PE20070011A1 - Formulaciones farmaceuticas de compuestos inhibidores de proteasa del vhc o catepsina - Google Patents
Formulaciones farmaceuticas de compuestos inhibidores de proteasa del vhc o catepsinaInfo
- Publication number
- PE20070011A1 PE20070011A1 PE2006000582A PE2006000582A PE20070011A1 PE 20070011 A1 PE20070011 A1 PE 20070011A1 PE 2006000582 A PE2006000582 A PE 2006000582A PE 2006000582 A PE2006000582 A PE 2006000582A PE 20070011 A1 PE20070011 A1 PE 20070011A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- catepsin
- hcv protease
- amino
- pharmaceutical formulations
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A61P37/00—Drugs for immunological or allergic disorders
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE: A) UN COMPUESTO DE FORMULAS I A XXVI, QUE SIGUEN LA FORMULA (I), EN DONDE Y ES ALQUILO, ALQUIL-ARILO, HETEROARILO, ENTRE OTROS; R1 ES CF3, C2F5, C3F7, ENTRE OTROS; R2, R3 Y R4 SON H, ALQUILO(C1-C10); ALQUENILO(C2-C10), ENTRE OTROS; W ES C=O, C=S, C(=N-CN), ENTRE OTROS; Z ES O, N, CH, ENTRE OTROS; Q ES CH, N, P, ENTRE OTROS; A ES O, CH2, SO2, ENTRE OTROS; E ES CH, N, CR, ENTRE OTROS; G ES (CH2)p, (CHR)p, DONDE p ES 0 A 6; J ES NH, SO2, ALQUILOXI, ALQUILO, ENTRE OTROS; L ES CH, O, S, ENTRE OTROS; M ES O, S, SO2, ENTRE OTROS; SIENDO SELECCIONADO: (1R,2S,5S)-N-[(1S)-3-AMINO-1-(CICLOBUTIL)-2,3-DIOXOPROPIL]-3-[(2S)-2-[[[(1,1-DIMETILETIL)AMINO]-CARBONIL]AMINO]-3,3-DIMETIL-1-OXOBUTIL]-6,6-DIMETIL-3-AZABICICLO[3.1.0]HEXAN-2-CARBOXAMIDA, ENTRE OTROS, EN UNA CANTIDAD COMPRENDIDA ENTRE 50 A 1000 mg, LOS CUALES TIENE ACTIVIDAD COMO INHIBIDORES DE PROTEASA DEL VHC O CATEPSINA Y B) UN TENSIOACTIVO SELECCIONADO ENTRE LAURIL SULFATO DE SODIO, ACIDO ESTEARICO, MONOETANOLAMINA, ENTRE OTROS; EN UNA CANTIDAD COMPRENDIDA ENTRE 0,1 A 10% EN PESO DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO DE TRASTORNOS ASOCIADOS CON EL VIRUS DE LA HEPATITIS C (VHC)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68694505P | 2005-06-02 | 2005-06-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20070011A1 true PE20070011A1 (es) | 2007-03-08 |
Family
ID=37482240
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006000582A PE20070011A1 (es) | 2005-06-02 | 2006-05-31 | Formulaciones farmaceuticas de compuestos inhibidores de proteasa del vhc o catepsina |
Country Status (17)
Country | Link |
---|---|
US (1) | US7772178B2 (es) |
EP (1) | EP1919478B1 (es) |
JP (2) | JP5160415B2 (es) |
KR (1) | KR20080021634A (es) |
CN (1) | CN101212970B (es) |
AR (1) | AR055198A1 (es) |
AU (1) | AU2006252553B2 (es) |
BR (1) | BRPI0610737A2 (es) |
CA (1) | CA2611155A1 (es) |
ES (1) | ES2572980T3 (es) |
MX (1) | MX2007015270A (es) |
NO (1) | NO20076613L (es) |
NZ (1) | NZ563365A (es) |
PE (1) | PE20070011A1 (es) |
TW (1) | TWI428138B (es) |
WO (1) | WO2006130628A2 (es) |
ZA (1) | ZA200709987B (es) |
Families Citing this family (55)
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MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
PT1730110E (pt) | 2004-02-27 | 2010-09-14 | Schering Corp | Compostos de enxofre como inibidores de serina-protease ns3 do vírus da hepatite c |
US7816326B2 (en) * | 2004-02-27 | 2010-10-19 | Schering Corporation | Sulfur compounds as inhibitors of hepatitis C virus NS3 serine protease |
WO2006130686A2 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Hcv protease inhibitors in combination with food |
EA019888B1 (ru) * | 2005-07-25 | 2014-07-30 | Интермьюн, Инк. | Промежуточное соединение для получения макроциклических ингибиторов репликации вируса гепатита с и способ его синтеза |
DK1999129T3 (da) | 2005-10-11 | 2011-02-07 | Intermune Inc | Forbindelser og fremgangsmåder til inhibering af replikationen af hepatitis C-virus |
WO2007120595A2 (en) * | 2006-04-11 | 2007-10-25 | Novartis Ag | Amines for the treatment of hcv |
US8420122B2 (en) | 2006-04-28 | 2013-04-16 | Merck Sharp & Dohme Corp. | Process for the precipitation and isolation of 6,6-dimethyl-3-aza-bicyclo [3.1.0] hexane-amide compounds by controlled precipitation and pharmaceutical formulations containing same |
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JP5755449B2 (ja) | 2007-12-21 | 2015-07-29 | セルジーン アビロミクス リサーチ, インコーポレイテッド | Hcvプロテアーゼ阻害剤およびその使用 |
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PE20091522A1 (es) * | 2007-12-21 | 2009-10-29 | Novartis Ag | Composicion farmaceutica solida que contiene 3-(1.h-indol-3-il)-4-[2-(4-metil-piperazin-1-il)-quinazolin-4-il]-quinazolin-4-il]-pirrol-2,5-diona |
US8163921B2 (en) | 2008-04-16 | 2012-04-24 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
WO2009148923A1 (en) | 2008-05-29 | 2009-12-10 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
US7964560B2 (en) | 2008-05-29 | 2011-06-21 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US20110207660A1 (en) * | 2008-08-07 | 2011-08-25 | Schering Corporation | Pharmaceutical formulations of an hcv protease inhibitor in a solid molecular dispersion |
US8188137B2 (en) | 2008-08-15 | 2012-05-29 | Avila Therapeutics, Inc. | HCV protease inhibitors and uses thereof |
US8207341B2 (en) | 2008-09-04 | 2012-06-26 | Bristol-Myers Squibb Company | Process or synthesizing substituted isoquinolines |
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2006
- 2006-05-31 BR BRPI0610737-0A patent/BRPI0610737A2/pt not_active IP Right Cessation
- 2006-05-31 AR ARP060102260A patent/AR055198A1/es unknown
- 2006-05-31 NZ NZ563365A patent/NZ563365A/en not_active IP Right Cessation
- 2006-05-31 EP EP06760571.7A patent/EP1919478B1/en active Active
- 2006-05-31 US US11/444,078 patent/US7772178B2/en not_active Expired - Fee Related
- 2006-05-31 AU AU2006252553A patent/AU2006252553B2/en not_active Ceased
- 2006-05-31 KR KR1020077028243A patent/KR20080021634A/ko not_active Application Discontinuation
- 2006-05-31 JP JP2008514785A patent/JP5160415B2/ja not_active Expired - Fee Related
- 2006-05-31 PE PE2006000582A patent/PE20070011A1/es not_active Application Discontinuation
- 2006-05-31 MX MX2007015270A patent/MX2007015270A/es active IP Right Grant
- 2006-05-31 ES ES06760571.7T patent/ES2572980T3/es active Active
- 2006-05-31 CN CN2006800195249A patent/CN101212970B/zh not_active Expired - Fee Related
- 2006-05-31 CA CA002611155A patent/CA2611155A1/en not_active Abandoned
- 2006-05-31 WO PCT/US2006/021003 patent/WO2006130628A2/en active Application Filing
- 2006-06-01 TW TW095119307A patent/TWI428138B/zh not_active IP Right Cessation
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2007
- 2007-11-19 ZA ZA200709987A patent/ZA200709987B/xx unknown
- 2007-12-21 NO NO20076613A patent/NO20076613L/no not_active Application Discontinuation
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2012
- 2012-09-19 JP JP2012205626A patent/JP2012250996A/ja active Pending
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CA2611155A1 (en) | 2006-12-07 |
WO2006130628A2 (en) | 2006-12-07 |
AR055198A1 (es) | 2007-08-08 |
EP1919478B1 (en) | 2016-03-23 |
MX2007015270A (es) | 2008-02-21 |
AU2006252553B2 (en) | 2012-03-29 |
ES2572980T3 (es) | 2016-06-03 |
JP2012250996A (ja) | 2012-12-20 |
US7772178B2 (en) | 2010-08-10 |
NZ563365A (en) | 2011-02-25 |
JP5160415B2 (ja) | 2013-03-13 |
CN101212970B (zh) | 2010-07-21 |
WO2006130628A3 (en) | 2007-09-13 |
US20070010431A1 (en) | 2007-01-11 |
EP1919478A2 (en) | 2008-05-14 |
KR20080021634A (ko) | 2008-03-07 |
CN101212970A (zh) | 2008-07-02 |
TW200716157A (en) | 2007-05-01 |
AU2006252553A1 (en) | 2006-12-07 |
BRPI0610737A2 (pt) | 2010-07-20 |
TWI428138B (zh) | 2014-03-01 |
JP2008542383A (ja) | 2008-11-27 |
ZA200709987B (en) | 2008-11-26 |
NO20076613L (no) | 2008-03-03 |
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