ES2159382T3 - Compuestos estilbenicos con grupo adamantilo, composiciones que los contienen y utilizaciones. - Google Patents
Compuestos estilbenicos con grupo adamantilo, composiciones que los contienen y utilizaciones.Info
- Publication number
- ES2159382T3 ES2159382T3 ES97403043T ES97403043T ES2159382T3 ES 2159382 T3 ES2159382 T3 ES 2159382T3 ES 97403043 T ES97403043 T ES 97403043T ES 97403043 T ES97403043 T ES 97403043T ES 2159382 T3 ES2159382 T3 ES 2159382T3
- Authority
- ES
- Spain
- Prior art keywords
- stilbenic
- compounds
- adamantilo
- compositions
- contain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/30—Compounds having groups
- C07C43/313—Compounds having groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/30—Compounds having groups
- C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/28—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups having unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Toxicology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
- Cosmetics (AREA)
Abstract
LA INVENCION SE REFIERE A NUEVOS COMPUESTOS ESTILBENICOS DE FORMULA GENERAL (I): Y A SU UTILIZACION EN COMPOSICIONES FARMACEUTICAS DESTINADAS AL USO EN MEDICINA HUMANA O VETERINARIA (EN PARTICULAR, AFECCIONES DERMATOLOGICAS, REUMATICAS, RESPIRATORIAS, CARDIOVASCULARES Y OFTALMOLOGICAS) O EN COMPOSICIONES COSMETICAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9616311A FR2757852B1 (fr) | 1996-12-31 | 1996-12-31 | Composes stilbeniques a groupement adamantyl, compositions les contenant et utilisations |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2159382T3 true ES2159382T3 (es) | 2001-10-01 |
Family
ID=9499383
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97403043T Expired - Lifetime ES2159382T3 (es) | 1996-12-31 | 1997-12-15 | Compuestos estilbenicos con grupo adamantilo, composiciones que los contienen y utilizaciones. |
Country Status (16)
Country | Link |
---|---|
US (3) | US6214878B1 (es) |
EP (1) | EP0850909B1 (es) |
JP (1) | JP2962699B2 (es) |
AR (1) | AR009849A1 (es) |
AT (1) | ATE199893T1 (es) |
AU (1) | AU699626B2 (es) |
BR (1) | BR9706311A (es) |
CA (1) | CA2224528C (es) |
DE (1) | DE69704335T2 (es) |
DK (1) | DK0850909T3 (es) |
ES (1) | ES2159382T3 (es) |
FR (1) | FR2757852B1 (es) |
GR (1) | GR3035917T3 (es) |
NZ (1) | NZ329462A (es) |
PT (1) | PT850909E (es) |
ZA (1) | ZA9711313B (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2785284B1 (fr) * | 1998-11-02 | 2000-12-01 | Galderma Res & Dev | Analogues de la vitamine d |
FR2801307B1 (fr) | 1999-11-24 | 2002-12-06 | Galderma Res & Dev | Analogues de la vitamine d |
FR2825087B1 (fr) | 2001-05-22 | 2005-01-14 | Galderma Res & Dev | Analogues de la vitamine d |
SE0102299D0 (sv) * | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
SE0102764D0 (sv) * | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
DE10208955A1 (de) * | 2002-02-28 | 2003-09-11 | Bayer Ag | Verfahren zur Herstellung von 2-Halogenalkylnicotinsäuren |
US6864264B1 (en) * | 2002-08-20 | 2005-03-08 | Gloria L. Anderson | 1-adamantyl chalcones for the treatment of proliferative disorders |
MXPA05002168A (es) | 2002-08-27 | 2005-05-23 | Galderma Res & Dev | Analogos de vitamina d. |
GB0226930D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
AU2005214137B2 (en) * | 2004-02-18 | 2008-05-29 | Astrazeneca Ab | Compounds |
CA2554310A1 (en) * | 2004-02-18 | 2005-09-01 | Astrazeneca Ab | Benzamide derivatives and their use as glucokinase activating agents |
TW200600086A (en) * | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
EP1802570A1 (en) | 2004-10-16 | 2007-07-04 | AstraZeneca AB | Process for making phenoxy benzamide compounds |
GB0423044D0 (en) * | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
GB0423043D0 (en) * | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
WO2006125958A1 (en) * | 2005-05-24 | 2006-11-30 | Astrazeneca Ab | 2-phenyl substituted imidazol [4 , 5b] pyridine/ pyrazine and purine derivatives as glucokinase modulators |
TW200714597A (en) * | 2005-05-27 | 2007-04-16 | Astrazeneca Ab | Chemical compounds |
US20080234273A1 (en) * | 2005-07-09 | 2008-09-25 | Mckerrecher Darren | Heteroaryl Benzamide Derivatives for Use as Glk Activators in the Treatment of Diabetes |
CA2614746C (en) * | 2005-07-09 | 2011-05-10 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes |
US20110053910A1 (en) * | 2005-07-09 | 2011-03-03 | Mckerrecher Darren | 2 -heterocyclyloxybenzoyl amino heterocyclyl compounds as modulators of glucokinase for the treatment of type 2 diabetes |
US9202182B2 (en) * | 2005-08-11 | 2015-12-01 | International Business Machines Corporation | Method and system for analyzing business architecture |
TW200738621A (en) * | 2005-11-28 | 2007-10-16 | Astrazeneca Ab | Chemical process |
US8092720B2 (en) * | 2006-07-25 | 2012-01-10 | National University Corporation Hokkaido University | Polymer-supported metal complex catalyst |
TW200825063A (en) * | 2006-10-23 | 2008-06-16 | Astrazeneca Ab | Chemical compounds |
TW200825060A (en) * | 2006-10-26 | 2008-06-16 | Astrazeneca Ab | Chemical compounds |
AR064625A1 (es) * | 2006-12-21 | 2009-04-15 | Astrazeneca Ab | Forma cristalina de 3-{[5-(azetidin-1-ilcarbonil)pirazin-2-il]oxi}-5-[(1-metiletil)oxi]-n-1h-pirazol-3-ilbenzamida |
FR2910321B1 (fr) | 2006-12-21 | 2009-07-10 | Galderma Res & Dev S N C Snc | Gel creme comprenant au moins un retinoide et du peroxyde de benzole |
FR2910320B1 (fr) | 2006-12-21 | 2009-02-13 | Galderma Res & Dev S N C Snc | Emulsion comprenant au moins un retinoide et du peroxyde de benzole |
FR2931661B1 (fr) | 2008-05-30 | 2010-07-30 | Galderma Res & Dev | Nouvelles compositions depigmentantes sous forme d'une composition anhydre sans vaseline et sans elastomere comprenant un derive phenolique solubilise et un retinoide. |
AU2009278929B2 (en) | 2008-08-04 | 2012-07-05 | Astrazeneca Ab | Pyrazolo [3,4] pyrimidin-4-yl derivatives and their uses to treat diabetes and obesity |
GB0902406D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Crystalline polymorphic form |
GB0902434D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Chemical process |
AR076221A1 (es) * | 2009-04-09 | 2011-05-26 | Astrazeneca Ab | Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad |
AR076220A1 (es) | 2009-04-09 | 2011-05-26 | Astrazeneca Ab | Derivados de pirazol [4,5 - e] pirimidina |
WO2016079262A1 (fr) * | 2014-11-20 | 2016-05-26 | Galderma Sa | Compositions comprenant un compose de la famille des avermectines et un compose agoniste d'au moins un des recepteurs de l'acide retinoique pour le traitement de l'acne |
KR20170096181A (ko) | 2014-12-19 | 2017-08-23 | 갈데르마 리써어치 앤드 디벨로프먼트 | 신규 화합물, 이의 합성 방법 및 의약 및 화장품에서의 이의 용도 |
WO2021064072A1 (en) | 2019-10-02 | 2021-04-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of retinoic acid receptor (rar) agonists for reversing, preventing, or delaying calcification of aortic valve |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LU86022A1 (fr) | 1985-07-25 | 1987-02-04 | Cird | Derives aromatiques polycyliques,leur procede de preparation et leur application dans les domaines pharmaceutique et cosmetique |
DE3926148A1 (de) * | 1989-08-08 | 1991-02-28 | Basf Ag | Diarylacetylene, ihre herstellung und verwendung |
FR2676052B1 (fr) | 1991-05-02 | 1994-04-29 | Cird Galderma | Nouveaux composes polycycliques aromatiques et leur utilisation en medecine humaine ou veterinaire et en cosmetique. |
US5436369A (en) | 1993-06-16 | 1995-07-25 | Bristol-Myers Squibb Company | Alicyclic phospholipase A2 inhibitors |
FR2719044B1 (fr) * | 1994-04-26 | 1996-05-31 | Cird Galderma | Nouveaux composés bi-aromatiques acétylénés à groupement adamantyle, compositions pharmaceutiques et cosmétiques les contenant et utilisations. |
FR2739557B1 (fr) | 1995-10-09 | 1997-11-14 | Cird Galderma | Utilisation d'un ligand agoniste specifique rar-gamma |
FR2741876B1 (fr) * | 1995-12-01 | 1998-01-09 | Cird Galderma | Composes biaromatiques portant un groupement adamantyl en para, compositions pharmaceutiques et cosmetiques les contenant et utilisations |
FR2741878B1 (fr) * | 1995-12-01 | 1998-01-09 | Cird Galderma | Composes biaromatiques portant un groupement adamantyl en ortho, compositions pharmaceutiques et cosmetiques les contenant et utilisations |
US5547893A (en) | 1995-12-27 | 1996-08-20 | Vanguard International Semiconductor Corp. | method for fabricating an embedded vertical bipolar transistor and a memory cell |
CN1279902C (zh) | 1996-07-08 | 2006-10-18 | 盖尔德马研究及发展公司 | 引起程序性细胞死亡的金刚烷基衍生物及其在制备抗癌药物中的应用 |
-
1996
- 1996-12-31 FR FR9616311A patent/FR2757852B1/fr not_active Expired - Fee Related
-
1997
- 1997-12-15 DE DE69704335T patent/DE69704335T2/de not_active Expired - Fee Related
- 1997-12-15 PT PT97403043T patent/PT850909E/pt unknown
- 1997-12-15 ES ES97403043T patent/ES2159382T3/es not_active Expired - Lifetime
- 1997-12-15 DK DK97403043T patent/DK0850909T3/da active
- 1997-12-15 AT AT97403043T patent/ATE199893T1/de not_active IP Right Cessation
- 1997-12-15 EP EP97403043A patent/EP0850909B1/fr not_active Expired - Lifetime
- 1997-12-17 ZA ZA9111313A patent/ZA9711313B/xx unknown
- 1997-12-18 AU AU48477/97A patent/AU699626B2/en not_active Ceased
- 1997-12-22 BR BR9706311A patent/BR9706311A/pt not_active Application Discontinuation
- 1997-12-22 NZ NZ329462A patent/NZ329462A/xx unknown
- 1997-12-30 AR ARP970106240A patent/AR009849A1/es active IP Right Grant
- 1997-12-30 CA CA002224528A patent/CA2224528C/fr not_active Expired - Fee Related
- 1997-12-31 US US09/002,040 patent/US6214878B1/en not_active Expired - Fee Related
-
1998
- 1998-01-05 JP JP10000501A patent/JP2962699B2/ja not_active Expired - Fee Related
-
2001
- 2001-02-21 US US09/788,469 patent/US20020010337A1/en not_active Abandoned
- 2001-05-22 GR GR20010400771T patent/GR3035917T3/el not_active IP Right Cessation
-
2003
- 2003-10-02 US US10/676,089 patent/US6992095B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6992095B2 (en) | 2006-01-31 |
DE69704335T2 (de) | 2001-07-05 |
BR9706311A (pt) | 1999-05-18 |
DE69704335D1 (de) | 2001-04-26 |
NZ329462A (en) | 1999-06-29 |
EP0850909A1 (fr) | 1998-07-01 |
JP2962699B2 (ja) | 1999-10-12 |
PT850909E (pt) | 2001-07-31 |
US6214878B1 (en) | 2001-04-10 |
US20020010337A1 (en) | 2002-01-24 |
ZA9711313B (en) | 1998-06-23 |
DK0850909T3 (da) | 2001-05-21 |
GR3035917T3 (en) | 2001-08-31 |
AU699626B2 (en) | 1998-12-10 |
EP0850909B1 (fr) | 2001-03-21 |
CA2224528A1 (fr) | 1998-06-30 |
AU4847797A (en) | 1998-07-02 |
FR2757852A1 (fr) | 1998-07-03 |
JPH10226667A (ja) | 1998-08-25 |
US20040067971A1 (en) | 2004-04-08 |
AR009849A1 (es) | 2000-05-03 |
MX9710466A (es) | 1998-09-30 |
FR2757852B1 (fr) | 1999-02-19 |
ATE199893T1 (de) | 2001-04-15 |
CA2224528C (fr) | 2006-07-18 |
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