GB1250677A - - Google Patents
Info
- Publication number
- GB1250677A GB1250677A GB1250677DA GB1250677A GB 1250677 A GB1250677 A GB 1250677A GB 1250677D A GB1250677D A GB 1250677DA GB 1250677 A GB1250677 A GB 1250677A
- Authority
- GB
- United Kingdom
- Prior art keywords
- reacting
- salt
- aug
- salts
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003839 salts Chemical class 0.000 abstract 4
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 abstract 2
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 abstract 1
- FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
- 230000026030 halogenation Effects 0.000 abstract 1
- 238000005658 halogenation reaction Methods 0.000 abstract 1
- 150000002440 hydroxy compounds Chemical class 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 150000004764 thiosulfuric acid derivatives Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
Abstract
1,250,677. Thiazolylcarbamoyl - ethylaminoethylthiosulphate and salts thereof. PARKE DAVIS & CO. 4 Aug., 1969 [5 Aug., 1968], No. 39002/69. Heading C2C. Novel, therapeutic, title compound I (ineluding salts thereof; the internal salt form of (I) is also illustrated) is obtained: (a) by reacting (II) (X is Cl or Br) with NH 2 .CH 2 CH 2 .S.SO 3 -M<SP>+</SP> (M is an alkali metal); (b) by reacting compound III (obtained by halogenation of the corresponding hydroxy compound which is itself obtained by interaction of 2-aminoethanol and (II), e.g. where X is Cl) with a thiosulphate salt; or (c) by reacting compound IV (obtained by interacting ethyleneimine and II, e.g. where X is Cl) with thiosulphuric acid or a salt thereof.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75002068A | 1968-08-05 | 1968-08-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1250677A true GB1250677A (en) | 1971-10-20 |
Family
ID=25016179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1250677D Expired GB1250677A (en) | 1968-08-05 | 1969-08-04 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US3553227A (en) |
| BR (1) | BR6911276D0 (en) |
| DE (1) | DE1939639A1 (en) |
| FR (1) | FR2015068B1 (en) |
| GB (1) | GB1250677A (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4217355A (en) * | 1978-04-24 | 1980-08-12 | Pfizer Inc. | Amide therapeutic agents |
| EP0880511A4 (en) * | 1996-01-16 | 1999-06-16 | Merck & Co Inc | Integrin receptor antagonists |
| US5952306A (en) * | 1996-01-16 | 1999-09-14 | Merck & Co., Inc. | Integrin receptor antagonists |
| US6294549B1 (en) | 1997-07-23 | 2001-09-25 | Merck & Co., Inc. | Method for eliciting an αvβ5 or dual αvβ3/αvβ5 antagonizing effect |
-
1968
- 1968-08-05 US US750020A patent/US3553227A/en not_active Expired - Lifetime
-
1969
- 1969-08-04 DE DE19691939639 patent/DE1939639A1/en active Pending
- 1969-08-04 FR FR696926691A patent/FR2015068B1/fr not_active Expired
- 1969-08-04 BR BR211276/69A patent/BR6911276D0/en unknown
- 1969-08-04 GB GB1250677D patent/GB1250677A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| US3553227A (en) | 1971-01-05 |
| FR2015068A1 (en) | 1970-04-24 |
| BR6911276D0 (en) | 1973-02-13 |
| DE1939639A1 (en) | 1970-02-12 |
| FR2015068B1 (en) | 1973-07-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |