DK2583677T1 - Fremgangsmåder til behandling af HCV omfattende mindst to direktevirkende antivirale midler, ribavirin, men ikke inteferon - Google Patents

Fremgangsmåder til behandling af HCV omfattende mindst to direktevirkende antivirale midler, ribavirin, men ikke inteferon Download PDF

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DK2583677T1
DK2583677T1 DK12189198.0T DK12189198T DK2583677T1 DK 2583677 T1 DK2583677 T1 DK 2583677T1 DK 12189198 T DK12189198 T DK 12189198T DK 2583677 T1 DK2583677 T1 DK 2583677T1
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treatment
combination
compound
hcv genotype
interferon
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DK12189198.0T
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Barry M Bernstein
Rajeev M Menon
Amit Khatri
Sven Mensing
Sandeep Dutta
Daniel E Cohen
Thomas Podsadecki
Scott C Brun
Walid M Awni
Emily O Dumas
Cheri E Klein
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Abbvie Inc
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Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of DK2583677T1 publication Critical patent/DK2583677T1/da

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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    • A—HUMAN NECESSITIES
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    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
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Claims (17)

1. Kombination af mindst to direktevirkende antivirale midler (DAA) til anvendelse ved behandling af HTV, hvor nævnte behandling omfatter administrering af ribavirin, men ikke interferon, og nævnte behandling varer i 8, 9, 10, 11 eller 12 uger.
2. Kombination ifølge krav 1, hvor nævnte behandling varer i 12 uger.
3. Kombination ifølge krav 2, hvor nævnte mindst to DAA omfatter BMS-790052 og BMS-650032.
4. Kombination ifølge krav 3, hvor nævnte behandling er til behandling af en behandlings-naiv patient, som er inficeret med HCV-genotype 1.
5. Kombination ifølge krav 2, hvor nævnte mindst to DAA omfatter PSI-7977 og TMC-435.
6. Kombination ifølge krav 5, hvor nævnte behandling er til behandling af en behandlings-naiv patient, som er inficeret med HCV-genotype 1.
7. Kombination ifølge krav 2, hvor nævnte mindst to DAA omfatter PSI-7977 og daclatasvir.
8. Kombination ifølge krav 7, hvor nævnte behandling er til en behandlings-naiv patient, som er inficeret med HCV-genotype 1.
9. Kombination ifølge krav 2, hvor nævnte mindst to DAA omfatter PSI-7977 og GS-5885.
10. Kombination ifølge krav 9, hvor nævnte behandling er til en behandlings-naiv patient, som er inficeret med HCV-genotype 1.
11. Kombination ifølge krav 2, hvor nævnte mindst to DAA omfatter: forbindelse 1 eller et farmaceutisk acceptabelt salt heraf, og forbindelse 4 eller et farmaceutisk acceptabelt salt heraf, hvor forbindelse 1 eller saltet heraf administreres samtidigt med ritonavir.
12. Kombination ifølge krav 11, hvor nævnte behandling er til en behandlings-naiv patient, som er inficeret med HCV-genotype 1.
13. Kombination ifølge krav 2, hvor nævnte mindst to DAA omfatter: forbindelse 1 eller et farmaceutisk acceptabelt salt heraf, forbindelse 2 eller et farmaceutisk acceptabelt salt heraf, og forbindelse 4 eller et farmaceutisk acceptabelt salt heraf, hvor forbindelse 1 eller saltet heraf administreres sammen med ritonavir.
14. Kombination ifølge krav 13, hvor nævnte behandling er til en behandlings-naiv patient, som er inficeret med HCV-genotype 1.
15. Kombination ifølge krav 13, hvor nævnte behandling er til en interferon-non-responder, som er inficeret med HCV-genotype 1.
16. PSI-7977 til anvendelse ved behandling af HCV, hvor nævnte behandling omfatter administrering af ribavirin, men ikke interferon, og nævnte behandling varer i 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23 eller 24 uger.
17. PSI-799 ifølge krav 16, hvor nævnte behandling varer i 12 uger.
DK12189198.0T 2011-10-21 2012-10-19 Fremgangsmåder til behandling af HCV omfattende mindst to direktevirkende antivirale midler, ribavirin, men ikke inteferon DK2583677T1 (da)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161550352P 2011-10-21 2011-10-21
US201161562181P 2011-11-21 2011-11-21
US201261587225P 2012-01-17 2012-01-17
US201261600276P 2012-02-17 2012-02-17
US201261619870P 2012-04-03 2012-04-03
US201261656251P 2012-06-06 2012-06-06
US201261711830P 2012-10-10 2012-10-10

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US (2) US8853176B2 (da)
EP (1) EP2583677A3 (da)
JP (2) JP5677645B2 (da)
CN (2) CN104383541A (da)
AR (1) AR088463A1 (da)
AU (1) AU2013201406B2 (da)
BR (1) BR112014006314A2 (da)
CA (1) CA2811203C (da)
CH (1) CH707029B1 (da)
CL (1) CL2014000777A1 (da)
DE (5) DE202012012956U1 (da)
DK (1) DK2583677T1 (da)
DO (1) DOP2014000049A (da)
EA (1) EA201490837A1 (da)
ES (4) ES2572329B1 (da)
GB (4) GB2506086A (da)
HK (2) HK1199816A1 (da)
IL (2) IL230625A0 (da)
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PT (2) PT107894A (da)
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TW (1) TWI532487B (da)
UY (1) UY34402A (da)
WO (1) WO2013059630A1 (da)
ZA (1) ZA201507080B (da)

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