GB1246606A - Dibenzo-azepine derivatives - Google Patents

Dibenzo-azepine derivatives

Info

Publication number
GB1246606A
GB1246606A GB1836270A GB1836270A GB1246606A GB 1246606 A GB1246606 A GB 1246606A GB 1836270 A GB1836270 A GB 1836270A GB 1836270 A GB1836270 A GB 1836270A GB 1246606 A GB1246606 A GB 1246606A
Authority
GB
United Kingdom
Prior art keywords
iminodibenzyl
chlorocarbonyl
dehydrobromination
dibenzo
azepine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1836270A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STAROGARDZKIE ZAKL FARMA
Original Assignee
STAROGARDZKIE ZAKL FARMA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PL133242A external-priority patent/PL64802B1/pl
Application filed by STAROGARDZKIE ZAKL FARMA filed Critical STAROGARDZKIE ZAKL FARMA
Publication of GB1246606A publication Critical patent/GB1246606A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/26—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a double bond between positions 10 and 11

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1,246,606. Dibenzazepine derivatives. STAROGARDZKIE ZAKLADY FARMACEUTYCZNE "POLFA". 17 April, 1970 [28 April, 1969], No. 18362/70. Heading C2C. The novel compound, 5 .chlorocarbonyl - 10- bromo-iminodibenzyl, is prepared by reacting iminodibenzyl with phosgene and treating the resulting 5 - chlorocarbonyl - iminodibenzyl with a brominating agent, preferably 1,3- dibromo-5,5-dimethylhydantoin. 5 - Carbamoyl - 5H - dibenzo - [b,f] - azepine is prepared by dehydrobromination and amidation of 5-chlorocarbonyl.10-bromo-iminodibenzyl. The dehydrobromination and amidation may be effected simultaneously by treatment with ammonia. Alternatively, dehydrobromination may first be effected, e.g. by heating in the presence of a polyamide such as polycaprolactam and preferably also in the presence of an alkali metal or alkaline earth metal salt of a weak acid, to produce 5-chlorocarbonyl-5H- dibem-[b,f]-azepine and this compound then amidated by treatment with ammonia.
GB1836270A 1969-04-28 1970-04-17 Dibenzo-azepine derivatives Expired GB1246606A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL133242A PL64802B1 (en) 1969-04-28

Publications (1)

Publication Number Publication Date
GB1246606A true GB1246606A (en) 1971-09-15

Family

ID=19950545

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1836270A Expired GB1246606A (en) 1969-04-28 1970-04-17 Dibenzo-azepine derivatives

Country Status (2)

Country Link
JP (1) JPS5022035B1 (en)
GB (1) GB1246606A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4307181C1 (en) * 1993-03-08 1994-11-10 Dresden Arzneimittel Process for the preparation of 5H-dibenz[b,f]azepine-5-carboxamide
DE4421294A1 (en) * 1994-06-17 1995-12-21 Chemie Linz Deutschland Carbamazepine mfr.
WO2007025709A2 (en) * 2005-08-31 2007-03-08 Novartis Ag Organic compounds
US7208501B2 (en) 2000-12-22 2007-04-24 Almirall Prodesfarma Ag Quinuclidine carbamate derivatives and their use as M3 antagonists
US7435742B2 (en) 2002-06-21 2008-10-14 Laboratorios Almirall S.A. Quinuclidine derivatives and pharmaceutical compositions containing the same
US7718670B2 (en) 2002-07-02 2010-05-18 Laboratorios Almirall S.A Quinuclidine amide derivatives
WO2020157257A1 (en) 2019-02-01 2020-08-06 H. Lundbeck A/S Injectable carbamazepine composition essentially free of 10-br-carbamazepine

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5320042U (en) * 1976-07-29 1978-02-20
JPS5420150U (en) * 1977-07-13 1979-02-08

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4307181C1 (en) * 1993-03-08 1994-11-10 Dresden Arzneimittel Process for the preparation of 5H-dibenz[b,f]azepine-5-carboxamide
DE4421294A1 (en) * 1994-06-17 1995-12-21 Chemie Linz Deutschland Carbamazepine mfr.
US7208501B2 (en) 2000-12-22 2007-04-24 Almirall Prodesfarma Ag Quinuclidine carbamate derivatives and their use as M3 antagonists
US7312231B2 (en) 2000-12-22 2007-12-25 Almirall Prodesfarma Ag Quinuclidine carbamate derivatives and their use as M3 antagonists
US7776879B2 (en) 2000-12-22 2010-08-17 Almirall, S.A. Quinuclidine carbamate derivatives and their use as M3 antagonists
US7435742B2 (en) 2002-06-21 2008-10-14 Laboratorios Almirall S.A. Quinuclidine derivatives and pharmaceutical compositions containing the same
US7718670B2 (en) 2002-07-02 2010-05-18 Laboratorios Almirall S.A Quinuclidine amide derivatives
WO2007025709A2 (en) * 2005-08-31 2007-03-08 Novartis Ag Organic compounds
WO2007025709A3 (en) * 2005-08-31 2007-05-10 Novartis Ag Organic compounds
EP2096104A1 (en) * 2005-08-31 2009-09-02 Novartis AG Organic diamines as mGluR7 modulators
WO2020157257A1 (en) 2019-02-01 2020-08-06 H. Lundbeck A/S Injectable carbamazepine composition essentially free of 10-br-carbamazepine
US11529357B2 (en) 2019-02-01 2022-12-20 H. Lundbeck A/S Injectable carbamazepine composition essentially free of 10-bromo-carbamazepine

Also Published As

Publication number Publication date
JPS5022035B1 (en) 1975-07-28

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