ES2131106T3 - Compuestos de benzotiazepina hipolipidemicos. - Google Patents

Compuestos de benzotiazepina hipolipidemicos.

Info

Publication number
ES2131106T3
ES2131106T3 ES93904212T ES93904212T ES2131106T3 ES 2131106 T3 ES2131106 T3 ES 2131106T3 ES 93904212 T ES93904212 T ES 93904212T ES 93904212 T ES93904212 T ES 93904212T ES 2131106 T3 ES2131106 T3 ES 2131106T3
Authority
ES
Spain
Prior art keywords
integer
pct
alkyl
phenylalkoxy
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93904212T
Other languages
English (en)
Inventor
Lawrence Edward Brieaddy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Application granted granted Critical
Publication of ES2131106T3 publication Critical patent/ES2131106T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE FORMULA (I) DONDE 1 ES UN NUMERO ENTERO DE 0A 4, M ES UN NUMERO ENTERO DE 0 A 5; N ES UN NUMERO ENTERO DE 0 A 2; R Y R'' SON ATOMOS DE GRUPOS INDEPENDIENTEMENTE ELEGIDOS DE HALOGENO, NITRO,FENILALCOXI, ALCOXI C1-C4, ALQUILO C1-6, Y -O(CH2)PSO3R" DONDE P ES UN NUMERO ENTERO DE 1 A 4 Y R" ES HIDROGENO O ALQUILO C1-6, DONDE DICHOS GRUPOS FENILALCOXI, ALCOXI Y ALQUILO ESTAN OPCIONALMENTE SUSTITUIDOS POR UNO O MAS ATOMOS DE HALOGENO; R4 ES UN GRUPO ALQUILO RECTO C1-6, Y R5 ES UN GRUPO ALQUILO RECTO C2-6, YSUS SALES, SOLVATOS Y DERIVADOS FISIOLOGICAMENTE FUNCIONALES, CON PROCESOS Y NUEVOS INTERMEDIOS PARA SU PREPARACION, CON COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y CON SU USO EN MEDICINA , PARTICULARMENTE EN LA PROFILAXIS Y TRATAMIENTO DE CONDICIONES HIPOERLIPIDEMICAS, TALES COMO LA ARTERIOSCLEROSIS.
ES93904212T 1992-02-17 1993-02-16 Compuestos de benzotiazepina hipolipidemicos. Expired - Lifetime ES2131106T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929203347A GB9203347D0 (en) 1992-02-17 1992-02-17 Hypolipidaemic compounds

Publications (1)

Publication Number Publication Date
ES2131106T3 true ES2131106T3 (es) 1999-07-16

Family

ID=10710542

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93904212T Expired - Lifetime ES2131106T3 (es) 1992-02-17 1993-02-16 Compuestos de benzotiazepina hipolipidemicos.

Country Status (22)

Country Link
US (2) US5663165A (es)
EP (1) EP0626952B1 (es)
JP (1) JP2904926B2 (es)
KR (1) KR100265529B1 (es)
AT (1) ATE178897T1 (es)
AU (1) AU675419B2 (es)
CA (1) CA2117485A1 (es)
DE (1) DE69324479T2 (es)
DK (1) DK0626952T3 (es)
ES (1) ES2131106T3 (es)
FI (1) FI943775A0 (es)
GB (1) GB9203347D0 (es)
GR (1) GR3030491T3 (es)
HK (1) HK1004217A1 (es)
HU (1) HUT71487A (es)
IL (1) IL104740A (es)
MX (1) MX9300821A (es)
MY (1) MY129970A (es)
NZ (1) NZ249189A (es)
TW (1) TW274547B (es)
WO (1) WO1993016055A1 (es)
ZA (1) ZA931073B (es)

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US20230398125A1 (en) 2022-06-09 2023-12-14 Albireo Ab Treating hepatitis
WO2024008766A1 (en) 2022-07-05 2024-01-11 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators

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MX9300821A (es) 1993-09-01
MY129970A (en) 2007-05-31
ATE178897T1 (de) 1999-04-15
HK1004217A1 (en) 1998-11-20
CA2117485A1 (en) 1993-08-19
TW274547B (es) 1996-04-21
US5859240A (en) 1999-01-12
KR100265529B1 (ko) 2000-11-01
US5663165A (en) 1997-09-02
AU675419B2 (en) 1997-02-06
IL104740A (en) 1996-09-12
EP0626952B1 (en) 1999-04-14
EP0626952A1 (en) 1994-12-07
FI943775A (fi) 1994-08-16
GB9203347D0 (en) 1992-04-01
IL104740A0 (en) 1993-06-10
JP2904926B2 (ja) 1999-06-14
GR3030491T3 (en) 1999-10-29
KR950700265A (ko) 1995-01-16
DK0626952T3 (da) 1999-10-25
HUT71487A (en) 1995-11-28
JPH07503724A (ja) 1995-04-20
ZA931073B (en) 1994-08-16
WO1993016055A1 (en) 1993-08-19
NZ249189A (en) 1996-02-27
AU3508293A (en) 1993-09-03
DE69324479D1 (de) 1999-05-20
DE69324479T2 (de) 1999-09-16
FI943775A0 (fi) 1994-08-16
HU9402365D0 (en) 1994-10-28

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