DE69515183T2 - Hypolipidämische benzothiazepine - Google Patents

Hypolipidämische benzothiazepine

Info

Publication number
DE69515183T2
DE69515183T2 DE69515183T DE69515183T DE69515183T2 DE 69515183 T2 DE69515183 T2 DE 69515183T2 DE 69515183 T DE69515183 T DE 69515183T DE 69515183 T DE69515183 T DE 69515183T DE 69515183 T2 DE69515183 T2 DE 69515183T2
Authority
DE
Germany
Prior art keywords
pct
date
sec
novel
pub
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69515183T
Other languages
English (en)
Other versions
DE69515183D1 (de
Inventor
Edward Brieaddy
Louis Handlon
Lewis Hodgson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of DE69515183D1 publication Critical patent/DE69515183D1/de
Application granted granted Critical
Publication of DE69515183T2 publication Critical patent/DE69515183T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
DE69515183T 1994-11-17 1995-11-16 Hypolipidämische benzothiazepine Expired - Fee Related DE69515183T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9423172A GB9423172D0 (en) 1994-11-17 1994-11-17 Hypolipidemic benzothiazepines
PCT/GB1995/002700 WO1996016051A1 (en) 1994-11-17 1995-11-16 Hypolipidemic benzothiazepines

Publications (2)

Publication Number Publication Date
DE69515183D1 DE69515183D1 (de) 2000-03-30
DE69515183T2 true DE69515183T2 (de) 2000-08-17

Family

ID=10764525

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69515183T Expired - Fee Related DE69515183T2 (de) 1994-11-17 1995-11-16 Hypolipidämische benzothiazepine

Country Status (22)

Country Link
US (1) US5998400A (de)
EP (1) EP0792268B1 (de)
JP (1) JP2868623B2 (de)
KR (1) KR970707111A (de)
CN (1) CN1059674C (de)
AT (1) ATE189891T1 (de)
AU (1) AU706325B2 (de)
BR (1) BR9509683A (de)
CZ (1) CZ147397A3 (de)
DE (1) DE69515183T2 (de)
DK (1) DK0792268T3 (de)
ES (1) ES2144151T3 (de)
FI (1) FI972085A0 (de)
GB (1) GB9423172D0 (de)
GR (1) GR3033450T3 (de)
HU (1) HUT77412A (de)
MX (1) MX9703546A (de)
NO (1) NO308470B1 (de)
NZ (1) NZ295426A (de)
PL (1) PL320093A1 (de)
PT (1) PT792268E (de)
WO (1) WO1996016051A1 (de)

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US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6107494A (en) * 1994-09-13 2000-08-22 G.D. Searle And Company Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6190513B1 (en) 1997-05-14 2001-02-20 Applied Materials, Inc. Darkspace shield for improved RF transmission in inductively coupled plasma sources for sputter deposition
GB9704208D0 (en) * 1997-02-28 1997-04-16 Glaxo Group Ltd Chemical compounds
GB9800428D0 (en) * 1998-01-10 1998-03-04 Glaxo Group Ltd Chemical compounds
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EA005815B1 (ru) 1998-12-23 2005-06-30 Джи.Ди.Сирл Ллс Комбинация ингибиторов транспорта желчных кислот в подвздошной кишке и ингибиторов белка, переносящего эфиры холестерина, для сердечно-сосудистых показаний
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DK4069360T3 (da) 2019-12-04 2024-02-26 Albireo Ab Benzothia(di)azepinforbindelser og anvendelse deraf som galdesyremodulatorer
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EP4069247A1 (de) 2019-12-04 2022-10-12 Albireo AB Benzothiadiazepinverbindungen und ihre verwendung als gallensäuremodulatoren
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EP4188541A1 (de) 2020-08-03 2023-06-07 Albireo AB Benzothia(di)azepin-verbindungen und ihre verwendung als gallensäuremodulatoren
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Also Published As

Publication number Publication date
CN1059674C (zh) 2000-12-20
ES2144151T3 (es) 2000-06-01
BR9509683A (pt) 1997-09-16
PT792268E (pt) 2000-06-30
NO972261L (no) 1997-07-16
US5998400A (en) 1999-12-07
DE69515183D1 (de) 2000-03-30
GB9423172D0 (en) 1995-01-04
MX9703546A (es) 1997-08-30
EP0792268A1 (de) 1997-09-03
NO972261D0 (no) 1997-05-16
ATE189891T1 (de) 2000-03-15
GR3033450T3 (en) 2000-09-29
EP0792268B1 (de) 2000-02-23
AU3876295A (en) 1996-06-17
NO308470B1 (no) 2000-09-18
JPH11500102A (ja) 1999-01-06
CN1164230A (zh) 1997-11-05
CZ147397A3 (en) 1997-11-12
NZ295426A (en) 1997-10-24
AU706325B2 (en) 1999-06-17
FI972085A (fi) 1997-05-15
PL320093A1 (en) 1997-09-15
DK0792268T3 (da) 2000-07-31
FI972085A0 (fi) 1997-05-15
KR970707111A (ko) 1997-12-01
WO1996016051A1 (en) 1996-05-30
JP2868623B2 (ja) 1999-03-10
HUT77412A (hu) 1998-04-28

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