BR0215348A - Derivados de carbamato de 1-alquil-1-azoniabiciclo[2-2]octano e uso destes como antagonistas do receptor muscarìnico - Google Patents

Derivados de carbamato de 1-alquil-1-azoniabiciclo[2-2]octano e uso destes como antagonistas do receptor muscarìnico

Info

Publication number
BR0215348A
BR0215348A BR0215348-3A BR0215348A BR0215348A BR 0215348 A BR0215348 A BR 0215348A BR 0215348 A BR0215348 A BR 0215348A BR 0215348 A BR0215348 A BR 0215348A
Authority
BR
Brazil
Prior art keywords
alkyl
octane
receptor antagonists
receptor
cycloalkyl
Prior art date
Application number
BR0215348-3A
Other languages
English (en)
Inventor
Juan Lorenzo Catena Ruiz
Carles Ferrerons Gallemi
Anna Fernandez Serrat
Ignacio Jose Miquel Bono
Dolors Balsa Lopez
Carmen Lagunas Arnal
Carolina Salcedo Roca
Natividad Toledo Mesa
Andres Fernandez Garcia
Original Assignee
S A L V A T Lab Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by S A L V A T Lab Sa filed Critical S A L V A T Lab Sa
Publication of BR0215348A publication Critical patent/BR0215348A/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"DERIVADOS DE CARBANATO DE 1-ALQUIL-1-AZONIABICICLO[2.2]OCTANO E USO DESTES COMO ANTAGONISTAS DO RECEPTOR MUSCARìNIO". Refere-se o presente invento a carbamatos de fórmula geral (I): em que R1, R2 e R3 são H, OH, NO~ 2~, SH, CN, F, Cl, Br, I, COOH, CONH~ 2~, (C~1-~C~ 4~)alquiloxicarbonila, (C~ 1~-C~ 4~)alquilsulfanila, (C~ 1-C~ 4~)alquilsulfinila, (C~ 1~-C~ 4~)alquilsulfonila, (C~ 1~-C~ 4~)alcoxila opcionalmente substituído com um ou vários F, e (C~ 1~-C~ 4~)alquila opcionalmente substituído com um ou vários F ou OH; R4 é cicloalquila, fenila, heteroarila ou um sistema de anéis bicíclico; R5 é uma cicloalquila, (C~ 5~-C~ 10~)-alquila, ou uma (C~ 1~-C~ 10~)alquila substituída; e X^ - ^ é um ânion fisiologicamente aceito. O carbamato (I) é um antagonista seletivo ao receptor M~ 3~ versus o receptor M~ 2~ e pode ser usado para o tratamento de incontinência urinária (particularmente, aquela causada por uma bexiga sobreativa), síndrome do intestino irritável, e desordens respiratórias (particularmente, doenças pulmonares obstrutivas crónicas, bronquite crónica, asma, enfisema e rinite), bem como em intervenções oftálmicas.
BR0215348-3A 2001-12-20 2002-12-18 Derivados de carbamato de 1-alquil-1-azoniabiciclo[2-2]octano e uso destes como antagonistas do receptor muscarìnico BR0215348A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200200043 2001-12-20
PCT/EP2002/014470 WO2003053966A2 (en) 2001-12-20 2002-12-18 1-alkyl-1-azoniabicyclo [2.2.2] octane carbamate derivatives and their use as muscarinic receptor antagonists

Publications (1)

Publication Number Publication Date
BR0215348A true BR0215348A (pt) 2004-11-16

Family

ID=32480019

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0215348-3A BR0215348A (pt) 2001-12-20 2002-12-18 Derivados de carbamato de 1-alquil-1-azoniabiciclo[2-2]octano e uso destes como antagonistas do receptor muscarìnico

Country Status (21)

Country Link
US (1) US7452904B2 (pt)
EP (1) EP1461336B1 (pt)
JP (1) JP4505227B2 (pt)
KR (1) KR100944580B1 (pt)
CN (1) CN1832948B (pt)
BR (1) BR0215348A (pt)
CA (1) CA2470956C (pt)
EA (1) EA006505B1 (pt)
ES (1) ES2425347T3 (pt)
GE (1) GEP20063958B (pt)
HK (1) HK1070057A1 (pt)
HR (1) HRP20040661A2 (pt)
HU (1) HUP0500107A3 (pt)
IL (1) IL162596A0 (pt)
MA (1) MA26385A1 (pt)
MX (1) MXPA04006206A (pt)
NO (1) NO329664B1 (pt)
PL (1) PL211250B1 (pt)
RS (1) RS52522B (pt)
UA (1) UA76571C2 (pt)
WO (1) WO2003053966A2 (pt)

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HUP0500107A3 (en) 2011-05-30
CA2470956C (en) 2011-08-02
NO20043064L (no) 2004-09-17
RS52522B (en) 2013-04-30
US7452904B2 (en) 2008-11-18
HRP20040661A2 (en) 2005-06-30
KR100944580B1 (ko) 2010-02-25
JP4505227B2 (ja) 2010-07-21
ES2425347T3 (es) 2013-10-14
EA006505B1 (ru) 2005-12-29
EA200400832A1 (ru) 2004-12-30
IL162596A0 (en) 2005-11-20
WO2003053966A2 (en) 2003-07-03
JP2005516954A (ja) 2005-06-09
HK1070057A1 (pt) 2005-06-10
EP1461336B1 (en) 2013-05-22
MA26385A1 (fr) 2004-11-01
HUP0500107A2 (hu) 2005-05-30
GEP20063958B (en) 2006-11-10
KR20040091614A (ko) 2004-10-28
AU2002361158A1 (en) 2003-07-09
RS53904A (en) 2006-12-15
PL370972A1 (en) 2005-06-13
UA76571C2 (en) 2006-08-15
US20050043349A1 (en) 2005-02-24
NO329664B1 (no) 2010-11-29
CN1832948B (zh) 2011-06-15
EP1461336A2 (en) 2004-09-29
WO2003053966A3 (en) 2003-11-13
PL211250B1 (pl) 2012-04-30
CN1832948A (zh) 2006-09-13
WO2003053966A8 (en) 2004-06-24
CA2470956A1 (en) 2003-07-03
MXPA04006206A (es) 2004-12-06

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