ES2115220T3 - Nuevo uso de compuestos bis-heterociclicos como agentes antiinflamatorios y composiciones farmaceuticas de los mismos. - Google Patents

Nuevo uso de compuestos bis-heterociclicos como agentes antiinflamatorios y composiciones farmaceuticas de los mismos.

Info

Publication number
ES2115220T3
ES2115220T3 ES94909794T ES94909794T ES2115220T3 ES 2115220 T3 ES2115220 T3 ES 2115220T3 ES 94909794 T ES94909794 T ES 94909794T ES 94909794 T ES94909794 T ES 94909794T ES 2115220 T3 ES2115220 T3 ES 2115220T3
Authority
ES
Spain
Prior art keywords
bis
hetero
pharmaceutical compositions
inflammatory agents
new use
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94909794T
Other languages
English (en)
Inventor
Oliver J Mcconnell
Gabriel Saucy
Robert Jacobs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harbor Branch Oceanographic Institution Inc
Original Assignee
Harbor Branch Oceanographic Institution Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harbor Branch Oceanographic Institution Inc filed Critical Harbor Branch Oceanographic Institution Inc
Application granted granted Critical
Publication of ES2115220T3 publication Critical patent/ES2115220T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE DESCRIBE UN NUEVO USO PARA LA CLASE DE BIS-HETEROCICLOS BIOLOGICAMENTE ACTIVOS, POR EJEMPLO, COMPUESTOS ALCALOIDES DE BIS-INDOL, QUE SE HAN LLAMADO TOPSENTINAS, NORTOPSENTINAS, HAMACANTINAS O DRAGMACIDINAS, COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN, METODOS PARA PRODUCIR LOS COMPUESTOS Y METODOS DE UTILIZACION DE LOS COMPUESTOS. ESPECIFICAMENTE, LA NUEVA UTILIDAD PERTENECE A LAS PROPIEDADES ANTIINFLAMATORIAS MOSTRADAS POR LOS COMPUESTOS DE BIS-INDOL Y SUS ANALOGOS.
ES94909794T 1993-02-24 1994-02-24 Nuevo uso de compuestos bis-heterociclicos como agentes antiinflamatorios y composiciones farmaceuticas de los mismos. Expired - Lifetime ES2115220T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/021,929 US5290777A (en) 1993-02-24 1993-02-24 Use for topsentin compounds and pharmaceutical compositions containing same

Publications (1)

Publication Number Publication Date
ES2115220T3 true ES2115220T3 (es) 1998-06-16

Family

ID=21806918

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94909794T Expired - Lifetime ES2115220T3 (es) 1993-02-24 1994-02-24 Nuevo uso de compuestos bis-heterociclicos como agentes antiinflamatorios y composiciones farmaceuticas de los mismos.

Country Status (8)

Country Link
US (3) US5290777A (es)
EP (1) EP0686154B1 (es)
JP (1) JP4028888B2 (es)
AT (1) ATE165357T1 (es)
CA (1) CA2155323C (es)
DE (1) DE69409796T2 (es)
ES (1) ES2115220T3 (es)
WO (1) WO1994019343A2 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639468A (en) * 1995-06-07 1997-06-17 University Of Southern California Method for reducing or preventing post-surgical adhesion formation using manoalide and analogs thereof
US5977117A (en) * 1996-01-05 1999-11-02 Texas Biotechnology Corporation Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
EP0935463B1 (en) * 1996-10-31 2004-01-21 Harbor Branch Oceanographic Institution, Inc. Use of anti-neurogenic inflammatory compounds and compositions
US6291501B1 (en) 1998-02-20 2001-09-18 Harbor Branch Oceanographic Institution, Inc. Compounds and methods of use for treatment of neurogenic inflammation
CA2335254A1 (en) 1998-07-08 2000-01-20 Harbor Branch Oceanographic Institution, Inc. Bis-indole derivatives and their use as antiinflammatory agents
US6589975B2 (en) 1998-07-08 2003-07-08 The Regents Of The University Of California Synthetic compounds for treatment of inflammation
US6492406B1 (en) 1999-05-21 2002-12-10 Astrazeneca Ab Pharmaceutically active compounds
US6087363A (en) * 1999-07-16 2000-07-11 Harbor Branch Oceanographic Institution, Inc. Use of imidazole and indole compounds as inhibitors of nitric oxide synthase
KR100404580B1 (ko) * 2000-04-20 2003-11-05 한국해양연구원 원도닌 ａ 및 그의 제조방법
AU2002323475B2 (en) 2001-09-13 2006-09-28 Synta Pharmaceuticals Corp 2-aroylimidazole compounds for treating cancer
US7573159B1 (en) 2001-10-22 2009-08-11 Apple Inc. Power adapters for powering and/or charging peripheral devices
WO2016023106A1 (en) * 2014-08-15 2016-02-18 The University Of British Columbia Bis-indole alkaloids for use in the treatment of infections
CN107810961B (zh) * 2016-09-12 2021-04-02 南开大学 Topsentin类生物碱在抗植物病毒和病菌中的应用
CN107814790B (zh) * 2016-09-12 2021-03-30 南开大学 Topsentin类衍生物及其制备和在抗植物病毒和病菌中的应用
CN109422734B (zh) * 2017-08-21 2021-03-30 南开大学 Nortopsentin类生物碱衍生物及其制备和在防治病虫害中的应用
CN109418267B (zh) * 2017-08-21 2021-03-30 南开大学 Nortopsentin类生物碱及其衍生物在防治植物病虫害中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0272810A3 (en) * 1986-11-26 1988-07-20 Harbor Branch Oceanographic Institution, Inc. Antitumor and antiviral alkaloids
US4895844A (en) * 1987-03-25 1990-01-23 Harbor Branch Oceanographic Institution, Inc. Indole alkaloid compositions and their methods of use
US4866084A (en) * 1987-07-17 1989-09-12 Harbor Branch Oceanographic Institution, Inc. Topsentin compounds effective against viruses and certain tumors
CZ280738B6 (cs) * 1988-02-10 1996-04-17 F. Hoffmann - La Roche And Co., Aktiengesellschaft Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi
US4970226A (en) * 1989-10-03 1990-11-13 Harbor Branch Oceanographic Institution, Inc. Bis-indole imidazole compounds which are useful antitumor and antimicrobial agents

Also Published As

Publication number Publication date
DE69409796T2 (de) 1998-08-13
JP4028888B2 (ja) 2007-12-26
ATE165357T1 (de) 1998-05-15
WO1994019343A3 (en) 1994-10-27
DE69409796D1 (de) 1998-05-28
JPH09500091A (ja) 1997-01-07
CA2155323C (en) 2005-06-14
CA2155323A1 (en) 1994-09-01
EP0686154A1 (en) 1995-12-13
EP0686154B1 (en) 1998-04-22
WO1994019343A2 (en) 1994-09-01
US5290777A (en) 1994-03-01
US5464835A (en) 1995-11-07
US5496950A (en) 1996-03-05

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