AR065628A1 - Compuestos triciclicos de utilidad en el tratamiento de trastornos por carencia de hierro en el organismo - Google Patents

Compuestos triciclicos de utilidad en el tratamiento de trastornos por carencia de hierro en el organismo

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Publication number
AR065628A1
AR065628A1 ARP080100936A ARP080100936A AR065628A1 AR 065628 A1 AR065628 A1 AR 065628A1 AR P080100936 A ARP080100936 A AR P080100936A AR P080100936 A ARP080100936 A AR P080100936A AR 065628 A1 AR065628 A1 AR 065628A1
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AR
Argentina
Prior art keywords
optionally substituted
independently
alkyl
hydrogen
haloalkyl
Prior art date
Application number
ARP080100936A
Other languages
English (en)
Inventor
Jianmin Fu
Jean-Jacques Cadieux
Shifeng Liu
Nagasree Chakka
Mikhail Chafeev
Rajender Kamboj
Vishnumurthy Kodumuru
Johnathan Langille
Original Assignee
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Publication of AR065628A1 publication Critical patent/AR065628A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/02—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with only hydrogen, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/06—Six-membered rings
    • C07D327/08—[b,e]-condensed with two six-membered carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/08—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing three- or four-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24—Anthracenes; Hydrogenated anthracenes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente también incluye composiciones farmacéuticas que comprenden los compuestos. Los compuestos son utiles en el tratamiento de trastornos por carencia de hierro en el organismo. Reivindicacion 1: Un compuesto caracterizado porque responde ala formula (1): donde: n y m son cada uno en forma independiente 0, 1 o 2; R1 y R2 son cada uno en forma independiente un enlace directo, -C(R9)2-, -S-, -O-, -C(O)-, -N(R9)- o -CH2R10-CH2-; R3 y R4 son diferentes y cada uno se selecciona en formaindependiente entre -R11-S-C(=NR12)N(R12)R13, -R11-O-C(=NR12)N(R12)R13, -R11-C(=NR12)N(R12)R13, o -R11-N(R9)-C(=NR12)N(R12)R13; o R3 y R4 son iguales y se seleccionan entre -R11-S-C(=NR12)N(R12)R13, -R11-O-C(=NR12)N(R12)R13, -R11-C(=NR12)N(R12)R13,o -R11-N(R9)-C(=NR12)N(R12)R13; R5 y R6 son diferentes y cada uno se selecciona en forma independiente entre hidrogeno, alquilo, halo, haloalquilo, -R11-CN, -R11-NO2, -R11-N(R14)2, -R11-C(O)OR14, -R-C(O)N(R14)2, -R11-S-C(=NR12)N(R12)R13, -R11-O-C(=NR12)N(R12)R13, -R11-C(=NR12)N(R12)R13, -R11-N(R9)-C(=NR12)N(R12)R13, -N(R14)S(O)tR15, -S(O)tOR15, -S(O)pR14, o S(O)tN(R14)2, donde cada t es en forma independiente 1 o 2 y cada p es 0, 1 o 2; o R5 y R6 son iguales y se seleccionan entrehidrogeno, alquilo, halo, haloalquilo, -R11-CN, -R11-NO2, -R11-N(R14)j2, -R11-C(O)OR14, -R11-C(O)N(R14)2, -R11-S-C(=NR12)N(R12)R13, -R11-O-C(=NR12)N(R12)R13, -R11-C(=NR12)N(R12)R13, -R11-N(R9)-C(=NR12)N(R12)R13, -N(R14)S(O)tR15, -S(O)tOR15, -S(O)pR14, o -S(O)tN(R14)2, donde cada t es en forma independiente 1 o 2 y cada p es 0, 1 o 2; cada R7 y R8 se selecciona en forma independiente entre el grupo que consiste de alquilo, alquenilo, alquinilo, halo, haloalquilo, haloalquenilo,haloalcoxi, cicloalquilo opcionalmente sustituido, cicloalquilalquilo opcionalmente sustituido, arilo opcionalmente sustituido, aralquilo opcionalmente sustituido, aralquenilo opcionalmente sustituido, heterociclilo opcionalmente sustituido,heterociclilalquilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, heteroarilalquilo opcionalmente sustituido, -R11-CN, -R11-NO2, -R11-OR9, -R5-OS(O)2R15, -R11-N(R14)2, -R11-S(O)pR14, -R11-C(O)R14, -R11-C(S)R15, -R11-C(O)OR4, -R11-OC(O)R14, -R11-C(S)OR14, -R11-C(O)N(R14)2, -R11-C(S)N(R14)2, - N=C(R15)2, -R11-N(R14)C(O)R15, -R11-N(R14)C(S)R15, -R11-N(R14)C(O)OR14, -R11-N(R14)C(S)OR14, -R11-N(R14)C(O)N(R14)2, -R11- N(R14)C(S)N(R14)2, -R11-N(R14)S(O)tR14, -R11-N(R14)S(O)tN(R14)2, -R11-S(O)tN(R14)2, -R11-N(R14)C(=NR14)N(R14)2, y -R11-N(R14)C(N=C(R14)2)N(R14)2, donde cada p es en forma independiente 0, 1, o 2 y cada t es en forma independiente 1 o 2; cada R9 es hidrogeno, alquilo, alquenilo, alquinilo,haloalquilo, alcoxialquilo, cicloalquilo opcionalmente sustituido, cicloalquilalquilo opcionalmente sustituido, arilo opcionalmente sustituido, aralquilo opcionalmente sustituido, heterociclilo opcionalmente sustituido, heterociclilalquiloopcionalmente sustituido, heteroarilo opcionalmente sustituido o heteroarilalquilo opcionalmente sustituido; R10 es -C(R9)2-, -S-, -O- o -N(R9)-; cada R11 es en forma independiente un enlace directo o una cadena alquileno lineal o ramificada; cadaR12 y R13 es en forma independiente hidrogeno, alquilo, o -OR9; cada R14 es en forma independiente hidrogeno, alquilo, arilo opcionalmente sustituido, aralquilo opcionalmente sustituido, heteroarilo opcionalmente sustituido o heteroariloopcionalmente sustituido; y cada R15 es alquilo; como un estereoisomero, enantiomero, tautomero del mismo o mezclas de los mismos; o una sal, solvato o prodroga aceptable para uso farmacéutico del mismo.
ARP080100936A 2007-03-07 2008-03-06 Compuestos triciclicos de utilidad en el tratamiento de trastornos por carencia de hierro en el organismo AR065628A1 (es)

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US89358507P 2007-03-07 2007-03-07

Publications (1)

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AR065628A1 true AR065628A1 (es) 2009-06-17

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US (1) US20090069408A1 (es)
EP (1) EP2061755A1 (es)
JP (1) JP2010520884A (es)
CN (1) CN101616892A (es)
AR (1) AR065628A1 (es)
AU (1) AU2008222666A1 (es)
BR (1) BRPI0808043A2 (es)
CA (1) CA2678895A1 (es)
CL (1) CL2008000666A1 (es)
MX (1) MX2009009466A (es)
RU (1) RU2009136996A (es)
TW (1) TW200845961A (es)
WO (1) WO2008109840A1 (es)

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US20100240713A1 (en) * 2007-06-05 2010-09-23 Xenon Pharmaceuticals Inc. Aromatic and heteroaromatic compounds useful in treating iron disorders
US20120196853A1 (en) 2009-08-20 2012-08-02 Vifor (International) Ag Novel Quinoline-Hepcidine Antagonists
AR077958A1 (es) 2009-08-27 2011-10-05 Vifor Int Ag Quinoxalinonas antagonistas de la hepcidina
AR077999A1 (es) 2009-09-02 2011-10-05 Vifor Int Ag Antagonistas de pirimidin y triazin-hepcidina
TW201113274A (en) 2009-09-07 2011-04-16 Vifor Int Ag Novel ethanediamine hepcidine antagonists
TW201111379A (en) 2009-09-09 2011-04-01 Vifor Int Ag Novel thiazole-and oxazole-hepcidine-antagonists
US20120214803A1 (en) 2011-02-18 2012-08-23 Vifor (International) Ag Novel Sulfonaminoquinoline Hepcidin Antagonists
EP3365339A1 (en) 2015-10-23 2018-08-29 Vifor (International) AG Novel ferroportin inhibitors
JOP20180036A1 (ar) 2017-04-18 2019-01-30 Vifor Int Ag أملاح لمثبطات فروبورتين جديدة
TW202102478A (zh) 2019-04-01 2021-01-16 瑞士商威佛（國際）股份有限公司 新穎的鐵螯合物
CN114163417B (zh) * 2021-12-06 2023-08-04 郑州海阔光电材料有限公司 一种3-溴硫芴的合成方法

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US4326525A (en) * 1980-10-14 1982-04-27 Alza Corporation Osmotic device that improves delivery properties of agent in situ
WO1994006802A1 (en) * 1992-09-18 1994-03-31 Yoshitomi Pharmaceutical Industries, Ltd. Thienodiazepine compound and medicinal use thereof
US6310243B1 (en) * 1994-09-23 2001-10-30 Nycomed Imaging As Iodinated x-ray contrast media
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GB9815880D0 (en) * 1998-07-21 1998-09-16 Pfizer Ltd Heterocycles
US20060269498A1 (en) * 2005-05-17 2006-11-30 Gerard Malle Hair shaping composition comprising at least one polyguanidine other than hydroxide
US20100240713A1 (en) * 2007-06-05 2010-09-23 Xenon Pharmaceuticals Inc. Aromatic and heteroaromatic compounds useful in treating iron disorders

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CL2008000666A1 (es) 2008-06-13
US20090069408A1 (en) 2009-03-12
AU2008222666A1 (en) 2008-09-12
CA2678895A1 (en) 2008-09-12
JP2010520884A (ja) 2010-06-17
BRPI0808043A2 (pt) 2014-06-24
WO2008109840A1 (en) 2008-09-12
RU2009136996A (ru) 2011-04-20
EP2061755A1 (en) 2009-05-27
CN101616892A (zh) 2009-12-30
MX2009009466A (es) 2009-09-15
TW200845961A (en) 2008-12-01

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