AR059176A1 - Compuesto de indol, composicion farmaceutica que lo comprende, metodo para prepararlo y su uso para preparar dicha composicion y para la manufactura de un medicamento para el tratamiento o prevencion de leiomiomas y endometriosis. - Google Patents
Compuesto de indol, composicion farmaceutica que lo comprende, metodo para prepararlo y su uso para preparar dicha composicion y para la manufactura de un medicamento para el tratamiento o prevencion de leiomiomas y endometriosis.Info
- Publication number
- AR059176A1 AR059176A1 ARP070100303A ARP070100303A AR059176A1 AR 059176 A1 AR059176 A1 AR 059176A1 AR P070100303 A ARP070100303 A AR P070100303A AR P070100303 A ARP070100303 A AR P070100303A AR 059176 A1 AR059176 A1 AR 059176A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- haloalkyl
- alkenyl
- cycloalkyl
- heteroaryl
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Steroid Compounds (AREA)
- Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
Abstract
Un compuesto de indol de la formula (1): en donde n es 1 o 2; R1 se selecciona de: alquilo C1-6, alquenilo C2-6, alquinilo C2-6, hidroxialquilo C1-6, haloalquilo C1-6, alquilarilo C1-6, alquilheteroarilo C1-6, cicloalquilo C3-8, alquilcicloalquilo C1-6, alquilheterociclilo C1-6, arilo, heteroarilo, alquilo C1-6-O-R9, alquilo C0-6 C(S)R9, alquilo C0-6COR9, -C(O)NR9R10, -SOnR11, en donde cada uno de los cicloalquilo, heterociclilo, arilo, y heteroarilo se enlistan ya sea singularmente o en combinacion con una porcion alquilo son opcionalmente substituidos, con un grupo seleccionado de: halo, -CN, -OH, oxo, alquilo C1-3, haloalquilo C1-3, alquilciano C1-3, alquenilo C2-5, alquilo C0-C3 NO-2, -O-alquilo C1-3, hidroxialquilo C1-3, alquilo C0-3NR12R13, alquilo C0-3C(O)R12, alquilo C0-3C(O)OR12, -C(O)NR12R1 3, -C(S)NR12R13, -CH2OR12, -SR12, -S(O)nR12, -S(O)nNR12R13, -N(R9)C(O)NR12R13, -N(R12)C(O)OR13, -N(R12)S(O)nR13, -N(R12)S(O)nNR12R13, -C=N-OR12, y -cicloCN4R9; con la condicion de que arilo y heteroarilo no son di o tri substituidos con substituyentes alcoxi; R2 se selecciona de H, halo, -CN, alquilo C1-6, haloalquilo C1-8, cicloalquilo C3-8, alquenilo C2-6, alquinilo C2-6, en donde el cicloalquilo es opcionalmente substituido con un grupo seleccionado de: halo, -CN, -OH, oxo, alquilo C1-3, haloalquilo C1-3, cianoalquilo C1-3, alquenilo C2-5, alquilo C0-3-NO-2, -O-alquilo C1-3, y hidroxialquilo C1-3; R3 se selecciona de un arilo opcionalmente substituido o un heteroarilo opcionalmente substituido; en donde el arilo substituido y el heteroarilo substituido se substituye con un grupo seleccionado de: halo, -CN, -OH, oxo, alquilo C1-3, haloalquilo C1-3, alquilciano C1-3, alquenilo C2-5, alquilo C0-3 NO-2, -O-alquilo C1-3, hidroxialquilo C1-3, alquilo C0-3NR12R13, alquilo C0-3C(O)R12, alquilo C0-C3C(O)OR12, -C(O)NR12R13, -C(S)NR12R13, -CH2OR12, -SR12, -S(O)nR12, -S(O)nNR12R13, -N(R9)C(O)NR12R13, -N(R12)C(O)OR13, -N(R12)S(O)nR13, - N(R12)S(O)nNR12R13, y -C=N-OR12; R4, R5, y R7 son cada uno independientemente seleccionados de: H, halo, -OH, -CN, alquilo C1-6, haloalquilo C1-6, alquenilo C2-6, alquinilo C2-6, -O-alquilo C1-6, -O-haloalquilo C1-6; R6 se selecciona de: alquilo C1- 6, haloalquilo C1-6, alquilheterociclilo C1-6, alquilheteroarilo C0-6, cicloalquilo C3-8, alquilcicloalquilo C1-6, alquenilo C2-6, heterociclilo, alquilo C0-6NR9R10, y -N(H)C(O)R9, en donde cada uno de los cicloalquilo, heterociclilo, y heteroarilo se enlistan ya sea singularmente o en combinacion con una porcion alquilo son opcionalmente substituidos con uno o más grupos seleccionados de halo, -CN, -OH, oxo, alquilo C1-3, haloalquilo C1-3, alquilciano C1-3, alquenilo C2-5, alquilo C0-3NO2, -O- alquilo C1-3, y hidroxialquilo C1-3; R8 se selecciona de: H, alquilo C1-4, haloalquilo C1-4; R9 y R10 son individualmente seleccionados de: H, alquilo C1-6, haloalquilo C1-6, alquilheterociclilo C0-6, alquilcicloalquilo C1-6 alquilarilo C1-6, alquilheteroarilo C0-6, hidroxialquilo C1-6, alquenilo C2-6, cicloalquilo C3-8, o R9 y R10 junto con el átomo al cual se enlazan forman un anillo cíclico de 4 hasta 7 miembros que contiene 0-2 heteroátomos y en donde cada uno de los anillo cíclicos, heterociclilo, cicloalquilo, arilo, y heteroarilo se enlistan ya sea singularmente o con una porcion alquilo son opcionalmente substituidos; R11 se selecciona de: alquilo C1-6, -NR9R10, alquilcicloalquilo C0-6, arilo, heteroarilo en donde cada uno de los cicloalquilo, arilo, y heteroarilo se enlistan ya sea singularmente o en combinacion con una porcion alquilo son opcionalmente substituidos con un grupo seleccionado de: halo, -CN, -OH, oxo, alquilo C1-3, haloalquilo C1-3, cianoalquilo C1-3, alquenilo C2-5, alquilo C0-3NO2-, -O- alquilo C1-3, e hidroxialquilo C1-3; R12 y R13 son individualmente seleccionados de: H, alquilo C1-6, haloalquilo C1-6, alquilcicloalquilo C1-6, alquilarilo C1-6, alquilheteroarilo C0-6, hidroxialquilo C1-6, alquenilo C2-6, y cicloalquilo C3-8; o una sal farmacéuticamente aceptable del mismo. Método para su preparacion, composiciones farmacéuticas que lo comprenden, y su uso para prepararlas. El compuesto es util para modular la actividad del receptor de progesterona, en especial sirve para tratar y/o prevenir leiomiomas o las secuelas patologicas debido a endometriosis en un mamífero.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76163706P | 2006-01-24 | 2006-01-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR059176A1 true AR059176A1 (es) | 2008-03-12 |
Family
ID=38180657
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070100303A AR059176A1 (es) | 2006-01-24 | 2007-01-24 | Compuesto de indol, composicion farmaceutica que lo comprende, metodo para prepararlo y su uso para preparar dicha composicion y para la manufactura de un medicamento para el tratamiento o prevencion de leiomiomas y endometriosis. |
Country Status (31)
Country | Link |
---|---|
US (1) | US7932284B2 (es) |
EP (1) | EP1979314B1 (es) |
JP (1) | JP4912414B2 (es) |
KR (1) | KR101126895B1 (es) |
CN (1) | CN101374808B (es) |
AR (1) | AR059176A1 (es) |
AU (1) | AU2007208109B2 (es) |
BR (1) | BRPI0706411A2 (es) |
CA (1) | CA2637933C (es) |
CR (1) | CR10236A (es) |
DK (1) | DK1979314T3 (es) |
DO (1) | DOP2007000018A (es) |
EA (1) | EA014470B1 (es) |
EC (1) | ECSP088641A (es) |
ES (1) | ES2399112T3 (es) |
HK (1) | HK1124328A1 (es) |
HR (1) | HRP20130058T1 (es) |
IL (1) | IL192021A (es) |
MA (1) | MA30207B1 (es) |
MY (1) | MY146494A (es) |
NO (1) | NO20083553L (es) |
NZ (1) | NZ568910A (es) |
PE (1) | PE20071245A1 (es) |
PT (1) | PT1979314E (es) |
SI (1) | SI1979314T1 (es) |
SV (1) | SV2008002986A (es) |
TN (1) | TNSN08311A1 (es) |
TW (1) | TWI368613B (es) |
UA (1) | UA94600C2 (es) |
WO (1) | WO2007087488A2 (es) |
ZA (1) | ZA200805757B (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009094224A1 (en) | 2008-01-25 | 2009-07-30 | Millennium Pharmaceuticals, Inc. | Thiophenes and their use as phosphatidylinositol 3-kinase (pi3k) inhibitors |
CN102395585A (zh) | 2009-01-30 | 2012-03-28 | 米伦纽姆医药公司 | 杂芳基化合物和其作为pi3k抑制剂的用途 |
US9090601B2 (en) | 2009-01-30 | 2015-07-28 | Millennium Pharmaceuticals, Inc. | Thiazole derivatives |
US8796314B2 (en) | 2009-01-30 | 2014-08-05 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
JP5687704B2 (ja) * | 2009-10-07 | 2015-03-18 | カロ バイオ アクチェブラーグ | 新規エストロゲン受容体リガンド |
CA2807971A1 (en) | 2010-08-11 | 2012-02-16 | Millenium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
US9062038B2 (en) | 2010-08-11 | 2015-06-23 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
EP2603216A4 (en) | 2010-08-11 | 2013-12-18 | Millennium Pharm Inc | HETEROARYLE AND USES THEREOF |
UY33671A (es) | 2010-10-13 | 2012-04-30 | Millenium Pharmaceuticals Inc | Heteroarilos y sus usos |
GB201113538D0 (en) | 2011-08-04 | 2011-09-21 | Karobio Ab | Novel estrogen receptor ligands |
AR091731A1 (es) | 2012-07-19 | 2015-02-25 | Merck Sharp & Dohme | Antagonistas del receptor de mineralocorticoides |
MX2016015005A (es) | 2014-05-15 | 2017-09-28 | Iteos Therapeutics | Derivados de pirrolidina-2,5-diona, composiciones farmaceuticas y metodos para usar como inhibidores ido1. |
MA41140A (fr) | 2014-12-12 | 2017-10-17 | Cancer Research Tech Ltd | Dérivés de 2,4-dioxo-quinazoline-6-sulfonamide en tant qu'inhibiteurs de la parg |
CN104529866A (zh) * | 2014-12-12 | 2015-04-22 | 广东东阳光药业有限公司 | 吲哚类衍生物及其在药物上的应用 |
MA41179A (fr) | 2014-12-19 | 2017-10-24 | Cancer Research Tech Ltd | Composés inhibiteurs de parg |
KR102013512B1 (ko) | 2015-03-17 | 2019-08-22 | 화이자 인코포레이티드 | 신규 3-인돌 치환 유도체, 제약 조성물 및 사용 방법 |
EP3334733A1 (en) | 2015-08-10 | 2018-06-20 | Pfizer Inc | 3-indol substituted derivatives, pharmaceutical compositions and methods for use |
CN105906530A (zh) * | 2016-04-27 | 2016-08-31 | 昆药集团股份有限公司 | 一种绿色环保的卤代芳基甲氰的制备方法 |
EP3454945B1 (en) * | 2016-05-12 | 2022-01-19 | The Regents Of The University Of Michigan | Ash1l inhibitors and methods of treatment therewith |
WO2019094773A1 (en) | 2017-11-10 | 2019-05-16 | The Regents Of The University Of Michigan | Ash1l inhibitors and methods of treatment therewith |
CN114903996B (zh) * | 2022-06-22 | 2023-10-20 | 武汉大学中南医院 | Hedgehog通路的特异性抑制剂在制备用于治疗宫腔粘连的药物中的应用 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9317764D0 (en) | 1993-08-26 | 1993-10-13 | Pfizer Ltd | Therapeutic compound |
US5756507A (en) * | 1995-12-14 | 1998-05-26 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
CA2271767A1 (en) * | 1996-11-19 | 1998-05-28 | Nathan B. Mantlo | Aryl and heteroaryl substituted fused pyrrole antiinflammatory agents |
DE19749453A1 (de) | 1997-11-10 | 1999-05-12 | Hoechst Marion Roussel De Gmbh | Sulfonamid-substituierte anellierte 5-Ring-Verbindungen, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
PL343007A1 (en) | 1998-02-25 | 2001-07-30 | Genetics Inst | Inhibitors of phospholipase enzymes |
US6417214B1 (en) * | 1999-05-04 | 2002-07-09 | Wyeth | 3,3-substituted indoline derivatives |
EP1432706A2 (en) | 2001-09-26 | 2004-06-30 | Bayer Pharmaceuticals Corporation | 3-pyridyl or 4-isoquinolinyl thiazoles as c17,20 lyase inhibitors |
ES2187300B1 (es) | 2001-11-14 | 2004-06-16 | Laboratorios Del Dr. Esteve, S.A. | Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos. |
EP1314733A1 (en) | 2001-11-22 | 2003-05-28 | Aventis Pharma Deutschland GmbH | Indole-2-carboxamides as factor Xa inhibitors |
US6933316B2 (en) * | 2001-12-13 | 2005-08-23 | National Health Research Institutes | Indole compounds |
US7247333B2 (en) * | 2003-03-19 | 2007-07-24 | Pepsico Inc. | Stabilized milk product containing fruit and fruit juice |
TW200307542A (en) | 2002-05-30 | 2003-12-16 | Astrazeneca Ab | Novel compounds |
KR20050036982A (ko) | 2002-08-29 | 2005-04-20 | 베링거 인겔하임 파마슈티칼즈, 인코포레이티드 | 염증, 알러지 및 증식성 질환의 치료에 글루코코르티코이드모사체로 사용하기 위한 3-(설폰아미도에틸)-인돌 유도체 |
ES2313002T3 (es) | 2003-05-09 | 2009-03-01 | Laboratorios Del Dr. Esteve, S.A. | Uso de derivados de sulfonamida para la fabricacion de un medicamento para la profilaxis y/o tratamiento de la ingestion de alimentos. |
ES2222832B1 (es) | 2003-07-30 | 2006-02-16 | Laboratorios Del Dr. Esteve, S.A. | Derivados de 6-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos. |
WO2005014543A1 (ja) | 2003-08-06 | 2005-02-17 | Japan Tobacco Inc. | 縮合環化合物及びそのhcvポリメラーゼ阻害剤としての利用 |
WO2005056522A2 (en) | 2003-12-04 | 2005-06-23 | National Health Research Institutes | Indole compounds |
CA2557745A1 (en) | 2004-03-03 | 2005-10-06 | Eli Lilly And Company | Bicyclic substituted indole-derivative steroid hormone nuclear receptor modulators |
JP5070042B2 (ja) | 2004-05-03 | 2012-11-07 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 選択的アンドローゲン受容体モジュレーター(sarms)としての新規インドール化合物 |
AU2005302706B2 (en) | 2004-10-27 | 2011-12-15 | Janssen Pharmaceutica N.V. | Indole derivatives useful as progesterone receptor modulators |
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- 2007-01-17 EP EP07762618A patent/EP1979314B1/en active Active
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- 2007-01-17 BR BRPI0706411-0A patent/BRPI0706411A2/pt not_active IP Right Cessation
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