DE69317436T2
(de)
*
|
1992-11-09 |
1998-07-02 |
Knoll Ag |
1,4-benzothiazepine verwendbar als neurologische mittel
|
IL108634A0
(en)
*
|
1993-02-15 |
1994-05-30 |
Wellcome Found |
Hypolipidaemic heterocyclic compounds, their prepatation and pharmaceutical compositions containing them
|
IL108633A
(en)
*
|
1993-02-15 |
1998-07-15 |
Wellcome Found |
History of Benzothiazepine Hypolipidemic Preparation and Pharmaceutical Preparations Containing Them
|
AU678503B2
(en)
*
|
1993-09-24 |
1997-05-29 |
Takeda Chemical Industries Ltd. |
Condensed heterocyclic compounds and their use as squalene synthetase inhibitors
|
ZA956647B
(en)
*
|
1994-08-10 |
1997-02-10 |
Wellcome Found |
Hypolipidaemic compounds.
|
US5994391A
(en)
*
|
1994-09-13 |
1999-11-30 |
G.D. Searle And Company |
Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
|
US6262277B1
(en)
|
1994-09-13 |
2001-07-17 |
G.D. Searle And Company |
Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
|
EP0781278B1
(en)
*
|
1994-09-13 |
2001-03-14 |
Monsanto Company |
Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
|
US6107494A
(en)
*
|
1994-09-13 |
2000-08-22 |
G.D. Searle And Company |
Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
|
US6268392B1
(en)
|
1994-09-13 |
2001-07-31 |
G. D. Searle & Co. |
Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
|
US6642268B2
(en)
|
1994-09-13 |
2003-11-04 |
G.D. Searle & Co. |
Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
|
GB9423172D0
(en)
*
|
1994-11-17 |
1995-01-04 |
Wellcom Foundation The Limited |
Hypolipidemic benzothiazepines
|
GB9616279D0
(en)
*
|
1996-08-02 |
1996-09-11 |
Knoll Ag |
Chemical process
|
GB9704208D0
(en)
*
|
1997-02-28 |
1997-04-16 |
Glaxo Group Ltd |
Chemical compounds
|
DE69815180T2
(de)
*
|
1997-03-14 |
2004-04-29 |
Aventis Pharma Deutschland Gmbh |
Hypolipidemische 1,4-Benzothiazepin-1,1-dioxide
|
ES2223091T3
(es)
*
|
1997-04-04 |
2005-02-16 |
Aventis Pharma Deutschland Gmbh |
Derivados de propanolamina hipolipidemicos.
|
US6221897B1
(en)
|
1998-06-10 |
2001-04-24 |
Aventis Pharma Deutschland Gmbh |
Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
|
DE19845405C2
(de)
|
1998-10-02 |
2000-07-13 |
Aventis Pharma Gmbh |
Arylsubstituierte Propanolaminderivate und deren Verwendung
|
DE19845403B4
(de)
*
|
1998-10-02 |
2005-02-10 |
Aventis Pharma Deutschland Gmbh |
Mit Gallensäuren verknüpfte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
|
EP1140189B1
(en)
|
1998-12-23 |
2003-05-14 |
G.D. Searle LLC. |
Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications
|
ATE248606T1
(de)
*
|
1998-12-23 |
2003-09-15 |
Searle Llc |
Kombinationen einem ibat inhibitor und einem mtp inhibitor für kardiovaskuläre indikationen
|
PT1140188E
(pt)
*
|
1998-12-23 |
2003-10-31 |
Searle Llc |
Combinacoes de inibidores do transporte de acidos biliares do ileo e de inibidores da proteina de transferencia de esteres de colesterilo para doencas cardiovasculares.
|
DK1140185T3
(da)
|
1998-12-23 |
2003-09-29 |
Searle Llc |
Kombinationer af cholesterylestertransferhæmmere og galdesyre kompleksdannende forbindelser til hjertekar indikationer
|
WO2000038722A1
(en)
|
1998-12-23 |
2000-07-06 |
G.D. Searle & Co. |
COMBINATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG CoA REDUCTASE INHIBITORS FOR CARDIOVASCULAR INDICATIONS
|
IL143949A0
(en)
|
1998-12-23 |
2002-04-21 |
Searle Llc |
Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications
|
ATE242007T1
(de)
|
1998-12-23 |
2003-06-15 |
Searle Llc |
Kombinationen von cholesteryl ester transfer protein inhibitoren und nicotinsäure derivaten für kardiovaskuläre indikationen
|
EA004877B1
(ru)
*
|
1998-12-23 |
2004-08-26 |
Джи.Ди.Сирл Ллс |
Сочетания ингибиторов транспорта желчных кислот в подвздошной кишке и агентов, секвестрирующих желчные кислоты, для сердечно-сосудистых показаний
|
DE19916108C1
(de)
*
|
1999-04-09 |
2001-01-11 |
Aventis Pharma Gmbh |
Mit Zuckerresten substituierte 1,4-Benzothiazepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und deren Verwendung
|
GB9914745D0
(en)
*
|
1999-06-24 |
1999-08-25 |
Knoll Ag |
Therapeutic agents
|
SE0000772D0
(sv)
|
2000-03-08 |
2000-03-08 |
Astrazeneca Ab |
Chemical compounds
|
AU2001247331A1
(en)
*
|
2000-03-10 |
2001-09-24 |
Pharmacia Corporation |
Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders
|
EP1286984A2
(en)
|
2000-03-10 |
2003-03-05 |
Pharmacia Corporation |
Method for the preparation of tetrahydrobenzothiepines
|
DE60110902T2
(de)
|
2000-03-24 |
2006-04-27 |
Pharmacia Corp., Chicago |
Amidino-verbindung sowie salze davon verwendbar als hemmstoffe der stickstoffmonoxid-synthase
|
US6956131B2
(en)
|
2000-04-13 |
2005-10-18 |
Pharmacia Corporation |
2-amino-3, 4 heptenoic compounds useful as nitric oxide synthase inhibitors
|
US6787668B2
(en)
|
2000-04-13 |
2004-09-07 |
Pharmacia Corporation |
2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
|
AR032318A1
(es)
|
2000-04-13 |
2003-11-05 |
Pharmacia Corp |
Compuesto derivado halogenado del acido 2-amino-5,6 heptenoico; composicion farmaceutica que lo comprende y su uso en la fabricacion de un medicamento util como inhibidor de la oxido nitrico sintetasa
|
US6545170B2
(en)
|
2000-04-13 |
2003-04-08 |
Pharmacia Corporation |
2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
|
AR030416A1
(es)
|
2000-04-13 |
2003-08-20 |
Pharmacia Corp |
COMPUESTO DERIVADO HALOGENADO DEL ACIDO 2-AMINO-3,4 HEPTENOICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE Y SU USO EN LA FABRICACION DE UN MEDICAMENTO uTIL COMO INHIBIDOR DE LA OXIDO NITRICO SINTETASA
|
AR034120A1
(es)
|
2000-04-13 |
2004-02-04 |
Pharmacia Corp |
Compuesto derivado halogenado del acido 2-amino-4,5 heptenoico, composicion farmaceutica que lo comprende y el uso de dicho compuesto y dicha composicion en la fabricacion de un medicamento para inhibir o modular la sintesis de acido nitrico
|
US7393652B2
(en)
*
|
2000-05-10 |
2008-07-01 |
The Trustees Of Columbia University In The City Of New York |
Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
|
US20040229781A1
(en)
*
|
2000-05-10 |
2004-11-18 |
Marks Andrew Robert |
Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias
|
US7718644B2
(en)
*
|
2004-01-22 |
2010-05-18 |
The Trustees Of Columbia University In The City Of New York |
Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
|
US20040048780A1
(en)
*
|
2000-05-10 |
2004-03-11 |
The Trustees Of Columbia University In The City Of New York |
Method for treating and preventing cardiac arrhythmia
|
US20060293266A1
(en)
*
|
2000-05-10 |
2006-12-28 |
The Trustees Of Columbia |
Phosphodiesterase 4D in the ryanodine receptor complex protects against heart failure
|
US7879840B2
(en)
*
|
2005-08-25 |
2011-02-01 |
The Trustees Of Columbia University In The City Of New York |
Agents for preventing and treating disorders involving modulation of the RyR receptors
|
US6489125B1
(en)
*
|
2000-05-10 |
2002-12-03 |
The Trustees Of Columbia University In The City Of New York |
Methods for identifying chemical compounds that inhibit dissociation of FKBP12.6 binding protein from type 2 ryanodine receptor
|
US8022058B2
(en)
|
2000-05-10 |
2011-09-20 |
The Trustees Of Columbia University In The City Of New York |
Agents for preventing and treating disorders involving modulation of the RyR receptors
|
US20020183307A1
(en)
*
|
2000-07-26 |
2002-12-05 |
Tremont Samuel J. |
Novel 1,4-benzothiazephine and 1,5-benzothiazepine compounds as inhibitors of apical sodium co-dependent bile acid transport and taurocholate uptake
|
MY131964A
(en)
|
2000-09-15 |
2007-09-28 |
Pharmacia Corp |
2-amino-2-alkyl-5 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors
|
AR031129A1
(es)
|
2000-09-15 |
2003-09-10 |
Pharmacia Corp |
Derivados de los acidos 2-amino-2-alquil-4-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa
|
EG26979A
(en)
|
2000-12-21 |
2015-03-01 |
Astrazeneca Ab |
Chemical compounds
|
EP1402061A2
(en)
*
|
2001-04-17 |
2004-03-31 |
Astrazeneca AB |
Chemical compounds for identification of slc10a2 gene polymorphisms
|
US20040072903A1
(en)
*
|
2001-05-08 |
2004-04-15 |
Auerbach Bruce Jeffrey |
Carboxyalkylether-acat inhibitors combinations
|
US20040077625A1
(en)
*
|
2001-07-25 |
2004-04-22 |
Tremont Samuel J. |
Novel 1,4-benzothiazepine and 1,5-benzothiazepine compounds as inhibitors of apical sodium codependent bile acid transport abd taurocholate uptake
|
GB0121337D0
(en)
|
2001-09-04 |
2001-10-24 |
Astrazeneca Ab |
Chemical compounds
|
GB0121622D0
(en)
|
2001-09-07 |
2001-10-31 |
Astrazeneca Ab |
Chemical compounds
|
GB0121621D0
(en)
|
2001-09-07 |
2001-10-31 |
Astrazeneca Ab |
Chemical compounds
|
BRPI0212346B1
(pt)
|
2001-09-08 |
2016-02-02 |
Albireo Ab |
Compostos derivados de benzotiadiazepina ou um sal farmaceuticamente aceitável do mesmo com efeito inibidor de transporte de ácido de bile ileal, processo para a preparação dos mesmos, uso destes, e, composição farmacêutica.
|
BR0213501A
(pt)
*
|
2001-11-02 |
2004-08-24 |
Searle Llc |
Compostos de benzotiepina mono- e di-fluorada como inibidores de transporte de ácido biliar co-dependente de sódio apical (asbt) e captação de taurocolato
|
EP1465885A4
(en)
|
2002-01-17 |
2005-04-27 |
Pharmacia Corp |
NOVEL ALKYL / ARYL HYDROXY OR CETOTHIEPINE COMPOUNDS AS INHIBITORS OF BILIARY ACID TRANSPORT OF THE ILEAL TYPE AND ABSORPTION OF TAUROCHOLATE
|
GB0209467D0
(en)
|
2002-04-25 |
2002-06-05 |
Astrazeneca Ab |
Chemical compounds
|
GB0213669D0
(en)
|
2002-06-14 |
2002-07-24 |
Astrazeneca Ab |
Chemical compounds
|
US7312208B2
(en)
|
2002-08-28 |
2007-12-25 |
Asahi Kasei Pharma Corporation |
Quaternary ammonium compounds
|
US7544678B2
(en)
*
|
2002-11-05 |
2009-06-09 |
The Trustees Of Columbia University In The City Of New York |
Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
|
GB0304194D0
(en)
|
2003-02-25 |
2003-03-26 |
Astrazeneca Ab |
Chemical compounds
|
WO2004080283A2
(en)
|
2003-03-07 |
2004-09-23 |
The Trustees Of Columbia University, In The City Of New York |
Type 1 ryanodine receptor-based methods
|
GB0307918D0
(en)
*
|
2003-04-05 |
2003-05-14 |
Astrazeneca Ab |
Therapeutic use
|
US8710045B2
(en)
*
|
2004-01-22 |
2014-04-29 |
The Trustees Of Columbia University In The City Of New York |
Agents for preventing and treating disorders involving modulation of the ryanodine receptors
|
US7973030B2
(en)
|
2004-02-27 |
2011-07-05 |
Asahi Kasei Pharma Corporation |
Benzothiazepine and benzothiepine compounds
|
US7704990B2
(en)
*
|
2005-08-25 |
2010-04-27 |
The Trustees Of Columbia University In The City Of New York |
Agents for preventing and treating disorders involving modulation of the RyR receptors
|
CN102316872B
(zh)
*
|
2008-11-26 |
2016-12-21 |
萨蒂奥根制药公司 |
治疗肥胖症和糖尿病的胆汁酸再循环抑制剂
|
JO3131B1
(ar)
*
|
2010-04-27 |
2017-09-20 |
Glaxosmithkline Llc |
مركبات كيميائية
|
ES2552657T3
(es)
|
2010-05-26 |
2015-12-01 |
Satiogen Pharmaceuticals, Inc. |
Inhibidores del reciclado de ácidos biliares y saciógenos para el tratamiento de diabetes, obesidad, y afecciones gastrointestinales inflamatorias
|
PL2637646T3
(pl)
|
2010-11-08 |
2017-01-31 |
Albireo Ab |
Kombinacja farmaceutyczna zawierająca inhibitor ibat i środek wiążący kwasy żółciowe
|
DK3400944T3
(da)
|
2010-11-08 |
2020-10-12 |
Albireo Ab |
Ibat-inhibitorer til behandling af leversygdomme
|
CN104023718B
(zh)
|
2011-10-28 |
2017-04-05 |
鲁美纳医药公司 |
用于治疗高胆血症和胆汁淤积性肝病的胆汁酸再循环抑制剂
|
PL2771003T3
(pl)
|
2011-10-28 |
2017-10-31 |
Lumena Pharmaceuticals Llc |
Inhibitory ponownego wykorzystania kwasów żółciowych do leczenia pediatrycznych cholestatycznych chorób wątroby
|
CA2907230A1
(en)
|
2013-03-15 |
2014-09-18 |
Lumena Pharmaceuticals, Inc. |
Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease
|
MX2015013196A
(es)
|
2013-03-15 |
2016-04-15 |
Lumena Pharmaceuticals Inc |
Inhibidores de reciclaje de acidos biliares para el tratamiento de la enfermedad de reflujo gastroesofagico y esofago de barrett.
|
JO3301B1
(ar)
|
2013-04-26 |
2018-09-16 |
Albireo Ab |
تعديلات بلورية على إيلوبيكسيبات
|
TWI499846B
(zh)
*
|
2014-04-16 |
2015-09-11 |
Au Optronics Corp |
顯示器模組
|
WO2015199147A1
(ja)
|
2014-06-25 |
2015-12-30 |
味の素株式会社 |
固形製剤及びその着色防止又は着色低減方法
|
EP3012252A1
(en)
|
2014-10-24 |
2016-04-27 |
Ferring BV |
Crystal modifications of elobixibat
|
US10441604B2
(en)
|
2016-02-09 |
2019-10-15 |
Albireo Ab |
Cholestyramine pellets and methods for preparation thereof
|
EP3413878B1
(en)
|
2016-02-09 |
2021-04-14 |
Albireo AB |
Oral cholestyramine formulation and use thereof
|
CA3011565C
(en)
|
2016-02-09 |
2024-01-02 |
Albireo Ab |
Oral cholestyramine formulation and use thereof
|
US10786529B2
(en)
|
2016-02-09 |
2020-09-29 |
Albireo Ab |
Oral cholestyramine formulation and use thereof
|
US10441605B2
(en)
|
2016-02-09 |
2019-10-15 |
Albireo Ab |
Oral cholestyramine formulation and use thereof
|
RU2019100575A
(ru)
*
|
2016-06-27 |
2020-07-28 |
ГлаксоСмитКлайн Интеллекчуал Проперти (N2) Лимитед |
Способы синтеза
|
JP7328207B2
(ja)
|
2017-08-09 |
2023-08-16 |
アルビレオ・アクチボラグ |
コレスチラミンペレット、経口コレスチラミン製剤、及びそれらの使用
|
EP3664781A1
(en)
|
2017-08-09 |
2020-06-17 |
Albireo AB |
Cholestyramine granules, oral cholestyramine formulations and use thereof
|
TW202015699A
(zh)
|
2018-06-05 |
2020-05-01 |
瑞典商艾爾比瑞歐公司 |
苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽汁酸調節劑之用途
|
US10793534B2
(en)
|
2018-06-05 |
2020-10-06 |
Albireo Ab |
Benzothia(di)azepine compounds and their use as bile acid modulators
|
US11801226B2
(en)
|
2018-06-20 |
2023-10-31 |
Albireo Ab |
Pharmaceutical formulation of odevixibat
|
SG11202012151XA
(en)
|
2018-06-20 |
2021-01-28 |
Albireo Ab |
Crystal modifications of odevixibat
|
US10722457B2
(en)
|
2018-08-09 |
2020-07-28 |
Albireo Ab |
Oral cholestyramine formulation and use thereof
|
US11549878B2
(en)
|
2018-08-09 |
2023-01-10 |
Albireo Ab |
In vitro method for determining the adsorbing capacity of an insoluble adsorbant
|
US11007142B2
(en)
|
2018-08-09 |
2021-05-18 |
Albireo Ab |
Oral cholestyramine formulation and use thereof
|
US10941127B2
(en)
|
2019-02-06 |
2021-03-09 |
Albireo Ab |
Benzothiadiazepine compounds and their use as bile acid modulators
|
EP3921027B1
(en)
|
2019-02-06 |
2023-07-19 |
Albireo AB |
Benzothiazepine compounds and their use as bile acid modulators
|
US10975045B2
(en)
|
2019-02-06 |
2021-04-13 |
Aibireo AB |
Benzothiazepine compounds and their use as bile acid modulators
|
SG11202108566VA
(en)
|
2019-02-06 |
2021-09-29 |
Albireo Ab |
Benzothiadiazepine compounds and their use as bile acid modulators
|
CN114096268A
(zh)
|
2019-02-12 |
2022-02-25 |
米鲁姆制药公司 |
用于增加患有胆汁淤积性肝病的儿科受试者的生长的方法
|
PT4069360T
(pt)
|
2019-12-04 |
2024-03-06 |
Albireo Ab |
Compostos de benzotia(di)azepina e a sua utilização como moduladores de ácido biliar
|
TW202134221A
(zh)
|
2019-12-04 |
2021-09-16 |
瑞典商艾爾比瑞歐公司 |
苯并噻二氮呯化合物及其作為膽酸調節劑之用途
|
US11014898B1
(en)
|
2020-12-04 |
2021-05-25 |
Albireo Ab |
Benzothiazepine compounds and their use as bile acid modulators
|
KR20220109450A
(ko)
|
2019-12-04 |
2022-08-04 |
알비레오 에이비 |
벤조티아(디)아제핀 화합물 및 담즙산 조절제로서의 이의 용도
|
EP4069361B1
(en)
|
2019-12-04 |
2024-01-03 |
Albireo AB |
Benzothia(di)azepine compounds and their use as bile acid modulators
|
CA3158184A1
(en)
|
2019-12-04 |
2021-08-10 |
Albireo Ab |
Benzothiadiazepine compounds and their use as bile acid modulators
|
TW202134218A
(zh)
|
2019-12-04 |
2021-09-16 |
瑞典商艾爾比瑞歐公司 |
苯并噻氮呯化合物及其作為膽酸調節劑之用途
|
EP4069359B1
(en)
|
2019-12-04 |
2024-01-03 |
Albireo AB |
Benzothia(di)azepine compounds and their use as bile acid modulators
|
TW202134220A
(zh)
|
2019-12-04 |
2021-09-16 |
瑞典商艾爾比瑞歐公司 |
苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
|
WO2021110884A1
(en)
|
2019-12-04 |
2021-06-10 |
Albireo Ab |
Benzothia(di)azepine compounds and their use as bile acid modulators
|
CA3186857A1
(en)
|
2020-08-03 |
2022-02-10 |
Per-Goran Gillberg |
Benzothia(di)azepine compounds and their use as bile acid modulators
|
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(en)
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