ES2147453T3 - Antagonistas de adenosina, procedimiento para su preparacion y su uso como medicamentos. - Google Patents

Antagonistas de adenosina, procedimiento para su preparacion y su uso como medicamentos.

Info

Publication number
ES2147453T3
ES2147453T3 ES97933683T ES97933683T ES2147453T3 ES 2147453 T3 ES2147453 T3 ES 2147453T3 ES 97933683 T ES97933683 T ES 97933683T ES 97933683 T ES97933683 T ES 97933683T ES 2147453 T3 ES2147453 T3 ES 2147453T3
Authority
ES
Spain
Prior art keywords
adenosine
medicines
procedure
preparation
adenosine antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97933683T
Other languages
English (en)
Inventor
Ulrike Kufner-Muhl
Werner Kummer
Gerald Pohl
Wolfram Gaida
Erich Lehr
Joachim Mierau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Priority claimed from CA002242097A external-priority patent/CA2242097C/en
Application granted granted Critical
Publication of ES2147453T3 publication Critical patent/ES2147453T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

LA INVENCION TRATA DE TRIAZOLPURINAS DE FORMULA (I). LAS COMPOSICIONES SEGUN LA INVENCION MUESTRAN AFINIDAD CON LOS RECEPTORES DE ADENOSINA, REPRESENTANDO ASI UNA NUEVA CLASE DE ANTAGONISTAS DE LA ADENOSINA. EN GENERAL, LOS ANTAGONISTAS DE LA ADENOSINA PUEDEN TENER UN EFECTO TERAPEUTICO UTIL SOBRE AQUELLAS ENFERMEDADES O SITUACIONES PATOLOGICAS ASOCIADAS A UNA ACTIVACION DE LOS RECEPTORES DE ADENOSINA.
ES97933683T 1996-07-20 1997-07-17 Antagonistas de adenosina, procedimiento para su preparacion y su uso como medicamentos. Expired - Lifetime ES2147453T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19629378A DE19629378A1 (de) 1996-07-20 1996-07-20 Neue Triazolopurine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CA002242097A CA2242097C (en) 1996-07-20 1998-06-26 Imidazotriazolopyrimidines, process for preparing them and their use as pharmaceutical compositions

Publications (1)

Publication Number Publication Date
ES2147453T3 true ES2147453T3 (es) 2000-09-01

Family

ID=32963000

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97933683T Expired - Lifetime ES2147453T3 (es) 1996-07-20 1997-07-17 Antagonistas de adenosina, procedimiento para su preparacion y su uso como medicamentos.

Country Status (25)

Country Link
EP (2) EP0978517A3 (es)
JP (1) JP3020281B2 (es)
CN (1) CN1219936A (es)
AT (1) ATE191913T1 (es)
AU (1) AU3695597A (es)
BG (1) BG102707A (es)
BR (1) BR9710747A (es)
CA (1) CA2256736A1 (es)
CZ (1) CZ265498A3 (es)
DE (2) DE19629378A1 (es)
DK (1) DK0880524T3 (es)
EE (1) EE9800451A (es)
ES (1) ES2147453T3 (es)
GR (1) GR3033842T3 (es)
HR (1) HRP970395A2 (es)
HU (1) HUP9902311A3 (es)
ID (1) ID19106A (es)
IL (1) IL126453A0 (es)
NO (1) NO983860L (es)
PL (1) PL328824A1 (es)
PT (1) PT880524E (es)
SK (1) SK114498A3 (es)
TR (1) TR199801659T2 (es)
WO (1) WO1998003511A1 (es)
ZA (1) ZA976331B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19826843A1 (de) * 1998-06-16 1999-12-23 Boehringer Ingelheim Pharma Neue Imidazotriazolopyrimidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US6492377B1 (en) 1998-06-25 2002-12-10 Boehringer Ingelheim Pharma Kg Imidazotriazolopyrimidines with adenosine-antagonistic activity
AU9347498A (en) * 1998-08-27 2000-03-21 Boehringer Ingelheim Pharma Kg Imidazotriazolopyrimidines
WO2004075846A2 (en) 2003-02-25 2004-09-10 Bristol-Myers Squibb Company Pyrazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same
US7071333B2 (en) 2003-07-30 2006-07-04 Bristol-Myers Squibb Company Triazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same
AU2007260851B2 (en) 2006-06-23 2013-01-17 Incyte Corporation Purinone derivatives as HM74a agonists
US20190292188A1 (en) 2018-02-27 2019-09-26 Incyte Corporation Imidazopyrimidines and triazolopyrimidines as a2a / a2b inhibitors
MA52940A (fr) 2018-05-18 2021-04-28 Incyte Corp Dérivés de pyrimidine fusionnés utilisés en tant qu'inhibiteurs de a2a/a2b
CN113166153B (zh) 2018-07-05 2024-11-01 因赛特公司 作为a2a/a2b抑制剂的稠合吡嗪衍生物
KR102653800B1 (ko) 2018-11-30 2024-04-01 머크 샤프 앤드 돔 엘엘씨 아데노신 수용체 길항제로서의 9-치환된 아미노 트리아졸로 퀴나졸린 유도체, 제약 조성물 및 그의 용도
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
CN112778311B (zh) * 2019-11-01 2024-06-04 上海翰森生物医药科技有限公司 含氮并环类衍生物抑制剂、其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU623755B2 (en) * 1989-03-29 1992-05-21 Merrell Pharmaceuticals Inc. Selective adenosine receptor compounds
IT1264901B1 (it) * 1993-06-29 1996-10-17 Schering Plough S P A Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina
JPH083169A (ja) * 1994-06-15 1996-01-09 Yamasa Shoyu Co Ltd ４−メチル−１Ｈ−［１，２，４］トリアゾロ［１，５−ａ］プリン−９（４Ｈ）−オン類

Also Published As

Publication number Publication date
NO983860L (no) 1998-10-21
GR3033842T3 (en) 2000-10-31
ATE191913T1 (de) 2000-05-15
EP0880524B1 (de) 2000-04-19
EP0978517A2 (de) 2000-02-09
JP3020281B2 (ja) 2000-03-15
EP0880524A1 (de) 1998-12-02
BG102707A (bg) 1999-09-30
ZA976331B (en) 1999-01-25
PT880524E (pt) 2000-07-31
CZ265498A3 (cs) 1998-12-16
AU3695597A (en) 1998-02-10
HRP970395A2 (en) 1998-08-31
WO1998003511A1 (de) 1998-01-29
DE59701467D1 (de) 2000-05-25
SK114498A3 (en) 1999-02-11
CN1219936A (zh) 1999-06-16
DE19629378A1 (de) 1998-01-29
ID19106A (id) 1998-06-18
HUP9902311A2 (hu) 1999-10-28
TR199801659T2 (xx) 1998-12-21
NO983860D0 (no) 1998-08-21
CA2256736A1 (en) 1998-01-29
PL328824A1 (en) 1999-02-15
HUP9902311A3 (en) 2000-06-28
IL126453A0 (en) 1999-08-17
DK0880524T3 (da) 2000-07-17
JP2000501420A (ja) 2000-02-08
EP0978517A3 (de) 2003-11-12
EE9800451A (et) 1999-06-15
BR9710747A (pt) 1999-08-17

Similar Documents

Publication Publication Date Title
ES2165122T3 (es) Nuevos derivados de amidina, su preparacion y utilizacion como medicamentos con efecto antagonista de ltb4.
ES2178298T3 (es) Compuestos anti-inflamatorios.
CL2004001129A1 (es) Compuestos derivados de halogenopirimidinas aril tio-eter; composicion pesticida; procedimiento de preparacion; compuestos intermediarios; y uso del compuesto como agente pesticida.
ES2058185T3 (es) Derivados de camptotecina y procedimiento para su preparacion.
ES2157027T3 (es) Oxazolidinonas sustituidas y su uso como farmacos antibacterianos.
ES2144151T3 (es) Benzotiazepinas hipolipidemicas.
ES2176795T3 (es) Composiciones a base de esfingomielanasa y su utilizacion.
GT199800158A (es) Agonistas de prostaglandinas.
EA200000251A1 (ru) Производные резорцинола
ES2178152T3 (es) Nuevas modificaciones de 2-amino-4-(4-fluorobenzilamino)-1-etoxicarbonilaminobenceno y procedimientos para la preparacion de dicho compuesto.
CY1108610T1 (el) Πεπτιδια της il-2 και παραγωγα αυτων και χρηση αυτων ως θεραπευτικοι παραγοντες
HN2002000300A (es) Nuevos derivados de piperazina
ES2154741T3 (es) Uso de agentes de union a cd23 en el tratamiento de enfermedades autoinmunes.
ES2147453T3 (es) Antagonistas de adenosina, procedimiento para su preparacion y su uso como medicamentos.
ES2119325T3 (es) Compuestos polienicos, composiciones farmaceuticas y cosmeticas que los contienen y utilizaciones.
ES2184131T3 (es) Derivados de benzamidina y su utilizacion como medicamentos con efecto antagonista de ltb4.
ES2170259T3 (es) Empleo de lipidos como agentes auxiliares en la obtencion de formas farmaceuticas solidas segun el procedimiento de extrusion en fusion.
ES2178055T3 (es) Derivados aminicos substituidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
ES2119326T3 (es) Compuestos biciclicos-aromaticos, composiciones farmaceuticas y cosmeticas que los contienen y utilizaciones.
ES2043665T3 (es) 6,11-dihidro-11-(4-piperidiliden)-5h-benzo-(5,6)-ciclohepta-(1,2-b)-piridinas y composiciones y metodos de uso.
HN2001000235A (es) Derivados puentes de piperazina
CR6398A (es) Antagonistas de 5ht1 para terapia antidepresiva
ES2145234T3 (es) Derivados de la diosmetina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
PA8449301A1 (es) Composiciones farmaceuticas
ES2159054T3 (es) Compuestos di-terc-butil-fenolicos que contienen azufre utiles como agentes antiinflamatorios.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 880524

Country of ref document: ES