PE20090620A1 - Derivados de 1,2,4,5-tetrahidro-3h-benzazepinas, su procedimiento de preparacion y las composiciones farmaceuticas que las contienen - Google Patents
Derivados de 1,2,4,5-tetrahidro-3h-benzazepinas, su procedimiento de preparacion y las composiciones farmaceuticas que las contienenInfo
- Publication number
- PE20090620A1 PE20090620A1 PE2008001405A PE2008001405A PE20090620A1 PE 20090620 A1 PE20090620 A1 PE 20090620A1 PE 2008001405 A PE2008001405 A PE 2008001405A PE 2008001405 A PE2008001405 A PE 2008001405A PE 20090620 A1 PE20090620 A1 PE 20090620A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- tetrahidro
- benzazepin
- amine
- preparation procedure
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B55/00—Racemisation; Complete or partial inversion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE 1,2,4,5-TETRAHIDRO-3H-BENZAZEPINAS DE FORMULA (I) DONDE R1 ES H, CICLOALQUILO(C3-C7), BENCILO O ALQUILO(C1-C6); R2, R3, R4 Y R5 SON CADA UNO H, OH, METILO, ALCOXI(C1-C6), ENTRE OTROS; R6, R7, R8 Y R9 SON CADA UNO H, ALCOXI(C1-C6), ENTRE OTROS; X ES O, NH O CH2; m Y p SON CADA UNO 0 O 1; n ES 1 O 2. SON COMPUESTOS PREFERIDOS: N-{[3,4-DIMETOXIBICICLO[4.2.0]OCTA-1,3,5-TRIEN-7-IL]METIL}-3-(7,8-DIMETOXI-1,2,4,5-TETRAHIDRO-3H-3-BENZAZEPIN-3-IL)-N-METIL-3-OXOPROPAN-1-AMINA, N-[2-(5,6-DIMETOXI-2,3-DIHIDRO-1H-INDEN-2-IL)METIL]-3-(7,8-DIMETOXI-1,2,4,5-TETRAHIDRO-3H-3-BENZAZEPIN-3-IL)-3-OXOPROPAN-1-AMINA, N-{[3,4-DIMETOXIBICICLO[4.2.0]OCTA-1,3,5-TRIEN-7-IL]METIL}-3-(7,8-DIMETOXI-1,2,4,5-TETRAHIDRO-3H-3-BENZAZEPIN-3-IL)-N-METIL-4-OXOBUTAN-1-AMINA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS BLOQUEAN LOS CANALES HCN (CANALES ACTIVADOS POR HIPERPOLARIZACION DEPENDIENTES DE NUCLEOTIDOS CICLICOS) SIENDO UTILES EN EL TRATAMIENTO DE CARDIOPATIA ISQUEMICA, INSUFICIENCIA CARDIACA, INFARTO DE MIOCARDIO
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0706346A FR2920773B1 (fr) | 2007-09-11 | 2007-09-11 | Derives de 1,2,4,5-tetrahydro-3h-benzazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20090620A1 true PE20090620A1 (es) | 2009-05-30 |
Family
ID=39323822
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008001405A PE20090620A1 (es) | 2007-09-11 | 2008-08-19 | Derivados de 1,2,4,5-tetrahidro-3h-benzazepinas, su procedimiento de preparacion y las composiciones farmaceuticas que las contienen |
Country Status (45)
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2961105B1 (fr) * | 2010-06-15 | 2013-02-08 | Servier Lab | Utilisation de l'association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion de l'angiotensine pour le traitement de l'insuffisance cardiaque |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
FR2984320B1 (fr) * | 2011-12-20 | 2013-11-29 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
FR2984319B1 (fr) * | 2011-12-20 | 2013-12-27 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
FR2988720B1 (fr) * | 2012-03-27 | 2014-03-14 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
TWI654180B (zh) | 2012-06-29 | 2019-03-21 | 美商艾佛艾姆希公司 | 殺真菌之雜環羧醯胺 |
FR3003859B1 (fr) * | 2013-03-26 | 2015-03-13 | Servier Lab | "procede de synthese de derives de la 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one et application a la synthese de l'ivabradine" |
US9333208B2 (en) | 2013-07-16 | 2016-05-10 | Movses H. Karakossian | HCN inhibitors affecting ganglion cell function and visual function |
FR3020810B1 (fr) * | 2014-05-06 | 2016-05-06 | Servier Lab | Nouveau sel de l'ivabradine et son procede de preparation. |
FR3046793B1 (fr) * | 2016-01-14 | 2018-01-05 | Les Laboratoires Servier | Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US20230140818A1 (en) * | 2017-04-27 | 2023-05-04 | The University Of Hong Kong | Use of hcn inhibitors for treatment of cancer |
CN112724001B (zh) * | 2019-10-28 | 2022-12-13 | 鲁南制药集团股份有限公司 | 一种伊伐布雷定手性中间体化合物 |
CN113372274B (zh) * | 2020-03-10 | 2023-03-24 | 鲁南制药集团股份有限公司 | 一种伊伐布雷定的制备方法 |
CN113372273B (zh) * | 2020-03-10 | 2023-05-09 | 鲁南制药集团股份有限公司 | 一种伊伐布雷定中间体化合物iv |
EP4361143A1 (en) | 2021-08-31 | 2024-05-01 | Eisai R&D Management Co., Ltd. | Method for producing monocyclic pyridine derivative |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3119874A1 (de) * | 1981-05-19 | 1982-12-09 | Dr. Karl Thomae Gmbh, 7950 Biberach | "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel" |
DE3418270A1 (de) * | 1984-05-17 | 1985-11-21 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
GB8707120D0 (en) * | 1987-03-25 | 1987-04-29 | Pfizer Ltd | Antiarrhythmic agents |
JPH02193971A (ja) * | 1989-01-20 | 1990-07-31 | Yamanouchi Pharmaceut Co Ltd | トリ置換―2,3,4,5―テトラヒドロベンズアゼピン誘導体とその中間体 |
FR2681862B1 (fr) * | 1991-09-27 | 1993-11-12 | Adir Cie | Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent. |
EP0700389A1 (en) * | 1993-05-27 | 1996-03-13 | Smithkline Beecham Laboratoires Pharmaceutiques | Anti-arrhythmic n-substituted 3-benzazepines or isoquinolines |
TW527355B (en) * | 1997-07-02 | 2003-04-11 | Bristol Myers Squibb Co | Inhibitors of farnesyl protein transferase |
US6514964B1 (en) * | 1999-09-27 | 2003-02-04 | Amgen Inc. | Fused cycloheptane and fused azacycloheptane compounds and their methods of use |
FR2882554B1 (fr) * | 2005-02-28 | 2007-05-04 | Servier Lab | Forme critalline beta d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
FR2894826B1 (fr) | 2005-12-21 | 2010-10-22 | Servier Lab | Nouvelle association d'un inhibiteur du courant if sinusal et d'un inhibiteur calcique et les compositions pharmaceutiques qui la contiennent |
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2007
- 2007-09-11 FR FR0706346A patent/FR2920773B1/fr not_active Expired - Fee Related
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2008
- 2008-08-19 PE PE2008001405A patent/PE20090620A1/es active IP Right Grant
- 2008-08-20 CR CR10229A patent/CR10229A/es unknown
- 2008-08-20 SG SG200806160-8A patent/SG151172A1/en unknown
- 2008-08-21 UY UY31305A patent/UY31305A1/es active IP Right Grant
- 2008-08-26 AP AP2008004589A patent/AP2384A/xx active
- 2008-08-27 MY MYPI20083304A patent/MY143079A/en unknown
- 2008-08-28 AU AU2008207585A patent/AU2008207585B2/en not_active Ceased
- 2008-09-01 MX MX2008011164A patent/MX2008011164A/es active IP Right Grant
- 2008-09-02 CA CA2639349A patent/CA2639349C/fr not_active Expired - Fee Related
- 2008-09-02 TW TW097133661A patent/TWI374029B/zh not_active IP Right Cessation
- 2008-09-03 ZA ZA2008/07586A patent/ZA200807586B/en unknown
- 2008-09-04 UA UAA200810902A patent/UA100003C2/ru unknown
- 2008-09-05 JP JP2008227956A patent/JP4932805B2/ja not_active Expired - Fee Related
- 2008-09-08 CL CL2008002654A patent/CL2008002654A1/es unknown
- 2008-09-08 HN HN2008001393A patent/HN2008001393A/es unknown
- 2008-09-08 MA MA31219A patent/MA30315B1/fr unknown
- 2008-09-09 AR ARP080103906A patent/AR068386A1/es active IP Right Grant
- 2008-09-09 US US12/283,110 patent/US8076325B2/en not_active Expired - Fee Related
- 2008-09-09 PA PA20088795301A patent/PA8795301A1/es unknown
- 2008-09-10 KR KR1020080089213A patent/KR101078076B1/ko active IP Right Grant
- 2008-09-10 JO JO2008404A patent/JO2652B1/en active
- 2008-09-10 EC EC2008008731A patent/ECSP088731A/es unknown
- 2008-09-10 NZ NZ571143A patent/NZ571143A/en not_active IP Right Cessation
- 2008-09-10 NI NI200800247A patent/NI200800247A/es unknown
- 2008-09-10 EA EA200801828A patent/EA014756B1/ru unknown
- 2008-09-10 SA SA08290567A patent/SA08290567B1/ar unknown
- 2008-09-11 DK DK08290851.8T patent/DK2036892T3/da active
- 2008-09-11 CN CN2008102135506A patent/CN101386594B/zh not_active Expired - Fee Related
- 2008-09-11 EP EP08290851A patent/EP2036892B1/fr active Active
- 2008-09-11 PL PL08290851T patent/PL2036892T3/pl unknown
- 2008-09-11 ME MEP-2010-45A patent/ME00981B/me unknown
- 2008-09-11 SI SI200830030T patent/SI2036892T1/sl unknown
- 2008-09-11 WO PCT/FR2008/001268 patent/WO2009066041A2/fr active Application Filing
- 2008-09-11 AT AT08290851T patent/ATE460401T1/de active
- 2008-09-11 CU CU20080165A patent/CU23706B7/es active IP Right Grant
- 2008-09-11 PT PT08290851T patent/PT2036892E/pt unknown
- 2008-09-11 CO CO08095781A patent/CO6020016A1/es active IP Right Grant
- 2008-09-11 DE DE602008000786T patent/DE602008000786D1/de active Active
- 2008-09-11 BR BRPI0804091A patent/BRPI0804091B8/pt not_active IP Right Cessation
- 2008-09-11 ES ES08290851T patent/ES2342511T3/es active Active
- 2008-09-11 RS RSP-2010/0245A patent/RS51305B/sr unknown
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2009
- 2009-08-24 HK HK09107750.6A patent/HK1129667A1/xx not_active IP Right Cessation
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2010
- 2010-05-11 HR HR20100259T patent/HRP20100259T1/hr unknown
- 2010-05-17 CY CY20101100438T patent/CY1110034T1/el unknown
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