ES2144151T3 - Benzotiazepinas hipolipidemicas. - Google Patents
Benzotiazepinas hipolipidemicas.Info
- Publication number
- ES2144151T3 ES2144151T3 ES95937940T ES95937940T ES2144151T3 ES 2144151 T3 ES2144151 T3 ES 2144151T3 ES 95937940 T ES95937940 T ES 95937940T ES 95937940 T ES95937940 T ES 95937940T ES 2144151 T3 ES2144151 T3 ES 2144151T3
- Authority
- ES
- Spain
- Prior art keywords
- pct
- date
- hipolipidemicas
- benzotiazepinas
- sec
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000055 hyoplipidemic effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Saccharide Compounds (AREA)
Abstract
LA INVENCION CONCIERNE A NUEVOS COMPUESTOS HIPOLIPIDEMICOS DE FORMULA (I), CON PROCEDIMIENTO Y NUEVOS INTERMEDIARIOS PARA SU PREPARACION, COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y A SU USO EN MEDICINA, EN PARTICULAR EN LA PROFILAXIS Y TRATAMIENTO DE CONDICIONES HIPERLIPIDEMICAS, Y ENFERMEDADES ASOCIADAS COMO ATEROSCLEROSIS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9423172A GB9423172D0 (en) | 1994-11-17 | 1994-11-17 | Hypolipidemic benzothiazepines |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2144151T3 true ES2144151T3 (es) | 2000-06-01 |
Family
ID=10764525
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95937940T Expired - Lifetime ES2144151T3 (es) | 1994-11-17 | 1995-11-16 | Benzotiazepinas hipolipidemicas. |
Country Status (22)
Country | Link |
---|---|
US (1) | US5998400A (es) |
EP (1) | EP0792268B1 (es) |
JP (1) | JP2868623B2 (es) |
KR (1) | KR970707111A (es) |
CN (1) | CN1059674C (es) |
AT (1) | ATE189891T1 (es) |
AU (1) | AU706325B2 (es) |
BR (1) | BR9509683A (es) |
CZ (1) | CZ147397A3 (es) |
DE (1) | DE69515183T2 (es) |
DK (1) | DK0792268T3 (es) |
ES (1) | ES2144151T3 (es) |
FI (1) | FI972085A (es) |
GB (1) | GB9423172D0 (es) |
GR (1) | GR3033450T3 (es) |
HU (1) | HUT77412A (es) |
MX (1) | MX9703546A (es) |
NO (1) | NO308470B1 (es) |
NZ (1) | NZ295426A (es) |
PL (1) | PL320093A1 (es) |
PT (1) | PT792268E (es) |
WO (1) | WO1996016051A1 (es) |
Families Citing this family (88)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA956647B (en) * | 1994-08-10 | 1997-02-10 | Wellcome Found | Hypolipidaemic compounds. |
US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
US5994391A (en) * | 1994-09-13 | 1999-11-30 | G.D. Searle And Company | Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
US6107494A (en) * | 1994-09-13 | 2000-08-22 | G.D. Searle And Company | Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
US6190513B1 (en) | 1997-05-14 | 2001-02-20 | Applied Materials, Inc. | Darkspace shield for improved RF transmission in inductively coupled plasma sources for sputter deposition |
GB9704208D0 (en) * | 1997-02-28 | 1997-04-16 | Glaxo Group Ltd | Chemical compounds |
GB9800428D0 (en) * | 1998-01-10 | 1998-03-04 | Glaxo Group Ltd | Chemical compounds |
US6221897B1 (en) * | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
EA004877B1 (ru) | 1998-12-23 | 2004-08-26 | Джи.Ди.Сирл Ллс | Сочетания ингибиторов транспорта желчных кислот в подвздошной кишке и агентов, секвестрирующих желчные кислоты, для сердечно-сосудистых показаний |
DK1140185T3 (da) | 1998-12-23 | 2003-09-29 | Searle Llc | Kombinationer af cholesterylestertransferhæmmere og galdesyre kompleksdannende forbindelser til hjertekar indikationer |
IL143949A0 (en) | 1998-12-23 | 2002-04-21 | Searle Llc | Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications |
WO2000038722A1 (en) | 1998-12-23 | 2000-07-06 | G.D. Searle & Co. | COMBINATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG CoA REDUCTASE INHIBITORS FOR CARDIOVASCULAR INDICATIONS |
ATE242007T1 (de) | 1998-12-23 | 2003-06-15 | Searle Llc | Kombinationen von cholesteryl ester transfer protein inhibitoren und nicotinsäure derivaten für kardiovaskuläre indikationen |
EP1140189B1 (en) | 1998-12-23 | 2003-05-14 | G.D. Searle LLC. | Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications |
PT1140188E (pt) | 1998-12-23 | 2003-10-31 | Searle Llc | Combinacoes de inibidores do transporte de acidos biliares do ileo e de inibidores da proteina de transferencia de esteres de colesterilo para doencas cardiovasculares. |
JP2002536440A (ja) * | 1999-02-12 | 2002-10-29 | ジー.ディー.サール エルエルシー | 回腸胆汁酸輸送およびタウロコール酸塩取り込みの阻害剤としての活性を有する新規1,2−ベンゾチアゼピン |
DE19916108C1 (de) * | 1999-04-09 | 2001-01-11 | Aventis Pharma Gmbh | Mit Zuckerresten substituierte 1,4-Benzothiazepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und deren Verwendung |
SE0000772D0 (sv) * | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | Chemical compounds |
EP1286984A2 (en) | 2000-03-10 | 2003-03-05 | Pharmacia Corporation | Method for the preparation of tetrahydrobenzothiepines |
US20020183307A1 (en) * | 2000-07-26 | 2002-12-05 | Tremont Samuel J. | Novel 1,4-benzothiazephine and 1,5-benzothiazepine compounds as inhibitors of apical sodium co-dependent bile acid transport and taurocholate uptake |
EG26979A (en) | 2000-12-21 | 2015-03-01 | Astrazeneca Ab | Chemical compounds |
GB0121337D0 (en) * | 2001-09-04 | 2001-10-24 | Astrazeneca Ab | Chemical compounds |
GB0121621D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
GB0121622D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
BRPI0212346B1 (pt) | 2001-09-08 | 2016-02-02 | Albireo Ab | Compostos derivados de benzotiadiazepina ou um sal farmaceuticamente aceitável do mesmo com efeito inibidor de transporte de ácido de bile ileal, processo para a preparação dos mesmos, uso destes, e, composição farmacêutica. |
EP1465885A4 (en) | 2002-01-17 | 2005-04-27 | Pharmacia Corp | NOVEL ALKYL / ARYL HYDROXY OR CETOTHIEPINE COMPOUNDS AS INHIBITORS OF BILIARY ACID TRANSPORT OF THE ILEAL TYPE AND ABSORPTION OF TAUROCHOLATE |
GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
GB0213669D0 (en) | 2002-06-14 | 2002-07-24 | Astrazeneca Ab | Chemical compounds |
JP2006506464A (ja) * | 2002-07-23 | 2006-02-23 | ニュートリノヴァ ニュートリション スペシャリティーズ アンド フード イングリーディエンツ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 食事性繊維およびコレステロール低下物質で造られたコレステロール低下剤 |
US20040147774A1 (en) * | 2002-12-20 | 2004-07-29 | Aventis Pharma S.A. | Novel chiral compounds derived from hexanoic acid esters, preparation process and intermediates, use in the synthesis of chiral 2-(bromomethyl)-2-ethylhexanoic acid |
DE10261061A1 (de) * | 2002-12-24 | 2004-07-15 | Nutrinova Nutrition Specialties & Food Ingredients Gmbh | Diätetisches Lebensmittel zur positiven Beeinflussung der kardiovaskulären Gesundheit |
DE10261067A1 (de) * | 2002-12-24 | 2004-08-05 | Nutrinova Nutrition Specialties & Food Ingredients Gmbh | Cholesterinsenkendes Mittel, enthaltend eine n-3-Fettsäure |
GB0304194D0 (en) | 2003-02-25 | 2003-03-26 | Astrazeneca Ab | Chemical compounds |
GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
WO2006006740A1 (ja) * | 2004-07-14 | 2006-01-19 | Japan Tobacco Inc. | 3−アミノベンズアミド化合物及びバニロイド受容体1型(vr1)活性阻害剤 |
KR101042490B1 (ko) | 2004-07-15 | 2011-06-16 | 니뽄 다바코 산교 가부시키가이샤 | 축합 벤즈아미드 화합물 및 바닐로이드 수용체 1형(vr1)활성 저해제 |
US7906508B2 (en) * | 2005-12-28 | 2011-03-15 | Japan Tobacco Inc. | 3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity |
CN102316872B (zh) * | 2008-11-26 | 2016-12-21 | 萨蒂奥根制药公司 | 治疗肥胖症和糖尿病的胆汁酸再循环抑制剂 |
ES2552657T3 (es) | 2010-05-26 | 2015-12-01 | Satiogen Pharmaceuticals, Inc. | Inhibidores del reciclado de ácidos biliares y saciógenos para el tratamiento de diabetes, obesidad, y afecciones gastrointestinales inflamatorias |
DK3400944T3 (da) | 2010-11-08 | 2020-10-12 | Albireo Ab | Ibat-inhibitorer til behandling af leversygdomme |
PL2637646T3 (pl) | 2010-11-08 | 2017-01-31 | Albireo Ab | Kombinacja farmaceutyczna zawierająca inhibitor ibat i środek wiążący kwasy żółciowe |
CN104023718B (zh) | 2011-10-28 | 2017-04-05 | 鲁美纳医药公司 | 用于治疗高胆血症和胆汁淤积性肝病的胆汁酸再循环抑制剂 |
PL2771003T3 (pl) | 2011-10-28 | 2017-10-31 | Lumena Pharmaceuticals Llc | Inhibitory ponownego wykorzystania kwasów żółciowych do leczenia pediatrycznych cholestatycznych chorób wątroby |
CA2907230A1 (en) | 2013-03-15 | 2014-09-18 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease |
MX2015013196A (es) | 2013-03-15 | 2016-04-15 | Lumena Pharmaceuticals Inc | Inhibidores de reciclaje de acidos biliares para el tratamiento de la enfermedad de reflujo gastroesofagico y esofago de barrett. |
JO3301B1 (ar) | 2013-04-26 | 2018-09-16 | Albireo Ab | تعديلات بلورية على إيلوبيكسيبات |
WO2015199147A1 (ja) | 2014-06-25 | 2015-12-30 | 味の素株式会社 | 固形製剤及びその着色防止又は着色低減方法 |
EP3012252A1 (en) | 2014-10-24 | 2016-04-27 | Ferring BV | Crystal modifications of elobixibat |
US10786529B2 (en) | 2016-02-09 | 2020-09-29 | Albireo Ab | Oral cholestyramine formulation and use thereof |
CA3011565C (en) | 2016-02-09 | 2024-01-02 | Albireo Ab | Oral cholestyramine formulation and use thereof |
US10441604B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Cholestyramine pellets and methods for preparation thereof |
EP3413878B1 (en) | 2016-02-09 | 2021-04-14 | Albireo AB | Oral cholestyramine formulation and use thereof |
US10441605B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Oral cholestyramine formulation and use thereof |
KR101844184B1 (ko) * | 2017-07-21 | 2018-04-02 | 씨제이헬스케어 주식회사 | 아미노알킬벤조티아제핀 유도체의 용도 |
EP3664781A1 (en) | 2017-08-09 | 2020-06-17 | Albireo AB | Cholestyramine granules, oral cholestyramine formulations and use thereof |
JP7328207B2 (ja) | 2017-08-09 | 2023-08-16 | アルビレオ・アクチボラグ | コレスチラミンペレット、経口コレスチラミン製剤、及びそれらの使用 |
US10793534B2 (en) | 2018-06-05 | 2020-10-06 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
TW202015699A (zh) | 2018-06-05 | 2020-05-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽汁酸調節劑之用途 |
US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
SG11202012151XA (en) | 2018-06-20 | 2021-01-28 | Albireo Ab | Crystal modifications of odevixibat |
US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
SG11202108566VA (en) | 2019-02-06 | 2021-09-29 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
US10941127B2 (en) | 2019-02-06 | 2021-03-09 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
EP3921027B1 (en) | 2019-02-06 | 2023-07-19 | Albireo AB | Benzothiazepine compounds and their use as bile acid modulators |
US10975045B2 (en) | 2019-02-06 | 2021-04-13 | Aibireo AB | Benzothiazepine compounds and their use as bile acid modulators |
CN114096268A (zh) | 2019-02-12 | 2022-02-25 | 米鲁姆制药公司 | 用于增加患有胆汁淤积性肝病的儿科受试者的生长的方法 |
KR20220109450A (ko) | 2019-12-04 | 2022-08-04 | 알비레오 에이비 | 벤조티아(디)아제핀 화합물 및 담즙산 조절제로서의 이의 용도 |
TW202134220A (zh) | 2019-12-04 | 2021-09-16 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
PT4069360T (pt) | 2019-12-04 | 2024-03-06 | Albireo Ab | Compostos de benzotia(di)azepina e a sua utilização como moduladores de ácido biliar |
CA3158184A1 (en) | 2019-12-04 | 2021-08-10 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
TW202134221A (zh) | 2019-12-04 | 2021-09-16 | 瑞典商艾爾比瑞歐公司 | 苯并噻二氮呯化合物及其作為膽酸調節劑之用途 |
EP4069361B1 (en) * | 2019-12-04 | 2024-01-03 | Albireo AB | Benzothia(di)azepine compounds and their use as bile acid modulators |
EP4069359B1 (en) | 2019-12-04 | 2024-01-03 | Albireo AB | Benzothia(di)azepine compounds and their use as bile acid modulators |
TW202134218A (zh) | 2019-12-04 | 2021-09-16 | 瑞典商艾爾比瑞歐公司 | 苯并噻氮呯化合物及其作為膽酸調節劑之用途 |
WO2021110884A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
WO2022029101A1 (en) | 2020-08-03 | 2022-02-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
CA3186857A1 (en) | 2020-08-03 | 2022-02-10 | Per-Goran Gillberg | Benzothia(di)azepine compounds and their use as bile acid modulators |
KR20230106651A (ko) | 2020-11-12 | 2023-07-13 | 알비레오 에이비 | 진행성 가족성 간내 담즙정체증(pfic)을 치료하기 위한 오데빅시바트 |
JP2024500309A (ja) | 2020-12-04 | 2024-01-09 | アルビレオ エービー | ベンゾチア(ジ)アゼピン化合物および胆汁酸モジュレータとしてのその使用 |
TW202313579A (zh) | 2021-06-03 | 2023-04-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
US20230398125A1 (en) | 2022-06-09 | 2023-12-14 | Albireo Ab | Treating hepatitis |
WO2024008766A1 (en) | 2022-07-05 | 2024-01-11 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
WO2024121434A1 (en) | 2022-12-09 | 2024-06-13 | Albireo Ab | Asbt inhibitors in the treatment of renal diseases |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59231018A (ja) * | 1983-06-10 | 1984-12-25 | Tanabe Seiyaku Co Ltd | 抗脂血剤 |
ATE116643T1 (de) * | 1989-04-28 | 1995-01-15 | Tanabe Seiyaku Co | Verfahren zur herstellung von 1,5- benzothiazepinderivaten. |
GB2255937B (en) * | 1991-05-21 | 1994-11-09 | Andrew Thomas Kinnaird | Sailboards |
GB9111376D0 (en) * | 1991-05-25 | 1991-07-17 | Boots Co Plc | Therapeutic agents |
GB9203347D0 (en) * | 1992-02-17 | 1992-04-01 | Wellcome Found | Hypolipidaemic compounds |
US5610153A (en) * | 1992-12-11 | 1997-03-11 | Ciba-Geigy Corporation | Benzazepinone derivatives |
IL108633A (en) * | 1993-02-15 | 1998-07-15 | Wellcome Found | History of Benzothiazepine Hypolipidemic Preparation and Pharmaceutical Preparations Containing Them |
IL108634A0 (en) * | 1993-02-15 | 1994-05-30 | Wellcome Found | Hypolipidaemic heterocyclic compounds, their prepatation and pharmaceutical compositions containing them |
GB9307017D0 (en) * | 1993-04-02 | 1993-05-26 | Bp Chem Int Ltd | Control of ammonia emission and odour |
EP0723449A1 (en) * | 1993-08-06 | 1996-07-31 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
ZA956647B (en) * | 1994-08-10 | 1997-02-10 | Wellcome Found | Hypolipidaemic compounds. |
GB9704208D0 (en) * | 1997-02-28 | 1997-04-16 | Glaxo Group Ltd | Chemical compounds |
-
1994
- 1994-11-17 GB GB9423172A patent/GB9423172D0/en active Pending
-
1995
- 1995-11-16 JP JP51666196A patent/JP2868623B2/ja not_active Expired - Fee Related
- 1995-11-16 CZ CZ971473A patent/CZ147397A3/cs unknown
- 1995-11-16 WO PCT/GB1995/002700 patent/WO1996016051A1/en not_active Application Discontinuation
- 1995-11-16 US US08/836,405 patent/US5998400A/en not_active Expired - Fee Related
- 1995-11-16 ES ES95937940T patent/ES2144151T3/es not_active Expired - Lifetime
- 1995-11-16 CN CN95196304A patent/CN1059674C/zh not_active Expired - Fee Related
- 1995-11-16 PL PL95320093A patent/PL320093A1/xx unknown
- 1995-11-16 AU AU38762/95A patent/AU706325B2/en not_active Ceased
- 1995-11-16 EP EP95937940A patent/EP0792268B1/en not_active Expired - Lifetime
- 1995-11-16 DK DK95937940T patent/DK0792268T3/da active
- 1995-11-16 HU HU9702189A patent/HUT77412A/hu unknown
- 1995-11-16 DE DE69515183T patent/DE69515183T2/de not_active Expired - Fee Related
- 1995-11-16 NZ NZ295426A patent/NZ295426A/en unknown
- 1995-11-16 PT PT95937940T patent/PT792268E/pt unknown
- 1995-11-16 BR BR9509683A patent/BR9509683A/pt not_active IP Right Cessation
- 1995-11-16 MX MX9703546A patent/MX9703546A/es not_active IP Right Cessation
- 1995-11-16 AT AT95937940T patent/ATE189891T1/de not_active IP Right Cessation
-
1997
- 1997-05-15 FI FI972085A patent/FI972085A/fi unknown
- 1997-05-16 NO NO972261A patent/NO308470B1/no unknown
- 1997-05-16 KR KR1019970703298A patent/KR970707111A/ko not_active Application Discontinuation
-
2000
- 2000-05-19 GR GR20000401138T patent/GR3033450T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK0792268T3 (da) | 2000-07-31 |
GB9423172D0 (en) | 1995-01-04 |
AU3876295A (en) | 1996-06-17 |
WO1996016051A1 (en) | 1996-05-30 |
CN1059674C (zh) | 2000-12-20 |
HUT77412A (hu) | 1998-04-28 |
KR970707111A (ko) | 1997-12-01 |
EP0792268B1 (en) | 2000-02-23 |
CZ147397A3 (en) | 1997-11-12 |
NO308470B1 (no) | 2000-09-18 |
NO972261L (no) | 1997-07-16 |
PT792268E (pt) | 2000-06-30 |
GR3033450T3 (en) | 2000-09-29 |
JPH11500102A (ja) | 1999-01-06 |
CN1164230A (zh) | 1997-11-05 |
DE69515183T2 (de) | 2000-08-17 |
AU706325B2 (en) | 1999-06-17 |
FI972085A0 (fi) | 1997-05-15 |
NO972261D0 (no) | 1997-05-16 |
PL320093A1 (en) | 1997-09-15 |
BR9509683A (pt) | 1997-09-16 |
FI972085A (fi) | 1997-05-15 |
MX9703546A (es) | 1997-08-30 |
DE69515183D1 (de) | 2000-03-30 |
JP2868623B2 (ja) | 1999-03-10 |
ATE189891T1 (de) | 2000-03-15 |
US5998400A (en) | 1999-12-07 |
EP0792268A1 (en) | 1997-09-03 |
NZ295426A (en) | 1997-10-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2144151T3 (es) | Benzotiazepinas hipolipidemicas. | |
MX9700890A (es) | 1, 4-benzotiazepina-1, 1-dioxidos hipolipidemicos. | |
TR200001816T2 (tr) | Hipolipidemik benzotiyazepin bileşikleri | |
ES2162934T3 (es) | Derivados de fenil xantina. | |
DE59409312D1 (de) | Imidazopyridine und ihre anwendung zur behandlung von magen-darm krankheiten | |
DE69520364D1 (de) | Benzothepines mit wirkung als inhibitoren des gallensäuretransports und der taurocholate-aufnahme | |
NL300175I2 (nl) | Methylsulfonylfenyl-2-(5H)-furanonen als remmers van COX-2. | |
ES2131106T3 (es) | Compuestos de benzotiazepina hipolipidemicos. | |
ATE189218T1 (de) | Bicyclische diarylheterocyclen als cyclooxygenase-2-inhibitoren | |
KR870700599A (ko) | 카르복실산유도체, 그의 제조방법, 이화합물을 함유한 약제조성물 및 그의 용도 | |
PL328225A1 (en) | Diphenylstilbenes as pro-medications used to produce cox-2-inhibitors | |
DE69504819T2 (de) | Chemische zwischenprodukte verwenbar in der landwirtschaft | |
PE57194A1 (es) | Hidroxiurea de fenoxifenil ciclopentenil | |
BR0010338A (pt) | Composto enanciomericamente enriquecido, composição farmacêutica, método para tratar uma doença ou condição mediada por cck-a, uso de um composto, e, processo para a preparação de um composto | |
ES2137665T3 (es) | Nuevos derivados de piridina o piridazina, procedimientos para su preparacion, y medicamentos que contienen estos compuestos. | |
DE69109293T2 (de) | Verwendung von 20(r)-22-oxa-vitamin d analoge zur herstellung eines medikaments für die behandlung des altershaut. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 792268 Country of ref document: ES |