WO2014122537A3 - Pharmaceutical compositions and methods of treating hepatitis c virus infection using a combination of hydroxychloroquine and ribavirin - Google Patents

Pharmaceutical compositions and methods of treating hepatitis c virus infection using a combination of hydroxychloroquine and ribavirin Download PDF

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Publication number
WO2014122537A3
WO2014122537A3 PCT/IB2014/000760 IB2014000760W WO2014122537A3 WO 2014122537 A3 WO2014122537 A3 WO 2014122537A3 IB 2014000760 W IB2014000760 W IB 2014000760W WO 2014122537 A3 WO2014122537 A3 WO 2014122537A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydroxychloroquine
methods
ribavirin
combination
pharmaceutical compositions
Prior art date
Application number
PCT/IB2014/000760
Other languages
French (fr)
Other versions
WO2014122537A2 (en
Inventor
Gideon Stein
Philippe Halfon
Original Assignee
Genoscience Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genoscience Sa filed Critical Genoscience Sa
Publication of WO2014122537A2 publication Critical patent/WO2014122537A2/en
Publication of WO2014122537A3 publication Critical patent/WO2014122537A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Unit dosage form compositions and methods for preventing hepatitis C virus (HCV) replication in an HCV-infected subject are described herein, The compositions disclosed herein comprise amounts of hydroxychloroquine, or a pharmaceutically acceptable salt thereof, and ribavirin sufficient to prevent HCV replication. The methods of treatment disclosed herein comprise co-administering to the subject in need thereof therapeutically effective amounts of hydroxychloroquine and an antiviral agent for preventing HCV replication.
PCT/IB2014/000760 2013-02-05 2014-02-04 Pharmaceutical compositions and methods of treating hepatitis c virus infection using a combination of hydroxychloroquine and ribavirin WO2014122537A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361760834P 2013-02-05 2013-02-05
US61/760,834 2013-02-05

Publications (2)

Publication Number Publication Date
WO2014122537A2 WO2014122537A2 (en) 2014-08-14
WO2014122537A3 true WO2014122537A3 (en) 2014-11-06

Family

ID=51014568

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2014/000760 WO2014122537A2 (en) 2013-02-05 2014-02-04 Pharmaceutical compositions and methods of treating hepatitis c virus infection using a combination of hydroxychloroquine and ribavirin

Country Status (1)

Country Link
WO (1) WO2014122537A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240016901A1 (en) * 2020-05-28 2024-01-18 The Regents Of The University Of Michigan Compositions and methods for preventing and treating sars-cov-2 infection

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011161644A1 (en) * 2010-06-24 2011-12-29 Panmed Ltd. Treatment of hepatitis c virus related diseases using hydroxychloroquine or a combination of hydroxychloroquine and an anti-viral agent

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2546658A (en) 1949-07-23 1951-03-27 Sterling Drug Inc 7-chloro-4-[5-(n-ethyl-n-2-hydroxyethylamino)-2-pentyl] aminoquinoline, its acid addition salts, and method of preparation
US5314894A (en) 1992-09-15 1994-05-24 Sterling Winthrop Inc. (S)-(+)-hydroxychloroquine
US6849254B1 (en) 1999-04-19 2005-02-01 Schering Corporation HCV combination therapy
WO2001081359A1 (en) 2000-04-20 2001-11-01 Schering Corporation Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rna in patients having chronic hepatitis c infection
US7410979B2 (en) 2003-11-19 2008-08-12 Rigel Pharmaceuticals, Inc. Synergistically effective combinations of dihaloacetamide compounds and interferon or ribavirin against HCV infections
WO2006005610A1 (en) 2004-07-14 2006-01-19 Novartis Ag Use of a combination of cyclosporine and pegylated interferon for treating hepatitis c (hcv)
WO2012176149A1 (en) 2011-06-23 2012-12-27 Panmed Ltd. Treatment of hepatitis c virus

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011161644A1 (en) * 2010-06-24 2011-12-29 Panmed Ltd. Treatment of hepatitis c virus related diseases using hydroxychloroquine or a combination of hydroxychloroquine and an anti-viral agent

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHANDRAMOHAN M ET AL: "Preliminary report of anti-hepatitis C virus activity of chloroquine and hydroxychloroquine in huh-5-2 cell line", INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, MEDKNOW PUBLICATIONS PVT LTD, IN, vol. 68, no. 4, February 2006 (2006-02-01), pages 538 - 540, XP002664360, ISSN: 0250-474X, DOI: 10.4103/0250-474X.27842 *
DIENSTAG ET AL: "American Gastroenterological Association Technical Review on the Management of Hepatitis C", GASTROENTEROLOGY, ELSEVIER, PHILADELPHIA, PA, vol. 130, no. 1, January 2006 (2006-01-01), pages 231 - 264, XP005245699, ISSN: 0016-5085, DOI: 10.1053/J.GASTRO.2005.11.010 *
JESPER BROK ET AL: "Ribavirin Monotherapy for Chronic Hepatitis C Infection: A Cochrane Hepato-Biliary Group Systematic Review and Meta-Analysis of Randomized Trials", THE AMERICAN JOURNAL OF GASTROENTEROLOGY, vol. 101, no. 4, April 2006 (2006-04-01), pages 842 - 847, XP055129030, ISSN: 0002-9270, DOI: 10.1111/j.1572-0241.2006.00505.x *
MALIK ARSHAD H ET AL: "A pilot study of hydroxychloroquine in the treatment of chronic hepatitis C", GASTROENTEROLOGY, ELSEVIER, PHILADELPHIA, PA, vol. 116, no. 4, April 1999 (1999-04-01), pages A1242 - A1243, XP009154231, ISSN: 0016-5085 *
TANABE Y ET AL: "998 Direct inhibition of intracellular hepatitis C virus replication by ribavirin and its synergistic action used in combination with interferon-alpha", HEPATOLOGY (AASLD ABSTRACTS), WILEY, USA, vol. 38, January 2003 (2003-01-01), pages 637, XP004624209, ISSN: 0270-9139, DOI: 10.1016/S0270-9139(03)81036-4 *
THOMPSON A ET AL: "Directly acting antivirals for the treatment of patients with hepatitis C infection: A clinical development update addressing key future challenges", JOURNAL OF HEPATOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 50, no. 1, January 2009 (2009-01-01), pages 184 - 194, XP025769626, ISSN: 0168-8278, [retrieved on 20081104], DOI: 10.1016/J.JHEP.2008.10.011 *

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