RU95104939A - Тетрациклические соединения, способ их получения и промежуточные соединения для этого и применение их в качестве противоопухолевых веществ - Google Patents

Тетрациклические соединения, способ их получения и промежуточные соединения для этого и применение их в качестве противоопухолевых веществ

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Publication number
RU95104939A
RU95104939A RU95104939/04A RU95104939A RU95104939A RU 95104939 A RU95104939 A RU 95104939A RU 95104939/04 A RU95104939/04 A RU 95104939/04A RU 95104939 A RU95104939 A RU 95104939A RU 95104939 A RU95104939 A RU 95104939A
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RU
Russia
Prior art keywords
compounds
synthesis
antitumor agents
indoles
heterocyclic compounds
Prior art date
Application number
RU95104939/04A
Other languages
English (en)
Inventor
Витольд Францманн Карл
Gb]
Найджел Стейблз Джереми
Вивиан Ричард Шэннон Патрик
Коданда Ранганата Рао Нагараджа
Чунчатпразерт Ладдаван
In]
Th]
Original Assignee
Дзе Веллкам Фаундейшн Лимитед (GB)
Дзе Веллкам Фаундейшн Лимитед
Юниверсити Колледж Кардифф Консалтантс Лимитед (GB)
Юниверсити Колледж Кардифф Консалтантс Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Дзе Веллкам Фаундейшн Лимитед (GB), Дзе Веллкам Фаундейшн Лимитед, Юниверсити Колледж Кардифф Консалтантс Лимитед (GB), Юниверсити Колледж Кардифф Консалтантс Лимитед filed Critical Дзе Веллкам Фаундейшн Лимитед (GB)
Publication of RU95104939A publication Critical patent/RU95104939A/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретение относится к гетероциклическим соединениям формулы (I), которые, как было установлено, проявляют противоопухолевую активность. В частности, изобретение касается пиррол [3, 2 - b] - карбазолов, IH-бензофуро [3, 2 - f] индолов и IH-[I] бензотиено [2, 3 - f]-индолов, способа их получения, промежуточных соединений, лекарственных форм, содержащих эти соединения, и применения их в качестве противоопухолевых средств.

Claims (1)

  1. Изобретение относится к гетероциклическим соединениям формулы (I), которые, как было установлено, проявляют противоопухолевую активность. В частности, изобретение касается пиррол [3, 2 - b] - карбазолов, IH-бензофуро [3, 2 - f] индолов и IH-[I] бензотиено [2, 3 - f]-индолов, способа их получения, промежуточных соединений, лекарственных форм, содержащих эти соединения, и применения их в качестве противоопухолевых средств.
RU95104939/04A 1992-07-20 1993-07-19 Тетрациклические соединения, способ их получения и промежуточные соединения для этого и применение их в качестве противоопухолевых веществ RU95104939A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9215361.8 1992-07-20
GB929215361A GB9215361D0 (en) 1992-07-20 1992-07-20 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
RU95104939A true RU95104939A (ru) 1996-10-27

Family

ID=10718981

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95104939/04A RU95104939A (ru) 1992-07-20 1993-07-19 Тетрациклические соединения, способ их получения и промежуточные соединения для этого и применение их в качестве противоопухолевых веществ

Country Status (23)

Country Link
EP (1) EP0651750A1 (ru)
JP (1) JPH08502037A (ru)
KR (1) KR950702563A (ru)
CN (1) CN1088209A (ru)
AU (1) AU4579593A (ru)
BG (1) BG99359A (ru)
CA (1) CA2140662A1 (ru)
CZ (1) CZ14995A3 (ru)
FI (1) FI950229A (ru)
GB (1) GB9215361D0 (ru)
HR (1) HRP931066A2 (ru)
HU (1) HUT76787A (ru)
IL (1) IL106385A0 (ru)
MX (1) MX9304355A (ru)
NO (1) NO950202L (ru)
NZ (1) NZ254207A (ru)
PL (1) PL307169A1 (ru)
RU (1) RU95104939A (ru)
SI (1) SI9300390A (ru)
SK (1) SK7595A3 (ru)
WO (1) WO1994002483A1 (ru)
YU (1) YU50293A (ru)
ZA (1) ZA935213B (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9401921D0 (en) * 1994-02-01 1994-03-30 Wellcome Found Heterocyclic compounds
GB9413758D0 (en) * 1994-07-07 1994-08-24 Wellcome Found Heterocyclic compounds
GB9804343D0 (en) * 1998-02-27 1998-04-22 Univ Cardiff Chemical compounds
CA2437579C (en) * 2001-02-14 2012-05-01 Hector F. Deluca Preparations and use of an ah receptor ligand, 2-(1'h-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester
US7419992B2 (en) 2001-02-14 2008-09-02 Wisconsin Alumni Research Foundation Use of aryl hydrocarbon receptor ligand as a therapeutic intervention in angiogenesis-implicated disorders
GB0302094D0 (en) 2003-01-29 2003-02-26 Pharmagene Lab Ltd EP4 receptor antagonists
GB0324269D0 (en) 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
WO2008051523A2 (en) * 2006-10-23 2008-05-02 Georgetown University Carbazole derivatives useful as medicaments in cancer therapy
WO2010019271A1 (en) 2008-08-15 2010-02-18 Georgetown University Fluorescent regulators of rassf1a expression and human cancer cell proliferation
JP2012051804A (ja) * 2008-12-26 2012-03-15 Kyoto Univ Ｅｇ５阻害剤
KR20160066490A (ko) * 2014-12-02 2016-06-10 주식회사 씨앤드씨신약연구소 헤테로사이클 유도체 및 그의 용도
US11053255B2 (en) 2015-06-22 2021-07-06 Georgetown University Synthesis of mahanine and related compounds
CN109776550B (zh) * 2019-01-17 2021-08-10 广东轻工职业技术学院 一种海洋真菌来源的生物碱化合物及其在制备食品防腐剂中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0300688A1 (en) * 1987-07-21 1989-01-25 FISONS plc Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them
US5166204A (en) * 1989-11-01 1992-11-24 Toyama Chemical Co., Ltd. Isoindole derivatives and salts thereof and antitumor agent comprising the same
JPH06503549A (ja) * 1990-03-20 1994-04-21 ザ　ウェルカム　ファウンデーション　リミテッド 殺生物性ヘテロ多環状化合物およびそれらの医療における使用

Also Published As

Publication number Publication date
CZ14995A3 (en) 1995-10-18
FI950229A (fi) 1995-03-10
GB9215361D0 (en) 1992-09-02
HUT76787A (en) 1997-11-28
FI950229A0 (fi) 1995-01-19
HU9500171D0 (en) 1995-03-28
CA2140662A1 (en) 1994-02-03
EP0651750A1 (en) 1995-05-10
NZ254207A (en) 1997-03-24
SI9300390A (en) 1994-03-31
JPH08502037A (ja) 1996-03-05
KR950702563A (ko) 1995-07-29
IL106385A0 (en) 1993-11-15
NO950202D0 (no) 1995-01-19
MX9304355A (es) 1994-04-29
PL307169A1 (en) 1995-05-15
YU50293A (sh) 1997-01-08
SK7595A3 (en) 1995-07-11
HRP931066A2 (en) 1995-12-31
CN1088209A (zh) 1994-06-22
NO950202L (no) 1995-01-19
ZA935213B (en) 1995-01-19
AU4579593A (en) 1994-02-14
BG99359A (bg) 1995-11-30
WO1994002483A1 (en) 1994-02-03

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