AR120674A1 - Compuestos de benzotiazepina y su uso como ácido biliar - Google Patents
Compuestos de benzotiazepina y su uso como ácido biliarInfo
- Publication number
- AR120674A1 AR120674A1 ARP200103386A ARP200103386A AR120674A1 AR 120674 A1 AR120674 A1 AR 120674A1 AR P200103386 A ARP200103386 A AR P200103386A AR P200103386 A ARP200103386 A AR P200103386A AR 120674 A1 AR120674 A1 AR 120674A1
- Authority
- AR
- Argentina
- Prior art keywords
- oxy
- benzothiazepin
- dioxido
- tetrahydro
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente se refiere a los derivados de fórmula (1) de 1,5-benzotiazepina. Estos compuestos son moduladores del ácido biliar que tienen el transportador apical del ácido biliar dependiente del sodio (ASBT) y/o actividad inhibidora del transporte del ácido biliar del hígado (LBAT). También se refiere a las composiciones farmacéuticas que comprenden estos compuestos y con el uso de estos compuestos en el tratamiento de enfermedades cardiovasculares, metabolismo del ácido graso y trastornos debido al uso de la glucosa, enfermedades gastrointestinales y enfermedades hepáticas. Reivindicación 1: Un compuesto de la fórmula (1) caracterizado por que R¹ y R² cada uno de manera independiente alquilo C₁₋₄; R³ se selecciona de manera independiente del grupo que consiste en hidrógeno, halógeno, hidroxi, alquilo C₁₋₄, haloalquilo C₁₋₄, alcoxi C₁₋₄, haloalcoxi C₁₋₄, ciano, nitro, amino, amino N-(alquilo C₁₋₄), amino N,N-di(alquilo C₁₋₄) y amino N-(aril-alquilo C₁₋₄); n es un número entero 1, 2 ó 3; R⁴ se selecciona del grupo que consiste en hidrógeno, halógeno, hidroxi, ciano, alquilo C₁₋₄, cicloalquilo C₃₋₆, alcoxi C₁₋₄, cicloalquiloxi C₃₋₆, alquilotio C₁₋₄, cicloalquiltio C₃₋₆, amino, amino N-(alquilo C₁₋₄) y amino N,N-di(alquilo C₁₋₄); o una sal farmacéuticamente aceptable de este, con la condición de que el compuesto no sea del grupo que consiste en: ácido 2-((3,3-dipropil-7-(metiltio)-5-fenil-1,1-dioxido-2,3,4,5-tetrahidro-1,5-benzotiazepin-8-il)oxi)acético; ácido 2-((3,3-dibutil-7-(metiltio)-5-fenil-1,1-dioxido-2,3,4,5-tetrahidro-1,5-benzotiazepin-8-il)oxi)acético; ácido 2-((3,3-dibutil-5-(4-clorofenil)-7-(metiltio)-1,1-dioxido-2,3,4,5-tetrahidro-1,5-benzotiazepin-8-il)oxi)acético; ácido 2-((3-butil-3-etil-7-(metiltio)-5-fenil-1,1-dioxido-2,3,4,5-tetrahidro-1,5-benzotiazepin-8-il)oxi)acético; ácido 2-((3-butil-3-etil-5-fenil-1,1-dioxido-2,3,4,5-tetrahidro-1,5-benzotiazepin-8-il)oxi)acético; ácido 2-((3-butil-3-etil-7-metoxi-5-fenil-1,1-dioxido-2,3,4,5-tetrahidro-1,5-benzotiazepin-8-il)oxi)acético; ácido 2-((3-butil-3-etil-7-isopropoxi-5-fenil-1,1-dioxido-2,3,4,5-tetrahidro-1,5-benzotiazepin-8-il)oxi)acético; ácido 2-((3,3-dibutil-7-metoxi-5-fenil-1,1-dioxido-2,3,4,5-tetrahidro-1,5-benzotiazepin-8-il)oxi)acético; ácido 2-((7-bromo-3,3-dibutil-5-fenil-1,1-dioxido-2,3,4,5-tetrahidro-1,5-benzotiazepin-8-il)oxi)acético; y ácido 2-((7-bromo-3-butil-3-etil-5-fenil-1,1-dioxido-2,3,4,5-tetrahidro-1,5-benzotiazepin-8-il)oxi)acético.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201911049985 | 2019-12-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR120674A1 true AR120674A1 (es) | 2022-03-09 |
Family
ID=73790065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP200103386A AR120674A1 (es) | 2019-12-04 | 2020-12-04 | Compuestos de benzotiazepina y su uso como ácido biliar |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR120674A1 (es) |
| TW (1) | TW202134218A (es) |
| WO (1) | WO2021110887A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3100113A1 (en) | 2018-06-05 | 2019-12-12 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| JOP20200297A1 (ar) | 2018-06-20 | 2020-11-22 | Albireo Ab | تعديلات بلورية للأوديفيكسيبات |
| US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| CN114786772B (zh) | 2019-12-04 | 2024-04-09 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| WO2022029101A1 (en) | 2020-08-03 | 2022-02-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| TW202313579A (zh) | 2021-06-03 | 2023-04-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
| WO2023164181A1 (en) | 2022-02-25 | 2023-08-31 | Assembly Biosciences, Inc. | Benzothia(dia)zepine compounds for treatment of hbv and hdv |
| WO2023164179A1 (en) | 2022-02-25 | 2023-08-31 | Assembly Biosciences, Inc. | Benzothia(dia)zepine compounds for treatment of hbv and hdv |
| WO2023164186A1 (en) | 2022-02-25 | 2023-08-31 | Assembly Biosciences, Inc. | Benzothia(dia)zepine compounds for treatment of hbv and hdv |
| WO2023164183A1 (en) | 2022-02-25 | 2023-08-31 | Assembly Biosciences, Inc. | Benzothia(dia)zepine compounds for treatment of hbv and hdv |
| WO2023203248A1 (en) | 2022-04-22 | 2023-10-26 | Albireo Ab | Subcutaneous administration of an asbt inhibitor |
| US20230398125A1 (en) | 2022-06-09 | 2023-12-14 | Albireo Ab | Treating hepatitis |
| US20240067617A1 (en) | 2022-07-05 | 2024-02-29 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| WO2024121434A1 (en) | 2022-12-09 | 2024-06-13 | Albireo Ab | Asbt inhibitors in the treatment of renal diseases |
Family Cites Families (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2096614T3 (es) | 1990-12-06 | 1997-03-16 | Hoechst Ag | Derivados de acidos biliares, procedimiento para su preparacion y utilizacion de este compuesto como medicamento. |
| NZ245503A (en) | 1991-12-20 | 1995-11-27 | Hoechst Ag | Polymers containing bile acids; pharmaceuticals and preparatory methods |
| GB9203347D0 (en) | 1992-02-17 | 1992-04-01 | Wellcome Found | Hypolipidaemic compounds |
| ES2111092T3 (es) | 1992-06-12 | 1998-03-01 | Hoechst Ag | Derivados de acidos biliares, procedimiento para su preparacion y utilizacion de estos compuestos como medicamentos. |
| ZA941003B (en) | 1993-02-15 | 1995-08-14 | Wellcome Found | Hypolipidaemic compounds |
| IL108634A0 (en) | 1993-02-15 | 1994-05-30 | Wellcome Found | Hypolipidaemic heterocyclic compounds, their prepatation and pharmaceutical compositions containing them |
| TW289021B (es) | 1993-05-08 | 1996-10-21 | Hoechst Ag | |
| EP0624593A3 (de) | 1993-05-08 | 1995-06-07 | Hoechst Ag | Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel. |
| TW289757B (es) | 1993-05-08 | 1996-11-01 | Hoechst Ag | |
| TW289020B (es) | 1993-05-08 | 1996-10-21 | Hoechst Sktiengesellschaft | |
| ZA956647B (en) | 1994-08-10 | 1997-02-10 | Wellcome Found | Hypolipidaemic compounds. |
| JP3304093B2 (ja) | 1994-09-13 | 2002-07-22 | モンサント カンパニー | 回腸の胆汁酸輸送及びタウロコール酸塩吸収の阻害活性を有する新規ベンゾチエピン類 |
| GB9423172D0 (en) | 1994-11-17 | 1995-01-04 | Wellcom Foundation The Limited | Hypolipidemic benzothiazepines |
| EP0888333B1 (en) | 1996-03-11 | 2005-08-31 | G.D. Searle LLC | Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| AU3940897A (en) | 1996-07-24 | 1998-02-10 | Zumtobel Staff Gmbh | Adapter for a retaining means used to secure a built-in lamp in a mounting hole,or retaining means or built-in lamp provided with such an adapter |
| DE19633268A1 (de) | 1996-08-19 | 1998-02-26 | Hoechst Ag | Polymere Gallensäure-Resorptionsinhibitoren mit gleichzeitiger Gallensäure-Adsorberwirkung |
| SK125099A3 (en) | 1997-03-11 | 2001-02-12 | Searle & Co | Combination of ileal bile acid transport inhibiting benzothiepines and hmg co-a reductase inhibitors |
| EP0864582B1 (en) | 1997-03-14 | 2003-06-04 | Aventis Pharma Deutschland GmbH | Hypolipidemic 1,4-benzothiazepine-1,-dioxides |
| GB9800428D0 (en) | 1998-01-10 | 1998-03-04 | Glaxo Group Ltd | Chemical compounds |
| DE19825804C2 (de) | 1998-06-10 | 2000-08-24 | Aventis Pharma Gmbh | 1,4-Benzothiepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| MXPA01006472A (es) | 1998-12-23 | 2004-03-10 | Searle Llc | Combinaciones de inhibidores de transporte de acido biliar ileal y derivados de acido fibrico para indicaciones cardiovasculares. |
| EP1140191B1 (en) | 1998-12-23 | 2002-10-23 | G.D. Searle LLC. | Combinations of ileal bile acid transport inhibitors and nicotinic acid derivatives for cardiovascular indications |
| JP2002533414A (ja) | 1998-12-23 | 2002-10-08 | ジー．ディー．サール エルエルシー | 心臓血管に適用するための回腸胆汁酸輸送阻害剤および胆汁酸隔離剤の組み合わせ |
| WO2000038725A1 (en) | 1998-12-23 | 2000-07-06 | G.D. Searle Llc | Combinations for cardiovascular indications |
| ATE241386T1 (de) | 1998-12-23 | 2003-06-15 | Searle Llc | Kombinationen von ileumgallensäuretransports inhibitoren und cholesteryl ester transfer protein inhibitoren |
| WO2000047568A2 (en) | 1999-02-12 | 2000-08-17 | G.D. Searle Llc | 1,2-benzothiazepines for the treatment of hyperlipidemic diseases |
| DE19916108C1 (de) | 1999-04-09 | 2001-01-11 | Aventis Pharma Gmbh | Mit Zuckerresten substituierte 1,4-Benzothiazepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und deren Verwendung |
| SE9901387D0 (sv) | 1999-04-19 | 1999-04-19 | Astra Ab | New pharmaceutical foromaulations |
| SE0000772D0 (sv) | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | Chemical compounds |
| AU2001247331A1 (en) | 2000-03-10 | 2001-09-24 | Pharmacia Corporation | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders |
| SE0003766D0 (sv) | 2000-10-18 | 2000-10-18 | Astrazeneca Ab | Novel formulation |
| EG26979A (en) | 2000-12-21 | 2015-03-01 | Astrazeneca Ab | Chemical compounds |
| GB0121337D0 (en) | 2001-09-04 | 2001-10-24 | Astrazeneca Ab | Chemical compounds |
| GB0121622D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| GB0121621D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| ATE349214T1 (de) | 2001-09-08 | 2007-01-15 | Astrazeneca Ab | Benzothiazepin und benzothiadiazepin derivative mit hemmender wirkung auf den säuretransport in den gallengängen zur behandlung von hyperlipidaemia |
| GB0201850D0 (en) | 2002-01-26 | 2002-03-13 | Astrazeneca Ab | Therapeutic treatment |
| GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| GB0213669D0 (en) | 2002-06-14 | 2002-07-24 | Astrazeneca Ab | Chemical compounds |
| GB0216321D0 (en) | 2002-07-13 | 2002-08-21 | Astrazeneca Ab | Therapeutic treatment |
| WO2004020421A1 (ja) | 2002-08-28 | 2004-03-11 | Asahi Kasei Pharma Corporation | 新規な４級アンモニウム化合物 |
| GB0304194D0 (en) | 2003-02-25 | 2003-03-26 | Astrazeneca Ab | Chemical compounds |
| US20050215882A1 (en) | 2004-03-23 | 2005-09-29 | The Regents Of The University Of Michigan | Noninvasive method to determine fat content of tissues using MRI |
| DE102005033100B3 (de) | 2005-07-15 | 2007-01-25 | Sanofi-Aventis Deutschland Gmbh | Neues 1,4-Benzothiazepin-1,1-Dioxidderivat mit verbesserten Eigenschaften, diese Verbindung enthaltene Arzneimittel und Verfahren zu deren Herstellung |
| DE102005033099A1 (de) | 2005-07-15 | 2007-01-18 | Sanofi-Aventis Deutschland Gmbh | Neues 1,4-Benzothiazepin-1,1-Dioxidderivat mit verbesserten Eigenschaften, Verfahren zu dessen Herstellung, diese Verbindung enthaltende Arzneimittel und dessen Verwendung |
| US9295677B2 (en) | 2008-02-26 | 2016-03-29 | Qing Bile Therapeutics Inc. | Polyhydroxylated bile acids for treatment of biliary disorders |
| JO3131B1 (ar) | 2010-04-27 | 2017-09-20 | Glaxosmithkline Llc | مركبات كيميائية |
| AU2015222754B2 (en) | 2014-02-27 | 2020-06-25 | Nusirt Sciences Inc. | Compositions and methods for the reduction or prevention of hepatic steatosis |
| KR101674806B1 (ko) | 2014-10-20 | 2016-11-10 | 씨제이헬스케어 주식회사 | 신규한 아미노알킬벤조티아제핀 유도체 및 이의 용도 |
| KR20160061492A (ko) | 2014-11-21 | 2016-06-01 | 삼성디스플레이 주식회사 | 휴대용 먼지 센서 및 이를 이용한 휴대전화 |
| RU2750937C2 (ru) | 2016-02-09 | 2021-07-06 | Альбирео Аб | Пероральный состав холестирамина и его применение |
| CA3011565C (en) | 2016-02-09 | 2024-01-02 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US11350844B2 (en) | 2016-11-23 | 2022-06-07 | Mayo Foundation For Medical Education And Research | System and method for generating nonalcoholic fatty liver disease activity score (NAS) using magnetic resonance elastography |
| CN110996915B (zh) | 2017-08-09 | 2023-10-03 | 阿尔比里奥公司 | 考来烯胺丸粒、口服考来烯胺制剂及其用途 |
| CA3071285A1 (en) | 2017-08-09 | 2019-02-14 | Albireo Ab | Cholestyramine granules, oral cholestyramine formulations and use thereof |
| MX2020009332A (es) * | 2018-03-09 | 2020-10-08 | Elobix Ab | Proceso para la preparacion de elobixibat. |
| CA3100113A1 (en) | 2018-06-05 | 2019-12-12 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| WO2020161216A1 (en) | 2019-02-06 | 2020-08-13 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| PL3921028T3 (pl) | 2019-02-06 | 2023-02-13 | Albireo Ab | Związki benzotiadiazepinowe i ich zastosowanie jako modulatory kwasów żółciowych |
-
2020
- 2020-12-04 TW TW109142852A patent/TW202134218A/zh unknown
- 2020-12-04 WO PCT/EP2020/084571 patent/WO2021110887A1/en unknown
- 2020-12-04 AR ARP200103386A patent/AR120674A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021110887A1 (en) | 2021-06-10 |
| TW202134218A (zh) | 2021-09-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR120674A1 (es) | Compuestos de benzotiazepina y su uso como ácido biliar | |
| AR120682A1 (es) | Compuestos de benzotiadiazepina y su uso como moduladores del ácido biliar | |
| AR120679A1 (es) | Compuestos de benzoti(di)azepina y su uso como moduladores ácido biliar | |
| AR120683A1 (es) | Compuestos de benzoti(di)azepina y su uso como ácido biliar | |
| AR120676A1 (es) | Compuestos de benzoti(di)azepina y su uso como ácido biliar | |
| AR126076A1 (es) | Compuestos de benzotia(di)azepina y su uso como moduladores del ácido biliar | |
| PE20212251A1 (es) | Compuestos de benzotiadiazepina y su uso como moduladores del acido biliar | |
| CO2022007172A2 (es) | Compuestos de benzoti(di)azepina y su uso como moduladores del ácido biliar | |
| ES2605152T3 (es) | Derivados de pirazolquinolinona, su preparación y su uso terapéutico | |
| RU2008123388A (ru) | Соединения и композиции в качестве модуляторов lxr | |
| AR072952A1 (es) | Compuestos de 2-imino-3-metilpirrolopirimidinona fenilo-sustituida como inhibidores de bace-1, composiciones y su uso | |
| CO6390038A2 (es) | Derivados de sulfonamida como agentes inductores de apoptosis con selectividad por bcl-2 para el tratamiento de cancer y enfermedades inmunes | |
| AR089019A1 (es) | Derivados modificados de 4-fenil-piridina | |
| PE20220705A1 (es) | Derivados de 6,7-dihidro-5h-pirido[2,3-c]piridazin y compuestos relacionados como inhibidores de proteina bcl-xl y agentes proapoptoticos para el tratamiento del cancer | |
| AR049399A1 (es) | Difenilimidazopirimidina e -imidazol aminas como inhibidores de b-secretasa y metodo de obtencion de los mismos | |
| EA201201031A1 (ru) | Ингибиторы вируса гепатита с | |
| AR057872A1 (es) | Inhibidores de la proteina activadora de 5-lipoxigenasa (flap) | |
| RU2014113539A (ru) | Тетрациклические гетероциклические соединения и способы их применения для лечения вирусных заболеваний | |
| AR052938A1 (es) | Compuestos de n-sulfonilaminofeniletil-2-fenoxiacetamida sustituidos, composiciones farmaceuticas que los comprenden y su uso en la preparacion de medicamentos para el tratamiento de enfermedades mediadas por el receptor vr1 | |
| AR081261A1 (es) | Metodos para tratar afecciones virales | |
| RU2016139978A (ru) | Производные полимиксина и их применение в комбинированной терапии совместно с различными антибиотиками | |
| AR065628A1 (es) | Compuestos triciclicos de utilidad en el tratamiento de trastornos por carencia de hierro en el organismo | |
| PE20081703A1 (es) | Nuevos derivados triciclicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen | |
| PE20220252A1 (es) | Compuestos de pirrol | |
| AR071780A1 (es) | Derivados de carbamoilo de carbonilamino-pirazoles biciclicos como profarmacos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |