |
KR (1) | KR950702563A (ru) |
CN (1) | CN1088209A (ru) |
AU (1) | AU4579593A (ru) |
BG (1) | BG99359A (ru) |
CA (1) | CA2140662A1 (ru) |
CZ (1) | CZ14995A3 (ru) |
FI (1) | FI950229A (ru) |
GB (1) | GB9215361D0 (ru) |
HR (1) | HRP931066A2 (ru) |
HU (1) | HUT76787A (ru) |
IL (1) | IL106385A0 (ru) |
MX (1) | MX9304355A (ru) |
NO (1) | NO950202L (ru) |
NZ (1) | NZ254207A (ru) |
PL (1) | PL307169A1 (ru) |
RU (1) | RU95104939A (ru) |
SI (1) | SI9300390A (ru) |
SK (1) | SK7595A3 (ru) |
WO (1) | WO1994002483A1 (ru) |
YU (1) | YU50293A (ru) |
ZA (1) | ZA935213B (ru) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9401921D0 (en) * | 1994-02-01 | 1994-03-30 | Wellcome Found | Heterocyclic compounds |
GB9413758D0 (en) * | 1994-07-07 | 1994-08-24 | Wellcome Found | Heterocyclic compounds |
GB9804343D0 (en) * | 1998-02-27 | 1998-04-22 | Univ Cardiff | Chemical compounds |
ES2327615T3 (es) * | 2001-02-14 | 2009-11-02 | Wisconsin Alumni Research Foundation | Preparaciones y uso de un ligando receptor de ah, ester metilico del acido 2-(1'h-indol-3'-carbonil)-tiazol-4-carboxilico. |
US7419992B2 (en) | 2001-02-14 | 2008-09-02 | Wisconsin Alumni Research Foundation | Use of aryl hydrocarbon receptor ligand as a therapeutic intervention in angiogenesis-implicated disorders |
GB0302094D0 (en) | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
GB0324269D0 (en) | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
WO2008051523A2 (en) * | 2006-10-23 | 2008-05-02 | Georgetown University | Carbazole derivatives useful as medicaments in cancer therapy |
CN102186820B (zh) | 2008-08-15 | 2013-08-28 | 乔治城大学 | Rassf1a表达和人癌细胞增殖的荧光调节剂 |
JP2012051804A (ja) * | 2008-12-26 | 2012-03-15 | Kyoto Univ | Eg5阻害剤 |
KR20160066490A (ko) * | 2014-12-02 | 2016-06-10 | 주식회사 씨앤드씨신약연구소 | 헤테로사이클 유도체 및 그의 용도 |
US11053255B2 (en) | 2015-06-22 | 2021-07-06 | Georgetown University | Synthesis of mahanine and related compounds |
CN109776550B (zh) * | 2019-01-17 | 2021-08-10 | 广东轻工职业技术学院 | 一种海洋真菌来源的生物碱化合物及其在制备食品防腐剂中的应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0300688A1 (en) * | 1987-07-21 | 1989-01-25 | FISONS plc | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them |
US5166204A (en) * | 1989-11-01 | 1992-11-24 | Toyama Chemical Co., Ltd. | Isoindole derivatives and salts thereof and antitumor agent comprising the same |
MC2251A1 (fr) * | 1990-03-20 | 1993-03-25 | Wellcome Found | Composes heterocycliques biocides,leur synthese et leurs internediaires,compositions les contenant et leur utilisation en medecine |
-
1992
- 1992-07-20 GB GB929215361A patent/GB9215361D0/en active Pending
-
1993
- 1993-07-19 PL PL93307169A patent/PL307169A1/xx unknown
- 1993-07-19 RU RU95104939/04A patent/RU95104939A/ru unknown
- 1993-07-19 AU AU45795/93A patent/AU4579593A/en not_active Abandoned
- 1993-07-19 JP JP6504272A patent/JPH08502037A/ja active Pending
- 1993-07-19 HU HU9500171A patent/HUT76787A/hu unknown
- 1993-07-19 EP EP93916105A patent/EP0651750A1/en not_active Withdrawn
- 1993-07-19 NZ NZ254207A patent/NZ254207A/en unknown
- 1993-07-19 MX MX9304355A patent/MX9304355A/es not_active IP Right Cessation
- 1993-07-19 WO PCT/GB1993/001512 patent/WO1994002483A1/en not_active Application Discontinuation
- 1993-07-19 HR HR931066A patent/HRP931066A2/hr not_active Application Discontinuation
- 1993-07-19 IL IL106385A patent/IL106385A0/xx unknown
- 1993-07-19 SK SK75-95A patent/SK7595A3/sk unknown
- 1993-07-19 CZ CZ95149A patent/CZ14995A3/cs unknown
- 1993-07-19 CA CA002140662A patent/CA2140662A1/en not_active Abandoned
- 1993-07-19 KR KR1019950700226A patent/KR950702563A/ko not_active Application Discontinuation
- 1993-07-19 SI SI9300390A patent/SI9300390A/sl unknown
- 1993-07-19 CN CN93116598A patent/CN1088209A/zh active Pending
- 1993-07-19 ZA ZA935213A patent/ZA935213B/xx unknown
- 1993-07-20 YU YU50293A patent/YU50293A/sh unknown
-
1995
- 1995-01-18 BG BG99359A patent/BG99359A/bg unknown
- 1995-01-19 FI FI950229A patent/FI950229A/fi unknown
- 1995-01-19 NO NO950202A patent/NO950202L/no unknown
Also Published As
Publication number | Publication date |
---|---|
NO950202D0 (no) | 1995-01-19 |
HRP931066A2 (en) | 1995-12-31 |
PL307169A1 (en) | 1995-05-15 |
HUT76787A (en) | 1997-11-28 |
FI950229A0 (fi) | 1995-01-19 |
MX9304355A (es) | 1994-04-29 |
NO950202L (no) | 1995-01-19 |
KR950702563A (ko) | 1995-07-29 |
AU4579593A (en) | 1994-02-14 |
NZ254207A (en) | 1997-03-24 |
CZ14995A3 (en) | 1995-10-18 |
HU9500171D0 (en) | 1995-03-28 |
EP0651750A1 (en) | 1995-05-10 |
JPH08502037A (ja) | 1996-03-05 |
IL106385A0 (en) | 1993-11-15 |
GB9215361D0 (en) | 1992-09-02 |
YU50293A (sh) | 1997-01-08 |
SI9300390A (en) | 1994-03-31 |
CN1088209A (zh) | 1994-06-22 |
CA2140662A1 (en) | 1994-02-03 |
ZA935213B (en) | 1995-01-19 |
WO1994002483A1 (en) | 1994-02-03 |
FI950229A (fi) | 1995-03-10 |
BG99359A (bg) | 1995-11-30 |
SK7595A3 (en) | 1995-07-11 |
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