PE20040644A1 - Nuevos derivados de quinuclidina-amina - Google Patents

Nuevos derivados de quinuclidina-amina

Info

Publication number
PE20040644A1
PE20040644A1 PE2003000662A PE2003000662A PE20040644A1 PE 20040644 A1 PE20040644 A1 PE 20040644A1 PE 2003000662 A PE2003000662 A PE 2003000662A PE 2003000662 A PE2003000662 A PE 2003000662A PE 20040644 A1 PE20040644 A1 PE 20040644A1
Authority
PE
Peru
Prior art keywords
azabicycle
oct
hydroxy
quinuclidine
phenyl
Prior art date
Application number
PE2003000662A
Other languages
English (en)
Inventor
Quinones Maria Prat
Original Assignee
Almirall Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Ag filed Critical Almirall Ag
Publication of PE20040644A1 publication Critical patent/PE20040644A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Abstract

REFERIDO AL PROCEDIMIENTO DE PREPARACION DE COMPOSICIONES FARMACEUTICAS ANTAGONISTAS DE RECEPTORES MUSCARINICOS M3 QUE CONTIENEN UN COMPUESTO DERIVADO DE QUINUCLIDINA-AMIDA DE FORMULA I DONDE R1 ES H, ALQUILO INFERIOR LINEAL O RAMIFICADO; R2 ES (A) Y (B); R3 ES FENILO, 2-FURILO, 2-TIENILO, ENTRE OTROS; R4 ES FENILO, FENETILO, CICLOALQUILMETILO, ENTRE OTROS; R5 ES H, HIDROXI, METILO, ENTRE OTROS; P ES 1-2; Q ES ENLACE SENCILLO, -CH2-, -O-, ENTRE OTROS. TAMBIEN SE REFIERE A SU SAL CUATERNARIA. SON COMPUESTOS PREFERIDOS: N-(1-AZABICICLO[2.2.2]OCT-3-IL)-2-HIDROXI-2,2-DITIEN-2-ILACETAMIDA; N-[(3R)-1-AZABICICLO[2.2.2]OCT-3-IL]-2-HIDROXI-2-TIEN-2-ILPENT-4-ENAMIDA Y N-[(3R)-1-AZABICICLO[2.2.2]OCT-3-IL]-2,3-DIFENILPROPANAMIDA, ENTRE OTROS. DICHOS COMPUESTOS SON UTILES EN TRASTORNOS UROLOGICOS, GASTROINSTITNALES Y RESPIRATORIOS
PE2003000662A 2002-07-02 2003-06-30 Nuevos derivados de quinuclidina-amina PE20040644A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200201539A ES2204295B1 (es) 2002-07-02 2002-07-02 Nuevos derivados de quinuclidina-amida.

Publications (1)

Publication Number Publication Date
PE20040644A1 true PE20040644A1 (es) 2004-09-18

Family

ID=30011350

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000662A PE20040644A1 (es) 2002-07-02 2003-06-30 Nuevos derivados de quinuclidina-amina

Country Status (24)

Country Link
US (2) US7488735B2 (es)
EP (1) EP1519933B1 (es)
JP (1) JP2005533826A (es)
CN (1) CN100404533C (es)
AR (1) AR040351A1 (es)
AT (1) ATE467631T1 (es)
AU (1) AU2003242757B2 (es)
BR (1) BR0312216A (es)
CA (1) CA2492535A1 (es)
DE (1) DE60332534D1 (es)
EC (1) ECSP045519A (es)
ES (1) ES2204295B1 (es)
IL (1) IL165923A (es)
MX (1) MXPA04012271A (es)
MY (1) MY130803A (es)
NO (1) NO20050164L (es)
NZ (1) NZ537341A (es)
PE (1) PE20040644A1 (es)
RU (1) RU2314306C2 (es)
TW (1) TW200402420A (es)
UA (1) UA80832C2 (es)
UY (1) UY27870A1 (es)
WO (1) WO2004005285A1 (es)
ZA (1) ZA200410404B (es)

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Also Published As

Publication number Publication date
US20080234316A1 (en) 2008-09-25
EP1519933B1 (en) 2010-05-12
MXPA04012271A (es) 2005-04-08
CN100404533C (zh) 2008-07-23
AU2003242757B2 (en) 2009-01-08
RU2005102585A (ru) 2005-10-10
ATE467631T1 (de) 2010-05-15
US7718670B2 (en) 2010-05-18
MY130803A (en) 2007-07-31
US7488735B2 (en) 2009-02-10
AU2003242757A1 (en) 2004-01-23
RU2314306C2 (ru) 2008-01-10
AR040351A1 (es) 2005-03-30
UA80832C2 (en) 2007-11-12
BR0312216A (pt) 2005-04-12
UY27870A1 (es) 2003-10-31
NZ537341A (en) 2006-04-28
TW200402420A (en) 2004-02-16
EP1519933A1 (en) 2005-04-06
WO2004005285A1 (en) 2004-01-15
ES2204295B1 (es) 2005-08-01
NO20050164L (no) 2005-04-04
CN1678610A (zh) 2005-10-05
ECSP045519A (es) 2005-03-10
ZA200410404B (en) 2005-09-05
IL165923A0 (en) 2006-01-15
US20060167042A1 (en) 2006-07-27
IL165923A (en) 2010-06-30
ES2204295A1 (es) 2004-04-16
DE60332534D1 (de) 2010-06-24
CA2492535A1 (en) 2004-01-15
JP2005533826A (ja) 2005-11-10

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