DE69704335T2 - Stilbenverbindungen mit Adamantylgruppe, diese enthaltende Zusammensetzungen und deren Verwendung - Google Patents
Stilbenverbindungen mit Adamantylgruppe, diese enthaltende Zusammensetzungen und deren VerwendungInfo
- Publication number
- DE69704335T2 DE69704335T2 DE69704335T DE69704335T DE69704335T2 DE 69704335 T2 DE69704335 T2 DE 69704335T2 DE 69704335 T DE69704335 T DE 69704335T DE 69704335 T DE69704335 T DE 69704335T DE 69704335 T2 DE69704335 T2 DE 69704335T2
- Authority
- DE
- Germany
- Prior art keywords
- compositions containing
- adamantyl group
- stilbene compounds
- group stilbene
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/30—Compounds having groups
- C07C43/313—Compounds having groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/30—Compounds having groups
- C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/28—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups having unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Cosmetics (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9616311A FR2757852B1 (fr) | 1996-12-31 | 1996-12-31 | Composes stilbeniques a groupement adamantyl, compositions les contenant et utilisations |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69704335D1 DE69704335D1 (de) | 2001-04-26 |
DE69704335T2 true DE69704335T2 (de) | 2001-07-05 |
Family
ID=9499383
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69704335T Expired - Fee Related DE69704335T2 (de) | 1996-12-31 | 1997-12-15 | Stilbenverbindungen mit Adamantylgruppe, diese enthaltende Zusammensetzungen und deren Verwendung |
Country Status (16)
Country | Link |
---|---|
US (3) | US6214878B1 (de) |
EP (1) | EP0850909B1 (de) |
JP (1) | JP2962699B2 (de) |
AR (1) | AR009849A1 (de) |
AT (1) | ATE199893T1 (de) |
AU (1) | AU699626B2 (de) |
BR (1) | BR9706311A (de) |
CA (1) | CA2224528C (de) |
DE (1) | DE69704335T2 (de) |
DK (1) | DK0850909T3 (de) |
ES (1) | ES2159382T3 (de) |
FR (1) | FR2757852B1 (de) |
GR (1) | GR3035917T3 (de) |
NZ (1) | NZ329462A (de) |
PT (1) | PT850909E (de) |
ZA (1) | ZA9711313B (de) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2785284B1 (fr) * | 1998-11-02 | 2000-12-01 | Galderma Res & Dev | Analogues de la vitamine d |
FR2801307B1 (fr) | 1999-11-24 | 2002-12-06 | Galderma Res & Dev | Analogues de la vitamine d |
FR2825087B1 (fr) | 2001-05-22 | 2005-01-14 | Galderma Res & Dev | Analogues de la vitamine d |
SE0102299D0 (sv) * | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
SE0102764D0 (sv) * | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
DE10208955A1 (de) * | 2002-02-28 | 2003-09-11 | Bayer Ag | Verfahren zur Herstellung von 2-Halogenalkylnicotinsäuren |
US6864264B1 (en) | 2002-08-20 | 2005-03-08 | Gloria L. Anderson | 1-adamantyl chalcones for the treatment of proliferative disorders |
ES2275106T3 (es) | 2002-08-27 | 2007-06-01 | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. | Analogos de la vitamina d. |
GB0226930D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
WO2005080359A1 (en) * | 2004-02-18 | 2005-09-01 | Astrazeneca Ab | Benzamide derivatives and their use as glucokinae activating agents |
EP1718625A1 (de) * | 2004-02-18 | 2006-11-08 | AstraZeneca AB | Verbindungen |
TW200600086A (en) * | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
GB0423043D0 (en) * | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
EP1802570A1 (de) | 2004-10-16 | 2007-07-04 | AstraZeneca AB | Verfahren zur herstellung von phenoxybenzamidverbindungen |
GB0423044D0 (en) * | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
US20110059941A1 (en) * | 2005-05-24 | 2011-03-10 | Peter William Rodney Caulkett | 2-phenyl substituted imidazol [4,5b] pyridine/pyrazine and purine derivatives as glucokinase modulators |
TW200714597A (en) * | 2005-05-27 | 2007-04-16 | Astrazeneca Ab | Chemical compounds |
US20080234273A1 (en) * | 2005-07-09 | 2008-09-25 | Mckerrecher Darren | Heteroaryl Benzamide Derivatives for Use as Glk Activators in the Treatment of Diabetes |
WO2007007040A1 (en) * | 2005-07-09 | 2007-01-18 | Astrazeneca Ab | 2 -heterocyclyloxybenzoyl amino heterocyclyl compounds as modulators of glucokinase for the treatment of type 2 diabetes |
NZ575514A (en) * | 2005-07-09 | 2009-11-27 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
US9202182B2 (en) * | 2005-08-11 | 2015-12-01 | International Business Machines Corporation | Method and system for analyzing business architecture |
TW200738621A (en) * | 2005-11-28 | 2007-10-16 | Astrazeneca Ab | Chemical process |
EP2045014B8 (de) * | 2006-07-25 | 2014-02-26 | National University Corporation Hokkaido University | Polymergestützter metalkomplexkatalysator |
TW200825063A (en) * | 2006-10-23 | 2008-06-16 | Astrazeneca Ab | Chemical compounds |
CL2007003061A1 (es) * | 2006-10-26 | 2008-08-01 | Astrazeneca Ab | Compuestos derivados de 3,5-dioxi-benzamida; proceso de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar una enfermedad mediada a traves de glk, tal como la diabetes tipo 2. |
FR2910320B1 (fr) | 2006-12-21 | 2009-02-13 | Galderma Res & Dev S N C Snc | Emulsion comprenant au moins un retinoide et du peroxyde de benzole |
FR2910321B1 (fr) | 2006-12-21 | 2009-07-10 | Galderma Res & Dev S N C Snc | Gel creme comprenant au moins un retinoide et du peroxyde de benzole |
BRPI0721143A2 (pt) * | 2006-12-21 | 2014-03-11 | Astrazeneca Ab | Forma cristalina do composto processo para a formação da mesma, uso de um composto, método para tratar doenças mediadas por ativador de glicocinase |
FR2931661B1 (fr) | 2008-05-30 | 2010-07-30 | Galderma Res & Dev | Nouvelles compositions depigmentantes sous forme d'une composition anhydre sans vaseline et sans elastomere comprenant un derive phenolique solubilise et un retinoide. |
EP2324028A2 (de) | 2008-08-04 | 2011-05-25 | AstraZeneca AB | Therapeutische mittel 414 |
GB0902434D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Chemical process |
GB0902406D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Crystalline polymorphic form |
AR076220A1 (es) | 2009-04-09 | 2011-05-26 | Astrazeneca Ab | Derivados de pirazol [4,5 - e] pirimidina |
AR076221A1 (es) * | 2009-04-09 | 2011-05-26 | Astrazeneca Ab | Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad |
EP3220903A1 (de) | 2014-11-20 | 2017-09-27 | Galderma S.A. | Zusammensetzungen mit einer verbindung aus der familie der avermectine und einer agonistenverbindung für wenigstens einen der retinsäurerezeptoren zur behandlung von akne |
JP6797800B2 (ja) | 2014-12-19 | 2020-12-09 | ガルデルマ・リサーチ・アンド・デヴェロップメント | 新規化合物、その合成方法、並びに医薬品及び化粧品におけるその使用 |
US20220339322A1 (en) | 2019-10-02 | 2022-10-27 | Inserm (Institut National De La Santé Et De La Researche Médecale) | Use of retinoic acid receptor (rar) agonists for reversing, preventing, or delaying calcification of aortic valve |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LU86022A1 (fr) | 1985-07-25 | 1987-02-04 | Cird | Derives aromatiques polycyliques,leur procede de preparation et leur application dans les domaines pharmaceutique et cosmetique |
DE3926148A1 (de) * | 1989-08-08 | 1991-02-28 | Basf Ag | Diarylacetylene, ihre herstellung und verwendung |
FR2676052B1 (fr) | 1991-05-02 | 1994-04-29 | Cird Galderma | Nouveaux composes polycycliques aromatiques et leur utilisation en medecine humaine ou veterinaire et en cosmetique. |
US5436369A (en) | 1993-06-16 | 1995-07-25 | Bristol-Myers Squibb Company | Alicyclic phospholipase A2 inhibitors |
FR2719044B1 (fr) * | 1994-04-26 | 1996-05-31 | Cird Galderma | Nouveaux composés bi-aromatiques acétylénés à groupement adamantyle, compositions pharmaceutiques et cosmétiques les contenant et utilisations. |
FR2739557B1 (fr) | 1995-10-09 | 1997-11-14 | Cird Galderma | Utilisation d'un ligand agoniste specifique rar-gamma |
FR2741878B1 (fr) * | 1995-12-01 | 1998-01-09 | Cird Galderma | Composes biaromatiques portant un groupement adamantyl en ortho, compositions pharmaceutiques et cosmetiques les contenant et utilisations |
FR2741876B1 (fr) * | 1995-12-01 | 1998-01-09 | Cird Galderma | Composes biaromatiques portant un groupement adamantyl en para, compositions pharmaceutiques et cosmetiques les contenant et utilisations |
US5547893A (en) | 1995-12-27 | 1996-08-20 | Vanguard International Semiconductor Corp. | method for fabricating an embedded vertical bipolar transistor and a memory cell |
BR9710255A (pt) | 1996-07-08 | 1999-08-10 | Galderma Res & Dev | Método para o tratamento de cáncer composto de retinóide de adamantila composição farmacéutica ou cosmética de matéria método de tratamento ou de prevenção e método para controlar |
-
1996
- 1996-12-31 FR FR9616311A patent/FR2757852B1/fr not_active Expired - Fee Related
-
1997
- 1997-12-15 DE DE69704335T patent/DE69704335T2/de not_active Expired - Fee Related
- 1997-12-15 EP EP97403043A patent/EP0850909B1/de not_active Expired - Lifetime
- 1997-12-15 AT AT97403043T patent/ATE199893T1/de not_active IP Right Cessation
- 1997-12-15 ES ES97403043T patent/ES2159382T3/es not_active Expired - Lifetime
- 1997-12-15 PT PT97403043T patent/PT850909E/pt unknown
- 1997-12-15 DK DK97403043T patent/DK0850909T3/da active
- 1997-12-17 ZA ZA9111313A patent/ZA9711313B/xx unknown
- 1997-12-18 AU AU48477/97A patent/AU699626B2/en not_active Ceased
- 1997-12-22 NZ NZ329462A patent/NZ329462A/xx unknown
- 1997-12-22 BR BR9706311A patent/BR9706311A/pt not_active Application Discontinuation
- 1997-12-30 CA CA002224528A patent/CA2224528C/fr not_active Expired - Fee Related
- 1997-12-30 AR ARP970106240A patent/AR009849A1/es active IP Right Grant
- 1997-12-31 US US09/002,040 patent/US6214878B1/en not_active Expired - Fee Related
-
1998
- 1998-01-05 JP JP10000501A patent/JP2962699B2/ja not_active Expired - Fee Related
-
2001
- 2001-02-21 US US09/788,469 patent/US20020010337A1/en not_active Abandoned
- 2001-05-22 GR GR20010400771T patent/GR3035917T3/el not_active IP Right Cessation
-
2003
- 2003-10-02 US US10/676,089 patent/US6992095B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE199893T1 (de) | 2001-04-15 |
FR2757852A1 (fr) | 1998-07-03 |
AU699626B2 (en) | 1998-12-10 |
GR3035917T3 (en) | 2001-08-31 |
BR9706311A (pt) | 1999-05-18 |
MX9710466A (es) | 1998-09-30 |
JP2962699B2 (ja) | 1999-10-12 |
NZ329462A (en) | 1999-06-29 |
FR2757852B1 (fr) | 1999-02-19 |
US20020010337A1 (en) | 2002-01-24 |
JPH10226667A (ja) | 1998-08-25 |
PT850909E (pt) | 2001-07-31 |
DK0850909T3 (da) | 2001-05-21 |
EP0850909B1 (de) | 2001-03-21 |
AR009849A1 (es) | 2000-05-03 |
AU4847797A (en) | 1998-07-02 |
ES2159382T3 (es) | 2001-10-01 |
CA2224528A1 (fr) | 1998-06-30 |
US6214878B1 (en) | 2001-04-10 |
CA2224528C (fr) | 2006-07-18 |
ZA9711313B (en) | 1998-06-23 |
DE69704335D1 (de) | 2001-04-26 |
US6992095B2 (en) | 2006-01-31 |
US20040067971A1 (en) | 2004-04-08 |
EP0850909A1 (de) | 1998-07-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |